Advanced search
Publication Cover
Scandinavian Journal of Gastroenterology Volume 37, 2002 - Issue 4
Submit an article Journal homepage
122
Views
37
CrossRef citations to date
0
Altmetric
Research Article

VEGF and Tumour Angiogenesis. Impact of Surgery, Wound Healing, Inflammation and Blood Transfusion

Mads Nordahl Svendsen
,
Kim Werther
,
Hans Jørgen Nielsen
&
Paul E. G Kristjansen
Pages 373-379 | Published online: 08 Jul 2009

  • Skobe M, Rockwell P, Goldstein N, Vosseler S, Fusenig NE. Halting angiogenesis suppresses carcinoma cell invasion. Nat Med 1997:3:1222-7.
  • Folkman J. Fighting cancer by attacking its blood supply. Sei Am 1996:275:150-4.
  • O'Reilly MS, Holmgren L, Chen C, Folkman J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med 1996:2:689-92.
  • Holmgren L, O'Reilly MS, Folkman J. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression [see comments]. Nat Med 1995;1 : 149-53.
  • Folkman J. Tumor angiogenesis and tissue factor [Comment]. Nat Med 1996;2:167-8.
  • McNamara DA, Harmey JH, Walsh TN, Redmond HP, Bouchier-Hayes DJ. Significance of angiogenesis in cancer therapy [published erratum appears in Br J Surg 1998 Oct; 85(10):1449]. Br J Surg 1998;85:1044-55.
  • Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989;161:851 -8.
  • Folkman J. Tumor angiogenesis. In: Holland JF, Freie III, Bast RCJ, Kufe DW, Polloc RE, Weichselbaum RR, editors. Cancer medicine. Ontario, Canada: B. C. Decker Inc.; 2000. p. 132-52.
  • Brown LF, Detmar M, Claffey K, Nagy JA, Feng D, Dvorak AM, Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine. EXS 1997:79:233-69.
  • Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiate d angiogenesis. Nature 1992;359:843-5.
  • Ratcliffe PJ, O'Rourke JF, Maxwell PH, Pugh CW. Oxygen sensing, hypoxia-inducibl e factor-1 and the regulation of mammalian gene expression. J Exp Biol 1998;201(Pt 8):115362.
  • Dachs GU, Tozer GM. Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation. Eur J Cancer 2000:36:1649-60.
  • Welch DR, Schissel DJ, Howrey RP, Aeed PA. Tumor-elicited polymorphonuclear cells, in contrast to 'normal' circulating polymorphonuclear cells, stimulate invasive and metastatic potentials of rat mammary adenocarcinoma cells. Proc Natl Acad Sei USA 1989;86:5859-63.
  • McCourt M, Wang JH, Sookhai S, Redmond HP. Proinflammatory mediators stimulate neutrophil-directed angiogenesis. Arch Surg 1999:134:1325-31.
  • Gasparini G. Prognostic value of vascular endothelial growth factor in breast cancer. Oncologist 2000;5 Suppl 1:37-44.
  • Lee JC, Chow NH, Wang ST, Huang SM. Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients. Eur J Cancer 2000;36:748-53.
  • Cascinu S, Staccioli MP, Gasparini G, Giordani P, Catalane V, Ghiselli R, Rossi C, Baldelli AM, Graziano F.Saba V, Muretto P, Catalane G. Expression of vascular endothelial growth factor can predict event-free survival in stage II colon cancer [In Process Citation]. Clin Cancer Res 2000;6:2803-7.
  • Werther K, Christensen IJ, Nielsen HJ. The association between preoperative concentration of soluble vascular endothelial growth factor, perioperative blood transfusion, and survival in patients with primary colorectal cancer. Eur J Surg 2001; 167:287-92.
  • George ML, Eccles SA, Tutton MG, Abulafi AM, Swift RI. Correlation of plasma and serum vascular endothelial growth factor levels with platelet count in colorectal cancer: clinical evidence of platelet scavenging? [In Process Citation]. Clin Cancer Res 2000;6:3147-52.
  • Lee JK, Hong YJ, Han CJ, Hwang DY, Hong SI. Clinical usefulness of serum and plasma vascular endothelial growth factor in cancer patients: which is the optimal specimen? Int J Oncol 2000:17:149-52.
