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Scandinavian Journal of Gastroenterology Volume 38, 2003 - Issue 8
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Research Article

Contrasting Action of IL-12 and IL-18 in the Development of Dextran Sodium Sulphate Colitis in Mice

Takagi H. Dept. of Internal Medicine School of Medicine Keio University Tokyo Japan
,
Kanai T. Dept. of Gastroenterology and Hepatology Graduate School Tokyo Medical and Dental University Tokyo Japan
,
Okazawa A. Dept. of Host Defense Research Institute for Microbial Diseases Osaka University Suita, Osaka Japan
,
Kishi Y. Dept. of Internal Medicine School of Medicine Keio University Tokyo Japan
,
Sato T. Dept. of Gastroenterology and Hepatology Graduate School Tokyo Medical and Dental University Tokyo Japan
,
Takaishi H. Dept. of Host Defense Research Institute for Microbial Diseases Osaka University Suita, Osaka Japan
,
Inoue N. Dept. of Internal Medicine School of Medicine Keio University Tokyo Japan
,
Ogata H. Dept. of Gastroenterology and Hepatology Graduate School Tokyo Medical and Dental University Tokyo Japan
,
Iwao Y. Dept. of Host Defense Research Institute for Microbial Diseases Osaka University Suita, Osaka Japan
,
Hoshino K. Dept. of Internal Medicine School of Medicine Keio University Tokyo Japan
,
Takeda K. Dept. of Gastroenterology and Hepatology Graduate School Tokyo Medical and Dental University Tokyo Japan
,
Akira S. Dept. of Host Defense Research Institute for Microbial Diseases Osaka University Suita, Osaka Japan
,
Watanabe M. Dept. of Internal Medicine School of Medicine Keio University Tokyo Japan
,
Ishii H. Dept. of Gastroenterology and Hepatology Graduate School Tokyo Medical and Dental University Tokyo Japan
&
Hibi T. Dept. of Host Defense Research Institute for Microbial Diseases Osaka University Suita, Osaka Japan
 show all
Pages 837-844 | Published online: 08 Jul 2009

  • Asseman C, Fowler S, Powrie F. Control of experimental inflammatory bowel disease by regulatory T cells. Am J Respir Crit Care Med 2000; 162:185-9.
  • Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Ann Rev Immunol 1995; 13:251-76.
  • Robinson D, Shibuya K, Mui A, Zonin F, Murphy E, Sana T, et al. IGIF does not drive Th1 development but synergizes with IL12 for interferon-gamma production and activates IRAK and NF-kB. Immunity 1997;7:571-81.
  • Okamura, Tsutsui, Komatsu, Yutsudo, Hakura, Tanimoto Cloning of a new cytokine that induces IFN-γ production by T cells. 1995; 378: 88-91Nature
  • Dinarello CA. Interleukin-18. Methods 1999;19:121-32.
  • Bazan JF, Timans JC, Kastelein RA. A newly defined interleukin-1? Nature 1996;379:591.
  • Takeda K, Tsutsui H, Yoshimoto T, Adachi O, Yoshida N, Kishimoto T, et al. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 1998;8:383-90.
  • Hoshino, Yagita, Ortaldo, Wiltout, Young In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4 + T cells. 2000; 30: 1998-2006Eur J Immunol
  • Yoshimoto T, Tsutsui H, Ominaga K, Hoshino K, Okamura H, Akira S, et al. IL-18, although antiallergic when administrated with IL-12, stimulates IL-4 and histamine release by basophils. Proc Natl Acad Sci USA 1999;96:13962-6.
  • Monteleone, Biancone, Marasco, Morrone, Marasco, Luzza Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. 1997; 112: 1169-78Gastroenterology
  • Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1995; 182:1281-90.
  • Pizarro, Michie, Bentz, Woraratanadharm, Smith, Foley IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. 1999; 162: 6829-35J Immunol
  • Monteleone, Trapasso, Parrello, Biancone, Stella, Iuliano Bioactive IL-18 expression is up-regulated in Crohn's disease. 1999; 163: 143-7J Immunol
  • Kanai, Watanabe, Okazawa, Nakamaru, Okamoto, Naganuma Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease. 2000; 119: 1514-23Gastroenterology
  • Siegmund B, Fantuzzi G, Rieder F, Gamboni-Robertson F, Lehr HA, Hartmann G, et al. Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production. Am J Physiol Regul Integr Comp Physiol 2001;281:1264-73.
  • Kanai, Watanabe, Okazawa, Sato, Yamazaki, Okamoto Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease. 2001; 121: 875-88Gastroenterology
  • Ten Hove T, Corbaz A, Amitai H, Aloni S, Beizer I, Graber P, et al. Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-alpha production in mice. Gastroenterology 2001;121:1372-9.
  • Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 1990;98:694-702.
  • Hoshino K, Kawase Y, Okamoto M, Yokota K, Yoshino K, Yamamura K, et al. Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J Immunol 1999;162:5041-4.
  • Mattner F, Magram J, Ferrante J, Launois P, Di Padova K, Bahin R, et al. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur J Immunol 1996;26:1553-9.
  • Cooper HS, Murphy SNS, Shah RS, Sedergran DJ. Clinicopathologjc study of dextran sulfate sodium experimental murine colitis. Lab Invest 1993;69:238-49.
  • Dieleman LA, Ridwan BU, Tennyson GS, Beagley KW, Bucy RP, et al. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 1994; 107:1643-52.
  • Hans W, Scholmerich J, Gross V, FaIk W. Interleukin-12 induced interferon-gamma increases inflammation in acute dextran sulfate sodium induced colitis in mice. Eur Cytokine Netw 2000; 11:67-74.
  • Davidson NJ, Hudak SA, Lesley RE, Menon S, Leach MW, Rennick DM. IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice. J Immunol 1998;161:3143-9.
  • Camoglio L, Juffermans NP, Peppelenbosch M, te Velde AA, te Kate FJ, SJHvan Deventer, et al. Contrasting roles of IL-12p40 and IL-12p3 5 in the development of hap ten-induced colitis. Eur J Immunol 2002;32:261-9.
  • Dieleman, Palmen, Akol, Bloemena, Pena, Meuwissen Chronic experimental colitis induced by dextran sulfate sodium (DSS) is characterized by Th1 and Th2 cytokines. 1998; 114: 385-91Clin Exp Immunol
  • Axelsson, Landstrom, Goldschmidt, Gronberg, Bylund-Fellenius Dextran sulfate sodium (DSS) induced experimental colitis in immunodeficient mice: effects in CD4(+)-cell depleted, athymic and NK-cell depleted SCID mice. 1996; 45: 181-91Inflamm Res
  • Kampfer H, Kalina U, Muhl H, Pfeilschifer J, Frank S. Counterregulation of interleukin-18 mRNA and protein expression during cutaneous wound repair in mice. J Invest Dermatol 1999; 113:369-74.

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