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Scandinavian Journal of Gastroenterology Volume 38, 2003 - Issue 9
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Research Article

Clinical Usefulness of Virulence Factors of Helicobacter pylori as Predictors of the Outcomes of Infection. What is the Evidence?

González C. A. Dept. of Epidemiology Catalan Institute of Oncology Gran Via s/n Km 2.7. S-08097 Hospitalet, Barcelona Spain
,
Peña S. Dept. of Gastroenterology and Laboratory of Immunogenetics VU University Medical Centre Amsterdam The Netherlands
&
Capellá G. Translational Research Laboratory Catalan Institute of Oncology Barcelona Spain
Pages 905-915 | Published online: 08 Jul 2009

  • Goodman KJ, Cockburn M. The role of epidemiology in understanding the health effects of Helicobucter pylori. Epidemiology 2001:12:266-71.
  • Covacci A, Telford JL, Del Giudice G, Parsonnet J, Rappuoli R. Helicobucter pylori virulence and genetic geography. Science 1999:284:1328-33.
  • Montecucco C, Rappuoli R. Living dangerously: how Helicobucter pylori survives in the human stomach. Nat Rev Mol Cell Biol 2001:2:457-66.
  • Logan RP, Berg DE. Genetic diversity of Helicobucter pylori. Lancet 1996:348:1462-3.
  • Blaser MJ. Heterogeneity of Helicobucter pylori. Eur J Gastroenterol Hepatol 1997:9 Suppl 1:S3-6.
  • Peek RM, Jr, Blaser MJ. Helicobucter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer 2002:2:28-37.
  • Axon AT. Are all helicobacters equal? Mechanisms of gastroduodenal pathology and their clinical implications. Gut 1999:45 Suppl 1:11-14.
  • Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, et al. The complete genome sequence of the gastric pathogen Helicobucterpylori. Nature 1997:388:539-47.
  • Stein M, Rappuoli R, Covacci A. Tyrosine phosphorylation of the Helicobucter pylori Cag A antigen after cag-driven host cell translocation. Proc Natl Acad Sci USA 2000:97:1263-8.
  • Segal ED, Cha J, Lo J, Falkow S, Tompkins LS. Altered states: involvement of phosphorylated Cag A in the induction of host cellular growth changes by Helicobucter pylori. Proc Natl Acad Sci USA 1999:96:14559-64.
  • Puls J, Fischer W, Haas R. Activation of Helicobucter pylori Cag A by tyrosine phosphorylation is essential for dephosphorylation of host cell proteins in gastric epithelial cells. Mol Microbiol 2002:43:961-9.
  • Van Doom LJ, Figueiredo C, Sauna R, Blaser MJ, Quint WG. Distinct variants of Helicobucter pylori cag A are associated with vac A subtypes. J Clin Microbiol 1999:37:2306-11.
  • Ikenoue T, Maeda S, Ogura K, Akanuma M, Mitsuno Y, Imai Y, et al. Determination of Helicobucter pylori virulence by simple gene analysis of the cag pathogenicity island. Clin Diagn Lab Immimol 2001:8:181-6.
  • Ogura K, Maeda S, Nakao M, Watanabe T, Tada M, Kyutoku T, et al. Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil. J Exp Med 2000; 192: 1601-10.
  • Fukuta K, Azuma T, Ito Y, Suto H, Keida Y, Wakabayashi H, et al. Clinical relevance of cag E gene from Helicobacter pylori strains in Japan. Dig Dis Sci 2002:47:667-74.
  • Aihara M, Tsuchimoto D, Takizawa H, Azuma A, Wakebe H, Ohmoto Y, et al. Mechanisms involved in Helicobacter prloriinduced interleukin-8 production by a gastric cancer cell line, MKN45. Infect Immun 1997:65:3218-24.
  • Shimoyama T, Crabtree JE. Bacterial factors and immune pathogenesis in Helicobacter pylori infection. Gut 1998:43 Suppl 1:S2-5.
