Advanced search
Publication Cover
Scandinavian Journal of Gastroenterology Volume 36, 2001 - Issue 12
Submit an article Journal homepage
144
Views
55
CrossRef citations to date
0
Altmetric
Research Article

Regular-dose versus High-dose Omeprazole in Peptic Ulcer Bleeding A Prospective Randomized Double-blind Study

M. Udd, P. Miettinen, A. Palmu, M. Heikkinen, E. Janatuinen, P. Pasanen, R. Tarvainen, M. V. Kairaluoma, M. Lohman, H. Mustonen, R. Julkunen
Pages 1332-1338 | Published online: 08 Jul 2009

  • Wara P. Endoscopie prediction of major rebleeding - a prospective study of stigmata of hemorrhage in bleeding ulcer. Gastroenterology 1985;88:1209-14.
  • Jaramillo JL, Gálvez C, Carmona C, Montero JL, Miño G. Prediction of further hemorrhage in bleeding peptic ulcer. Am J Gastroenterol 1994;89:2135-8.
  • Mueller X, Rothenbuehler J-M, Amery A, Harder F. Factors predisposing to further hemorrhage and mortality after peptic ulcer bleeding. J Am Coll Surg 1994;179:457-61.
  • Branicki FJ, Coleman SY, Lam TCF, Schroeder D, Tuen HH, Cheung WL, et al. Hypotension and endoscopie stigmata of recent haemorrhage in bleeding peptic ulcer: risk models for bleeding and mortality. J Gastroenterol Hepatol 1992;7:184-90.
  • Griffiths WJ, Neumann DA, Welsh JD. The visible vessel as an indicator of uncontrolled or recurrent gastrointestinal hemorrhage. N Engl J Med 1979;300:1411-3.
  • Williams RA, Vartany A, Davis IP, Wilson SE. Impact of endoscopie therapy on outcome of operation for bleeding peptic ulcers. Am J Surg 1993;166:712-5.
  • O'Brien JD, Days SJ, Burnham WR. Controlled trial of small bipolar probe in bleeding peptic ulcers. Lancet 1986;1:464-7.
  • Lin HJ, Lee FY, Kang WM, Tsai YT, Lee SD, Lee CH. Heat probe thermocoagulation and pure alcohol injection in massive peptic haemorrhage. A prospective randomised controlled trial. Gut 1990;31:753-87.
  • Rutgeerts P, Rauws E, Wara P, Swain P, Hoos A, Solleder E, et al. Randomised trial of single and repeated fibrin glue compared with injection of polidocanol in treatment of bleeding peptic ulcer. Lancet 1997;350:692-6.
  • Sacks HS, Chalmers TC, Blum AL, Berrier J, Pagano D. Endoscopie haemostasis. An effective therapy for bleeding peptic ulcers. JAMA 1990;264:494-9.
  • Green FW, Kaplan MM, Curtis LE, Levine PR Effect of acid and pepsin on blood coagulation and platelet aggregation. Gastroenterology 1978;74:38-43.
  • Cederberg C, Thomson A, Mahachai V, Westin J-U+0226, Kirdeikis P, Fisher D, et al. Effect of intravenous and oral omeprazole on 24 hour intragastric acidity in duodenal ulcer patients. Gastroenterology 1992;103:913-8.
  • Kiilerich S, Elsborg L. Effect of intravenous omeprazole on twenty-four-hour intragastric pH in patients with a history of peptic ulcer. Digestion 1991;48:75-80.
  • Merki HS, Wilder-Smith CH. Do continuous infusions of omeprazole and ranitidine retain their effect with prolonged dosing? Gastroenterology 1994;106:60-4.
  • Cederberg C, RU+0217öhss K, Lundborg P, Olbe L. Effect of once daily intravenous and oral omeprazole on 24 hour intragastric acidity in healthy subjects. Scand J Gastroenterol 1993;28:179-84.
  • Baak LC, Biemond I, Jansen JBMJ, Lamers CBHW. Repeated intravenous bolus injections of omeprazole: effects of 24-hour intragastric pH, serum gastrin and serum pepsinogen A and C. Scand J Gastroenterol 1991;26:737-46.
  • Schaffalitzsky de Muckadell OM, Havelund T, Harling H, Boesby S, Snel P, Vreeburg EM, et al. Effect of omeprazole on the outcome of endoscopically treated bleeding peptic ulcers. Randomized double-blind placebo-controlled multicentre study. Scand J Gastroenterol 1997;32:320-7.
  • Hasselgren G, Lind T, Lundell L, Aadland E, Efskind P, FaIk A, et al. Continuous intravenous infusion of omeprazole in elderly patients with peptic ulcer bleeding. Results of placebocontrolled multicenter study. Scand J Gastroenterol 1997;32: 328-33.
  • Lau JYW, Sung JJY, Lee KKC, Yung M-Y, Wong SKH, Wu JCY, et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopie treatment of bleeding peptic ulcers. N Engl J Med 2000;343:310-6.
  • Schonekas H, Ahrens H, Pannewick U, Ell C, Koop H, Petritsch W, et al. Comparison of two doses of intravenous pantoprazole in peptic ulcer bleeding. Gastroenterology 1999;116:A305.
  • Forrest JA, Finlayson ND, Shearman DJ. Endoscopy in gastrointestinal bleeding. Lancet 1974;2:394-7.
  • Dunnet CW, Gent M. Significance testing to establish equivalence between treatments with special reference to data in the form of 2 x 2 tables. Biometrics 1977;33:593-602.
  • Blackwelder WC. In: Armitage P, Colton T, editors. Encyclopedia of biostatistics. New York: John Wiley & Sons Inc.; 1998. p. 1367-72.
  • Peterson W. Bleeding peptic ulcer. Epidemiology and non-surgical management. Gastroenterol Clin NA 1990;19:155-70.
  • Grosso C, Rossi A, Gambitta P, Bini M, Zanasi G, Pirone Z, et al. Non-bleeding visible vessel treatment: perendoscopic injection therapy versus omeprazole infusion. Scand J Gastroenterol 1995;30:872-5.
  • Villanueva C, Balanzo J, Torres X, Sáinz S, Soriano G, Gonzalez D, et al. Omeprazole versus ranitidine as adjunct therapy to endoscopie injection in actively bleeding ulcers: a prospective randomised study. Endoscopy 1995;27:308-12.
  • Lin H-J, Lo W-C, Lee F-Y, Perng C-L, Tseng G-Y. A prospective randomized comparative trial showing that omeprazole prevents rebleeding in patients with peptic ulcer bleeding after successful endoscopie therapy. Arch Int med 1998;158: 54-8.
  • Khuroo MS, Yattoo GN, Javid G, Khan BA, Shah AA, Gulzar GM, et al. A comparison of omeprazole and placebo for bleeding peptic ulcer. N Engl J Med 1997;336:1054-8.
  • Lanas A, Artal A, Blás JM, Arroyo M, Lopez-Zaborras J, Sáinz R. Effect of parenteral omeprazole and ranitidine on gastric pH and the outcome of bleeding peptic ulcer. J Clin Gastroenterol 1995;21:103-6.
  • Choudari CP, Rajgopal C, Elton RA, Palmer KR. Failures of endoscopie therapy for bleeding peptic ulcer: an analysis of risk factors. Am J Gastroenterol 1994;89:1968-72.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.