101
Views
114
CrossRef citations to date
0
Altmetric
Research Article

Serum YKL-40, a Potential New Marker of Disease Activity in Patients with Inflammatory Bowel Disease

, , &
Pages 599-605 | Published online: 08 Jul 2009

  • Matthes H, Herbst H, Schuppen D. Cellular localisation of procollagen gene transcripts in inflammatory bowel diseases. Gastroenterology 1992; 102:431-42.
  • Lawrence IC, Fiocchi C, Charkravarti S. Differential expression of metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TlMP)-1 and extracellular matrix (ECM) components in fibrosed, inflamed and normal intestine. Gastroenterology 1999;116:A758-9.
  • Veloso FT, Ferreira JT, Barros L, Almeida S. Clinical outcome of Crohn's disease: analysis according to the Vienna Classification and clinical activity. Inflamm Bowel Dis 2001(4):306-13.
  • Hakala BE, White C, Recklies AD. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. J Biol Chem 1993;268:25803-10.
  • Johansen JS, Jensen HS, Price PA. A new biochemical marker for joint injury. Analysis of YKL-40 in serum and synovial fluid. Br J Rheumatol 1993;32:949-55.
  • Hu B, Trinh K, Figueira WF, Price PA. Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family. J Biol Chem 1996;271: 19415-20.
  • Shackelton LM, Mann DM, Millis AJT. Identification of a 38-kDa heparin-binding glycoprotein (gp38k) in differentiating vascular smooth muscle cells as a member of a group of proteins associated with tissue remodeling. J Biol Chem 1995; 270: 13076-83.
  • Renkema GH, Boot RG, Au FL, Donker-Koopman WE, Strijland A, Muijsers AO, et al. Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages. Eur J Biochem 1998;251:504-9.
  • Recklies AD, White C, Ling H. The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathways. Biochem J 2002;365:119-26.
  • De Ceuninck F, Gaufillier S, Bonnaud A, Sabatini M, Lesur C, Pastoureau P. YKL-40 (Cartilage gp-39) induces proliferative events in cultured chondrocytes and synoviocytes and increases glycosaminoglycan synthesis in chondrocytes. Biochem Biophys Res Commun 2001;285:926-31.
  • Malinda KM, Ponce L, Kleiman HK, Shack LM, Millis AJT. Gp38k, a protein synthesized by vascular smooth muscle cells stimulates directional migration of human umbilical vein endothelial cells. Exp Cell Res 1999;250:168-73.
  • Volck B, Price PA, Johansen JS, Sørensen O, Benfield TL, Nielsen HJ, et al. YKL-40, a mammalian member of the bacterial chitinase family, is a matrix protein of specific granules in human neutrophils. Proc Assoc Am Phys 1998;110:351-60.
  • Krause SW, Rehli M, Kreutz M, Schwarzfischer L, Paulauskis JD, Andreesen R. Differential screening identifies genetic markers of monocyte to macrophage maturation. J Leukoc Biol 1996;60:540-5.
  • Rehli M, Krause SW, Andresen R. Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation. Genomics 1997;43:221-5.
  • Kirkpatrick RB, Emery JG, Connor JR, Dodds R, Lysko PG, Rosenberg M. Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages. Exp Cell Res 1997;237: 46-54.
  • Baeten D, Boots AMH, Steenbakkers PGA, Elewaut D, Bos E, Verheijden GFM, et al. Human cartilage gp-39+, CD16+ monocytes in peripheral blood and synovium. Correlation with joint destruction in rheumatoid arthritis. Arthritis Rheum 2000; 43:1233-43.
  • Volck B, Johansen JS, Stoltenberg M, Garbarsch C, Price PA, Østergaard M, et al. Studies on YKL-40 in knee joints of patients with rheumatoid arthritis and osteoarthritis. Involvement of YKL-40 in the joint pathology. Osteoarthritis Cartilage 2001;9:203-14.
  • Boot RG, van Achterberg TAE, van Aken BE, Renkema GH, Jacobs MJHM, Aerts JMFG, et al. Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages. Arterioscler Thromb Vase Biol 1999;19:687-94.
  • Johansen JS, Baslund B, Garbarsch C, Hansen M, Stoltenberg M, Lorenzen I, et al. YKL-40 in giant cells and macrophages from patients with giant cell arteritis. Arthritis Rheum 1999;42: 2624-30.
  • Johansen JS, Olee T, Price PA, Hashimoto S, Ochs RL, Lotz M. Regulation of YKL-40 production by human articular chondrocytes. Arthritis Rheum 2001;44:826-37.
  • Johansen JS, Williamson MK, Rice JS, Price PA. Identification of proteins secreted by human osteoblastic cells in culture. J Bone Miner Res 1992;7:501-12.
  • Morrison BW, Leder P. neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors. Oncogene 1994;9:3417-26.
  • Harvey S, Weisman M, O'Dell J, Scott T, Krusemeier M, Visor J, et al. Chondrex: new marker of joint disease. Clin Chem 1998; 44:509-16.
