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Research Article

Low Frequency of Upper Gastrointestinal Complications in a Cohort of High-Risk Patients Taking Low-Dose Aspirin or NSAIDS and Omeprazole

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Pages 693-700 | Published online: 08 Jul 2009

  • Antiplatelet Trialist Collaboration: Collaborative overview of randomised trials of antiplatelet therapy. I. Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Br Med J 1994:308:81106.
  • Hawkey CJ, Lanas A, on behalf of the Sardinia NSAID meeting participants Doubt and certainty about NSAIDs in the year 2000: a rnultidisciplinary expert statement. Am J Med 2001; 110 (1A)79S-100S.
  • Henry D, Dobson A, Turner C. Variability in the risk of major gastrointestinal complications from nonaspirin nonsteroidal antiinflammatory drugs. Gastroenterology 1993;105:1078-88.
  • Lanas A, Bajador E, Serrano P, Fuentes J, Carreño S, Guardia J, et al. Nitrovasodilators, low-dose aspirin, nonsteroidal antiinflammatory drugs, and the risk of upper gastrointestinal bleeding. N Engl J Med 2000;343:834-9.
  • Weil J, Colin Jones D, Langman MJS, Lawson D, Logan R, Murphy M, et al. Prophylactic aspirin and risk of peptic ulcer bleeding. Br Med J 1995 ;310:827-30.
  • Garcia Rodriguez LA, Jick H. Risk of upper gastrointestinal bleeding and perforation associated with individual nonsteroidal anti-inflammatory drugs. Lancet 1994;343:769-72.
  • Simon LS, Hatoum HT, Bittman RM, Archambault WT, Polisson RP. Risk factors for serious nonsteroidal-induced gastrointestinal complications: regression analysis of the MUCOSA trial. Fam Med 199628:204-10.
  • Hemandez S, Garcia Rodriguez LA. Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation. Arch Intern Med 2000; 160:2093-9.
  • Lanas A. Current approaches to reducing gastrointestinal toxicity of low-dose aspirin. Am J Med 2001;110 (1A)70 S-3S.
  • Silverstein FE, Graham DY, Senior JR, Davies HW, Struthers BJ, Bittman RM, et al. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 1995; 123:241-9.
  • Chan FKL, Chung SCS, Suen BY, Lee YT, Leung WK, Leung VKS, et al. Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen. N Engl J Med 2001;344:967-73.
  • Lai KC, Lam SK, Chu KM, Hui WM, Wong CY, Hu W, et al. H. pylori eradication vs combined proton pump inhibitor and H. pylori eradication in the prevention of recurrent ulcer complications in high-risk patients receiving low-dose aspirin. N Engl J Med 2002:346:2033-8.
  • Yeomans N, Tulassay Z, Juhasz L, Racz I, Howard JM, Van Rensburg CJ, et al, for the Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-Associated Ulcer Treatment (ASTRONAUT). A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. N Engl J Med 1998;338:719-26.
  • Hawkey CJ, Karrasch JA, Szczepanski L, Walker DG, Barkun A, Swwannell AJ, et al, for the Omeprazole versus Misoprostol for NSAID-Induced Ulcer Management (OMNIUM) Study Group. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. N Engl J Med 1998:338:727-734.
  • Cullen D, Bardhan KD, Eisner M, Kogut DG, Peacock RA, Thomson JM, et al. Primary gastroduodenal prophylaxis with omeprazole for non-steroidal anti-inflammatory drug users. Aliment Pharmacol Ther 1998; 12:135-40.
  • Raskin JB, White RH, Jackson JE, Weaver AL, Tindall EA, Lies RB, et al. Misoprostol dosage in the prevention of nonsteroidal anti-inflammatory drug-induced gastric and duodenal ulcers: a comparison of three regimens. Ann Intern Med 1995;123:34450.
  • Serrano P, Lanas A, Arroyo M, Casanovas JA, Ferreira I. Risk stratification of upper gastrointestinal bleeding in cardiovascular patients on low dose aspirin: a cohort study. Aliment Pharmacol Ther 2002:16:1945-53.
  • Chan FKL, Wu JYW, Suen BY, Leung W, To KF, Hung LCT, et al. Eradication of H. pylori to prevent recurrent ulcer complications associated with low-dose aspirin: a long-term cohort study. Gastroenterology 2002; 122 4 Suppl:696A86.
  • Deny S, Loke YK. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. Br Med J 2000; 321: 1183-7.
  • Wallentin LC. Aspirin (75 mg/day) after an episode of unstable coronary artery disease: long-term effects on the risk for myocardial infarction, occurrence of severe angina and the need for revascularization. Research Group on Instability in Coronary Artery Disease in Southeast Sweden. J Am Coll Cardiol 1991; 18:1587-93.
  • Silagy CA, McNeil JJ, Donnan GA, Tonkin AM, Worsam B, Campion K. Adverse effects of low-dose aspirin in a healthy elderly population. Clin Pharmacol Ther 1993;54:84-9.
  • Gavaghan TP, Gebski V, Baron DW. Immediate postoperative aspirin improves vein graft patency early and late after coronary artery bypass graft surgery. A placebo-controlled, randomized study. Circulation 1991;83:1526-33.
  • Olivotto IA, Kim-Sing C, Bajdik CD, Trevisan CH, Ludgate CM, Weir LM, et al. Effect of acetylsalicylic acid on radiation and cosmetic results after conservative surgery for early breast cancer: a randomized trial. Radiother Oncol 1996;41:1-6.
  • Elwood PC, Sweetnam PM. Aspirin and secondary mortality after myocardial infarction. Lancet 1979;2:1313-5.
  • Petersen P, Boysen G, Godtfredsen J, Andersen ED, Andersen B. Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study. Lancet 1989:1:175-9.
  • Diener HC, Forbes C, Riekkinen PJ, Sivenius J, Smets P, Lowenthal A. European stroke prevention study. 2. Efficacy and safety data: the ESPS 2 group. J Neurol Sci 1997;151 Suppl:S:161.
  • Hess H, Mietaschk A, Deichsel G. Drug-induced inhibition of platelet function delays progression of peripheral occlusive arterial disease. A prospective double-blind arteriographically controlled trial. Lancet 1985;1:415-9.
  • Canadian Cooperative Study Group. A randomized trial of aspirin and sulfinpyrazone in threatened stroke. N Engl J Med 1978:299:53-9.
  • EAFT (European Atrial Fibrillation Trial) Study Group. Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke. Lancet 1993; 342: 1255-62.
  • Bombardier C, Laine L, Reicin A, Shapiro D, Burgos-Vargas R, Davis D, et al. Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis. N Engl J Med 2000;343:1520-8.

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