A Multicenter, Randomized, Double-Blind Clinical Trial Examining the Effect of Oral Human Recombinant Epidermal Growth Factor on the Healing of Duodenal Ulcers

References

• Wright NA, Pike C, Elia G. Induction of a novel epidermal growth factor secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells. Nature 1990;343:82–5.
   PubMed Web of Science ®Google Scholar
• Barton CM, Hall PA, Hughes CM, Gullick WJ, Lemoine NR. Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer. J Pathol 1991;163:111–6.
   PubMed Web of Science ®Google Scholar
• Konturek SJ. Role of epidermal growth factor in gastroprotection and ulcer healing. Scand J Gastroenterol 1989;23:129–33.
   Web of Science ®Google Scholar
• Thompson JS, Saxena SK, Greaton C, Schultz G, sharp JG. The effect of route of delivery of urogastrone on intestinal regeneration. Surgery 1989;106:45–51.
   PubMed Web of Science ®Google Scholar
• Konturek SJ, Brzozowski T, Bielanski W, Warzecha Z, Drozdowicz D. Epidermal growth factor in the gastroprotective and ulcer-healing actions of sucralfate in rats. Am J Med 1989; 86:32–7.
   PubMed Web of Science ®Google Scholar
• Konturek SJ, Brzozowski T, Majka J, Dembinski A, Slomiany BL. Transforming growth factor alpha and epidermal growth factor in protection and healing of gastric mucosal injury. Scand J Gastroenterol 1992;27:649–55.
   PubMed Web of Science ®Google Scholar
• Blay J, Brown KD. Epidermal growth factor promotes the chemotactic migration of culture rat intestinal epithelial cells. J Cell Physiol 1985;124:107–12.
   PubMed Web of Science ®Google Scholar
• Goodlad RA, Wilson TJG, Lenton W, Gregory H, Mc Cullagh KG, Wright NA. Proliferative effects of urogastrone-EGF on the intestinal epithelium. Gut 1987;28:37–42.
   PubMed Web of Science ®Google Scholar
• Gregory H, Thomas CE, Young JA, Willshire IR, Garner A. The contribution of the C-terminal undecapeptide sequence of urogastrone-epidermal growth factor to its biological action. Regul Pep 1988;22:217–26.
   PubMedGoogle Scholar
• Barnard JA, Beauchamp RD, Russel WE, Dubois RN, Coffey RJ. Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology 1995;108: 564–80.
   PubMed Web of Science ®Google Scholar
• Sarosiek J, Bilski J, Murty VLN, Slomiany A, Slomiany BL. Role of salivary epidermal growth factor in the maintenance of physiochemical characteristics of oral and gastric mucosal mucus coat. Biochem Biophys Res Commun 1988;152:1421–7.
   PubMed Web of Science ®Google Scholar
• Kelly SM, Hunter JO. Epidermal growth factor stimulates synthesis and secretion of mucus glycoproteins in human gastric mucosa. Clin Sci 1990;79:425–7.
   Web of Science ®Google Scholar
• Cartlidge SA, Elder JB. Transforming growth factor and epidermal growth factor levels in normal human gastrointestinal mucosa. Br J Cancer 1989;60:657–60.
   PubMed Web of Science ®Google Scholar
• Mori M, Naito R, Tsukitani K, Okada Y, Tsujimura T. Widespread distribution of human epidermal growth factor in human tissues and organs under normal and tumorous conditions immunohistochemical studies with the use of polyclonal and monoclonal antibodies. Acta Histochem Cytochem 1989;22:15–34.
   Web of Science ®Google Scholar
• Borges H, Martínez A, López LD, Ung-Lau E, Mella CM, Hernández-Bernal F, et al. Human recombinant epidermal growth factor accelerate the burns healing in children. Double blind study. Biotecnol Apl 1994;11:204–8.
   Google Scholar
• Martínez A, López LD, Pérez R, Hernández-Bernal F, Gonzalez T, Lépez-Saura P, et al. Use of human recombinant epidermal growth factor in silver sulfadiazine cream in the treatment of burned patients. Biotecnol Apl 1994;11:209–12.
   Google Scholar
• Barroso MC, Diaz C, Alsina S, Areces F, Vazquez E. Human recombinant epidermal growth factor in the treatment of radiogenic ulcers. Biotecnol Apl 1993;10:12–3.
   Google Scholar
• Berlanga J, Caballero ME, Remírez D, Torres A, Valenzuela C, Playford RJ. Epidermal Growth Factor protects against carbon tetrachloride-induced hepatic injury. Clin Sci 1998;94:219–23.
   Google Scholar
• Berlanga J, Caballero ME, Lodos J, Lopez-Saura P, Remirez D, RJ, Playford. Epidermal growth factor prevents multi-organ failure induced by thioacetamide. Gut 1999;44 Suppl 1:W280.
   Google Scholar
• González T, Berlanga J, Pérez LC. Progresses in non clinical studies of the human recombinant epidermal growth factor in Cuba. Adv Mod Biotechnol 1994;2:202.
