Advanced search
Publication Cover
Scandinavian Journal of Gastroenterology Volume 37, 2002 - Issue 5
Submit an article Journal homepage
40
Views
9
CrossRef citations to date
0
Altmetric
Research Article

Cholestatic Effect of Large Bilirubin Loads and Cholestasis Protection Conferred by Cholic Acid Co-infusion: a Molecular and Ultrastructural Study

K. J. Labori
,
K. Arnkvaern
,
B. A. Bjørnbeth
,
C. McL. Press
&
M. G. Raeder
Pages 585-596 | Published online: 08 Jul 2009

  • Crawford JM. Role of vesicle-mediated transport pathways in hepatocellular bile secretion. Semin Liver Dis 1996;16:169-89.
  • Ruetz S, Gros P. Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell 1994:77:1071 -81.
  • Ruetz S, Gros P. Enhancement of mdr2-mediated phosphatidylcholine translocation by the bile salt taurocholate: implications for hepatic bile formation. J Biol Chem 1995;270:25388-95.
  • Smit JJM, Schinkel AH, Oude Elferink RPJ, Groen AK, Wagenaar E, van Deemter L, et al. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 1993;75:451 -62.
  • Smit JJM, Schinkel AH, MoI CAAM, Mool WJ, Jongsma APM, Lincke CR, et al. Tissue distribution of the human MDR3 Pglycoprotein. Lab Invest 1994;71:638-49.
  • Van Helvoort A, Smith AJ, Sprang H, Fritzsche I, Schinkel AH, Borst P, et al. MDRl P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 1996;87:507-17.
  • Crawford AR, Smith AJ, Hatch VC, Elferink RP, Borst P, Crawford JM. Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression: visualization by electron microscopy. J Clin Invest 1997;100:2562-67.
  • Lee MH, Lu K, Hazard S, Yu H, Shulenin S, Hidaka H, et al. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nature Genet 2001:27:79-83.
  • Berge KE, Tian H, Graf GA, Yu L, Grishin NV, Schultz J, et al. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 2000;290: 1771-5.
  • Labori KJ, Bjørnbeth BA, Hvattum E, Lyberg T, Rder MG. Intravenous bilimbin, dibromosulfophthalei n and bromosulfophthalein infusions uncouple bililary phospholipid- and cholesterol secretion from bile acid secretion through inhibiting hepatic phosphoglycoprotei n 3 activity in pigs. Scand J Gastroenterol 2000;35:873-82.
  • Villanger O, Bjømbeth BA, Lyberg T, Rseder MG. Bile acids protect the liver against the cholestatic effect of large bilirubin loads. Scand J Gastroenterol 1995;30:1186-93.
  • Bjørnbeth BA, Endresen M, Hvattum E, Lyberg T, Villanger O, Ræder MG. Large intravenous bilirubin loads increase the cytotoxicity of bile and lower the resistance of the canalicular membrane to cytotoxic injury and cause cholestasis in pigs. Scand J Gastroenterol 1998;33:201 -8.
  • Gerloff T, Stieger B, Hagenbuch B, Madon J, Landmann L, Roth J, et al. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem 1998; 273:10046-50.
  • Childs S, Yeh RL, Georges E, Ling V. Identification of a sister gene to P-glycoprotein. Cancer Res 1995;55:2029-34.
  • Stieger B, Fattinger K, Madon J, Kullak-Ublick GA, Meier PJ. Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology 2000;118:422-30.
  • Böhme M, Müller M, Leier I, Jedlitschky G, Keppler D. Cholestasis caused by inhibition of the adenosine triphosphatedependent bile salt transport in rat liver. Gastroenterology 1995; 107:255-65.
  • Vos TA, Hooiveld GJ, Koning H, Childs S, Meijer DK, Moshage H, et al. Up-regulation of the multidrug resistance genes, Mrpl and Mdrib, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. Hepatology 1998;28:1637-44.
