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Original Article

The elimination of trypsin-α-macroglobulin complexes from the blood circulation in pigs during acute pancreatitis and after massive intravenous trypsin infusion

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Pages 131-141 | Received 29 May 1986, Accepted 05 Sep 1986, Published online: 17 Mar 2010

References

  • Ranson J HC. Acute pancreatitis—where are we?. Surg Clin North Am 1981; 61: 55–70
  • Lasson å, Laurell A-B, Ohlsson K. Correlation among complement activation, protease inhibitors, and clinical course in acute pancreatitis in man. Scand J Gastroenterol 1985; 20: 335–45
  • Lasson å, Ohlsson K. Changes in the kallikrein kinin system during acute pancreatitis in man. Thromb Res 1984; 35: 27–41
  • Lasson å, Ohlsson K. Consumptive coagulopathy, fibrinolysis and protease-antiprotease interactions during acute human pancreatitis. Thromb Res 1986; 41: 167–84
  • Lombardi B, Rao K N. Acute hemorrhagic pancreatic necrosis in mice. Digestion 1982; 23: 57–64
  • Imrie C W, Mackenzie M. Effective aprotinin therapy in canine experimental bile-trypsin pancreatitis. Digestion 1981; 22: 32–8
  • MRC Multicentre Trial of Glucagon and Aprotinin. Death from acute pancreatitis. Lancet 1977; ii: 632–5
  • MRC Multicentre Trial. Morbidity of acute pancreatitis: The effect of aprotinin and glucagon. Gut 1980; 21: 334–9
  • Lasson å, Ohlsson K. Protease inhibitors in acute human pancreatitis. Correlation between biochemical changes and clinical course. Scand J Gastroenterol 1984; 19: 779–86
  • Lasson å, Ohlsson K. An in vitro study of the influence of plasma protease inhibitors and aprotinin on trypsin-induced C3 cleavage in human serum. Biochim Biophys Acta 1982; 709: 227–33
  • Lasson å, Dittmann B, Ohlsson K. Influence of plasma proteinase inhibitors and aprotinin on trypsin-induced bradykinin release in vitro in man. Hoppe Seylers Z Physiol Chem 1983; 364: 1315–22
  • Ohlsson K, Laurell C-B. The disappearance of enzyme-inhibitor complexes from the circulation of man. Clin Sci Mol Med 1976; 51: 87–92
  • Weström B R, Karlsson B W, Ohlsson K. Immuno-cross-reactivity between α-macro-globulins from pig, dog, rat and man including human pregnancy-associated α2-glycoprotein. Hoppe Seylers Z Physiol Chem 1983; 364: 375–81
  • Ohlsson K, Ganrot P-O, Laurell C-B. In vivo interaction between trypsin and some plasma proteins in relation to tolerance to intravenous infusion of trypsin in dog. Acta Chir Scand 1971; 137: 113–21
  • Weström B. Identification and characterization of trypsin, chymotrypsin and elastase inhibitors in porcine serum. Hoppe Seylers Z Physiol 1979; 360: 1869–78
  • Ohlsson K. Elimination of 125I-trypsin-α2-macroglobulin complexes from blood by reticuloendothelial cells in dog. Acta Physiol Scand 1971; 81: 269–72
  • Brodrick J W, Largman C, Ray S B, Geokas M C. Proteolysis of parathyroid hormone in vitro by sera from acute pancreatitis patients. Proc Soc Exp Biol Med 1981; 167: 588–96
  • Harpel P C, Mosesson M W. Degradation of human fibrinogen by plasma α2-macroglobulin-enzyme complexes. J Clin Invest 1973; 52: 2175–84
  • Hermon-Taylor J, Magee A I, Grant D AW, Jones P A, Marshall C E, Dunham J. Cleavage of peptide hormones by α2-macroglobulin-trypsin complex and its relation to the pathogenesis and chemotherapy of acute pancreatitis. Clin Chim Acta 1981; 109: 203–9
  • Largman C, Johnson J H, Brodrick J W, Geokas M C. Proinsulin conversion to desalanyl insulin by α2-macroglobulin-bound trypsin. Nature 1977; 269: 168–70
  • Rinderknecht H, Geokas M C. On the physiological role of α2-macroglobulin. Biochim Biophys Acta 1973; 295: 233–44
  • Adham N F, Song M K, Haberfelde G C. Relationship between the functional status of the reticuloendothelial system and the outcome of experimentally induced pancreatitis in young mice. Gastroenterology 1983; 84: 461–9
  • Ganz W, Dinoso R, Marcus H S, Forrester J S, Swan H JC. A new technique for measurement of cardiac output by thermodilution in man. Am J Cardiol 1971; 27: 393–6
  • Elliot D W, Williams R D, Zollinger R M. Activations in the pancreatic resistance to bile in the pathogenesis of acute pancreatitis. Ann Surg 1957; 146: 669–82
  • Balldin G, Eddeland A, Ohlsson K. Studies on the role of the plasma protease inhibitors on C3-activation in vitro and in acute pancreatitis. Scand J Gastroenterol 1981; 16: 603–9
  • Thorell J I, Johansson B G. Enzymatic iodination of polypeptides with 125I to high specific activity. Biochim Biophys Acta 1971; 251: 363–9
  • Laurell C-B. Electroimmunoassay. Scand J Clin Lab Invest 1972; 29(Suppl. 124)21–37
  • Weström B. Protease inhibitors in porcine serum and their immunological relationships to human protease inhibitors. Hoppe Seylers Z Physiol Chem 1979; 360: 1861–7
  • Ganrot P O. Crossed immunoelectrophoresis. Scand J Clin Lab Invest 1972; 29(Suppl. 124)39–47
  • Vernersson E, Ahlgren I, Aronsen K F, Koopmann H. The effects of lysine-vasopressin on haemodynamics during early post burned periods in pigs. Acta Chir Scand 1982; 148: 491–7
  • McMahon M J, Bowen M, Mayer A D, Cooper E H. Relation of α2-macroglobulin and other antiproteases to the clinical features of acute pancreatitis. Am J Surg 1984; 147: 164–70
  • Barrett A J, Starkey P M. The interaction of α2rnacroglobulin with proteinases. Biochem J 1973; 133: 709–24

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