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Scandinavian Journal of Clinical and Laboratory Investigation Volume 36, 1976 - Issue 7
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Original

Salicylate- and Aspirin-Induced Uncoupling of Oxidative Phosphorylation in Mitochondria Isolated from the Mucosal Membrane of the Stomach

T. Glarborg Jörgensen Institute for Experimental Research in Surgery, and Institute of Medical Anatomy B, University of Copenhagen, Copenhagen, Denmark
,
Ulla Sivertsen Weis-Fogh Institute for Experimental Research in Surgery, and Institute of Medical Anatomy B, University of Copenhagen, Copenhagen, Denmark
,
H. H. Nielsen Institute for Experimental Research in Surgery, and Institute of Medical Anatomy B, University of Copenhagen, Copenhagen, Denmark
&
H. P. Olesen Institute for Experimental Research in Surgery, and Institute of Medical Anatomy B, University of Copenhagen, Copenhagen, Denmark
Pages 649-654 | Received 01 Dec 1975, Accepted 02 Sep 1976, Published online: 14 Feb 2011

References

  • Brodie B.B., Hogben C.A.M. Some physico-chemical factors in drug action. J. Pharm. Pharmacol. 1957; 9: 345
  • Brody T.M. Action of sodium salicylate and related compounds on tissue metabolism in vivo. J. Pharmacol. exp. Ther. 1956; 117: 39
  • Chance B., Williams G.R. A simple and rapid assay of oxidative phosphorylation. Nature (Lond.) 1955; 175: 1120
  • Croft D.N. Aspirin and the exfoliation of gastric epithelial cells. Cytological and biochemical observations. Brit. med. J. 1963; 2: 897
  • Davenport H.W., Chaurg V.J. Evidence that glycosis contributes to gastric acid secretion. Amer. J.Physiol. 1952; 171: 1
  • Davenport H.W. Gastric mucosal injury by fatty and acetylsalicylic acids. Gastroenterohgy 1964; 46: 245
  • Estabrook R.W. Mitochrondrial respiratory control and the polarographic measurement of ADP: O ratio. Methods in Enzymology, R.W. Estabrook, H.E. Pullman. Academic Press, New York 1967; vol. 10: 41–57
  • Forte J.G. Metabolism of gastric mucosa. Fed. Proc. 1965; 24: 1382
  • Forte J.G., Adams P.H., Davies R.E. Acid secretion and phosphate metabolism in bullfrog gastric mucosa. Biochem. biophys. Acta (Amst.) 1965; 104: 25
  • Gilsdorf R.B., Sörensen R.M. Circulatory effectors of gastric mucosal potential difference. Gastroenterohgy 1974; 66: A-45
  • Jörgensen GlarborgT., Kaplan E.L., Peskin G.W. The mechanisms of action of salicylates on gastric acid secretion in vitro. Surg. Forum 1971; 22: 315
  • Jörgensen GlarborgT., Kaplan E.L., Pesking G.W. Salicylate effects on gastric acid secretion. Scand. J. clin. Lab. Invest. 1974; 33: 31
  • Jörgensen GlarborgT. The effect of salicylate on gastric mucosal potential difference and acid secretion. Europ. Surg. Res. 1974; 6(Suppl. 1)47
  • Huber W.G., Wallin R.F. Gastric secretion and ulcer formation in the pig. Swine in Biomedical Research, L.K. Bustad, R.O. McClellan. Batelle Memorial Institute. 1966; 121–27
  • Jagdish C.M., Young M.K., Rubulis A.A. Aspirin induced gastric mucosal injury in rats and adenyl cyclase. Biochem. Med. 1974; 11: 376
  • Janota I., Wincey C.W., Sandiford M., Smith M.J.H. Effect of salicylate on the activity of plasma enzymes in the rabbit. Nature (Lond.) 1960; 185: 935
  • Kent P.W., Allen A. The biosynthesis of intestinal mucins. The effect of salicylate on glyco-protein biosynthesis by sheep colonic and human gastric tissues in vitro. Biochem. J 1968; 106: 645
  • Lehninger A.L. The Mitochondrion. Molecular Basis of Structure and Function. W. A. Benjamin, Inc., New York & Amsterdam 1964
  • Lowry O., Rosebrough N.J., Farr A.L., Rose RandallJ. Protein measurement with folin phenol reagent. J. biol. Chem. 1951; 193: 265
  • Martin B.K. Accumulation of drug anions in gastric mucosal cells. Nature (Lond.) 1963; 198: 896
  • Max M., Menguy R. Influence of aspirin and phenylbutazone on rate of turn over of gastric mucosal cells. Digestion 1969; 2: 67
  • Menguy R., Masters Y.F. Effects of aspirin on gastric mucous secretion. Surg. Gynec. Obstet. 1965; 120: 92
  • Menguy R., Desbaillets L., Masters Y.F. Mechanism of stress ulcer. Influence of hypo-volemic shock on energy metabolism in the gastric mucosa. Gastroenterohgy 1974; 66: 46
  • Morris E., Noujaim A.A., Miya T.S., Christian J.E. Relationship between lesion production, absorption and distribution of 14C-labeled acetylsalicylic acid. J. pharm. Sci. 1967; 56: 896
  • Piper D.W., Clarke A.D., Whitecross D., Croydon M. Lactic acid in gastric juice. Scand. J. Gastroent. 1971; 6: 465
  • Ritchie W.P., Fisher R.P. Effect of metabolic inhibitors on the gastric mucosal barrier. Surgery 1973; 73: 614
  • Schneider W.C. Intracellular distribution of enzymes. J. biol. Chem. 1948; 176: 259
  • Thompkins L., Lee K.H. Studies on the mechanism of action of salicylates. IV: Effect of salicylates on oxidative phosphorylation. J. pharm. Sci. 1969; 58: 102
  • Weinbach E.C., Garbus J. Mechanism of action of reagents that uncouple oxidative phosphorylation. Nature (Lond.) 1969; 221: 1016
  • Whitehouse M.W., Bostrom H. Studies on the action of some anti-inflammatory agents in inhibiting the biosynthesis of mucopolysaccharide sulphates. Biochem. Pharmacol. 1961; 7: 135
  • Whitehouse M.W. Uncoupling of oxidative phosphorylation in a connective tissue (cartilage) and liver mitochondria by salicylate analogues: relationship of structure to activity. Biochem. Pharmacol. 1964; 13: 319

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