  • Werther K, Christensen D, Brunner N, Nielsen HJ. Soluble vascular endothelial growth factor levels in patients with primary colorectal carcinoma. Eur J Surg Oncol 2000;26:657-62.
  • Nielsen HJ, Werther K, Mynster T, Brunner N. Soluble vascular endothelial growth factor in various blood transfusion components. Transfusion 1999;39:1078-83.
  • Banks RE, Forbes MA, Kinsey SE, Stanley A, Ingham E, Walters C, Selby PJ. Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology [see Comments]. Br J Cancer 1998:77556-64.
  • Sporn MB, Roberts AB. Peptide growth factors and inflammation, tissue repair, and cancer. J Clin Invest 1986;78:329-32.
  • Sunderkotter C, Steinbrink K, Goebeler M, Bhardwaj R, Sorg C. Macrophages and angiogenesis. J Leukoc Biol 1994:55:410-22.
  • Pinedo HM, Verheul HM, D'Amato RJ, Folkman J. Involvement of platelets in tumour angiogenesis? Lancet 1998;352: 1775-7.
  • Tonnesen MG, Feng X, Clark RA. Angiogenesis in wound healing. J Invest Dermatol Symp Proc 2000;5:40-6.
  • Lingen MW. Role of leukocytes and endothelial cells in the development of angiogenesis in inflammation and wound healing. Arch Pathol Lab Med 2001;125:67-71.
  • Verheul HM, Joma AS, Hoekman K, Broxterman HJ, Gebbink MF, Pinedo HM. Vascular endothelial growth factor-stimulated endothelial cells promote adhesion and activation of platelets. Blood 2000:96:4216-21.
  • Poon RT, Fan ST, Wong J. Clinical implications of circulating angiogenic factors in cancer patients. J Clin Oncol 2001 ;19: 1207-25.
  • Nissen NN, Polverini PJ, Koch AE, Volin MV, Gamelli RL, DiPietro LA. Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing. Am J Palhol 1998;152:1445-52.
  • Nissen NN, Polverini PJ, Gamelli RL, DiPietro LA. Basic fibroblast growth factor mediates angiogenic activity in early surgical wounds. Surgery 1996;119:457-65.
  • Pierce GF, Tarpley JE, Yanagihara D, Mustoe TA, Fox GM, Thomason A. Platelet-derived growth factor (BB homodimer), transforming growth factor-beta 1, and basic fibroblast growth factor in dermal wound healing. Neovessel and matrix formation and cessation of repair. Am J Pathol 1992;140:1375-88.
  • Nielsen HJ, Werther K, Mynster T, Svendsen MN, Rosendahl S, Elley T, Skov F. Bacteria-induced release of white cell and platelet-derived vascular endothelia growth factor in vitro. Vox Sang 2001;80:170-8.
  • Li WW, Grayson G, Folkman J, D'Amore PA. Sustained-release endotoxin. A model for inducing comeal neovascularization. Invest Ophthalmol.Vis Sei 1991;32:2906-11.
  • Mattsby-Baltzer I, Jakobsson A, Sorbo J, Norrby K. Endotoxin is angiogenic. Int J Exp Pathol 1994;75:191 -6.
  • Pidgeon GP, Harmey JH, Kay E, Da Costa M, Redmond HP, Bouchier-Hayes DJ. The role of endotoxin/lipopolysaccharid e in surgically induced tumour growth in a murine model of metastatic disease. Br J Cancer 1999;81:1311 -7.
  • Woodcock NP, Sudheer V, El Barghouti N, Perry EP, MacFie J. Bacterial translocation in patients undergoing abdominal aortic aneurysm repair. Br J Surg 2000;87:439-42.
  • Gabrilovich DI, Chen HL, Girgis KR, Cunningham HT, Meny GM, Nadaf S, Kavanaugh D, Carbone DP. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med 19962:1096103.
  • Oyama T, Ran S, Ishida T, Nadaf S, Kerr L, Carbone DP, Gabrilovich DI. Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells. J bnmunol 1998;160:1224-32.
  • Gabrilovich D, Ishida T, Oyama T, Ran S, Kravtsov V, Nadaf S, Carbone DP. Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 1998:92:4150-66.
  • Gabrilovich DI, Ishida T, Nadaf S, Ohm JE, Caroone DP. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin Cancer Res 1999:5:2963-70.
