Advanced search
Publication Cover
Scandinavian Journal of Gastroenterology Volume 36, 2001 - Issue 12
Submit an article Journal homepage
28
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Transfer of Clarithromycin to Gastric Juice is Enhanced by Omeprazole in Helicobacter pylori -Infected Individuals

J. Pedrazzoli Jr, S. A. Calafatti, R. A. M. Ortiz, F. E. Dias, M. Deguer, F. D. Mendes, A. P. Bento, A. A. Pereira, H. Piovesana, J. G. P. Ferraz, F. Lerner, G. de Nucci
Pages 1248-1253 | Published online: 08 Jul 2009

  • NIH Consensus Conference. NIH Consensus development panel on Helicobacter pylori in peptic ulcer disease. JAMA 1994;272: 65-9.
  • Erah PO, Goddard AF, Barrett, DA, Shaw PN, Spiller RC. The stability of amoxycillin, clarithromycin and metronidazole in gastric juice: relevance to the treatment of Helicobacter pylori infection. JAC 1997:39:5-12.
  • Penston JG, McCoIl KEL. Eradication of Helicobacter pylori: an objective assessment of current therapies. Br J Clin Pharmacol 1997;43:223-43.
  • Van Zanten SJV, Pollack T, Kapoor H, Yeung PK. Effect of omeprazole on movement of intravenous! y administered metronidazole into gastric juice and its significance in treatment of Helicobacter pylori. Dig Dis Sci 1996;41:1845-52.
  • El-Omar EM, Penman ID, Ardill JES, Chittajallu RS, Howie C, McCoIl EL Helicobacter pylori infection and abnormalities of secretion in patients with duodenal ulcer disease. Gastroenterology 1995;109:681-91.
  • El-Omar EM, Oien K, El-Nujumi A, Gillen D, Wirz A, Dahill S, et al. Helicobacter pylori infection and chronic gastric acid secretion. Gastroenterology 1997;113:15-24.
  • Kuipers EJ. Helicobacter pylori and the risk and management of associated diseases: gastritis, ulcer disease, atrophie gastritis and gastric cancer. Aliment Pharmacol Ther 1997;11 suppl 1:71-88.
  • Kromer W. Similarities and differences in the properties of substituted benzimidazoles : a comparison between pantoprazole and related compounds. Digestion 1995;56:443-54.
  • Howden CW, Forrest JAH, Reid JL. Effects of single and repeated doses of omeprazole on gastric acid and pepsin secretion in man. Gut 1984;24:707-10.
  • Calafatti AS, Santos A, Da Silva CMF, Deguer M, Carvalho AF Jr, Mendes FD. Transfer of metronidazole to gastric juice: impact of Helicobacter pylori infection and omeprazole. Scand J Gastroenterol 2000;35:699-704.
  • Peterson WL, Graham DY, Marshall B, Blaser MJ, Genta RM, Klein PD. Clarithromycin as monotherapy for eradication of Helicobacter pylori: a randomized, double blind trial. Am J Gastroenterol 1993;88:1860-4.
  • Gustavson LE, Kaiser JF, Edmonds AL, Locke CS, De Bartolo ML, Schneck DW. Effect of omeprazole on gastric concentrations of clarithromycin in plasma and gastric tissue at steady state. Antimicrob Agents Chemother 1995;39:2078-87.
  • Chu S-Y, Deaton R, Cavanaugh J. Absolute bioavailability of clarithromycin after oral administration in humans. Antimicrob Agents Chemother 1992;36:1147-50.
  • Goddard AF, Jessa MJ, Barrett DA, Shaw N, Idstrom J-P, Cederberg C, et al. Effect of omeprazole on the distribution of metronidazole, amoxicillin and clarithromycin in human gastric juice. Gastroenterology 1996;111:358-67.
  • Lind T, Mégraud F, Unge P, Bayerdoerffer E, O'Morain C, Spiller R, et al. The MACH 2 study: role of omeprazole in eradication of Helicobacter pylori with 1-week triple therapies. Gastroenterology 1999;116:248-54.
  • Hassan MA, Hobsley M. Positioning of subject and of nasogastric tube during a gastric secretion study. Br Med J 1970;1: 458-60.
  • Hauschke D, Steinjans VW, Diletti E. A distribution-free procedure for the statistical analysis of bioequivalence studies. Int J Clin Pharmacol Ther Toxicol 1990;28:72-7.
  • Schall R, Hundt HT, Luus HG. Pharmacokinetics characteristics for extent of absorption and clearance in drug/drug interaction studies. Int J Clin Pharmacol Ther Toxicol 1994;32:633-7.
  • Gruebel P, Cave DR. Factors affecting solubility and penetration of clarithromycin through gastric mucus. Aliment Pharmacol Ther 1998;12:569-76.
  • Ota H, Genta RM. Morphological characterization of the gastric mucosa during infection with H. pylori. In: Ernst PB, Michetti P, Smith PD, editors. The immunobiology of H. pylori. From pathogenesis to prevention. Philadelphia, Pa.: Lippincott-Raven; 1997. p. 15-28.
  • Goddard AF. Getting the route of Helicobacter pylori treatment. JAC 1998;42:1-3.
  • Rowland M, Tozer TN. Clinical pharmacokinetics: Concepts and applications, 3rd ed. Baltimore, MD. Williams & Wilkins; 1995. p. 109-18.
  • Goddard AF. Factors influencing antibiotic transfer across the gastric mucosa [review]. Aliment Pharmacol Ther 1998;12: 1175-84.
  • Shore PA, Brodie BB, Hogben CAM. The gastric secretion of drugs: a pH partition hypothesis. J Pharm Exp Ther 1957;119: 361-9.
  • Sherwood PV, Wibawa JI, Goddard AF, Barret DA, Shaw PN, Spiller RC. Acid secretion determines gastric metronidazole transfer. Gastroenterology 1999;14 Suppl:G1352.
  • Holm-Rutili L. Effects of omeprazole on gastric mucosal microcirculation and acid secretion in the rat. Gastroenterology 1987;92:716-23.
  • Crothers JM, Jr., Chow DC, Forte JG. Omeprazole decreases H(+)-K(+)-ATPase protein and increases permeability of oxyntic secretory membranes in rabbits. Am J Physiol 1993 265: G231-41.
  • Goddard AF, Spiller RC. The effect of omeprazole on gastric juice viscosity, pH and bacterial counts. Aliment Pharmacol Ther 1996;10:105-9.
  • Adamek RJ, Suerbaum Ó, Pfaffenbach B, Opferkuch W. Primary and acquired Helicobacter pylori resistance to clarithromycin, metronidazole, and amoxicillin--influence on treatment outcome. Am J Gastroenterol 1998;93:386-9.
  • Hartzen SH, Andersen LP, Bremmelgaard A, Colding H, Arpi M, Kristiansen J. Antimicrobial susceptibility testing of 230 Helicobacter pylori strains: importance of medium, inoculum and incubation time. Antimicrob Agents Chemother 1997;41: 2634-9.
  • Loo VG, Fallone CA, De Souza E, Lavallée J, Barkun NA. In-vitro susceptibility of Helicobacter pylori to ampicillin, clarithromycin, metronidazole and omeprazole. JAC 1997;40: 881-3.
  • Atherton JC, Cockayne A, Balsitis M, Kirk GE, Hawkey CJ, Spiller RC. Detection of the intragastric sites at which Helicobacter pylori evades treatment with amoxycillin and cimetidine. Gut 1995;00:670-4.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.