  • Atherton JC, Tham KT, Peek RM, Jr, Cover TE, Blaser MJ. Density of Helicobacter pylori infection in vivo as assessed by quantitative culture and histology. J Infect Dis 1996:174:552-6.
  • Twisk M, Kusters JG, Balk AG, Kuipers EJ, Eoffeld RJ. Colonisation density and topographic localisation of Helicobacter pylori do not depend on the cag A status. J Clin Pathol 2001:54:771-3.
  • Yamaoka Y, Kodama T, Kita M, Imanishi J, Kashima K, Graham DY. Relation between clinical presentation, Helicobacter priori density, interleukin !beta and 8 production, and cag A status. Gut 1999:45:804-11.
  • Go MF. What are the host factors that place an individual at risk for Helicobacter pylori-associated disease? Gastroenterology 1997:113:S15-20.
  • Kuipers EJ, Thijs JC, Festen HP. The prevalence of Helicobacter pylori in peptic ulcer disease. Aliment Pharmacol Ther 1995:9 Suppl 2:59-69.
  • * 23. Cover TE, Glupczynski Y, Eage AP, Burette A, Tummuru MK, Perez-Perez GI, et al. Serologie detection of infection with cag A+ Helicobacter pylori strains. J Clin Microbiol 1995:33: 1496-500.
  • Van Doom LJ, Figueiredo C, Sauna R, Plaisier A, Schneeberger P, De Boer W, et al. Clinical relevance of the cag A, vac A, and ice A status of Helicobacter pylori. Gastroenterology 1998:115: 58-66.
  • Graham DY, Genta RM, Graham DP, Crabtree JE. Serum Cag A antibodies in asymptomatic subjects and patients with peptic ulcer: lack of correlation of IgG antibody in patients with peptic ulcer or asymptomatic Helicobacter pylori gastritis. J Clin Pathol 1996:49:829-32.
  • Yamaoka Y, Souchek J, Odenbreit S, Haas R, Arnqvist A, Boren T, et al. Discrimination between cases of duodenal ulcer and gastritis on the basis of putative virulence factors of Helicobacter pylori. 3 Clin Microbiol 2002:40:2244-6.
  • Palli D, Menegatti M, Masala G, Ricci C, Saieva C, Holton J, et al. Helicobacter pylori infection, anti-cag A antibodies and peptic ulcer: a case-control study in Italy. Aliment Pharmacol Ther 2002:16:1015-20.
  • Santolaria S, Eanas A, Benito R, Piazuelo E, Sainz R. Cag A and Vac A cytotoxin antibodies and risk for peptic ulcer disease in patients with Helicobacter pylori infection. Med Clin (Bare) 2001:116:641-4.
  • Nomura AM, Perez-Perez GI, Lee J, Stemmermann G, Blaser MJ. Relation between Helicobacter pylori cag A status and risk of peptic ulcer disease. Am J Epidemiol 2002:155:1054-9.
  • Botterweck AA, Schonten LJ, Volovics A, Dorant E, Van den Brandt PA. Trends in incidence of adenocarcicoma of the oesophagus and gastric cardia in ten countries. Int J Epidemiol 2000:29:645-54.
  • Richter JE, FaIk GW, Vaezi MF. Helicobacter pylori and gastroesophageal reflux disease: the bug may not be all bad. Am J Gastroenterol 1998:93:1800-2.
  • Henrik SJ, Forsgren A, Berglund G, Floren CH. Helicobacter pylori infection is associated with a decreased risk of developing oesophageal neoplasms. Helicobacter 2001:6:3 10-6.
  • Wu JC, Sung JJ, Ng EK, Go MY, Chan WB, Chan FK, et al. Prevalence and distribution of Helicobacter pylori in gastro-esophageal reflux disease: a study from the East. Am J Gastroenterol 1999:94:1790-4.
