HFE Haemochromatosis Gene Mutations in Liver Transplant Patients

References

• Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996;13: 399–408.
   PubMed Web of Science ®Google Scholar
• Calandro L, Thorsen T, Barcellos L, Griggs J, Baer D, Sensabaugh GE. Mutation analysis in hereditary hemochromatosis. Blood Cell Mol Dis 1996;22:194A–94B.
   Google Scholar
• Jazwinska EC, Cullen LM, Busfield F, Pyper WR, Webb SI, Powell LW, et al. Haemochromatosis and HLA-H. Nat Genet 1996;14:249–51.
   PubMed Web of Science ®Google Scholar
• Jouanolle AM, Gandon G, Jezequel P, Blayau M, Champion ML, Yaouang J, et al. Haemochromatosis and HLA-H. Nat Genet 1996;14:251–2.
   PubMed Web of Science ®Google Scholar
• Adams PC, Chakrabarti S. Genotypic/phenotypic correlations in genetic hemochromatosis: evolution of diagnostic criteria. Gastroenterology 1998;114:319–23.
   PubMed Web of Science ®Google Scholar
• EASL international consensus conference on haemochromatosis. J Hepatology 2000;33:485–504.
   PubMed Web of Science ®Google Scholar
• Grove J, Daly AK, Burt AD, Guzail M, James OFW, Basendine MF, et al. Heterozygotes for HFE mutations have no increased risk of advanced alcoholic liver disease. Gut 1998;43:262–6.
   PubMedGoogle Scholar
• Ludwig J, Hashimoto E, Porayko MK, Moyer TP, Baldus WP. Hemosiderosis in cirrhosis: a study of 447 native livers. Gastroenterology 1997;112: 882–8.
   Google Scholar
• Bulaj ZJ, Griffen LM, Jorde LB, Edwards CQ, Kushner JP. Clinical and biochemical abnormalities in people heterozygous for hemochromatosis. N Engl J Med 1996;335:1799–805.
   Google Scholar
• Bonkovsky HL, Jawaid Q, Tortorelli K, LeClair P, Cobb J, Lambrecht RW, et al. Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in nonalcoholic steatohepatitis. J Hepatol 1999;31:421–9.
   PubMedGoogle Scholar
• Kazemi-Shirazi L, Datz C, Maier-Dobbersberger T, Kaserer K, Hackl F, Polli C, et al. The relation of iron status and hemochromatosis gene mutations in patients with chronic hepatitis C. Gastroenterology 1999;116:127–34.
   Google Scholar
• Rabinovitz M, Gavaler JS, Kelly RH, Van Thiel DH. Association between heterozygous alpha 1-antitrypsin deficiency and genetic hemochromatosis. Hepatology 1992;16: 145–8.
   Google Scholar
• Beutler E. Genetic irony beyond hemochromatosis: clinical effects of HLA-H mutations. Lancet 1997;349:296–7.
   PubMed Web of Science ®Google Scholar
• Syvänen A-C, Aalto-Setälä K, Haiju L, Kontula K, Söderlund H. A primer-guided nucleotide incorporation assay in the genotyping of apolipoprotein E. Genomics 1990;8:684–92.
   PubMedGoogle Scholar
• Searle JW, Kerr JFR, Halliday JW, Powell LW. Iron storage disease. In: MacSween RNM, Anthony PP, Scheuer PJ, editors. Pathology of the liver, 3rd ed. Edinburgh: Churchill Livingstone; 1994.
   Google Scholar
• Alanen K, Chakrabarti S, Rawlings J, Howson W, Jeffrey G, Adams P. Prevalence of the C282Y mutation of the hemochromatosis gene in liver transplant recipients and donors. Hepatology 1999;30:665–9.
   PubMedGoogle Scholar
• Merryweather-Clarke AT, Pointon JJ, Shearman JD, Robson KJH. Global prevalence of putative haemochromatosis mutations. J Med Genet 1997;34:275–8.
   Google Scholar
• Distante S, Berg JP, Lande K, Haug E, Bell H. High prevalence of the hemochromatosis-associated Cys282Tyr HFE gene mutation in a healthy Norwegian population in the city of Oslo and its phenotypic expression. Scand J Gastroenterol 1999; 34:529–34.
   Google Scholar
• Ajioka RS, Jorde LB, Gruen JR, Yu P, Dimitrova D, Barrow J, et al. Haplotype analysis of hemochromatosis: evaluation of different lingake-disequilibrium approaches and evolution of disease chromosomes. Am J Hum Genet 1997;60:1439–47.
   PubMedGoogle Scholar
• Tuomainen TP, Kontula K, Nyyssönen K, Lakka TA, Heliö T, et al. Increased risk of acute myocardial infarction in carriers of the haemochromatosis gene Cys282Tyr mutation: a prospective cohort study in eastern Finland. Circulation 1999;100: 1274–9.
   Google Scholar
• Brandhagen DJ, Alvarez W, Therneau TM, Kruckeberg KE, Thibodeau SN, Ludwig J, et al. Iron overload in cirrhosis: HFE genotypes and outcome after liver transplantation. Hepatology 2000;31:456–60.
   PubMedGoogle Scholar
• Hezode C, Cazeneuve C, Coue O, Roudot-Thoraval F, Lonjon I, Bastie A, et al. Liver iron accumulation in patients with chronic active hepatitis C: prevalence and role of hemochromatosis gene mutations and relationship with hepatic histological lesions. J Hepatol 1999;31:979–84.
   Google Scholar
• Smith BC, Grove J, Guzail MA, Dau CP, Daly AK, Burt AD, et al. Heterozygosity for hereditary hemochromatosis is associated with more fibrosis in chronic hepatitis C. Hepatology 1998;27: 1695–9.
   PubMed Web of Science ®Google Scholar
• George DK, Goldwurm S, MacDonald GA, Cowley LL, Walker NI, Ward PJ, et al. Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. Gastroenterology 1998;114:311–8.
   PubMed Web of Science ®Google Scholar
• Fargion S, Bissoli F, Fracanzani AL, Suigo E, Sergi C, Taioli E, et al. No association between genetic hemochromatosis and α1-antitrypsin deficiency. Hepatology 1996;24:11614.
   Google Scholar
• Sharrard MJ, Durkie M, Tanner MS. Genetic hemochromatosis in α1-antitrypsin deficient liver disease. Hepatology 1997;26: 1366.
   Google Scholar
• Fiel MI, Schiano TD, Bodenheimer HC, Thung SN, King TW, Varma CR, et al. Hereditary hemochromatosis in liver transplantation. Liver Transpl Surg 1999;5:50–6.
   PubMedGoogle Scholar
• Cotler SJ, Bronner MP, Press RD, Carlson TH, Perkins JD, Emond MJ, et al. End-stage liver disease without hemochromatosis associated with elevated hepatic iron index. J Hepatol 1998;29:257–62.
   PubMed Web of Science ®Google Scholar
• Pascoe A, Kerlin P, Steadman C, Clouston A, Jones D, Powell L, et al. Spur cell anaemia and hepatic iron stores in patients with alcoholic liver disease undergoing orthotopic liver transplantation. Gut 1999;45:301–5.
   PubMed Web of Science ®Google Scholar