  • Lee JM, Trauner M, Soroka CJ, Stieger B, Meier PJ, Boyer JL. Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology 2000;118:16372.
  • Moseley RH, Wang W, Takeda H, Lown K, Stock L, Ananthanarayana n M, et al. Effect of endotoxin on bile acid transport in rat liver: a potential model for sepsis-associated cholestasis. Am J Physiol 1996;271:G137-46.
  • Green RM, Beier D, Gollan JL. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 1996;111:193-8.
  • Jendrassik L, Gróf P. Vereinfachte photometrische Methoden zur Bestimmung des Blutbtbilirubins. Biochem Z 1938;297:81 -9.
  • Röschlau P, Bernt E, Gruber W. Enzymatische Bestimmung des Gesamt-Cholesterin s im Serum. Z Klein Chem Klein Biochem 1974;12:403-7.
  • Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, et al. Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/Pglycoprotein. MoI Pharmacol 2000;57:24-35.
  • Georges E, Bradley G, Gariepy J, Ling V. Detection of Pglycoprotein isoform s by gene-specific monoclonal antibodies. Proc Natl Acad Sci USA 1990;87:152-6.
  • Kullak-Ublick GA, Glasa J, Boker C, Oswald M, Grutzner U, Hagenbuch B, et al. Chlorambucil-taurocholat e is transported by bile acid carriers expressed in human hepatocellular carcinomas. Gastroenterology 1997; 113:1295-305.
  • Stieger B, Hagenbuch B, Landmann L, Hochli M, Schroeder A, Meier PJ. In situ localization of the hepatocytic Na+/Taurocholate cotransporting polypeptide in rat liver. Gastroenterology 1994;107:1781-7.
  • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970227: 680-5.
  • Kipp H, Arias IM. Newly synthesized canalicular ABC transporters are directly targeted from the Golgi to the hepatocyte apical domain in rat liver. J Biol Chem 2000;275:15917-25.
  • Verkade HJ, Havinga R, Gerding A, Vonk RJ, Kuipers F. Mechanism of bile acid-induced biliary lipid secretion in the rat: effect of conjugated bilirubin. Am J Physiol (Gastrointest Liver Physiol). 1993;264:G462-9.
  • Apstein MD. Inhibition of biliary phospholipid and cholesterol secretion by bilirubin in the Sprague-Dawley and Gunn rat. Gastroenterology 1984;87:634-8.
  • Bjørnbeth BA, Labori KJ, Hvattum E, Lyberg T, Christensen T, Woldseth B, et al. Effect of intravenous bilirubin infusion on biliary phospholipid secretion, hepatic P-glyocoprotein exprssion and biliary cytotoxicity in pigs. Scand J Gastroenterol 1999;34:1042-9.
  • Van Nieuwkerk CMJ, Oude Elferink RPJ, Groen AK, Ottenhoff R, Tytgat GNJ, Dingemans KP, et al. Effects of ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene. Gastroenterology 1996; 111:165-71.
  • De Vree JML, Ottenhoff R, Bosnia PJ, Smith AJ, Aten J, Elferink RPJO. Correction of liver disease by hepatocyte transplantation in a mouse model of progressiv e familial intrahepati c cholestasis. Gastroenterology 2000;119:1720-30.
  • Kipp H, Arias IM. Intracellular trafficking and regulation of canalicular ATP-binding cassette transporters. Semin Liver Dis 2000;20:339-51.
  • Schmitt M, Kubitz R, Wettstein M, vom Dahl S, Häussinger D. Retrieval of the mrp2 gene encoded conjugate export pump from the canalicular membrane contributes to cholestasis induced by tert-butyl hydroperoxide and chloro-dinitrobenzene. Biol Chem 2000;381:487-95.
  • Veel T, Villanger O, Holthe MR, Skjørten FS, Rseder MG. Intravenous biliiubin infusion causes vacuolization of the cytoplasm of hepatocytes and canalicular cholestasis. Acta Physiol Scand 1991:143:421-9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.