  • Weston AP, Badr AS, Topalovski M, Cherian R, Dixon A, Hassanein RS. Prospective evaluation of the prevalence of gastric Helicobacter pylori infection in patients with GERD, Barren's esophagus, Barren's dysplasia, and Barren's adenocarcinoma. Am J Gastroenterol 2000:95:387-94.
  • Lord RV, Frommer DJ, Inder S, Tran D, Ward RL. Prevalence of Helicobucter pylori infection in 160 patients with Barren's oesophagus or Barren's adenocarcinoma. Aust NZ J Surg 2000; 70:26-33.
  • Vicari JJ, Peek RM, FaIk GW, Goldhlum JR, Easley KA, Schnell J, et al. The seroprevalence of cag A-positive Helicohucter pylori strains in the spectrum of gastroesophageal reflux disease. Gastroenterology 1998:1 15:50-7.
  • Vaezi MF, FaIk GW, Peek RM, Vicari JJ, Goldhlum JR, PerezPerez GI, et al. Cag A-positive strains of Helicobucter pylori may protect against Barren's esophagus. Am J Gastroenterol 2000:95:2206-11.
  • Arents NL, van Zwet AA, Thijs JC, Kooistra-Smid AM, van Slochteren KR, Degener JE, et al. The importance of vac A, cag A, and ice A genotypes of Helicobucter pylori infection in peptic ulcer disease and gastroesophageal reflux disease. Am J Gastroenterol 2001:96:2603-8.
  • Chow WH, Blaser MJ, Blot WJ, Gammon MD, Vaughan TL, Risch HA, et al. An inverse relation between cag A+ strains of Helicobucter pylori infection and risk of esophageal and gastric cardia adenocarcinoma. Cancer Res 1998:58:588-90.
  • Helicobacter and cancer collaborative group., Gastric cancer and Helicobucter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut 2001:49:347-53.
  • Limburg P, Qiao Y, Mark S, Wang G, Perez-Perez G, Blaser M, et al. Helicobucter pylori seropositivity and subsite-specific gastric cancer risks in Linxian, China. J Natl Cancer hist 2001; 93:226-33.
  • Schwizer W, Thumshrni M, Dent J, Guldenschiuhi I, Menne D, Cathomas G, et al. Helicobucter pylori and symptomatic relapse of gastro-oesophageal reflux disease: a randomised controlled trial. Lancet 2001:357:1738-42.
  • Moayyedi P, Bardhan C, Young L, Dixon MF, Brown L, Axon AT. Helicobucter pylori eradication does not exacerbate reflux symptoms in gastroesophageal reflux disease. Gastroenterology 2001:121:1120-6.
  • FaIk GW. The possible role of Helicobucter pylori in GERD. Semin Gastrointest Dis 2001:12:186-95.
  • Correa P, Shiao YH. Plienotypic and genotypic events in gastric carcinogenesis. Cancer Res 1994;54:1941s-3s.
  • Gonzalez CA, Sala N, Capella G. Genetic susceptibility and gastric cancer risk, hit J Cancer 2002:100:249-60.
  • Yamaguchi N, Kakizoe T. Synergistic interaction between Helicobucter pylori gastritis and diet in gastric cancer. Lancet Oncol 2001:2:88-94.
  • Jang WH, Yang YI, Yea SS, Lee YJ, Cliun JH, Kim HI, et al. The -238 tumor necrosis factor-a promoter polymorphism is associated with decreased susceptibility to cancers. Cancer Lett 2001:166:41-6.
  • Azuma T, Ito S, Sato F, Yamazaki Y, Miyaji H, Ito Y, et al. The role of the HLA-DQAl gene in resistance to atrophie gastritis and gastric adenocarcinoma induced by Helicobucter pylori infection. Cancer 1998:82:1013-8.
  • Magnusson PKE, Enroth H, Eriksson I, Held M, Nyrén O, Engstrand L, et al. Gastric cancer and human leukocyte antigen: distinct DQ and DR alleles are associated with development of gastric cancer and infection by Helicobucter pylori. Cancer Res 2001:61:2684-9.
