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Scandinavian Journal of Gastroenterology Volume 37, 2002 - Issue 10
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Research Article

Eosinophils in Gastrointestinal Inflammation: From Innocent Bystanders to Offenders

A. Egesten
,
P. Andersson
&
T. Persson
Pages 1117-1125 | Published online: 08 Jul 2009

  • Spry CJF. Eosinophils. A comprehensive review and guide to the scientific and medical literature. Oxford: Oxford University Press; 1988.
  • Rosenberg HF. The eosinophil. In: Gallin JI, Snyderman R, editors. Inflammation: basic principles and clinical correlates. Philadelphia: Lippincott Williams & Wilkins Co.; 1999. p. 61-77.
  • Egesten A, Calafat J, Janssen H, Knol EF, Malm J, Persson T. Granules of human eosinophilic leukocytes and mechanisms involved in their mobilization. Clin Exp Allergy 2001 ;31:1173-88.
  • Broide D, Sriramarao P. Eosinophil trafficking to sites of allergic inflammation. Immunol Rev 2001;179:163-72.
  • Erie DJ, Briskin MJ, Butcher EC, Garcia-Pardo A, Lazarovits AI, Tidswell M. Expression and function of the MAdCAM-I receptor, integrin alpha 4 beta 7, on human leukocytes. J Immunol 1994; 153:517-28.
  • Mishra A, Hogan SP, Brandt EB, Wagner N, Crossman MW, Foster PS, et al. Enterocyte expression of the eotaxin and IL-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking. J Biol Chem 2002;277:4406-412.
  • Mishra A, Hogan SP, Brandt EB, Rothenberg ME. Peyer's patch eosinophils: identification, characterization, and regulation by mucosal allergen exposure, interleukin-5, and eotaxin. Blood 2000:96:1538-44.
  • Mishra A, Hogan SP, Lee JJ, Foster PS, Rothenberg ME. Fundamental signals that regulate eosinophil homing to the gastrointestinal tract. J Clin Invest 1999;103:1719-27.
  • Mosmann TR, Coffman RL. Th 1 and Th 2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann Rev Immunol 1989;7:145-73.
  • Lucey DR. Evolution of the type-1 (Th1)-type-2 (Th2) cytokine paradigm. Infect Dis Clin North Am 1999;13:1 -9.
  • Walsh GM. Eosinophil apoptosis: mechanisms and clinical relevance in asthmatic and allergic inflammation. Br J Haematol 2000;111:61-7.
  • Kita H, Adolphson CR, Gleich GJ. Biology of eosinophils. In: Middleton E, Reed CE, Ellis EF, et al., editors. Allergy. Principles and practice, 5th ed. St. Louis: Mosby Year Book, Inc.; 1998. p. 242-60.
  • Pujisawa T, Abu-Ghazaleh R, Kita H, Sanderson CJ, Gleich GJ. Regulatory effect of cytokines on eosinophil degranulation. J Immunol 1990; 144:642-6.
  • Lamkhioued B, Gounni AS, Gruart V, Pierce A, Capron A, Capron M. Human eosinophil s express a receptor for secretory component. Role in secretory IgA-dependent activation. Eur J Immunol 1995;25:117-25.
  • Motegi Y, Kita H. Interaction with secretory component stimulates effector functions of human eosinophils but not of neutrophils. J Immunol 1998; 161:4340-6.
  • Rosenberg HF. Recombinant human eosinophil cat ionic protein. Ribonuclease activity is not essential for cytotoxicity. J Biol Chem 1995;270:7876-81.
  • Young JD, Peterson CG, Venge P, Cohn ZA. Mechanism of membrane damage mediated by human eosinophil cat ionic protein. Nature 1986:321:613-6.
  • Domachowske JB, Dyer KD, Bon ville CA, Rosenberg HF. Recombinant human eosinophil-derive d neurotoxin/RNase 2 functions as an effective antiviral agent against respiratory syncytial virus. J Infect Dis 1998; 177:1458-64.
  • Klebanoff SJ. Oxygen metabolites from phagocytes. In: Gallin JI, Snyderman R, editor. Inflammation: basic principles and clinical correlates. Philadelphia: Lippincott Wiliams & Wilkins Co.; 1999. p. 721-68.
