Advanced search
Publication Cover
Scandinavian Journal of Gastroenterology Volume 37, 2002 - Issue 10
Submit an article Journal homepage
103
Views
29
CrossRef citations to date
0
Altmetric
Research Article

APC and CTNNB1 Mutations in a Large Series of Sporadic Colorectal Carcinomas Stratified by the Microsatellite Instability Status

T. Løvig
,
G. I. Meling
,
C. B. Diep
,
L. Thorstensen
,
S. Norheim Andersen
,
R. A. Lothe
&
T. O. Rognum
 show all
Pages 1184-1193 | Published online: 08 Jul 2009

  • Su LK, Johnson KA, Smith KJ, Hill DE, Vogelstein B, Kinder KW. Association between wild type and mutant APC gene products. Cancer Res 1993;53:2728-31.
  • Rubinfeld B, Souza B, Albeit I, Muller O, Chamberlain SH, Masiarz FR, et al. Association of the APC gene product with beta-catenin. Science 1993;262:1731-4.
  • Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC (see comments). Science 1997;275:1787-90.
  • Kinder KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-70.
  • Eyas M, Tomlinson I, Rowan A, Pignatelli M, Bodmer W. ß-catenin mutations in cell lines established from human colorectal cancers. Proc Natl Acad Sei USA 1997:94:10330-4.
  • Iwao K, Nakamori S, Kameyama M, Imaoka S, Kinoshita M, Fukui T, et al. Activation of the beta-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations. Cancer Res 1998:58:1021-6.
  • Sparkes AB, Morin PJ, Vogelstein B, Kinder KW. Mutational analysis of the APC/ß-catenin/Tcf pathway in colorectal cancer. Cancer Res 1998:58:1130-4.
  • Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinder KW, et al. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 1997:275:1784-7.
  • He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, et al. Identification of c-MYC as a target of the APC pathway (see comments). Science 1998281:1509-12.
  • Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R, et al. The cyclin Dl gene is a target of the beta-catenin/ LEF-1 pathway. Proc Natl Acad Sei USA 1999:96:5522-7.
  • Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin Dl in colon carcinoma cells. Nature 1999:398:422-6.
  • Olschwang S, Hamelin R, Laurent-Puig P, Thuille B, De Rycke Y, Li YJ, et al. Alternative genetic pathways in colorectal carcinogenesis. Proc Natl Acad Sei USA 1997:94:12122-7.
  • Salahshor S, Kressner U, Påhlman L, Glimelius B, Lindmark G, Lindblom A. Colorectal cancer with and without microsatellite instability involves different genes. Genes Chromosomes Cancer 1999:26:247-52.
  • Shitoh K, Furukawa T, Kojima M, Konishi F, Miyaki M, Tsukamoto T, et al. Frequent activation of the beta-catenin-Tcf signaling pathway in nonfamilial colorectal carcinomas with microsatellite instability (In Process Citation). Genes Chromosomes Cancer 2001;30:32-7.
  • Homfray TF, Cottrell SE, Eyas M, Rowan A, Talbot IC, Bodmer WF, et al. Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumours. Hum Mutat 1998:11:114-20.
  • Huang J, Papadopoulos N, McKinley A. APC mutations in colorectal tumors with mismatch repair deficiency. Proc Natl Acad Sei USA 1996:9049-54.
  • Kitaeva MN, Grogan L, Williams JP, Dimond E, Nakahara K, Hausner P, et al. Mutations in beta-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors. Cancer Res 1997:57:4478-81.
  • Muller O, Nimmrich I, Finke U, Friedl W, Hoffmann I. A beta-catenin mutation in a sporadic colorectal tumor of the RER phenotype and absence of beta-catenin germline mutations in FAP patients. Genes Chromosomes Cancer 1998:22:37-41.
  • Mirabelli-Primdahl L, Gryfe R, Kim H, Millar A, Luceri C, Dale D, et al. Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of imitator pathway. Cancer Res 1999:59:3346-51.
