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Research Article

Effect of Glutathione Depletion and Hydrophilic Bile Acids on Hepatic Acute Phase Reaction in Rats with Extrahepatic Cholestasis

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Pages 878-885 | Published online: 08 Jul 2009

  • Kushner I. The phenomenon of the acute phase response. Ann NY Acad Sci 1982;389:39-49.
  • Gordon AH, Koj A. The acute-phase response to injury and infection. In: Research monographs in cell and tissue physiology vol. 10 Amsterdam/New York: Eisevier; 1985.
  • Mackiewicz A, Kushner I, Baumann H, editors. Acute phase proteins: molecular biology, biochemistry, clinical application. Boca RatonFloridaCRC Press; 1993.
  • Roeb E, Graeve L, Hoffmann R, Decker K, Edwards DR, Heinrich PC. Regulation of tissue inhibitor of metalloproteinases-1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures. Hepatology 1993;18:1437-42.
  • Roeb, Graeve, Müllberg, Matern, Rose-John TIMP-1 protein expression is stimulated by IL-1β and IL-6 in primary rat hepatocytes. 1994; 349: 45-9FEBS Lett
  • Kumerova AO, Petukhov VI, Shkesters AP, Silova AA, Letse AG. Possible use of erythrocyte antioxidant enzymes as markers of the course of disease in patients with hemoblastoses. Vop Med Khim 1996;42:144-7.
  • Kimura F, Miyazaki M, Suwa T, Hayashida K, Kakizaki S, Ito H, et aL Hepatic protein synthesis and cytokines in obstructive jaundice. Nippon Shokakibyo Gakkai Zasshi 1992:92673-681.
  • Suthanthiran M, Anderson ME, Shamrma VK, Meister A. Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 abd CD3 antigens. Proc Natl Acad Sci USA 1990; 87: 3343-7.
  • Hutter DE, Till BG, Greene JJ. Redox state changes in densitydependent regulation of proliferation. Exp Cell Res 1997;232: 435-8.
  • Fernández-Checa, Kaplowitz, Garcia-Ruiz, Colell, Miranda, Mai Glutathione transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect. 1997; 273: G7-17Am J Physiol
  • Lu SC. Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J 1999;13:1169-83.
  • DeLeve LD, Kaplowitz N. Glutathione metabolism and its role in hepatotoxicity. Pharmocol Ther 1991;52:287-305.
  • Neuschwander-Tetri BA, Nicholson C, Wells LD, Tracy TF Jr. Cholestatic liver injury down-regulates hepatic glutathione synthesis. J Surg Res 1996;63:447-51.
  • Purucker E, Wernze H, Krandik G. Glutathione in plasma, liver, and kidney in the development of CC14-induced cirrhosis of the rat Res Exp Med 1995; 195:193-9.
  • Hassan AS, Bunick D, Lund LA, Bottje WG. Gluthatione and bile acid synthesis. Effect of glutathione content of HepG2 cells on the activity and mRNA levels of cholesterol 7 alphahydroxylase. Biochem Pharmacol 1992;44:1475-7.
  • Leuschner, Fischer, Kurtz, Güldütuna, Hübner, Hellstern Ursodeoxycholic acid in primary biliary cirrhosis: results of a controlled double-blind study. 1998; 97: 1268-74Gastroenterology
  • Poupon RE, Lindor KD, Cauch-Dudek K, Dickson ER, Poupon R, Heathcote EJ. Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis. Gastroenterology 1997;! 13:884-90.
  • Marschall HU, Roeb E, Yildiz Y, Busch N, Nguyen H, Purucker E, et al. Study of human isoursodeoxycholic acid metabolism. J Hepatol 1997;26:863-70.
  • Purucker E, Marschall H, Winograd R, Matern S. Metabolism and effects on cholestasis of isoursodeoxycholic acids in bile duct ligated rats. Biochim Biophys Acta 2001; 1526:44-52.
  • Griffith OW, Meister A. Glutathione: interorgan translocation, turnover, and metabolism. Proc Natl Acad Sci 1979;76:5606-10.
  • Roeb E, Purucker E, Breuer B, Nguyen H, Heinrich PC, Rose-John S, et al. TIMP expression in toxic and cholestatic liver injury in rat. J Hepatol 1997;27:535-9.
  • Griffith, Meister Potent and specific inhibition of glutathione synthesis by buthionine sulfoxime (S-n-butyl homocysteine sulfoximine). 1979; 254: 7558-560J Biol Chem
  • Neuwelt EA, Pagel M, Hasler BP, Deloughery TG, Muldoon LL. Therapeutic efficacy of aortic administration of N-acetylcystein as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model. Cancer Res 2001;61:7868-74.
  • Rose-John, Dietrich, Marks Molecular cloning of mouse protein kinase C (PKC) cDNA from Swiss 3T3 fibroblasts. 1988; 74: 465-71Gene
