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Research Article

Role of Nitric Oxide and Endothelin-1 in a Portal Hypertensive Rat Model

Pages 1097-1105 | Published online: 08 Jul 2009

References

  • Genecin P, Groszmann RJ. Portal hypertension. In: Schiff L, editor. Diseases of the liver. 7th ed. Philadelphia: JB Lippincott; 1993. p. 935–73.
  • Genecin P, Groszmann RJ. Biology of portal hypertension. In: Arias I, Boyer JL, Fausto N, et al., editors. The liver: biology and pathophysiology. New York: Raven Press; 1994. p. 1327–42.
  • Vorobioff J, Bredfeldt JE, Groszmann RJ. Hyperdynamic circulation in portal-hypertensive rat model: a primary factor maintenance of chronic portal hypertension. Am J Physiol 1983;244 (Gastrointest Liver Physiol):G52.
  • Rockey DC, Chung JJ. Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension. Gastroenterology 1998;114:344–51.
  • Gupta TK, Toruner M, Chung MK, Groszmann RJ. Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats. Hepatology 1998; 28:926–31.
  • Garcia-Tsao G, Angulo P, Garcia JC, Groszmann RJ, Cadeline G. The diagnostic and predictive value of ascites nitric oxide levels in patients with spontaneous bacterial peritonitis. Hepatology 1998;28:17–21.
  • Tanoue K, Ohta M, Tarnawski AS, Wahlstrom KJ, Sugimachi K, Sarfeh IJ. Portal hypertension activates the nitric oxide synthase genes in the esophageal mucosa of rats. Gastroenterology 1996;110:549–57.
  • Martínez-Cuesta MA, Moreno L, Piqué JM, Bosch J, Radigo J, Esplugues JV. Nitric oxide-mediated β2-adrenocepter relaxation is impaired in mesenteric veins from portal-hypertensive rats. Gastroenterology 1996;111: 727–35.
  • Fernández M, García-Pagán JC, Casadevall M, Mourelle MI, Pique JM, Bosch J, et al. Acute and chronic cyclooxygenase blockade in portal-hypertensive rats: influence on nitric oxide biosynthesis. Gastroenterology 1996;110:1529–35.
  • Casadevall M, Piqué JM, Cirera I, Goldin E, Elizalde I, Panes J, et al. Increased blood hemoglobin attenuates splanchnic vasodilatation in portal-hypertensive rats by nitric oxide inactivation. Gastroenterology 1996;110:1156–65.
  • Niederberger M, Genès P, Martin PY, Tsai P, Morris K, McMurtry I, et al. Comparison of vascular nitric oxide production and systemic hemodynamics in cirrhosis versus prehepatic portal hypertension in rats. Hepatology 1996;24: 947–51.
  • Mathie RT, Ralevic V, Moore KP, Burnstock G. Mesenteric vasodilatation responses in cirrhotic rats: a role for nitric oxide? Hepatology 1996;23:130–6.
  • Ferraz JGP, Wallace JL. Prostaglandins modulate the responsiveness of the gastric microcirculation to sodium nitroprusside in cirrhotic rats. Hepatology 1996;23:123–9.
  • Niederberger M, Martin PY, Ginès P, Morris K, Tsai P, Xu DL, et al. Normalization of nitric oxide production corrects arterial vasodilation and hyperdynamic circulation in cirrhotic rats. Gastroenterology 1995;109:1624–30.
  • Fernández M, García-Pagán JC, Casadevall M, Bernadich C, Piera C, Whittle BJR, et al. Evidence against a role for inducible nitric oxide synthase in the hyperdynamic circulation of portalhypertensive rats. Gastroenterology 1995;108:1487–95.
  • Ros J, Clària J, Jiménez W, Bosch-Marce M, Angeli P, Arroyo V, et al. Role of nitric oxide and prostacyclin in the control of renal perfusion in experimental cirrhosis. Hepatology 1995;22: 915–20.
  • Cahill PA, Foster C, Redmond EM, Gingalewski C, Wu Y, Sitzmann JV, et al. Enhanced nitric oxide synthase activity in portal hypertensive rabbits. Hepatology 1995;22:598–606.
  • Clària J, Jiménez W, Ros J, Rigol M, Angeli P, Arroyo V, et al. Increased nitric oxide-dependent vasorelaxation in aortic rings of cirrhotic rats with ascites. Hepatology 1994;20:1615–21.
  • Sieber CC, Lopez-Talavera JC, Groszmann RJ. Role of nitric oxide in vitro splanchnic vascular hyporeactivity in ascitic cirrhotic rats. Gastroenterology 1993;104:1750–4.
  • Castro A, Jiménez W, Clària J, Martinez J, Bosch J, Arroyo AV, et al. Impaired responsiveness to angiotensin II in experimental cirrhosis: role of nitric oxide. Hepatology 1993;18:367–72.