  • El Omar EM, Carrington M, Chow WH, McCoIl KE, Bream JH, Young HA, et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000:404:398402.
  • Webb PM, Crabtree JE, Forman D. Gastric cancer, cytotoxinassociated gene A-positive Helicohucter pylori, and serum pepsinogens: an international study. The Eurogast Study Group. Gastroenterology 1999:116:269-76.
  • Perez-Perez GI, Bhat N, Gaensbauer .1, Fraser A, Taylor DN, Kuipers EJ, et al. Country-specific constancy by age in cag A+ proportion of Helicohucter pylori infections, hit J Cancer 1997; 72:453-6.
  • Mitchell HM, Hazell SL, Li YY, Hu PJ. Serological response to specific Helicohucter pylori antigens: antibody against Cag A antigen is not predictive of gastric cancer in a developing country. Am J Gastroenterol 1996:91:1785-8.
  • Groves FD, Perez-Perez G, Zhang L, You WC, Lipsitz SR, Gail MH, et al. Serum antibodies to Helicobucter pylori and the Cag A antigen do not explain differences in the prevalence of precancerous gastric lesions in two Chinese populations with contrasting gastric cancer rates. Cancer Epidemiol Biomarkers Prev 2002; 11:1091-4.
  • Torres J, Perez-Perez GI, Leal-Herrera Y, Munoz O. Infection with Cag A+ Helicohucter pylori strains as a possible predictor of risk in the development of gastric adenocarcinoma in Mexico. Im J Cancer 1998:78:298-300.
  • Kuipers EJ, Perez-Perez GI, Meuwissen SG, Blaser MJ. Helicohucter pylori and atrophie gastritis: importance of the cag A status. J Natl Cancer hist 1995:87:1777-80.
  • Beales IL, Crabtree JE, Scunes D, Covacci A, Calam J. Antibodies to Cag A protein are associated with gastric atrophy in Helicohucter pylori infection. Eur J Gastroenterol Hepatol 1996:8:645-9.
  • Sozzi M, Valentini M, Figura N, De Paoli P, Tedeschi RM, Gloghini A, et al. Atrophie gastritis and intestinal metaplasia in Helicohucter pylori infection: the role of Cag A status. Am J Gastroenterol 1998:93:375-9.
  • Maaroos HI, Vorobjova T, Sipponen P, Tammur R, Uibo R, Wadstrom T, et al. An 18-year follow-up study of chronic gastritis and Helicohucter pylori association of Cag A positivity with development of atrophy and activity of gastritis. Scand J Gastroenterol 1999:34:864-9.
  • Sande N, Nikulin M, Nilsson I, Wadstrom T, Laxen F, Harkonen M, et al. Increased risk of developing atrophie gastritis in patients infected with Cag A+ Helicohucter pylori. Scand J Gastroenterol 2001:36:928-33.
  • Nogueira C, Figueiredo C, Carneiro F, Gomes AT, Barreira R, Figueira P, et al. Helicohucter pylori genotypes may determine gastric histopathology. Am J Pathol 2001:158:647-54.
  • Campbell DI, Warren BF, Thomas JE, Figura N, Telford JL, Sullivan PB. The African enigma: low prevalence of gastric atrophy, high prevalence of chronic inflammation in West African adults and children. Helicobacter 2001:6:263-7.
  • Shimoyama T, Fukuda S, Tanaka M, Mikami T, Munakata A, Crabtree JE. Cag A seropositivity associated with development of gastric cancer in a Japanese population. J Clin Pathol 1998; 51:225-8.
  • Ekstrom AM, Held M, Haussen LE, Engstrand L, Nyren O. Helicohucter pylori in gastric cancer established by Cag A immunoblot as a marker of past infection. Gastroenterology 2001:121:784-91.
  • Figueiredo C, Machado JC, Pharoah P, Semca R, Sousa S, Carvalho R, et al. Helicohucter pylori and Interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer lust 2002:94:1680-7.