  • Almand B, Resser JR, Lindman B, Nadaf S, Clark JI, Kwon ED, Carbone DP, Gabrilovich DI. Clinical significance of defective dendritic cell differentiation in cancer. CHn Cancer Res 2000;6: 1755-66.
  • Eggermont AM, Steller EP, Sugarbaker PR Laparotomy enhances intraperitoneal tumor growth and abrogates the antitumor effects of interleukin-2 and lymphokine-activate d killer cells. Surgery 1987;102:71-8.
  • Eggermont AM, Steller EP, Marquet RL, Jeekel J, Sugarbaker PH. Local regional promotion of tumor growth after abdominal surgery is dominant over immunotherapy with interleukin-2 and lymphokine activated killer cells. Cancer Detect Prev 1988;12: 421-9.
  • Skipper D, Jeffrey MJ, Cooper AJ, Alexander P, Taylor I. Enhanced growth of tumour cells in healing colonie anastomoses and laparotomy wounds. Int J Colorectal Dis 1989:4:172-7.
  • Murthy SM, Goldschmidt RA, Rao LN, Ammirati M, Buchmann T, Scanion EF. The influence of surgical trauma on experimental metastasis. Cancer 1989;64:2035-44.
  • Lee JY, Murphy SM, Scanlon EF. Effect of trauma on implantation of metastalic tumor in bone in mice. J Surg Oncol 1994:56:178-84.
  • Ammirati M, Rao LN, Murthy MS, Buchmann T, Goldschmidt RA, Scanlon EF. Partial nephrectomy in mice with milliwatt carbon dioxide laser and its influence on experimental metastasis. J Surg Oncol 1989:41:153-9.
  • Bogden AE, Moreau JP, Eden PA. Proliferative response of human and animal tumours to surgical wounding of normal tissues: onset, duration and inhibition. Br J Cancer 1997;75: 1021-7.
  • Bouvy ND, Maiquet RL, Hamming JF, Jeekel J, Bonjer HJ. Laparoscopic surgery in the rat. Beneficial effect on body weight and tumor take. Surg Endosc 1996; 10:490-4.
  • Allendorf JD, Bessler M, Kayton ML, Whelan RL, Treat MR, Nowygrod R. Tumor growth after laparotomy or laparoscopy. A preliminary study. Surg Endosc 1995;9:49-52.
  • Kehlet H, Nielsen HJ. Impact of laparoscopic surgery on stress responses, immunofunction, and risk of infectious complications. New Horizons 1998;6:S80-8.
  • Da Costa ML, Redmond HP, Bouchier-Hayes DJ. Increased tumor establishment and growth after laparotomy vs laparoscopy [Letter; Comment]. Arch Surg 1996;131:1003.
  • Svendsen MN, Werther K, Nielsen HJ. Bacteria-induced release of VEGF from white blood cells and platelets during surgery. Proc AACR 2001:42:720.
  • Nielsen HJ. The effect of histamine type-2 receptor antagonists on posttraumatic immune competence. Dan Med Bull 1995;42: 162-74.
  • Grandis JR, Snyderman CH, Johnson JT, Yu VL, D'Amico F. Postoperative wound infection. A poor prognostic sign for patients with head and neck cancer. Cancer 1992;70:2166-70.
  • Rikimaru T, Ide S, Sueyasu Y, Koga T, Ichiki M, Kinosfta M, Oizumi K. Role of infection during chemotherapy for long-term survival in patients with NSCLC Proceedings of ASCO.
  • Aukhil I. Biology of wound healing. Periodontology 2000. 2000; 22:44-50.
  • Mynster T, Christensen LF, Moesgaard F, Nielsen HJ. Effects of the combination of blood transfusion and postoperative infectious complications on prognosis after surgery for colorectal cancer. Danish RANX05 Colorectal Cancer Study Group [In Process Citation]. Br J Surg 2000;87:1553-62.
  • Blumberg N, Heal JM. Immunomodulation by blood transfusion : an evolving scientific and clinical challenge. Am J Med 1996; 101:299-308.
  • Edna TH, Bjerkeset T. Association between transfusion of stored blood and infective bacterial complications after resection for colorectal cancer. Eur J Surg 1998;164:449-56.