  • Wu W, Samoszuk MK, Comhair SA, Thomassen MJ, Farver CF, Dweik RA, et al. Eosinophils generate brominating oxidants in allergen-induced asthma. J Clin Invest 2000:105:1455-63.
  • Persson T, Andersso n P, Bodelsson M, Laurell M, Malm J, Egesten A. Bactericidal activity of human eosinophilic granulecytes against Escherichia coli. Infect Immun 2001 ;69: 3591-6.
  • Bozza PT, Yu W, Weiler PF. Mechanisms of formation and function of eosinophil lipid bodies: inducible intracellular sites involved in arachidonic acid metabolism. Mem Inst Oswaldo Cruz 1997:92:135-40.
  • Henderson WR Jr, Lewis DB, Albert RK, Zhang Y, Lamm WJ, Chiang GK, et al. The importance of leukotrienes in airway inflammation in a mouse model of asthma. J Exp Med 1996; 184:1483-94.
  • Blom M, Tool AT, Roos D, Verhoeven AJ. Priming of human eosinophil s by platelet-activatin g factor enhances the number of cells able to bind and respond to opsonized particles. J Immunol 1992:149:3672-7.
  • Lacy P, Moqbel R. Eosinophil cytokines. Chem Immunol 2000; 76:134-55.
  • Belperio JA, Keane MP, Arenberg DA, Addison CL, Ehlert JE, Burdick MD, Stricter RM. CXC chemokines in angiogenesis. J LeukocBiol 2000;68:1-8.
  • Roche WR, Beasley R, Williams JH, Holgate ST. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1989;l:520-4.
  • Weller PF, Bubley GJ. The idiopathic hypereosinophilic syndrome. Blood 1994;83:2759-79.
  • WHO Expert Committee on Onchocerciasis : third report. Technical Report Series No. 752. Geneva: World Health Organization; 1987. p. 38-42.
  • Weller PF, Rand TH, Barrett T, Elovic A, Wong DT, Finberg RW. Accessory cell function of human eosinophils. HLA-DRdependent, MHC-restricted antigen-presentatio n and IL-1 alpha expression. J Immunol 1993;150:2554-62.
  • Shi HZ, Humbles A, Gerard C, Jin Z, Weller PF. Lymph node trafficking and antigen presentation by endobronchial eosinophils. J Clin Invest 2000; 105:945-53.
  • Leckie MJ, ten Blinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000;356: 2144-8.
  • Bryan SA, O'Connor BJ, Matti S, Leckie MJ, Kanabar V, Khan J, et al. Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000;356:2149-53.
  • Persson CG, Erjefalt JS, Korsgren M, Sundler F. The mouse trap. Trends Pharmacol Sci 1997; 18:465-7.
  • Denzler KL, Horchers MT, Crosby JR, Cieslewicz G, Hines EM, Justice J, et al. Extensive eosinophil degranulation and peroxidase-mediate d oxidation of airway proteins do not occur in a mouse ovalbumin-challeng e model of pulmonary inflammation. J Immunol 2001; 167:1672-82.
  • Kato M, Kephart GM, Talley NJ, Wagner JM, Sarr MG, Bonno M, et al. Eosinophil infiltration and degranulation in normal human tissue. Anat Rec 1998;252:418-25.
  • Matthews AN, Friend DS, Zimmermann N, Sarafi MN, Luster AD, Pearlman E, et al. Eotaxin is required for the baseline level of tissue eosinophils. Proc Natl Acad Sci USA. 1998:95:6273-8.
  • Wilson ME, Weller PF. Eosinophilia. In: Guerrant RL, Walker DH, Weller PF, editors. Essentials of tropical infectious diseases. Philadelphia: Churchill Livingstone; 2001. p. 16-30.
  • Behm CA, Ovington KS. The role of eosinophils in parasitic infections: insights from genetically modified mice. Parasitol Today 2000:16:202-9.
  • Meeusen ENT, Balic A. Do eosinophil s have a role in the killing of helminth parasites? Parasitol Today 2000; 16:95-101.
  • Butterfleld JH, Gleich GJ. Response of six patients with idiopathic hypereosinophili c syndrome to interferon alfa. J Allergy Clin Immunol 1994;94:1318-26.
