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Research Article

Genetic Polymorphisms of Aldehyde Dehydrogenase 2, Cytochrome p450 2E1 for Liver Cancer Risk in HCV Antibody-Positive Japanese Patients and the Variations of CYP2E1 mRNA Expression Levels in the Liver due to its Polymorphism

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Pages 886-893 | Published online: 08 Jul 2009

  • Ikeda K, Saitoh S, Suzuki Y, Kobayashi M, Tubota A, Koida I, et al. Disease progression and hepatocellular carcinogenesis in patients with chronic viral hepatitis: a prospective observation of 2251 patients. J Hepatol 1998;28:930-8.
  • Bellentani S, Pozzato G, Saccoccio G, Masutti F, Muratori L, Cassani F, et al. Clinical course and risk factors of hepatitis C virus related liver disease in the general population: report from the Dionysus study. Gut 1999;44:874-80.
  • Tagger A, Donate F, Ribero M, Chisea R, Portera G, Gellati U, et al. Case-control study on hepatitis C virus (HCV) as a risk factor for hepatocellular carcinoma: the role of HCV genotypes and the synergism with hepatitis B virus and alcohol. Int J Cancer 1999;81:695-9.
  • International Agency for Research of Cancer Alcohol Drinking. IARC Monographs on the Evaluation of the Carcinogenic Risks to Human, Vol. 44IARC Lyon: ; 1988.
  • Ohnishi K, Iida S, Iwama S, Goto N, Nomura F, Takashi M, et al. The effect of chronic habitual alcohol intake on the development of liver cirrhosis and hepatocellular carcinoma: relation to hepatitis B surface antigen carriage. Cancer 1982;49:672-7.
  • Austin H, Delzell E, Grufferman S, Levine R, Morrison AS, Stolley PD, et al. A case-control study of hepatocellular carcinoma and the hepatitis B virus, cigarette smoking, and alcohol consumption. Cancer Research 1986;46:962-6.
  • Higuchi S, Matsushita S, Imazeki H, Kinoshita T, Takagj S, Kono H. Aldehyde dehydrogenase genotypes in Japanese Alcoholics. Lancet 1994;343:741-2.
  • Takeda A. Alcohol and hepatic carcinogenesis. In: Yimiya R, et al, editors. Alcohol, immunity and cancer. Boca Raton: CRC Press; 1993. p. 187-209.
  • Sun F, Tsuritani I, Honda R, Ma ZY, Yoshida Y. Association of genetic polymorphisms of alcohol-metabolizing enzymes with excessive alcohol consumption in Japanese men. Hum Genet 1999;105:295-300.
  • Tanaka F, Shiratori Y, Yokosuka O, Imazaki F, Tsukada Y, Omata M. Polymorphism of alcohol-metabolizing genes affects drinking behavior and liver disease in Japanese men. Alcohol Clin Exp Res 1997;21:596-601.
  • Tsutaya S, Shoji M, Saito Y, Kitaya H, Nakata S, Takamatsu H, et al. Analysis of aldehyde dehydrogenase 2 gene polymorphism and ethanol patch test as a screening method for alcohol sensitivity. Tohoku J Exp Med 1999;187:305-10.
  • Yoshida A, Ikawa M, Hsu LC, Tani K. Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases. Alcohol 1985;2:103-6.
  • Yoshida A, Huang IY, Ikawa M. Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc Natl Acad Sci USA 1984;81:258-61.
  • Takeshita T, Morimoto K. Development of a questionnaire method to determine between typical and atypical genotypes of low Km aldehyde dehydrogenase in a Japanese population. Alcohol Clin Exp Res 1998;22:1409-13.
  • Lieber CS. Cytochrome p-4502El: Its physiological and pathological role. Physiol Rev 1997;77:517-4.
  • Guengerich FP, Kim DH, Iwasaki M. Role of human cytochrome P-450 UEl in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol 1991;4:168-79.
  • Hayashi S, Watanabe J, Kawajiri K. Genetic polymorphisms in the 5'-flanking region change transcriptional regulation of the human cytochrome p4502El gene. J Biochem (Tokyo) 1991; 110:559-65.