  • Feinberg AP, Vogelstein B. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 1983;132:1326-13.
  • Kimura F, Miyazaki M, Suwa T, Sugiura T, Shinoda T, Itoh H, et al. Anti-inflammatory response in patients with obstructive jaundice caused by biliary malignancy. J Gastroenterol Hepatol 2001;16:467-72.
  • Baumann H, Prowse KR, Marinkovic S, Vonn KA, Jahreis GP. Stimulation of hepatic acute-phase response by cytokines and glucoccorticoids. Ann NY Acad Sci 1989;557:280-95.
  • Horn, Wegenka, Lütticken, Yuan, Roeb, Boers Regulation of α2-macroglobulin gene expression by interleukin-6. 1994; 737: 308-23Ann NY Acad Sci
  • Crawford JM. Cellular and molecular biology of the inflamed liver. Curr Opin Gastroenterol 1997; 13:175-85.
  • Nolan JP. Intestinal endotoxins as mediators of hepatic injury: an idea whose time has come again. Hepatology 1989;10:887-91.
  • Bemelmans MHA, Gouma DJ, Greve JW, Buurman WA. Cytokines tumor necrosis factor and interleukin-6 in experimental biliary obstruction in mice. Hepatology 1992;15:1132-6.
  • Grinko I, Geerts A, Wisse B. Experimental biliary fibrosis correlates with increased numbers of fat-storing and Kupffer cells, and portal endotoxemia. J Hepatol 1995;23:449-58.
  • Grève JWM, Gouma DJ, Buurman WA. Complications in obstructive jaundice: role of endotoxins. Scand J Gastroenterol 1992;27 Suppl 194:8-12.
  • Clements WDB, Parks R, Erwin P. Role of the gut in the pathophysiology of extrahepatic biliary obstruction. Gut 1996; 39:587-93.
  • Ide T, Sata M, Suzuki H, Uchimura Y, Murashima S, Shirachi M, et al. An experimental animal model of primary biliary cirrhosis induced by lipopolysaccharide and pyruvate dehydrogenase. Kuruma Med J 1996;43:185-8.
  • Weng S, Leng X, Wei Y. Interleukin-10 inhibits the activation of cultured rat hepatic stellate cells induced by Kupffer cells. Zhonghua Yi Xue Za Zhi 2002;82:104-7.
  • Rajasekaran, Devaraj, Devaraj The effect of glutathione monoester (GME) on glutathione (GSH) depleted rat liver. 2002; 13: 302-6J Nutr Biochem
  • Portoles MT, Catala M, Anton A, Pagani R. Hepatic response to the oxidative stress induced by E. coli endotoxin: glutathione as an index of the acute phase during the endotoxic shock. Mol Cell Biochem 1996;159:115-21.
  • Ookhtens, Kaplowitz Role of the liver in interorgan homeostasis of glutathione and cyst(e)ine. 1998; 18: 313-29Sem Liv Dis
  • Orellana M, Rodrigo R, Thielemann L, Guajardo V. Bile duct ligation and oxidative stress in the rat: effects in liver and kidney. Comp Biochem Physiol C Toxicol Pharmacol 2000; 126: 105-11.
  • Mottino AD, Hoffman T, Dawson PA, Luquita MG, Monti JA, Sanchez Pozzi EJ, et al. Increased expression of ileal apical sodium-dependent bile acid transporter in postpartum rats. Am J Physiol Gastrointest Liver Physiol. 2002;282:G41-50.
  • Yoshida H, Kuronuma Y, lijima M, Harada T, Kuhlenkamp J, Kaplowitz N. The relationship between biliary secretion of bilirubin and GSH in the rat. Gastroenterol Jpn 199227:369-73.
  • Mesa ML, Carrizosa R, Martinez-Honduvilla C, Benito M, Fabregat I. Changes in rat liver gene expression induced by thioacetamide: protective role of S-adenosyl-L-methionine by a glutathione-dependent mechanism. Hepatology 1996;23:600-6.
  • Goulis J, Leandro G, Burroughs AK. Randomised controlled trials of ursodeoxycholic-acid therapy for primary biliary cirrhosis: a meta-analysis. Lancet 1999;354:1053-60.
  • Andus T, Gross V, Tran-Thi TA, Schreiber G, Nagashima M, Heinrich PC. The biosynthesis of acute-phase proteins in primary cultures of rat hepatocytes. Eur J Biochem 1988; 133: 561-71.
  • Marinkovic S, Jahreis GP, Wong GG, Baumann H. IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo. J Immunol 1989; 142:808-12.
  • Paumgartner G, Beuers U. Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited. Review. Hepatology 2002;36:525-31.
  • Fickert P, Zollner G, Fuchsbichler A, Stumptner C, Weiglein AH, Lammert F, et al. Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangjoles. Gastroenterology 2002;123:1238-51.

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