  • Masi AT, Hunder GG, Lie JT, Michel BA, Bloch DA, Arend WP, et al. The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosi s and angiitis). Arthritis Rheum 1990:33:1094-100.
  • Churg A. Recent advances in the diagnosis of Churg-Strauss syndrome. Mod Pathol 2001;14:1284-93.
  • Weller PF, Flaut M, Taggart V, Trontell A. The relationship ofasthma therapy and Churg-Strauss syndrome: NIH workshop summary report. J Allergy Clin Immunol 2001;108:175-83.
  • Wechsler ME, Finn D, Gunawardena D, Westlake R, Barker A, Haranath SP. Churg-Strauss syndrome in patients receiving montelukast as treatment for asthma. Chest 2000;117:708-13.
  • Iwasaki K, Torisu M, Fujimura T. Malignant tumor and eosinophils. I. Prognostic significance in gastric cancer. Cancer 1986:58:1321-7.
  • Shepherd NA, Blackshaw AI, Hall PA, Bostad L, Coates PJ, Lowe DG, et al. Malignant lymphoma with eosinophilia of the gastrointestinal tract. Histopathology 1987;11:115-30.
  • Pretlow TP, Keith EF, Cryar AK, Bartolucci AA, Pitts AM, Pretlow TG 2nd, et al. Eosinophil infiltration of human colonie carcinomas as a prognostic indicator. Cancer Res 1983; 43:2997-3000.
  • Femandez-Acenero MJ, Galindo-Gallego M, Sanz J, Aljama A. Prognostic influence of tumor-associated eosinophilic infiltrate in colorectal carcinoma. Cancer 2000;88:1544-8.
  • Wong DT, Bowen SM, Elovic A, Gallagher GT, Weller PF. Eosinophil ablation and tumor development. Oral Oncol 1999; 35:496-501.
  • Tepper RI, Coffman RL, Leder P. An eosinophil-dependen t mechanism for the antitumor effect of interleukin-4. Science 1992:257:548-51.
  • Kruger-Krasagakes S, Li W, Richter G, Diamantstein T, Blankenstein T. Eosinophils infiltrating interleukin-5 genetransfected tumors do not suppress tumor growth. Eur J Immunol 1993:23:992-5.
  • Macdonald FI, Ashraf S, Picton M, Dyer PA, Parrott NR, Short CD, et al. Banff criteria as predictors of outcome following acute renal allograft rejection. Nephrol Dial Transplant 1999; 14:1692-7.
  • Kormendi F, Amend WJ Jr. The importance of eosinophil cells in kidney allograft rejection. Transplantation 1988:45:537-9.
  • Nagral A, Ben-Ari Z, Dhillon AP, Burroughs AK. Eosinophils in acute cellular rejection in liver allografts. Liver Transpl Surg 1998:4:355-62.
  • Le Moine A, Flamand V, Demoor FX, Noel JC, Surquin M, Kiss R, et al. Critical roles for IL-4, IL-5, and eosinophil s in chronic skin allograft rejection. J Clin Invest 1999:103:1659-67.
  • Ahmad M, Soetikno RM, Ahmed A. The differential diagnosis of eosinophilic esophagitis. J Clin Gastroenterol 2000;30: 242-4.
  • Orenstein SR, Shalaby TM, Di Lorenzo C, Putnam PE, Sigurdsson L, Kocoshis SA. The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 children. Am J Gastroenterol 2000:95:1422-30.
  • Welsh SV, Antonioli DA, Goldman H, Fox VL, Bousvaros A, Leichtner AM, et al. Allergic esophagitis in children: a clinicopathological entity. Am J Surg Pathol 1999:23:390-6.
  • Straumann A, Bauer M, Fischer B, Blaser K, Simon HU. Idiopathic eosinophilic esophagitis is associated with a TH2type allergic inflammatory response. J Allergy Clin Immunol 2001; 108:954-61.
  • Liacouras CA, Markowitz JE. Eosinophilic esophagitis: a subset of eosinophilic gastroenteritis. Curr Gastroenterol Rep 1999:1:253-8.
  • Furuta GT. Eosinophils in the esophagus: acid is not the only cause. J Pediatr Gastroenterol Nutr 1998:26:468-71.