  • Meling GI, Lothe RA, Børresen A-L, Hauge S, Grue C, Clausen OPF, et al. Genetic alterations within the retinoblastoma locus in colorectal carcinomas: relation to DNA ploidy pattern studied by flow cytometric analysis. Br J Cancer 1991:64:475-80.
  • Presser J, Condie A, Wright M, Horn JM, Fantes JA, Wyllie AH, et al. APC mutation analysis by chemical cleavage of mismatch and a protein truncation assay in familial adenomatous polyposis. Br J Cancer 1994;70:841-6.
  • Norheim Andersen S, Løvig T, Fausa O, Rognum TO. Germline and somatic mutations in exon 15 of the APC gene and K-ras mutations in duodenal adenomas in patients with familial adenomatous polyposis (see comments). Scand J Gastroenterol 1999:34:611-7.
  • Groden J, Thliveris A, Samowitz W, Carlson M, Gelbert L, Albertsen H, et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 1991;66:589-600.
  • Lothe RA, Peltomaki P, Meling GI, Aaltonen LA, Nystrøm-Lahti M, Pylkkanen L, et al. Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res 1993;53:5849-52.
  • Thorstensen L, Diep CB, Meling GI, Aagensen T, Ahrens CH, Rognum TO, et al. WNT1 inducible signaling pathway protein 3, WISPS, a novel target gene in colorectal carcinomas with microsatellite instability. Gastroenterology 2001;121:1275-80.
  • Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, et al. A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998;58:5248-57.
  • APC database: http://p53.curie.fr/
  • Nagase H, Nakamura Y. Mutations of the APC gene. Hum Mutat 1993:2:425-34.
  • Miyoshi Y, Nagase H, Ando H, Hori A, Ichii S, Nakatsuru S, et al. Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum MoI Genet 1992:1:229-33.
  • Kapiteijn E, Liefers GJ, Los LC, Kranenbarg EK, Hermans J, Tollenaar RA, et al. Mechanisms of oncogenesis in colon versus rectal cancer. J Palhol 2001:195:171-8.
  • Benedetti LD, Sciallero S, Gismondi V, James R, Bafico A, Biticchi R, et al. Association of APC gene mutations and histological characteristics of colorectal adenomas. Cancer Res 1994:54:3553-6.
  • Lengauer C, Kinzer KW, Vogelstein B. Genetic instability in colorectal cancers. Nature 1997:386:623-7.
  • Nowell PC. The clonal evolution of tumor cell populations. Science 1976:194:23-8.
  • Munemitsu S, Albeit I, Souza B, Rubinfeld B, Polakis P. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Nail Acad Sei USA 1995;92:3046-50.
  • Rubinfeld B, Albert I, Porfiri E, Munemitsu S, Polakis P. Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene. Cancer Res 1997;57:4624-30.
  • Kaplan KB, Burds AA, Swedlow JR, Bekir SS, Sorger PK, Nathke IS. A role for the adenomatous polyposis coli protein in chromosome segregation. Nature Cell Biol 2001;3:429-32.
  • Fodde R, Kuipers J, Rosenberg C, Smits R, Kielman M, Caspar C, et al. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nature Cell Biol 2001;3:433-8.
  • von Kries JP, Winbeck G, Asbrand C, Schwarz-Romond T, Sochnikova N, Dell'Oro A, et al. Hot spots in beta-catenin for interactions with LEF-1, conductin and APC. Nat Struct Biol 2000:7:800-7.
  • Liu W, Dong X, Mai M, Sedan RS, Taniguchi K, Krishnadath KK, et al. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling, (erratum appears in Nat Genet 2000 Dec;26(4):501 ). Nat Genet 200026:146-7.
  • Duval A, Gayet J, Zhou XP, Iacopetta B, Thomas G, Hamelin R. Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability. Cancer Res 1999;59: 4213-5.
  • Duval A, Rolland S, Tubacher E, Bui H, Thomas G, Hamelin R. The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines. Cancer Res 2000:60:3872-9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.