Inhibition of nitric oxide synthase does not affect survival in a rat model of abdominal sepsis

References

• Moncada S, Palmer R MJ, Higgs E A. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 1991; 43: 109–42
   PubMed Web of Science ®Google Scholar
• Thiemermann C, Vane J. Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccaride in the rat in vivo. Eur J Pharmacol 1990; 182: 591–5
   PubMed Web of Science ®Google Scholar
• Nava E, Palmer R MJ, Moncada S. Inhibition of nitric oxide synthesis in septic shock: how much is beneficial?. Lancet 1991; 338: 1555–7
   PubMed Web of Science ®Google Scholar
• Kilbourne R G, Jubran A, Gross S S, Griffith O W, Levi R, Adams J, Lodato R F. Reversal of endo-toxin mediated shock by N-g-monomethyl-arginine, an inhibitor of nitric oxide synthesis. Biochem Biophys Res Commun 1990; 172: 1132–8
   PubMed Web of Science ®Google Scholar
• Robertson F M, Offner P J, Ciceri D P, Becker W K, Pruitt B A, Jr. Detrimental hemody-namic effects of nitric oxide synthase inhibition in septic shock. Arch Surg 1994; 129: 149–56
   PubMedGoogle Scholar
• Kilbourne R G, Gross S S, Lodato R F, Adams J, Levi R, Miller L L, et al. Inhibition of interleukin-1-induced nitric oxide synthase in vascular smooth muscle and full reversal of interleukin-1-alfa induced hypotension by N-omega-amino-L-arginine. J Natl Cancer Inst 1992; 84: 1008–16
   PubMedGoogle Scholar
• Petros A, Bennett D, Vallance P. Effect of nitric oxide synthase inhibitors in patients with septic shock. Lancet 1991; 338: 1557–8
   PubMed Web of Science ®Google Scholar
• Petros A, Lamb G, Leone A, Moncada S, Bennett D, Vallance P. Effects of nitric oxide synthase inhibitors in humans with septic shock. Cardiovasc Res 1994; 28: 34–9
   PubMed Web of Science ®Google Scholar
• Billar T R, Curran R D, Harbrecht B J, Stuehr D J, Demetris A J, Simmons R L. Modulation of nitric oxide synthesis in vivo: N-g-monomethyl-1-ar-ginine inhibits endotoxin-induced nitrite/nitrate biosynthesis while promoting hepatic damage. J Leu Biol 1990; 48: 565–9
   PubMedGoogle Scholar
• Nava E, Palmer R MJ, Moncada S. The role of nitric oxide in endotoxin shock: effects of L-NMMA. J Cardiovasc Pharmacol 1992; 20(Suppl 12)S132–4
   Google Scholar
• Hutcheson I R, Whittle B J, Boughton-Smith N K. Role of nitric oxide in maintaining vascular integrity in endotoxin-induced acute intestinal damage in the rat. Br J Pharmacol 1990; 101: 815–20
   PubMed Web of Science ®Google Scholar
• Shultz P, Raji L. Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis. J Clin Invest 1992; 90: 1718–25
   PubMed Web of Science ®Google Scholar
• Lundblad R, Giercksky K-E. The effect of volume support, antibiotic therapy and monoclonal anti-endotoxin antibodies on mortality and blood concentration of endothelin and other mediators in fulminant intra-abdominal sepsis in rats. Crit Care Med 1995; 23: 1382–90
   PubMedGoogle Scholar
• Brandtzág P, Kierulf P, Gaustad P, Skulberg A, Bruun J B, Halvorsen S, et al. Plasma endotoxin as a predictor of multiple organ failure and death in systemic meningococcal disease. J Inf Dis 1989; 159: 195–204
   PubMedGoogle Scholar
• Casey L, Balk R A, Bone R C. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Int Med 1993; 119: 771–8
   PubMed Web of Science ®Google Scholar
• Lowry S F. Sepsis and its complications: clinical definitions and therapeutic prospects. Crit Care Med 1994; 22: S1–2
   PubMedGoogle Scholar
• Teale D M, Atkinson A M. Inhibition of nitric oxide synthesis improves survival in a murine peritonitis model of sepsis that is not cured by antibiotics alone. J Antimicrob Chemother 1992; 30: 839–42
   PubMed Web of Science ®Google Scholar