  • Winter HS, Madara JL, Stafford RJ, Grand RJ, Quintan JE, Goldman H. Intraepithelial eosinophils: a new diagnostic criterion for reflux esophagitis. Gastroenterology 1982;83: 818-23.
  • Ruchelli E, Wenner W, Voytek T, Brown K, Liacouras C. Severity of esophageal eosinophilia predicts response to conventional gastroesophagea 1 reflux therapy. Pediatr Dev Pathol 1999:2:15-8.
  • Justinich CJ, Ricci A Jr, Kalafus DA, Treem WR, Hyams JS, Kreutzer DL. Activated eosinophil s in esophaghi s in children : a transmission electron microscopic study. J Pediatr Gastroenterol Nutr 1997;25:194-8.
  • Mishra A, Hogan SP, Brandt EB, Rothenberg ME. Anetiological role for aeroallergens and eosinophils in experimental esophagitis. J Clin Invest 2001;107:83-90.
  • Wallaert B, Desreumaux P, Copin MC, Tillie I, Benard A, Colombel JF, et al. Inununoreactivity for interleukin 3 and 5 and granulocyte/macrophage colony-stimulating factor of intestinal mucosa in bronchial asthma. J Exp Med 1995; 182:1897-904.
  • McGovern TW, Talley NJ, Kephart GM, Carpenter HA, Gleich GJ. Eosinophil infiltration and degranulatio n in Helicobacter pylori-associated chronic gastritis. Dig Dis Sei 1991;36:435-40.
  • Herrera-Goepfert R, Arista-Nasr J, Alba-Campomanes A. Pathologic features of the gastric mucosa adjacent to primary MALT-lymphomas. J Clin Gastroenterol 1999;29: 266-9.
  • Talley NJ, Shorter RG, Phillips SF, Zinsmeister AR. Eosinophilic gastroenteritis: a clinicopathologica 1 study of patients with disease of the mucosa, muscle layer, and subserosal tissues. Gut 1990;31:54-8.
  • Caldwell JH. Eosinophilic gastroenteritis. Curr Treat Options Gastroenterol 2002;5:9-16.
  • Lee M, Hodges WG, Huggins TL, Lee EL. Eosinophilic gastroenteritis. South Med J 1996;89:189-94.
  • Colombel JF, Torpier G, Janin A, Klein O, Cortot A, Capron M. Activated eosinophils in adult coeliac disease: evidence for a local release of major basic protein. Gut 1992;33:1190-4.
  • Lavo B, Knutson L, Loof L, Odlind B, Venge P, Hallgren R. Challenge with gliadin induces eosinophil and mast cell activation in the jejunum of patients with celiac disease. Am J Med 1989:87:655-60.
  • Bischoff SC, Mayer JH, Manns MP. Allergy and the gut. Int Arch Allergy Immunol 2000; 121:270-83.
  • Schwab D, Raithel M, Klein P, Winterkamp S, Weidenhiller M, Radespiel-Troeger M, et al. Immunoglobulin E and eosinophilic cationic protein in segmentai lavage fluid of the small and large bowel identify patients with food allergy. Am J Gastroenterol 2001:96:508-14.
  • Machida HM, Catto Smith AG, Gall DG, Trevenen C, Scott RB. Allergic colitis in infancy: clinical and pathologic aspects. J Pediatr Gastroenterol Nutr 1994; 19:22-6.
  • Sampson HA, Anderson JA. Summary and recommendations : classification of gastrointestinal manifestations due to immunologie reactions to foods in infants and young children. J Pediatr Gastroenterol Nutr 2000;30:87-94.
  • Lake AM. Food-induced eosinophilic proctocolitis. J Pediatr Gastroenterol Nutr 2000:30:58-60.
  • Hogan SP, Mishra A, Brandt EB, Royalty MP, Pope SM, Zimmermann N, et al. A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation. Nat Immunol. 2001;2:353-60.
  • Sleisinger MH, Fordtran JS. Gastrointestinal disease pathophysiology, diagnosis, management. Philadelphia: Saunders; 1989. p. 1402-18.
  • Chen W, Paulus B, Shu D, Wilson, Chadwick V. Increased serum levels of eotaxin in patients with inflammatory bowel disease. Scand J Gastroenterol 2001;36:515-20.