  • Nielsen HJ, Reimert CM, Pedersen AN, Brunner N, Edvardsen L, Dybkjaer E, Kehlet H, Skov PS. Time-dependent, spontaneous release of white cell- and platelet-derived bioactive substances from stored human blood. Transfusion 1996;36:960-5.
  • Nielsen HJ. Clinical impact of bioactive substances in blood components: implications for leukocyte filtration. Infusionsther Transfusionsmed 1998;25:296-304.
  • Mynster T, Dybkjoer E, Kronborg G, Nielsen HJ. Immunomodulating effect of blood transfusion: is storage time important? Vox Sang 1998;74:176-81.
  • Zallen G, Offner PJ, Moore EE, Blackwell J, Ciesla DJ, Gabriel J, Denny C, Silliman CC. Age of transfused blood is an independent risk factor for postinjury multiple organ failure. Am J Surg 1999:178:570-2.
  • Mynster T, Nielsen HJ. The impact of storage time of transfused blood on postoperative infectious complications in rectal cancer surgery. Danish RANX05 Colorectal Cancer Study Group. Scand J Gastroenterol 2000:35:212-7.
  • Blajchman MA, Bordin JO. The tumor growth-promoting effect of allogeneic blood transfusions. Immunol Invest 1995;24: 311-7.
  • Edna TH, Bjerkeset T. Perioperative blood transfusions reduce long-term survival following surgery for colorectal cancer. Dis Colon Rectum 1998;41:451 -9.
  • Braun S, Pantel K, Muller P, Janni W, Hepp F, Kentenich CR, Gastroph S, Wischnik A, Dimpfl T, Kinderman G, RiethmullerG, Schlimok G. Cytokeratin-positiv â cells in the bone marrow and survival of patients with stage I, II, or III breast cancer [see Comments] [published erratum appears in N Engl J Med 2000 JuI 27;343(4):308]. N Engl J Med 2000:342:525-33.
  • Pantel K, Cote RJ, Fodstad O. Detection and clinical importance of micrometastatic disease. J Nail Cancer Inst 1999;91:1113-24.
  • Hansen E, Wolff N, Knuechel R, Ruschoff J, Hofetaedter F, Taeger K. Tumor cells in blood shed from the surgical field. Arch Surg 1995:130:387-93.
  • Thompson WD, Li WW, Maragoudakis M. The clinical manipulation of angiogenesis: pathology, side-effects, surprises, and opportunities with novel human therapies. J Pathol 2000; 190:330-7.
  • Nielsen HJ, Christensen TJ, Moesgaard F, Kehlet H, The RANX05 Study Group. Ranitidine as adjuvant treatment in colorectal cancer. Proc AACR 2001;42:697.
  • Ghosh AK, Hirasawa N, Ohuchi K. Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H(2) receptors. Br J Pharmacol 2001:134:1419-28.
  • Sorbo J, Jakobsso n A, Norrby K. Mast-cell histamine is angiogenic through receptors for histamine 1 and histamine2. Int J Exp Pathol 1994:75:43-50.
  • Browder T, Folkman J, Pine-Shepherd S. The hemostatic system as a regulator of angiogenesis. J Biol Chem 2000;275:1521 -4.
  • Matsukawa A, Yoshinaga M. Neutrophils as a source of cytokines in inflammation. Histol Histopathol 1999;14:511 -6.
  • Cassatella MA, Gasperini S, Russo MP. Cytokine expression and release by neutrophils. Ann NY Acad Sei 1997;832:233-42.
  • Gompertz S, Stockley RA. Inflammation-role of the neutrophil and the eosinophil. Semin Respir Infect 2000; 15:14-23.
  • Norrby K, Woolley D. Role of mast cells in mitogenesis and angiogenesis in normal tissue and tumour tissue. In: GarciaGaballero M, Brandes LJ, Hosoda S, editors. Histamine in normal and cancer cell proliferation. Oxford: Pergamon Press; 1993; p. 71-116.
  • Norrby K. Angiogenesis : new aspects relating to its initiation and control. APMIS 1997;105:417-37.
  • Freeman MR, Schneck FX, Gagnon ML, Corless C, Soker S, Niknejad K, Peoples GE, Klagsbrun M. Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: a potential role for T cells in angiogenesis. Cancer Res 1995;55:4140-5.
  • Janeway CA, Travers P. Immunobiology. London/New York: Current Biology Ltd./Garland Publishing Inc.; 1997.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.