  • Brenner H, Amdt V, Bode G, Stegmaier C, Ziegler H, Stumer T. Risk of gastric cancer among smokers infected with Helicohucter pylori, lut J Cancer 2002:98:446-9.
  • Queiroz DM, Mendes EN, Rocha GA, Oliveira AM, Oliveira CA, Magalhaes PP, et al. Cag A-positive Helicohucter pylori and risk for developing gastric carcinoma in Brazil, hit J Cancer 1998:78:135-9.
  • Kikuchi S, Crabtree JE, Forman D, Kurosawa M. Association between infections with Cag A-positive or -negative strains of Helicohucter pylori and risk for gastric cancer in young adults. Research Group on Prevention of Gastric Carcinoma Among Young Adults. Am J Gastroenterol 1999:94:3455-9.
  • Maeda S, Yoshida H, Ogura K, Yamaji Y, Ikenoue T, Mitsushima T, et al. Assessment of gastric carcinoma risk associated with Helicohucter pylori may vary depending on the antigen used: Cag A specific enzyme-linked immunoadsorbent assay (ELISA) versus commercially available H. pylori ELISAs. Cancer 2000:88:1530-5.
  • Rudi J, KoIh C, Maiwald M, Zuna I, von Herbay A, Galle PR, et al. Serum antibodies against Helicobacter pylori proteins Vac A and Cag A are associated with increased risk for gastric adenocarcinoma. Dig Dis Sci 1997:42:1652-9.
  • Enroth H, Kraaz W, Engstrand L, Nyren O, Rohan T. Helicobacter pylori strain types and risk of gastric cancer: a casecontrol study. Cancer Epidemiol Biomarkers Prev 2000; 9: 981-5.
  • Yamaoka Y, Kodama T, Kashima K, Graham DY. Antibody against Helicobacter pylori Cag A and Vac A and the risk for gastric cancer. J Clin Pathol 1999:52:215-8.
  • Louw JA, Kidd MS, Kummer AF, Taylor K, Kotze U, Hanslo D. The relationship between Helicobacter pylori infection, the virulence genotypes of the infecting strain and gastric cancer in the African setting. Helicobacter 2001:6:268-73.
  • Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, Cliyou PH, et al. Infection with Helicobacter pylori strains possessing cag A is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 1995; 55:2111-5.
  • Nomura AM, Lee J, Stemmermann GN, Nomura RY, PerezPerez GI, Blaser MJ. Helicobacter pylori Cag A seropositivity and gastric carcinoma risk in a Japanese American population. J Infect Dis 2002; 186:1138-44.
  • Parsonnet J, Friedman GD, Orentreich N, Vogelman H. Risk for gastric cancer in people with Cag A positive or Cag A negative Helicobacter pylori infection. Gut 1997:40:297-301.
  • Pelicic V, Reyrat JM, Sartori L, Pagliaccia C, Rappuoli R, Telford JL, et al. Helicobacter pylori Vac A cytotoxin associated with the bacteria increases epithelial permeability independently of its vacuolating activity. Microbiology 1999; 145:2043-50.
  • Suerbaum S, Michetti P. Helicobacter priori infection. N Engl J Med 2002:347:1175-86.
  • Xiang Z, Censini S, Bayeli PF, Telford JL, Figura N, Rappuoli R, et al. Analysis of expression of Cag A and Vac A virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that Cag A is not necessary for expression of the vacuolating cytotoxin. Infect Immun 1995:63:94-8.
  • Van Doom LJ, Figueiredo C, Sauna R, Pena S, Midolo P, Ng EK, et al. Expanding allelic diversity of Helicobacter pylori vac A. J Clin Microbiol 1998:36:2597-603.
  • Ito Y, Azuma T, Ito S, Miyaji H, Hirai M, Yamazaki Y, et al. Analysis and typing of the vac A gene from cag A-positive strains of Helicobacter pylori isolated in Japan. J Clin Microbiol 1997:35:1710-4.