   Google Scholar
• Slomiani BL, Liu J, Yao P, Wu-wang CY, Keogh JP, Wang SL, et al. Characterization of the epidermal growth factor receptor in the gastric mucosa. Digestion 1990;47:181–90.
   Google Scholar
• Haedo W, González T, Más JA, Franco S, Gra B, Alonso A, et al. Oral human recombinant epidermal growth factor in the treatment of patients with duodenal ulcer. Rev Esp Enf Digest 1996;88:409–13.
   PubMed Web of Science ®Google Scholar
• Burgess AW. Epidermal growth factor and transforming growth factor alpha. Br Med Bull 1989;45:401–24.
   PubMed Web of Science ®Google Scholar
• Orsini B, Brocchi A, Calabro A. Radioimmunoassay of epidermal growth factor in human saliva and gastric juice. Clin Biochem 1991;24:135–41.
   PubMed Web of Science ®Google Scholar
• Hayashi T, Sakamoto S. Radioimmunoassay of human epidermal growth factor levels in human body fluids. J Pharmacobio- dyn 1988;11:146–51.
   PubMedGoogle Scholar
• Cochet C. Epidermal growth factor receptor: structure and regulation. Growth Factors Oncogenes 1989;190:13–24.
   Google Scholar
• Thompson JF. Specific receptors for epidermal growth factor in rat intestinal microvillus membranes. Am J Physiol 1988;254: G429–35.
   PubMed Web of Science ®Google Scholar
• Playford RJ, Hanby AM, Gschmeissner S, Peiffer LP, Wright NA, McGarrity T. The epidermal growth factor is present on the basolateral, but not the apical, surface of enterocytes in the human gastrointestinal tract. Gut 1996;39:262–6.
   PubMed Web of Science ®Google Scholar
• Sarosiek J, McCallum. The interrelationship between salivary epidermal growth factor and the functional integrity of the esophageal mucosal barrier in the rat. Am J Med Sci 1991;302: 359–63.
   PubMed Web of Science ®Google Scholar
• Wu MS, Shun CT, Lee WC, Chen CJ, Wang HP, Lee WJ, et al. Gastric cancer risk in relation to Helicobacter pylori infection and subtypes of intestinal metaplasia. Br J Cancer 1998;78: 125–8.
   PubMed Web of Science ®Google Scholar
• Konturek PC, Bobrzynski A, Konturek SJ, Bielanski W, Faller G, Kirchner T, et al. Epidermal growth factor and transforming growth factor alpha in duodenal ulcer and non-ulcer dyspepsia patients before and after Helicobacter pylori eradication. Scand J Gastroenterol 1998;33:143–51.
   PubMed Web of Science ®Google Scholar
• Slomiany BL, Piotrowski J, Slomiany A. Susceptibility of growth factors to degradation by Helicobacter pylori protease: effect of ebrotidine and sucralfate. Biochem Mol Biol Int 1996; 40:209–15.
   Google Scholar
• Itoh M, Matsuo Y. Gastric ulcer treatment with intravenous human epidermal growth factor: a double-blind controlled clinical study. J Gastroenterol Hepatol 1994;9:S78–83.
   PubMed Web of Science ®Google Scholar
• Hixson LJ. Current trends in the pharmacotherapy for peptic ulcer disease. Arch Intern Med 1992;152:726–32.
   PubMedGoogle Scholar
• Hu PJ, Li Y, Zhou MH, Chen MH, Du GG, Huang BJ, et al. Helicobacter pylori associated with a high prevalence of duodenal ulcer disease and a low prevalence of gastric cancer in a developing nation. Gut 1995;36:198–202.
   PubMed Web of Science ®Google Scholar
• Feldman M, Cryer B, Lee E. Effects of Helicobacter pylori gastritis on gastric secretion in healthy human beings. Am J Physiol 1998;37:G1011–7.
   Google Scholar
• Talley NJ, Ormand JE. Is antibacterial therapy against Campylobacter pylori useful in the treatment of indigestion and chronic peptic ulceration? Trends Pharmacol Sci 1989; 10:36–40.
   PubMed Web of Science ®Google Scholar
• Slomiani BL, Nishikawa H, Bilski J, Slomiani A. Colloidal bismuth subcitrate inhibits peptic degradation of gastric mucus and epidermal growth factor in vitro. Am J Gastroenterol 1990; 85:390–3.
   PubMed Web of Science ®Google Scholar
• Slomiani BL, Liu J, Keogh JP, Piotrowski J, Slomiani A. Enhancement of gastric mucosal epidermal growth factor and platelet-derived growth factor receptor expression by sucralfate. Gen Pharmacol 1992;23:715–8.
   PubMedGoogle Scholar
• Slomiani BL, Piotrowski J, Czajkowski A, Yotsumoto F, Slomiany A. Gastric mucosal EGF and PDGF receptor expression with ulcer healing by ebrotidine. Am J Gastroenterol 1994;89:894–7.
   PubMed Web of Science ®Google Scholar
• Andrade RJ, Lucena MI, Martin-Vivaldi R, Fernandez MC, Nogueras F, Pelaez G, et al. Acute liver injury associated with the use of ebrotidine, a new H2-receptor antagonist. J Hepatol 1999;31: 641–6.
   Google Scholar