23
Views
13
CrossRef citations to date
0
Altmetric
Research Article

Not all HLA DR3 DQ2 Haplotypes Confer Equal Susceptibility to Coeliac Disease: Transmission Analysis in Families

Pages 56-61 | Published online: 08 Jul 2009

  • Marsh MN. Mucosal pathology in gluten sensitivity. In: March MN, editor. Coeliac disease. Oxford: Blackwell Scientific Publications; 1992. p. 136-91.
  • Hervonen K, Karell K, Holopainen P, Collin P, Partanen J, Reunala T. Concordance of dermatitis herpetiformis and coeliac disease in monozygous twins. J Inv Dermatol 2000;115:990-3.
  • Mäki M, Collin P. Coeliac disease. Lancet 1997;349:1755-9.
  • Sollid LM, Thorsby E. HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. Gastroenterology 1993;105:910-22.
  • Catassi C, Fanciulli G, D'Appello AR, El Asmar R, Rondina C, Fabiani E, et al. Antiendomysium versus antigliadin antibodies in screening the general population for coeliac disease. Scand J Gastroenterol 2000;35:732-6.
  • Brett PM, Yiannakou JY, Morris M-A, Vaughan R, Curtis D, Ciclitira PJ. Common HLA alleles, rather than rare mutants, confer susceptibility to coeliac disease. Ann Hum Genet 1999; 63:217-25.
  • Lundin KEA, Scott H, Hansen T, Paulsen G, Halstensen TS, Fausa O, et al. Gliadin-speciflc, HLA-DQ (a1*0501, ß1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 1993;178:187-96.
  • Sollid LM, Markussen G, Ek J, Gjerde H, Vartdal F, Thorsby E. Evidence for a primary association of celiac disease to a particular HLA-DQ a/ß heterodimer. J Exp Med 1989:169:34550.
  • Kagnoff MF, Harwood JI, Bugawan TL, Erlich HA. Structural analysis of the HLA-DR, -DQ, and -DP alleles on the celiac disease-associated HLA-DR3 (DRw 17) haplotype. Proc Natl Acad Sci USA 1989;86:6274-8.
  • Polvi A, Eland C, Koskimies S, Mäki M, Partanen J. HLA DQ and DP in Finnish families with celiac disease. Eur J Immunogenet 1996;23:221-34.
  • Nejentsev S, Koskinen S, Sjöroos M, Reijonen H, Schwartz EI, Kovalchuk L, et al. Distribution of insulin-dependent diabetes mellitus (IDDM)-related HLA alleles correlates with the difference in IDDM incidence in four populations of the Eastern Baltic region. Tissue Antigens 1998;52:473-7.
  • The MHC sequencing consortium. Complete sequence and gene map of human major histocompatibility complex. Nature 1999; 401:921-3.
  • Hanifi Moghaddam P, de Knijff P, Roep BO, van der Auwera B, Naipal A, Gorus F, et al. Genetic structure of IDDM1; two separate regions in the major histocompatibility complex contributes to susceptibility or protection. Diabetes 1998;47: 263-8.
  • Lie BA, Todd JA, Pociot F, Nerup J, Akselsen HE, Joner G, et al. The predisposition to type 1 diabetes linked to the human leukocyte antigen complex includes at least one non-class II gene. Am J Hum Genet 1999;64:793-800.
  • Polvi A, Mäki M, Partanen J. Celiac patients predominantly inherit HLA-DPB1*0101 positive haplotype from HLA-DQ2 homozygous parent. Hum Immunol 1997;53:156-8.
  • Foissac A, Salhi M, Cambon-Thomsen A. Microsatellites in the HLA region: 1999 update. Tissue Antigens 2000;55:477-509.
  • Karell K, Klinger N, Holopainen P, Levo A, Partanen J. Major histocompatibility complex (MHC)-linked microsatellite markers in a founder population. Tissue Antigens 2000;56:45-51.
  • Price P, Witt C, Allcock R, Sayer D, Garlepp M, Kok CC, et al. The genetic basis for the association of the 8.1 ancestral haplotype (Al, BS, DR3) with multiple immunopathological diseases. Immunol Rev 1999; 167:275-4.
