26
Views
60
CrossRef citations to date
0
Altmetric
Original Article

L-Pyroglutamyl-L-prolyl-L-valine-p-nitroanilide, a highly specific substrate for granulocyte elastase

, &
Pages 427-432 | Received 05 Jan 1983, Accepted 21 Apr 1983, Published online: 17 Mar 2010

References

  • Baugh R. J., Travis J. Human leukocyte granule elastase: rapid isolation and characterization. Biochemistry 1976; 15: 836
  • Bieger W., Scheele G. A sensitive and specific enzyme assay for elastase activity using α-(3H) elastin as substrate. Analyt. Biochem. 1980; 104: 239
  • Bieth J., Spiess B., Wermuth C. G. The synthesis and analytical use of a highly sensitive and convenient substrate of elastase. Biochem. Med. 1974; 11: 350
  • Blow A. M. J. Action of human lysosomal elastase on the oxidized β chain of insulin. Biochem. J. 1977; 161: 13
  • Castillo M. J., Nakajima K., Zimmerman M., Powers J. C. Sensitive substrates for human leukocyte and porcine pancreatic elastase: a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases. Analyt. Biochem. 1979; 99: 53
  • Feinstein G., Janoff A. A rapid method of purification of human granulocyte cationic neutral proteases: purification and further characterization of human granulocyte elastase. Biochim. biophys. acta. 1975; 404: 493
  • Hinman L. M., Stevens C. A., Matthay R. A., Gee J. B. L. Elastase and lysozyme activities in human alveolar macrophages. Effects of cigarette smoking. Am. Rev. resp. Dis. 1980; 121: 263
  • Keller S., Mandl I. Solubilized elastin as a substrate for elastase and elastase inhibitor determinations. Biochem. Med. 1971; 5: 342
  • Kramps J. A., Bakker W., Dijkman J. H. A matched-pair study of the leukocyte elastase-like activity in normal persons and in emphysematous patients with and without alpha1-antitrypsin deficiency. Am. Rev. resp. Dis 1980; 121: 253
  • Kramps J. A., Bakker W., Dijkman J. H. Reply to a letter to the editor from Janoff, A., Crawford, I. P. & Galdston, M. Am. Rev. resp. Dis. 1980; 21: 1059
  • Kramps J. A., Franken C. Low-molecular-weight protease inhibitor of the respiratory tract. Survey of Immunol. Res. 1982; 1: 30
  • Mainardi C. L., Dixit S. N., Kang A. H. Degradation of Type IV (basement membrane) collagen by a proteinase isolated from human polymorphonuclear leukocyte granules. J. biol. Chem. 1980; 255: 5435
  • McGillivray D. H., Burnett D., Afford S. C., Stockley R. A. An evaluation of four methods for the measurement of elastase activity. Clinica chim. Acta 1981; 111: 289
  • Nakajima K., Powers J. C., Ashe B. M., Zimmerman M. Mapping the extended substrate binding site of Cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the α1-protease inhibitor reactive site. J. biol. Chem. 1979; 254: 4027
  • Ogawa M., Kosaki G., Tanaka S., Iwaki K., Nomoto M. An activity of hydrolysing elastase substrate succinyltrialanine p-nitroanilide in human bile. Clinica chim. Acta 1979; 93: 235
  • Ohlsson K., Tegner H. Granulocyte collagenase, elastase and plasma protease inhibitors in purulent sputum. Eur. J. clin. Invest. 1975; 5: 221
  • Ohlsson K., Tegner H. Inhibition of elastase from granulocytes by the low molecular weight bronchial protease inhibitor. Scand. J. clin. Lab. Invest. 1976; 36: 437
  • Schiessler H., Hochstrasser K., Ohlsson K. Acid-stable inhibitors of granulocyte neutral proteases in human mucous secretions: Biochemistry and possible biological function. Neutral proteases of human polymorphonuclear leukocytes, K. Havemann, A. Janoff. Urban & Schwarzenberg, Baltimore 1978; 195
  • Simonsson R., Arielly S., Friberger P., Aurell L. Chromogenic substrates for granulocyte elastase, chymotrypsin and the subcomponents of C1-esterase. Thrombos. Haemostas. 1981; 46: 313, (abstract)
  • Snider G. L. Pathogenesis of emphysema and chronic bronchitis. Medical Clinics of North America 1981; 65: 647
  • Tegner H., Ohlsson K., Olsson I. The interactions between a low molecular weight protease inhibitor of bronchial mucus and chymotrypsin-like cationic proteins of granulocytes. Hoppe-Seyler's Z. physiol. Chem. 1977; 358: 431
  • Thompson R. C., Blout E. R. Restriction on the binding of proline-containing peptides to elastase. Biochemistry 1973; 12: 51
  • Visser L., Blout E. R. The use of p-nitrophenyl-N-tert-butyloxycarbonyl-L-alaninate as substrate for elastase. Biochim. biophys. acta 1972; 268: 257
  • Wenzel H. R., Engelbrecht S., Reich H., Mondry W., Tschesche H. Synthesis and analytical use of 3-carboxypropionyl-ananyl-ananyl- valine-4-nitroanilide: A specific substrate for human leukocyte elastase. Hoppe-Seyler's Z. physiol. Chem. 1980; 361: 1413
  • Werb Z., Gordon S. Elastase secretion by stimulated macrophages. Characterization and regulation. J. exp. Med. 1975; 142: 361
  • Zimmerman M., Ashe B. M. Substrate specificity of the elastase and the chymotrypsin-like enzyme of the human granulocyte. Biochim. biophys. acta 1977; 480: 241

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.