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Scandinavian Journal of Gastroenterology Volume 37, 2002 - Issue 8
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Research Article

Lack of Correlation between Disease Activity and Decreased Stimulated Secretion of IL-10 in Lymphocytes from Patients with Celiac Disease

A. Mizrachi
,
E. Broide
,
A. Buchs
,
A. Kornberg
,
D. Aharoni
,
T. Bistritzer
&
M. J. Rapoport
 show all
Pages 924-930 | Published online: 08 Jul 2009

  • Przemioslo RT, Kontakou M, Nobili V, Ciclitira PJ. Raised proinflammatory cytokines interleukin 6 and tumor necrosis factor alpha in coeliac disease mucosa detected by immunohistochemistry. Gut 1994;35:1398-403.
  • Kontakou M, Przemioslo RT, Sturgess RP, Limb GA, Ellis HJ, Day P, et al. Cytokine mRNA expressio n in the mucosa of treated coeliac patients after wheat peptide challenge. Gut 1995;37: 52-7.
  • Kontakou M, Przemioslo RT, Sturgess RP, Limb AG, Ciclitira PJ. Expression of tumor necrosis factor-alpha, interleukin-6, and interleukin-2 mRNA in the jejunum of patients with coeliac disease. Scand J Gastroenterol 1995;30:456-63.
  • Kontakou M, Sturgess PR, Przemioslo RT, Limb GA, Nelufer JM, Ciclitira PJ. Detection of interferon gamma mRNA in the mucosa of patients with celiac disease by in situ hybridization. Gut 1994:35:1037-41.
  • Romagnani S, Parronchi P, D'Elios MM, Romagnani P, Annunziato F, Piccini MP, et al. An update on human Th1 and Th2 cells. Int Arch Allergy Immunol 1997; 113:153-6.
  • Kroemer G, Hirsch F, Gonzalez-Garcia A, Martinez C. Differential involvement of Th1 and Th2 cytokines in autoimmune diseases. Autoimmunity 1996;24:25-33.
  • Nilsen EM, Jahnsen, FL, Lundin KE, Johansen FE, Fausa O, Sollid LM, et al. Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease. Gastroenterology 1998;115:551 -63
  • Nilsen EM, Gjertsen HA, Jensen K, Brandtzaeg P, Lundin KE. Gluten activation of peripheral blood T cells induced a thO-like cytokine pattern in both coeliac patients and controls. Clin Exp Immunol 1996;103:295-303.
  • Hansson T, Dannaeus A, Klareskog L. Cytokine-producin g cells in peripheral blood of children with coeliac disease secret cytokines with a type 1 profile. Clin Exp Immunol 1999;116: 246-50.
  • Pena AS, Garrote JA, Crusius JB. Advances in the immunogenetics of coeliac disease. Clues for understanding the pathogenesis and disease heterogeneity. Scand J Gastroenterol 1998; Suppl 225:56-8.
  • Karban A, Lerner A, Shapiro S. Th1/Th2 cytokine profile in celiac disease. Isr J Med Sci 1997;33:209-14.
  • Beckett CG, Dell'Olio D, Kontakou M, Przemioslo RT, Rosen-Bronson S, Ciclitira PJ. Analysis of IL-4 and IL-10 and their associatio n with the lymphocyte infiltrate in the small intestine of patients with celiac disease. Gut 1996;39:818-23.
  • Nilsen EM, Lundin KE, Krajci P, Scott H, Sollid LM, Brandtzaeg P. Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma. Gut 1995;37:766-76.
  • Lahat N, Shapiro S, Karban A, Gerstein R, Kinarty A, Lemer A. Cytokine profile in coeliac disease. Scand J Immunol 1999; 49:441-6.
  • Dixon WJ. BMDP Statistical Software (1990) University of California Press.
  • Barcena A, Toribio ML, Gutierrez-Ramos JC, Kroemer G, Martinez AC. Interplay between IL-2 and IL-4 in human thymocyte differentiation : antagonism or agonism. Int Immunol 1991:3:419-25.
  • Martinez CM, Gibbons RC, Garovoy MR, Aronson FR. IL-4 inhibits IL-2 receptor expression and IL-2 dependent proliferation of human T cells. J Immunol 1990;144:2211 -5.
  • Rapoport MJ, Mor A, Vaidi P, Ramot Y, Winker R, Hindi A, et al. Decreased secretion of Th2 cytokines precedes up-regulatedand delayed secretion of Th1 cytokines in activated peripheral blood mono nuclear cells from patients with insulin-dependent diabetes mellitus. J Autoimmun 1998; 11:635 -42.
  • Pena AS, Crusius JB. Food allergy, coeliac disease and chronic inflammatory bowel disease in man. Vet Q 1998;20 Suppl 3S4952.
  • Kerttula TO, Collin P, Maki M, Hurme M. Normal T-helper 1/Thelper 2 balance in peripheral blood of coeliac disease patients. Scand J Immunol 1999;49:197-202.
  • Berman MA, Sandborg CI, Wang Z, Imfeld KL, Zaldivar FJ, Dadufalza V, et al. Decreased IL-4 Production in new onset type I insulin-dependent diabetes mellitus. J Immunol 1996;157: 4690-6.
  • Rapoport MJ, Jaramillo A, Zipris D, et al. Interleukin 4 reverses T cell proliferative unresponsivenes s and prevents the onset of diabetes in non-obese diabetic mice. J Exp Med 1993;178:8799.
  • Giron-Gonzalez JA, Morel FJ, Elvira J, Garcia-Gil D, Guerro F, Gavilan I, et al. Consistent production of a higher Th1:Th2 cytokine ratio by stimulated T cell in men compared with women. Euro J Endocrine 1 2000; 143:31 -6

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