  • Van Doom LJ, Figueiredo C, Megraud F, Pena S, Midolo P, Queiroz DM, et al. Geographic distribution of vac A allelic types of Helicobacter pylori. Gastroenterology 1999: 116:823-30.
  • Shimoyama T, Yoshimura T, Mikami T, Fukuda S, Crabtree JE, Munakata A. Evaluation of Helicobacter pylori vac A genotype in Japanese patients with gastric cancer. J Clin Pathol 1998:51: 299-301.
  • Kodama K, Ito A, Nishizono A, Fujioka T, Nasu M, Yahiro K, et al. Divergence of virulence factors of Helicobacter pylori among clinical isolates does not correlate with disease specificity. J Gastroenterol 1999:34 Suppl 1 1:6-9.
  • Maeda S, Ogura K, Yoshida H, Kanai F, Ikenoue T, Kalo N, et al. Major virulence factors, Vac A and Cag A, are commonly positive in Helicobacter pylori isolates in Japan. Gut 1998:42: 338-43.
  • Yamaoka Y, Kodama T, Gutierrez O, Kim JG, Kashima K, Graham DY. Relationship between Helicobacter priori ice A, cag A, and vac A status and clinical outcome: studies in four different countries. J Clin Microbiol 1999:37:2274-9.
  • Yamaoka Y, Kodama T, Kita M, Imanishi J, Kashima K, Graham DY. Relationship of vac A genotypes of Helicobacter pylori to cag A status, cytotoxin production, and clinical outcome. Helicobacter 1998:3:241-53.
  • Figueiredo C, Van Doom LJ, Nogueira C, Soares JM, Pinho C, Figueira P, et al. Helicobacter priori genotypes are associated with clinical outcome in Portuguese patients and show a high prevalence of infections with multiple strains. Scand J Gastroenterol 2001:36:128-35.
  • Shimoyama T, Neelam B, Fukuda S, Tanaka M, Munakata A, Crahtree JE. Vac A seropositivity is not associated with the development of gastric cancer in a Japanese population. Eur J Gastroenterol Hepatol 1999:1 1:887-90.
  • de Figueiredo ST, Magalhaes Queiroz DM, Mendes EN, Rocha GA, Rocha Oliveira AM, Alvares Cabrai MM, et al. The interrelationship between Helicobucter priori vacuolating cytotoxin and gastric carcinoma. Am J Gastroenterol 1998:93: 1841-7.
  • Ilver D, Arnqvist A, Ogren J, Frick IM, Kersulyte D, Incecik ET, et al. Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging. Science 1998:279:373-7.
  • Clyne M, Drumm B. Absence of effect of Eewis A and Eewis B expression on adherence of Helicobacter pylori to human gastric cells. Gastroenterology 1997:113:72-80.
  • Gerhard M, Lehn N, Neumayer N, Boren T, Rad R, Schepp W, et al. Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin. Proc Nad Acad Sci USA 1999:96:12778-83.
  • Rad R, Gerhard M, Lang R, Schoniger M, Rosch T, Schepp W, et al. The Helicobacter pylori blood group antigen-binding adhesin facilitates bacterial colonization and augments a nonspecific immune response. J Immunol 2002:168:3033-41.
  • Evans DJ, Jr, Evans DG. Helicobacter priori adhesins: review and perspectives. Helicobacter 2000:5:183-95.
  • Peek RM, Jr, Thompson SA, Donahue JP, Tham KT, Atherton JC, Blaser MJ, et al. Adherence to gastric epithelial cells induces expression of a Helicobacter priori gene, ice A, that is associated with clinical outcome. Jnl Proc Assoc Am Phys 1998:110:531-44.
  • Figueiredo C, Quint WG, Sauna R, Sablon E, Donahue JP, Xu Q, et al. Genetic organization and heterogeneity of the ice A locus of Helicobacter pylori. Gene 2000:246:59-68.
  • Ito Y, Azuma T, Ito S, Suto H, Miyaji H, Yamazaki Y, et al. Sequence analysis and clinical significance of the ice A gene from Helicobacter pylori strains in Japan. J Clin Microbiol 2000:38:483-8.