• Evans T, Carpenter A, Silva A, Cohen J. Inhibition of nitric oxide synthase in experimental gram-negative sepsis. J Infect Dis 1994; 169: 343–9
   PubMed Web of Science ®Google Scholar
• Szabó C, Southan G J, Thiemermann C. Beneficial effects and improved survival in a rodent model of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of induc-ible nitric oxide synthase. Proc Natl Acad Sci (USA) 1995; 91: 12472–6
   Google Scholar
• Southan G J, Szabó C, Thiemermann C. Iso-thioureas: potent inhibitors of nitric oxide syn-thases with variable isoform selectivity. Br J Pharmacol 1995; 114: 510–16
   PubMed Web of Science ®Google Scholar
• Noether G. Introduction to statistics: a nonpara-metric approach2nd ed. Houghton Mifflin, Boston, Massachusetts 1976; 128–35
   Google Scholar
• Win N HH, Ishikawa T, Saito N, Kato M, Yokokura H, Watanabe Y, et al. A new and potent calmodulin antagonist, HF-2035, which inhibits vascular relaxation induced by nitric oxide synthase. Eur J Pharmacol 1996; 299: 119–26
   PubMedGoogle Scholar
• Griffiths M JD, Messent M, MacAllister R J, Evans T W. Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br J Pharmacol. 1993; 110: 963–8
   PubMed Web of Science ®Google Scholar
• MacAllister R J, Whitley G ST, Vallance P. Effects of guanidino and uremic compounds on nitric oxide pathways. Kidney Int 1994; 45: 737–42
   PubMed Web of Science ®Google Scholar
• Ohru T, Yamauchi K, Sekizawa K, Ohrawara Y, Maeyama K, Sasaki M, et al. Histamine N-methyltransferase controls the contractile responses of guinea pig trachea to histamine. J Pharmacol Exp Ther 1992; 261: 1268–72
   PubMedGoogle Scholar
• Eaton J D, Stevens E J, Tomlinson D R. Effects of aminoguanidine on prostacyclin release and interactions with L-N AME. Br J Pharmacol 1993; 108: 128P
   Google Scholar
• Kilbourne R G, Fonseca G A, Griffith O W, Ewer M, Price K, Striegel A, et al. NG-methyl-L-arginine, an inhibitor of nitric oxide synthase, reverses interleukin-2-induced hypotension. Crit Care Med 1995; 23: 1018–24
   PubMedGoogle Scholar
• Gross S S, Stuehr D, Aisaka K, Jaffe E A, Levi R, Griffith O W. Macrophage and endothelial cell nitric oxide synthesis: cell type selective inhibition by NG-nitroarginine and NG-methylarginine. Biochem Biophys Res Commun 1990; 170: 96–103
   PubMed Web of Science ®Google Scholar
• Buxton I LO, Cheek D J, Eckman D, Westfall D P, Sanders K M, Keef K D. NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarine receptor antagonists. Circ Res 1993; 72: 387–95
   PubMed Web of Science ®Google Scholar
• Almedahl S M, Nordstrand K, Melby K, Østerud B, Giercksky K-E. Faecal peritonitis in the rat—an experimental model for evaluation of surgical and adjuvant therapies. Acta Chirurg Scand 1985; 151: 213–16
   PubMedGoogle Scholar
• Almedahl S M, Østerud B, Melby K, Giercksky K-E. Mononuclear phagocyte throm-boplastin, bacterial counts and endotoxin levels in experimental endogenous gram negative sepsis. Acta Chirurg Scand 1986; 152: 351–5
   PubMedGoogle Scholar
• Lundblad R, Giercksky K-E. Endothelin concentrations in experimental sepsis: profiles of big endothelin and endothelin 1–21 in lethal peritonitis in rats. Eur J Surg 1995; 161: 9–16
   PubMedGoogle Scholar
• Lundblad R, Sandven P, Giercksky K E. The physical nature of large bowel perforation predicts severity of the subsequent inflammatory response. Shock 1995; 3: 455–61
   PubMedGoogle Scholar
• Lundblad R, Giercksky K E. The synergistic effects of E5, imipenem and volume support during fulminant intraabdominal sepsis in rats. J Infect Dis 1995; 172: 152–60
   PubMedGoogle Scholar
• Wright C E, Rees D D, Moncada S. The protective and pathological roles of nitric oxide in endotoxin shock. Cardiovasc Res 1992; 26: 48–57
   PubMed Web of Science ®Google Scholar