  • Johansen JS, Stoltenberg M, Hansen M, Florescu A, HørslevPetersen K, Lorenzen I, et al. Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity. Rheumatology 1999;38:618-26.
  • Vos K, Steenbakkers P, Miltenburg AMM, Bos E, van den Heuvel MW, van Hogezand RA, et al. Raised human cartilage glycoprotein-39 plasma levels in patients with rheumatoid arthritis and other inflammatory conditions. Ann Rheum Dis 2000:59:544-8.
  • Nordenbaek C, Johansen JS, Junker P, Borregaard N, Sørensen O, Price PA, et al. YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with communityacquired pneumonia requiring hospitalization. J Infect Dis 1999; 180:1722-6.
  • Kronborg G, Østergaard C, Weis N, Nielsen H, Obel N, Pedersen SS, et al. Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated to the outcome of the disease. Scand J Infect Dis 2002;34:323-6.
  • Østergaard C, Johansen JS, Benfield T, Price PA, Lundgren JD. YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis. Clin Diagn Lab Immunol 2002;9:598-604.
  • Johansen JS, Cintin C, Jorgensen M, Kamby C, Price PA. Serum YKL-40: a new potential marker of prognosis and location of metastases of patients with recurrent breast cancer. Eur J Cancer 1995;31A:1437-42.
  • Cintin C, Johansen JS, Christensen IJ, Price PA, Sørensen S, Nielsen HJ. Serum YKL-40 and colorectal cancer. Br J Cancer 1999;79:1494-9.
  • Johansen JS, Christoffersen P, Møller S, Price PA, Henriksen JH, Garbarsch C, et al. Serum YKL-40 is increased in patients with hepatic fibrosis. J Hepatol 2000;32:911-20.
  • Tran A, Benzaken S, Saint-Paul M-C, Guzman-Granier E, Hastier P, Pradier C, et al. Chondrex (YKL-40), a potential new serum fibrosis marker in patients with alcoholic liver disease. Eur J Gastroenterol Hepatol 2000;12:989-93.
  • Vos K, Miltenburg AMM, van Meijgaarden KE, van den Heuvel M, Elferink DJ, van Galen PJM, et al. Cellular immune responses to human cartilage glycoprotein-39 (HC gp-39)-derived peptides in rheumatoid arthritis and other inflammatory conditions. Rheumatology 2000;39:1326-31.
  • Verheijden GFM, Rijnders AWM, Bos E, Coenen-de Roo CJJ, van Staveren CJ, Miltenburg AMM, et al. Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoid arthritis. Arthritis Rheum 1997;40:1115-25.
  • Cope AP, Patel SD, Hall F, Congia M, Hubers HAJM, Verheijden GF, et al. T cell responses to a human cartilage autoantigen in the context of rheumatoid arthritis-associated and nonassociated HLA-DR4 alleles. Arthritis Rheum 1999; 42: 1497-507.
  • Joosten LAB, Coenen-de Roo CJJ, Helsen MMA, Lubberts E, Boots AMH, van den Berg WB, et al. Induction of tolerance with intranasal administration of human cartilage gp-39 in DBA/ 1 mice. Arthritis Rheum 2000;43:645-55.
  • Munkholm P. Crohn's disease-occurrence, course and prognosis. An epidemiologic cohort study [review thesis]. Dan Med Bull 1997:44:287-302.
  • Walmsley RS, Ayres RCS, Pounder RE, Allan RN. A simple clinical colitis activity index. Gut 1998;43:29-32.
  • Harvey RF, Bradshaw JM. A simple index of Crohn's disease activity. Lancet 1980;i:514.
  • Jowett SL, Seal CJ, Barton JR, Welfare MR. Use of the simple colitis activity index (SCCAI). Gut 2001;48 Suppl:A1-A124.
  • Forbes A. Inflammatory bowel disease. A clinicians' guide, 2nd edn. Appendix A, p. 243: Scoring systems in inflammatory bowel disease. London: Arnold; 2001.
  • Johansen JS, Hvolris J, Hansen M, Backer V, Lorenzen I, Price PA. Serum Ykl-40 levels in healthy children and adults. Comparison with serum and synovial fluid levels of YKL-40 in patients with osteoarthritis or trauma of the knee joint. Br J Rheumatol 1996;35:553-9.
  • Rugtveit J, Brandtzaeg P, Halstensen TS, Fausa O, Scott H. Increases macrophage subset in inflammatory bowel disease. Apparent recruitment from peripheral blood monocytes. Gut 1994;35:669-74.
  • Kucharzik T, Lgering N, Adolf M, Domschke W, Stoll R. Synergistic effect of immunoregulatory cytokines on peripheral blood monocytes from patients with inflammatory bowel disease. Dig Dis Sci 1997;42:805-12.
  • Munkholm P, Langholz E, Davidsen M, Binder V. Intestinal cancer risk and mortality in patients with Crohn's disease. Gastroenterology 1993;105:1716-23.
  • Munkholm P, Langholz E, Davidsen M, Binder V. Disease activity courses in a regional cohort of Crohn's disease patients. Scand J Gastroenterol 1995;30:699-706.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.