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Scandinavian Journal of Gastroenterology Volume 36, 2001 - Issue 12
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Research Article

Lactose Malabsorption and Intolerance in the Elderly

M. Di Stefano, G. Veneto, S. Malservisi, A. Strocchi, G. R. Corazza
Pages 1274-1278 | Published online: 08 Jul 2009

  • Flatz G. Genetics of lactose digestion in humans. Adv Human Genet 1987;16:1-77.
  • Sahi T. Genetics and epidemiology of adult-type hypolactasia. Scand J Gastroenterol 1994;29 Suppl 202:7-20.
  • Bayless TM, Rothfeld B, Massa C, Wise L, Paige D, Bedline MS. Lactose and milk intolerance: clinical implications. N Engl J Med 1975;292:1156-9.
  • Büller HA, Kothe MJC, Goldman DA, Grubman SA, Sasak WV, Matsudaiza PT, et al. Coordinate expression of lactase-phlorizin hydrolase mRNA and enzyme levels in rat intestine during development. J Biol Chem 1990;265:6978-83.
  • Holt PR, Tierney AR, Kotler DP. Delayed enzyme expression: a defect of aging rat gut. Gastroenterology 1985;89:1026-34.
  • Holt PR, Heller TD, Richardson AG. Food restriction retards age-related biochemical changes in rat small intestine. J Gerontol 1991;46:B89-94.
  • Lee MF, Russell RM, Montgomery RK, Krasinski SD. Total intestinal lactase and sucrase activities are reduced in aged rats. J Nutr 1997;127:1382-7.
  • Welsh JD, Poley JR, Bhatia M, Stevenson DE. Intestinal disaccharidase activities in relation to age, race, and mucosal damage. Gastroenterology 1978;75:847-55.
  • Wallis JL, Lipski PS, Mathers JC, James OFW, Hirst BH. Duodenal brush-border mucosal glucose transport and enzyme activities in aging man and effect of bacterial contamination of the small intestine. Dig Dis Sci 1993;38:403-9.
  • Triadou N, Bataille J, Schmitz J. Longitudinal study of the human intestinal brush border membrane proteins. Distribution of the main disaccharidases and peptidases. Gastroenterology 1983;85:1326-32.
  • Rorick MH, Scrimshaw NS. Comparative tolerance of elderly from differing ethnic backgrounds to lactose-containing and lactose-free dairy drinks: a double-blind study. J Gerontol 1979; 34:191-6.
  • Rao DR, Bello H, Warren AP, Brown GE. Prevalence of lactose maldigestion. Influence and interaction of age, race and sex. Dig Dis Sei 1994;39:1519-24.
  • Suarez FL, Savaiano DA. Lactose digestion and tolerance in adult and elderly Asian-Americans. Am J Clin Nutr 1994;59: 1021-4.
  • Godding A, Taylor RW, Keil D, Gold E, Lewis-Earned NJ, Williams SM. Lactose malabsorption and rate of bone loss in older women. Age Ageing 1999;28:175-80.
  • Saltzberg DM, Levine GM, Lubar C. Impact of age, sex, race, and functional complaints on hydrogen (H2) production. Dig Dis Sei 1988;33:308-13.
  • Haboubi NY, Hudson P, Rahman Q, Lee GS, Ross A. Small-intestinal transit time in the elderly. Lancet 1988;i:933.
  • McEvoy A, Dutton J, James OFW. Bacterial contamination of the small intestine is an important cause of occult malabsorption in the elderly. Br Med J 1983;287:789-93.
  • Corazza GR, Benati G, Strocchi A, Malservisi S, Gasbarrini G. The possible role of breath methane measurement in detecting carbohydrate malabsorption. J Lab Clin Med 1994;124:695-700.
  • Hankin JH. Development of a diet history questionnaire for studies of older persons. Am J Clin Nutr 1989;50:1121-7.
  • Istituto Italiano della Nutrizione. Tabelle di composizione degli alimenti. Roma, 1983.
  • Corazza GR, Strocchi A, Gasbarrini G. Fasting breath hydrogen in celiac disease. Gastroenterology 1987;93:53-8.
  • Corazza GR, Strocchi A, Sorge M, Benati G, Gasbarrini G. Prevalence and consistency of low breath H2 excretion following lactulose ingestion. Possible implications for the clinical use of the H2 breath test. Dig Dis Sci 1993;38:2010-6.
  • Kotler DP, Holt PR, Rosensweig NS. Modification of the breath hydrogen test: increased sensitivity for the detection of carbohydrate malabsorption. J Lab Clin Med 1982;100:798-805.
  • LaBrooy SJL, Male PJ, Beavis AK, Misiewicz JJ. Assessment of reproducibility of the lactulose H2 breath test as a measure of mouth to caecum transit time. Gut 1983;24:893-6.
  • Strocchi A, Levitt MD. Factors affecting hydrogen production and consumption by human fecal flora. The critical roles of hydrogen tension and methanogenesis. J Clin Invest 1992;89: 1304-11.
  • Metz G, Jenkins DJA, Peters TJ, Newman A, Blendis LM. Breath hydrogen as a diagnostic method for hypolactasia. Lancet 1975;1:1155-7.
  • Rosado JD, Solomons NW. Sensitivity and specificity of the hydrogen breath-analysis test for detecting malabsorption of physiological doses of lactose. Clin Chem 1983;29:545-8.
  • Suarez FL, Savaiano DA, Levitt MD. A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance. N Engl J Med 1995;333:1-4.
  • Rodhes JM, Middleton P, Jewell DP. The lactulose hydrogen breath test as a diagnostic test for small-bowel bacterial over-growth. Scand J Gastroenterol 1979;14:333-6.
  • Holt PR, Yeh KY, Kotier DP. Altered control s of proliferation in proximal small intestine of the senescent rat. Proc Natl Acad Sci 1988;85:2771-5.
  • Corazza GR, Ginaldi L, Quaglione G, Ponzielli F, Vecchio L, Quaglino D, et al. Proliferating cell nuclear antigen expression is increased in small bowel epithelium in the elderly. Mech Ageing Develop 1998;104:1-9.
  • Lasch H, Castell DO, Castell JA. Evidence for diminished visceral pain with aging: studies using graded intraesophageal balloon distension. Am J Physiol 1997;272 (Gastrointestinal Liver Phisiol 35):G1-3.
  • Ren J, Shaker R, Kusano M, Podvrsan B, Metwally N, Dua KS, et al. Effect of aging on the secondary esophageal peristalsis: presbyesophagus revisited. Am J Physiol 1995;268 (Gastroin-testinal Liver Physiol 31):G772-9.
  • Corazza GR, Benati G, Di Sario A, Tarozzi C, Strocchi A, Passed M, et al. Lactose intolerance and bone mass in post-menopausal Italian women. Br J Nutr 1995;73:479-87.
  • Suarez FL, Savaiano D, Arbisi P, Levitt MD. Tolerance to the daily ingestion of two cups of milk by individuals claiming lactose intolerance. Am J Clin Nutr 1997:65:1502-6.
  • Suarez FL, Adshead J, Furne JK, Levitt MD. Lactose maldigestion is not an impediment to the intake of 1500mg calcium daily as dairy products. Am J Clin Nutr 1998;68:1118-22.
  • Bullamore JR, Wilkinson R, Gallagher JC, Nordin BE, Marshall DH. Effects of age on calcium absorption. Lancet 1970;2:535-7.
  • Ireland P, Fordtran JS. Effect of dietary calcium and age on jejunal calcium absorption in humans studied by intestinal perfusion. J Clin Invest 1973;52:2672-81.

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