Advanced search
Publication Cover
Scandinavian Journal of Clinical and Laboratory Investigation Volume 59, 1999 - Issue 1
Submit an article Journal homepage
128
Views
32
CrossRef citations to date
0
Altmetric
Research Article

Influence of iron deficiency anaemia on haemoglobin A2 levels: possible consequences for ß?thalassaemia screening

E. J Harthoorn-Lasthuizen Laboratory of Haematology; Bosch Medicentrum's-Hertogenbosch, The Netherlands,
,
J Lindemans Department of Clinical Chemistry, Akademisch Ziekenhuis Rotterdam, The Netherlands and
&
M. M. A. C Langenhuijsen Department of Haematology; Vrije Universiteit Amsterdam, The Netherlands
Pages 65-70 | Published online: 08 Jul 2009

REFERENCES

  • Steinberg MH, Adams JG. Hemoglobin A2: Origin, evolution and aftermath. Blood 1991; 78: 2165 — 77.
  • Galanello R, Turco MP, Barella S, et al. Iron stores and iron deficiency anemia in children heterozy-gous for fl-thalassemia. Haematologica 1990; 75: 319 — 22.
  • Hinchliffe RF, Lilleyman JS. Frequency of coinci-dent iron deficiency and fl-thalassaemia trait in British Asian children. J Clin Pathol 1995; 48: 594 — 5.
  • England JM, Fraser PM. Discrimination between iron-deficiency and heterozygous thalassemia syn-dromes in differential diagnosis of microcytosis. Lancet 1979; i: 145 — 8.
  • Hastka J, Lasserre J-J, Schwarzbeck A, Reiter A, Hehlmann R. Laboratory tests of iron status: cor-relation or common sense. Clin Chem 1996; 42: 718— 24.
  • Pootrakul P, Wattanasaree J, Anuwatanakulchai M, Wasi P. Increased red blood cell protoporphyrin in thalassemia: a result of relative iron deficiency. Am J Clin Pathol 1984; 82: 289 — 93.
  • Harthoorn-LasthuizenEJ,LindemansJ,Langenhuijsen MMAC. Combined use of erythro- cyte zinc protoporphyrin and mean corpuscular volume in differentiation of thalassaemia from iron deficiency anaemia. Eur J Haematol 1998; 60: 245 — 51.
  • Cook JD. Iron-deficiency anaemia. In: Hershko C, editor. Baillière's clinical haematology; clinical dis-orders of iron metabolism. Bailliere Tindall 1994; 7: 787 — 805.
  • Schifman RB, Finley PR. Measurement of near-normal concentrations of erythrocyte protopor-phyrin with the hematofluorimeter: influence of plasma on front surface illumination assay. Clin Chem 1981; 27: 153 — 6.
  • Galan P, Mekki N, Hereberg S. Effect of sample storage on the assay of erythrocyte protoporphyrin by the hematofluorometer method. Acta Haematol 1987; 78: 57 — 8.
  • Wasi P, Disthasongchan P, Na-Nakorn S. The effect of iron deficiency on the levels of hemoglobin A2 and E. J Lab Clin Med 1968; 71: 85 — 91.
  • Steiner J, Marti HR, Dean D. Decreased hemoglo-bin A2 concentration in iron deficiency anemia. Acta Haematol 1971; 45: 77 — 81.
  • Ali MAM, Schwertner E. Hemoglobin A2 level. A proposed test for confirming the diagnosis of iron deficiency. Am J Clin Pathol 1975; 63: 549 — 53.
  • Okuno T, Chou A. The significance of small ery-throcytes. Am J Clin Pathol 1975; 64: 48— 52.
  • Alperin JB, Dow PA, Petteway MB. Hemoglobin A2 levels in health and various hematologic disor-ders. Am J Clin Pathol 1977; 67: 219 — 26.
  • Galanello R, Ruggeri R, Addis M, Paglietti E, Cao A. Hemoglobin A2 in iron deficient fl-thalassemia heterozygotes. Hemoglobin 1981; 5: 613 — 18.
  • Zago MA, Bottura C. Bone marrow and peripheral blood globin chain biosynthesis in iron deficiency. Blut 1982; 44: 159 — 64.
  • Samperi P, Testa R, Mancuso M, Schiliro G. Com-parative approach to the evaluation of hemoglobin A2 by two different methods: High-performance liquid chromatography and DE-52 microchromato-graphy. Acta Haematol 1990; 83: 179 — 82.
  • Rai R, Pati H, Sehgal AK, Sundaram KR, Saraya AK. Hemoglobin A2 in iron deficiency and megalo-blastic anemia: relation with severity and etiology of anemia. Indian Pediatr 1987; 24: 301 — 5.
  • Aghai E, Shabbad E, Quitt M, Froom P. Discrimi-nation between iron deficiency and heterozygous beta-thalassemia in children. Am J Clin Pathol 1986; 85: 710— 12.
  • Labbe RF, Rettmer RL. Zinc protoporphyrin: a product of iron deficient erythropoiesis. Semin Hematol 1989; 26: 40 — 6.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.