  • Nishiya D, Shimoyama T, Fukuda S, Yoshimura T, Tanaka M, Munakata A. Evaluation of the clinical relevance of the ice A gene in patients with Helicobacter pylori infection in Japan. Scand J Gastroenterol 2000:35:36-9.
  • Kidd M, Peek RM, Lastovica AJ, Israel DA, Kummer AF, Louw JA. Analysis of ice A genotypes in South African Helicobacter pylori strains and relationship to clinically significant disease. Gut 2001:49:629-35.
  • Evans Jr DJ, Evans DG, Takemura T, Nakano H, Lampert HC, Graham DY, et al. Characterization of a Helicobacter pylori neutrophil-activating protein. Infect Immun 1995:63:2213-20.
  • Obst B, Wagner S, Sewing KF, Beil W. Helicobacter pylori causes DNA damage in gastric epithelial cells. Carcinogenesis 2000:21:1111-5.
  • Satin B, Del Giudice G, Delia Bianca V, Dusi S, Laudanna C, Tonello F, et al. The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor. J Exp Med 2000:191:1467-76.
  • van Doom NE, Namavar F, Kusters JG, van Rees EP, Kuipers EJ, de Graaff J. Genomic DNA fingerprinting of clinical isolates of Helicobacter pylori by REP-PCR and restriction fragment end-labelling. FEMS Microbiol Lett 1998:160:145-50.
  • Perez-Perez GI, Peek RM, Legath AJ, Heine PR, draff LB. The role of Cag A status in gastric and extragastric complications of Helicobacter priori. J Physiol Pharmacol 1999:50:833-45.
  • Graham DY, Yamaoka Y. H. pylori and cag A: relationships with gastric cancer, duodenal ulcer, and reflux esophagitis and its complications. Helicobacter 1998:3:145-51.
  • Graham DY, Yamaoka Y. Disease-specific Helicobacter pylori virulence factors: the unfulfilled promise. Helicobacter 2000:5 Suppl 1:S3-S9.
  • Harris RA, Owens DK, Witherell H, Personnel J. Helicohucter pylori and gastric cancer: what are the benefits of screening only for the Cag A phenotype of H. pylori? Helicobacter 1999:4:6976.
  • Blaser MJ, Berg DE. Helicobacter pylori genetic diversity and risk of human disease. J. Clin Invest 2001; 107:767-73.
  • Sorherg M, Engstrand L, Strom M, Jonsson KA, Jorheck H, Granstrom M. The diagnostic value of enzyme immunoassay and immunohlot in monitoring eradication of Helicohucter pylori. Scand J. Infect Dis 1997:29:147-51.
  • Nyrén O, Adami HO. Stomach Cancer. In: Adami HO, Hunter D, Trichopoiilos D, eds. Textbook of cancer epidemiology. New York: Oxford University Press: 2002. p. 162-187.
  • Everhart JE, Kruszon-Moran D, Perez-Perez G. Reliability of Helicobucter pylori and Cag A serological assays. Clin Diagn Eab Immunol 2002:9:412-6.
  • Figueiredo C, Quint W, Nouhani N, van den Munckhof H, Herbrink P, Scherpenisse J, et al. Assessment of Helicobacter pylori vac A and cag A genotypes and host serological response. J Clin Microbiol 2001:39:1339-44.
  • Yamaoka Y, Kodama T, Graham DY, Kashima K. Comparison of four serological tests to determine the Cag A or Vac A status of Helicobacter pylori strains. J. Clin Microbiol 1998; 36: 3433-4.
  • Blaser MJ, Kirschner D. Dynamics of Helicobacter pylori colonization in relation to the host response. Proc Natl Acad Sci USA 1999:96:8359-64.
  • Pena AS. Peptic ulcer and gastritis. In: King RA, Rotter JI, Motulsky AG, editors. Genetic basis of common diseases. Oxford University Press; 2002. p. 229-249.

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