  • D'Arienzo A, Manguso F, Astarita C, D'Armiento FP, Scarpa R, Gargano D, et al. Allergy and mucosal eosinophil infiltrate in ulcerative colitis. Scand J Gastroenterol 2000;35:624-31.
  • Levy AM, Gleich GJ, Sandborn WJ, Tremaine WJ, Steiner BL, Phillips SF. Increased eosinophil granule proteins in gut lavage fluid from patients with inflammatory bowel disease. Mayo Clin Proc 1997;72:117-23.
  • Carlson M, Raab Y, Peterson C, Hallgren R, Venge P. Increasedintraluminal release of eosinophil granule proteins EPO, ECP, EPX, and cytokines in ulcerative colitis and proctitis in segmentai perfusion. Am J Gastroenterol 1999;94:1876-83.
  • Oshitani N, Campbell A, Kitano A, Kobayashi K, Jewell DP. In situ comparison of phenotypical and functional activity of infiltrating cells in ulcerative colitis mucosa. J Pathol 1996; 178:95-9.
  • Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 1990;98:694-702.
  • Stevceva L, Pavli P, Husband A, Matthaei KI, Young IG, Doe WF. Eosinophilia is attenuated in experimental colitis induced in IL-5 deficient mice. Genes Immun 2000; 1:213-8.
  • Grip O, Malm J, Veiess B, Bjartell A, Lindgren S, Egesten A. Increased presence of cells containing transforming growth factor alpha (TCP-alpha) in ulcerative colitis, both during active inflammation and in remission. Eur J Gastroenterol Hepatol 2000;12:761 -6.
  • Van Deventer SJ. Immunotherapy of Crohn's disease. Scand J Immunol 2000:51:18-22.
  • Dubucquoi S, Janin A, Klein O, Desreumaux P, Quandalle P, Cortot A, et al. Activated eosinophil s and interleukin 5 expression in early recurrence of Crohn's disease. Gut 1995; 37:242-5.
  • Beil WJ, Weller PF, Peppercorn MA, Galli SJ, Dvorak AM. Ultrastructural immunogold localization of subcellular sites of TNF-alpha in colonie Crohn's disease. J Leukoc Biol 1995; 58:284-98.
  • Mansi A, Cucchiara S, Greco L, Samelli P, Pisanti C, Franco MT, et al. Bronchial hyperresponsivenes s in children and adolescents with Crohn's disease. Am J Respir Crit Care Med 2000;161:1051-4.
  • Louis E, Louis R, Shute J, Lau L, Franchimont D, Lamproye A, et al. Bronchial eosinophilic infiltration in Crohn's disease in the absence of pulmonary disease. Clin Exp Allergy. 1999:29:660-66.
  • Bohr J. A review of collagenous colitis. Scand J Gastroenterol 1998:33:2-9.
  • Aigner T, Neureiter D, Muller S, Kuspert G, Belke J, Kirchner T. Extracellular matrix composition and gene expression in collagenous colitis. Gastroenterology 1997;113:136-43.
  • Jämerot G, Tysk C, Bohr J, Eriksson S. Collagenous colitis and fecal stream diversion. Gastroenterology 1995:109:449-55.
  • Levy AM, Yamazaki K, Van Keulen VP, Burgart LJ, Sandborn WJ, Phillips SF, et al. Increased eosinophil infiltration and degranulation in colonie tissue from patients with collagenous colitis. Am J Gastroenterol 2001;96:1522-8.
  • Ignotz RA, Massague J. Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem 1986; 261:4337-45.
  • Edwards DR, Murphy G, Reynolds JJ, Whitham SE, Docherty AJ, Angel P, et al. Transforming growth factor beta modulates the expression of colagenase and metalloproteinas e inhibitor. EMBO J 1987:6:1899-904.
  • Ståhle-Bäckdahl M, Maim J, Veress B, Benoni C, Bruce K, Egesten A. Increased presence of eosinophilic granulocytes expressing transforming growth factor-beta 1 in collagenous colitis. Scand J Gastroenterol 2000:35:742-6.
  • Taha Y, Carlson M, Thorn M, Loof L, Raab Y. Evidence of local eosinophil activation and altered mucosal permeability in collagenous colitis. Dig Dis Sei 2001;46:888-97.

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