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Research Article

p21/waf1/cip1 in Gastric Cancer: Associations with Histopathological Subtypes, Lymphonodal Metastasis, Prognosis and p53 Status

Pages 975-980 | Published online: 08 Jul 2009

References

  • Tahara E. Molecular biology of gastric cancer. World J Surg 1995;19:484–8.
  • Pines J. Protein kinases and cell cycle control. Semin Cell Biol 1994;5:399–408.
  • Sherr CJ. Cancer cell cycles. Science 1996;274:1672–7.
  • Tsihlias J, Kapusta L, Slingerland J. The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. Annu Rev Med 1999;50:401–23.
  • Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D. P21 is an universal inhibitor of cyclin kinases. Nature (Lond) 1993;366:701–4.
  • Michieli P, Chedid M, Lin D, Pierce JH, Mercer WE, Givol D. Induction of p21/waf1/cip1 by a p53-independent pathway. Cancer Res 1994;54:3391–5.
  • El Eiry WS. P21/p53, cellular growth control and genomic integrity. Curr Top Microbiol Immunol 1998;227:121–37.
  • Park YE, Choi KC, Choi YH. P21 expression and mutation in gastric carcinoma: analysis by immunohistochemistry and PCR-SSCP. J Korean Med Sci 1998;13: 507–12.
  • Gomyo Y, Ikeda M, Osaki M, Tatebe S, Tsujitani S, Ikeguchi M, et al. Expression of p21 (waf1/cip1/sdi1), but not p53 protein, is a factor in the survival of patients with advanced gastric carcinoma. Cancer 1997;79:2067–72.
  • Jang SJ, Ahn MJ, Paik SS, Kong, G, Keum JS, Park YW, et al. Expression of cyclin dependent kinase inhibitor p21WAF1 alone and in combination with p27KIP1 shows prognostic value in gastric carcinoma. J Korean Med Sci 1998;13:369–76.
  • Ogawa M, Maeda K, Onoda N, Chung YS, Sowa M. Loss of p21WAF1/CIP1 expression correlates with disease progression in gastric carcinoma. Br J Cancer 1997;75: 1617–20.
  • Oyagi K, Oufuji K, Odama I, Yano S, Ohta J, Takamiya H, et al. The significance of p21 expression in gastric cancer. Gan To Kagaku Ryoho 1997;24 Suppl 2:285–91.
  • Ikeguchi M, Saito H, Katano K, Tsujitani S, Maeta M, Kaibara N. Expression of p53 and p21 are independent prognostic factors in patients with serosal invasion by gastric carcinoma. Dig Dis Sci 1998;43:964–70.
  • Merz H, Malisius R, Mannweiler S, Zhou R, Hartmann W, Orscheschek K, et al. Immunomax, a maximized immunohistochemical method for the retrieval and enhancement of hidden antigens. Lab Invest 1995;73:145–56.
  • Zirbes TK, Baldus SE, Moenig SP, Nolden S, Kunze D, Shafizadeh ST, et al. Prognostic impact of p21/waf1/cip1 in colorectal cancer. Int J Cancer (Pred Oncol) 2000;89:14–8.
  • Zirbes TK, Baldus SE, Monig SP, Schneider PM, Fromm S, Nolden S, et al. Immunohistochemical detection of p53 protein in gastric and colorectal cancer: a comparative study of different methods. Arch Anat Cytol Path Clin Exp Path 1998;46:417.
  • Jackson DP, Lewis FA, Taylor GR, Boylston AW, Quirke P. Tissue extraction of DNA and RNA and analysis by the polymerase chain reaction. J Clin Pathol 1990;43:499–504.
  • Shibata D. Extraction of DNA from paraffin-embedded tissue for analysis by polymerase chain reaction: new tricks from an old friend. Hum Pathol 1994;25:561–3.
  • Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, et al. Mutations in the p53 gene occur in diverse human tumour types. Nature 1989;342:705–8.
  • Schneider PM, Casson AG, Levin B, Garewal HS, Hoelscher AH, Becker K, et al. Mutations of p53 in Barrett’s oesophagus and Barrett’s cancer: a prospective study of ninety-eight cases. J Thorac Cardiovasc Surg 1996;111:323–31.
  • Müller W, Noguchi T, Wirtz HC, Hommel G, Gabbert HE. Expression of cell-cycle regulatory proteins D1, cyclin E, and their inhibitor p21 WAF1/CIP1 in gastric cancer. J Pathol 1999; 189:186–93.
  • Martin HM, Filipe MI, Morris RW, Lane DP, Silvestre F. P53 expression and prognosis in gastric carcinoma. Int J Cancer 1992;50: 859–62.
  • Joypaul BV, Hopwood D, Newman EL, Qureshi S, Grant A, Ogston SA, et al. The prognostic significance of the accumulation of p53 tumor-suppressor gene protein in gastric adenocarcinoma. Br J Cancer 1994;69:943–6.
  • Starzynska T, Markiewski M, Domagala W, Marlicz K, Mietkiewski J, Roberts SA, et al. The clinical significance of p53 accumulation in gastric carcinoma. Cancer 1996;77:2005–12.
  • Motojima K, Furui J, Kohara N, Ito T, Kanematsu T. Expression of p53 protein in gastric carcinomas is not independently prognostic. Surgery 1994;116: 890–5.
  • Lim BHG, Soong R, Grieu F, Robbins PD, House AK, Iacopetta BJ. P53 accumulation and mutation are prognostic indicators of poor survival in human gastric carcinoma. Int J Cancer (Pred Oncol) 1996;69:200–4.
  • Müller W, Borchard F. Prognostic influence of p53 expression in gastric cancer. J Pathol 1996;178: 255–8.
  • Victorzon M, Nordling S, Haglund C, Lundin J, Roberts PJ. Expression of p53 protein as a prognostic factor in patients with gastric cancer. Eur J Cancer 1996;32A:215–20.
  • Mönig SP, Eidt S, Zirbes TK, Stippel D, Baldus SE, Pichlmaier H. P53 expression in gastric cancer: clinicopathological correlation and prognostic significance. Dig Dis Sci 1997;42: 2463–7.
  • Hurlimann J, Saraga EP. Expression of p53 protein in gastric carcinomas. Am J Surg Pathol 1994;18:1247–53.
  • Schneider BG, Hilsenbeck SG, Hensel CH, Pekkel V, Shelton CH, Rodriguez-Martinez HA, et al. P53 mutations in gastric and colorectal cancers in Texas Hispanics versus Anglos. Virchows Archiv 1994;424: 187–93.
  • Gabbert HE, Müller W, Schneiders A, Meier S, Hommel G. The relationship of p53 expression to the prognosis of 418 patients with gastric carcinoma. Cancer 1995;76:720–6.
  • Miyazaki M, Ohashi R, Tsuji T, Mihara K, Gohda E, Namba M. Transforming growth factor beta 1 stimulates or inhibits cell growth via down-or up-regulation of p21/waf1. Biochem Biophys Res Commun 1998;246:873–80.
  • Soong R, Robbins PD, Dix BR, Grieu F, Lim B, Knowles S, et al. Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas. Hum Pathol 1996;27:1050–5.

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