33
Views
11
CrossRef citations to date
0
Altmetric
Research Article

Utilization of Short-Chain Fatty Acids by Colonic Mucosal Tissue Strips: A New Method of Assessing Colonic Mucosal Metabolism

Pages 659-666 | Published online: 08 Jul 2009

References

  • References
  • Roediger WEW. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut 1980;21:793–8.
  • Roediger WEW. Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterology 1982;83:424–9.
  • Roediger WEW. The colonic epithelium in ulcerative colitis— an energy deficiency disease? Lancet 1980;2:712–5.
  • Finnie IA, Taylor BA, Rhodes JM. Ileal and colonic epithelial metabolism in quiescent ulcerative colitis: increased glutamine metabolism in distal colon but no defect in butyrate metabolism. Gut 1993;34:1552–8.
  • Chapman MAS, Grahn MF, Giamundo P, O’Connell PR, Onwu D, Hutton M, et al. New technique to measure mucosal metabolism and its use to map substrate utilization in the healthy human large bowel. Br J Surg 1993;80:445–9.
  • Harig JM, Soergel KH, Komorowski RA, Wood CM. Treatment of diversion colitis with short-chain fatty acid irrigation. N Engl J Med 1989;320:23–8.
  • Zhang J, Wu G, Chapkin RS, Lupton JR. Energy metabolism of rat colonocytes changes during the tumorigenic process and is dependent on diet and carcinogen. J Nutr 1998;128:1262–9.
  • Fitch MD, Fleming SE. Metabolism of short-chain fatty acids by rat colonic mucosa in vivo. Am J Physiol 1999;277:G31–40.
  • Clausen MR, Mortensen PB. Kinetic studies on the metabolism of short-chain fatty acids and glucose by isolated rat colonocytes. Gastroenterology 1994;106:423–32.
  • Jørgensen JR, Mortensen PB. Oxidation of short and medium chain C2-C8 fatty acids in Sprague-Dawley rat colonocytes. Gut 1997;40: 400–5.
  • Clausen MR, Mortensen PB. Kinetic studies on colonocyte metabolism of short chain fatty acids and glucose in ulcerative colitis. Gut 1995;37:684–9.
  • Kight CE, Fleming SE. Nutrient Oxidation by rat intestinal epithelial cells is concentration dependent. J Nutr 1993;123:876–81.
  • Roediger WEW, Truelove SC. Method of preparing isolated colonic epithelial cells (colonocytes) for metabolic studies. Gut 1979;20:484–8.
  • Krebs HA, Henseleit K. Untersuchungen über die harnstoffbildung im tierkörper. Hoppe-Seylers Z Physiol Chem 1932;210:33–66.
  • Williamson DH, Mellanby J. D-(-)-3-Hydroxybutyrate. In: HU Bergmeyer, editor. Methods of enzymatic analysis. New York: Academic Press; 1974. p. 1836–9.
  • Mellanby J, Williamson DH. Acetoacetate. In: HU Bergmeyer, editor. Methods of enzymatic analysis. New York: Academic Press; 1974. p. 1840–3.
  • Stryer L, editor. Biochemistry. San Francisco: WH Freeman; 1975.
  • Roediger WEW, Duncan A, Kapaniris O, Millard S. Reducing sulfur compounds of the colon impair colonocyte nutrition: implications for ulcerative colitis. Gastroenterology 1993;104:802–9.
  • Darcy-Vrillon B, Cherbuy C, Morel M-T, Durand M, Duée P-H. Short chain fatty acid and glucose metabolism in isolated pig colonocytes: modulation by NH4+. Moll Cell Biochem 1996;156: 145–51.
  • Jørgensen JR, Mortensen PB. Influence of feces from patients with ulcerative colitis on butyrate oxidation in rat colonocytes. Dig Dis Sci 1999;44:2099–109.
  • Cummings JH, Pomare EW, Branch WJ, Naylor CP, Macfarlane GT. Short chain fatty acids in the human large intestine, portal, hepatic and venous blood. Gut 1987;28:1221–7.
  • Dankert J, Zijlstra JB, Wolthers BG. Volatile fatty acids in human peripheral and portal blood: quantitative determination by vacuum distillation and gas chromatography. Clin Chim Acta 1981;110:301–7.
  • Peters SG, Pomare EW, Fisher CA. Portal and peripheral blood short chain fatty acid concentrations after caecal lactulose instillation at surgery. Gut 1992;33:1249–52.
  • Chapman MA, Grahn MF, Boyle MA, Hutton M, Rogers J, Williams NS. Butyrate oxidation is impaired in the colonic mucosa of sufferers of quiescent ulcerative colitis. Gut 1994;35:73–6.
  • Lewis SJ, Heaton KW. Increasing butyrate concentration in the distal colon by accelerating intestinal transit. Gut 1997;41:245–51.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.