  • Reiling N, Ulmer AJ, Duchrow M, Ernst M, Flad HD, Hauschildt S, et al. Nitric oxide synthase: mRNA expression of different isoforms in human monocytes/macrophages. Eur J Immunol 1994;24:1941–4.
  • MacNaul KL, Hutchinson NI. Differential expression of iNOS and cNOS mRNA in human vascular smooth muscle cells and endothelial cells under normal and inflammatory conditions. Biochem Biophys Res Commun 1993;196:1330–4.
  • Poo JL, Jimenez W, Munoz RM, Bosch-Marce M, Bordas N, Morales-Ruiz M, et al. Chronic blockade of endothelin receptors in cirrhotic rats: hepatic and hemodynamic effect. Gastroenterology 1998;116:161–7.
  • Sogni P, Moreau R, Gomola A, Gadano A, Cailmail S, Calmus Y, et al. Beneficial hemodynamic effects of Bosentan, a mixed ETA and ETB receptor antagonist, in portal hypertensive rats. Hepatology 1998;28:655–9.
  • Cahill PA, Hou MC, Hendrickson R, Wang YN, Zhang S, Redmond EM, et al. Increased expression of endothelin receptors in the vasculature of portal hypertensive rats: role in splanchnic hemodynamics. Hepatology 1998;28: 396–403.
  • Rockey DC, Weisiger RA. Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance. Hepatology 1996; 24:233–40.
  • Tanoue K, Kitano S, Hashizume M, Wada H, Sugimachi KI. A rat model of esophageal varices. Hepatology 1991;13:353–8.
  • Panes J, Bordas JM, Pique JM, Bosch J, Garcia-Pagen JC, Feu F, et al. Increased gastric mucosal perfusion in cirrhotic patients with portal hypertensive gastropathy. Gastroenterology 1992; 103:1875–82.
  • Ohta M, Hashizume M, Higashi H, Ueno K, Tomikawa M, Kishihara F, et al. Portal and gastric mucosal hemodynamics in cirrhotic patients with portal-hypertensive gastropathy. Hepatology 1994;20:1432–6.
  • Kotzampassi K, Eleftheriadis E, Aletras H. Gastric mucosal blood flow in portal hypertension patients: a laser Doppler flowmetry study. Hepatogastroenterology 1992;39:39–42.
  • Guslandi M, Sorghi M, Foppa L, Braga PC, Tittobello A. Congestive gastropathy versus chronic gastritis: a comparison of some pathophysiological aspects. Digestion 1993;54:160–2.
  • Iwao T, Toyonaga A, Ikegami M, Oho K, Sumino M, Harada H, et al. Reduced gastric mucosal blood flow in patients with portal-hypertensive gastropathy. Hepatology 1993;18:36–40.
  • Feld AD, Fondacaro JD, Holloway GA, Jacobsen ED. Laser Doppler velocimetry: a new technique for the measurement of intestinal mucosal blood flow. Gastrointest Endosc 1984;30: 225–30.
  • Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and 15N-nitrate in biological fluids. Anal Biochem 1982;126:131–8.
  • Archer S. Measurement of nitric oxide in biological models. FASEB J 1993;7:349–60.
  • Stewart DJ, Levy RD, Cernacek P, Langleben D. Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease? Ann Intern Med 1991;114:464–9.
  • Dupuis J, Stewart DJ, Cernacek P, Gosselin G. Human pulmonary circulation is an important site for both clearance and production of endothelin-1. Circulation 1996;94:1578–84.
  • Buxton ILO, Cheek DJ, Eckman D, Westfall DP, Sanders KM, Keef KD, et al. NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists. Circ Res 1993;72:387–95.
  • Corbett JA, Tilton RG, Chang K, Hasan KS, Ido Y, Wang JL, et al. Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. Diabetes 1992;41:552.
  • Misko TP, Moore WM, Kasten TP, Nickols GA, Corbett JA, Tilton RG, et al. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur J Pharm 1993;233:119–25.
  • Moore K, Wendon J, Frazer M, Karani J, Williams R, Badr K. Plasma endothelin immunoreactivity in liver disease and the hepatorenal syndrome. N Engl J Med 1992;327:1774–8.
  • Asbert M, Gines A, Gines P, Jimenez W, Claria J, Salo J, et al. Circulating levels of endothelin in cirrhosis. Gastroenterology 1993;104:1485–91.
  • Yu PC, Kuo JS, Lin HC, Yang MC. Effects of endothelin in portal hypertensive rats. Clin Sci 1992;83:165–70.
  • Hartleb M, Moreau R, Caimail S, Gaudin C, Lebrec D. Vascular hyporesponsiveness to endothelin-1 in rats with cirrhosis. Gastroenterology 1994;107: 1085–93.

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