  • Sollid LM. Molecular basis of celiac disease. Annu Rev Immunol 2000; 18:53-81.
  • Contu L, Deschamps I, Lestradet H, Hors J, Schmid M, Busson M, et al. HLA haplotype study of 53 juvenile insulin-dependent diabetic (I.D.D.) families. Tissue Antigens 1982;20:123-40.
  • Herr M, Dudbridge F, Zavattari P, Cucca F, Guja C, March R, et al. Evaluation of fine mapping strategies for a multifactorial disease locus: systematic linkage and association analysis of IDDMl in the HLA region on chromosome 6p21. Hum MoI Genet 2000;9:1291-301.
  • Hattori M, Yamato E, Itoh N, Senpuku H, Fujisawa T, Yoshino M, et al. Homologous recombination of the MHC class I K region defines new susceptibility gene(s) in nonobese diabetic mice. J Immunol 1999;163:1721 -4.
  • Lie BA, Sollid LM, Asher H, Ek J, Akselsen HE, Ronningen KS, et al. A gene telomeric of the HLA class I region is involved in predisposition to both type 1 diabetes and coeliac disease. Tissue Antigens 1999;54:162-8.
  • de la Concha EG, Fernandez-Arquero M, Vigil P, Rubio A, Maluenda C, PolancoI, et al. Celiac disease and TNF promoter polymorphisms. Hum Immunol 2000;61:513-7.
  • McManus R, Wilson AG, Mansfield J, Weir DG, Duff GW, Kelleher D. TNF2, a polymorphism of the tumor negrosis-a gene promoter, is a component of the celiac disease major histocompatibility complex haplotype. Eur J Immunol 1996;26: 2113-8.
  • Partanen J, Milner C, Campbell RD, Mäki M, Lipsanen V, Koskimies S. HLA-linked heat-shock protein 70 (HSP70-2) gene polymorphism and celiac disease. Tissue Antigens 1993; 41:15-9.
  • Polvi A, Mäki M, Collin P, Partanen J. TNF miciosatellite alleles a2 and b3 are not primarily associated with celiac disease in the Finnish population. Tissue Antigens 1998;51:553-5.
  • Alper CA, Marcus-Bagley D, Awdeh Z, Kruskall MS, Eisenbarth GS, Brink SJ, et al. Prospective analysis suggests susceptibility genes for deficiencies of IgA and several other immunoglobulins on the [HLA-BS1SCOl,DR3] conserved extended haplotype. Tissue Antigens 2000;56:207-16.
  • Egea E, Iglesias A, Salazar M, Morimoto C, Kruskall MS, Awdeh Z, et al. The cellular basis for lack of antibody response to hepatitis B vaccine in humans. J Exp Med 1991;173:531 -8.
  • Awdeh Z, Raum D, Yunis EJ, Alper CA. Extended HLA/complement allele haplotypes: evidence for T/t-like complex in man. Proc Natl Acad Sci USA 1983;80:259-63.
  • Clerget-Darpoux F. The HLA component of type I diabetes. Am J Hum Genet 2000;66:1468.
  • Zavattari P, Lampis R, Mulargia A, Loddo M, Angius E, Todd JA, et al. Conformation of the DRB1-DQB1 loci as the major component of IDDMl in the isolated founder population of Sardinia. Hum MoI Genet 2000;9:2967-72.
  • Bevan S, Popat S, Braegger CP, Busch A, O'Donoghue D, Falth-Magnusson K, et al. Contribution of the MHC region to the familial risk coeliac disease. J Med Genet 1999;36:687-90.
  • Greco L, Corazza G, Babron M-L, Clot F, Fulchignoni-Lataud M-C, Percopo S, et al. Genome search in celiac disease. Am J Hum Genet 1998;62:669-75.
  • Zhong F, McCombs CC, Olson JM, Elston RC, Stevens FM, McCarthy CF, et al. An autosomal screen for genes that predispose to celiac disease in the western counties of Ireland. Nat Genet 1996;14:329-33.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.