  • Tsutsumi M, Wang JS, Takase S, Takada A. Hepatic messenger RNA contents of cytochrome P4502E1 in patients with different P4502E1 genotypes. Alcohol Alcohol 1994;29:29-32.
  • Hildesheim A, Chen CJ, Caporaso NE, Cheng YJ, Hoover RN, Hsu MM, et al. Cytochrome P4502E1 genetic polymorphisms and risk of nasophaiyngeal carcinoma: results from a casecontrol study conducted in Taiwan. Cancer Epidemiol Biomark Prevention, 1995;4:607-10.
  • Kato S, Onda M, Matsukura N, Tokunaga A, Matsuda N, Yamashita K, et al. Genetic polymorphisms of the cancer related gene and Helicobacter pylori infection in Japanese gastric cancer patients. An age and gender-matched case-control study. Cancer 1996;77:1654-61.
  • Harada S, Zhang S. New strategy for detection of ALDH2 mutation. Alcohol Alcohol 1993;28:11-13.
  • Pan J, Xiang Q, Ball S. Use of a novel real-time quantitative reverse transcription-polymerase chain reaction method to study the effects of cytokines on cytochrome p450 mRNA expression in mouse liver. Am Parmaco Exp Theraputics 2000; 28:709-13.
  • Bowen WP, Carey JE, Miah A, McMurry HF, Munday PW, James RS, et al. Measurement of cytochrome p450 gene induction in human hepatocytes using quantitative real-time reverse transcriptase-polymerase chain reaction. Am Parmaco Exp Theraputics 2000;28:781-8.
  • Higuchi S, Matsushita S, Murayama M, Takagi S, Hayashida M. Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism. Am J Psychiatr 1995;152:1219-21.
  • Yamauchi M, Maezawa Y, Mizuhara Y, Ohata M, Hirakawa J, Nakajima H, et al. Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: a multivariate analysis. Hepatology 1995;22:1136-42.
  • Monna T. Epidemiology for alcohol and liver disease. KAN. TAN. SUI. 1996;32:615-22. In Japanese.
  • Yu MW, Gladek-Yarborough A, Chiamprasert S, et al. Cytochrome p450 2El and glutathione S-transferase Ml polymorphisms and susceptibility to hepatocellular carcinoma. Gastroenterology 1995;109:1266-73.
  • Fang JL, Vaca CE. Detection of DNA adducts of acetaldehyde in peripheral white blood cells of alcohol abusers. Carcinogenesis 1997; 18:627-32.
  • Tanaka K, Sakai H, Hashizume M, Hirohata T. A long-term follow-up study on risk factors for hepatocellular carcinoma among Japanese patients with liver cirrhosis. Jpn J Cancer Res 1998;98:1241-50.
  • Shibata A, Fukuda K, Nishiyori A, Nishiyori A, Ogimoto I, Sakata R, et al. A case-control study on male hepatocellular carcinoma based on hospital and community controls. J Epidemiol 1997;8:l-5.
  • Kirn RB, Yamazaki H, Chiba K, O'Shea D, Mimura M, Guengerich FP, et al. In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians. J Pharmacol Exp Ther 1996;279:4-11.
  • Lucas D, Menez C, Floch F, Gourlaouen Y, Sparfel O, Joannet I, et al. Cytochromes P4502E1 and P4501A1 genotypes and susceptibility to cirrhosis or upper aero digestive tract cancer in alcoholic Caucasians. Alcohol Clin Exp Res 1996;20:1033-7.
  • Powell H, Kitteringham N, Pirmohamed M, Smith DA, Park BK. Expression of cytochrome p4502E1 in human liver, assessment by mRNA, genotype and phenotype. Pharmacogenetics 1998;8:411-21.
  • Matsuo K, Hamajima N, Shinoda M, Hatooka S, Inoue M, Takezaki T, et al. Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer. Carcinogenesis 2001;22:913-6.
  • Takeshita T, Yang X, Inoue Y, Sato S, Morimoto K. Relationship between alcohol drinking, ADH2 and ALDH2 genotypes, and risk for hepatocellular carcinoma in Japanese. Cancer Lett 2000; 149:69-76.
  • Yokoyama A, Marumatsu T, Ohmori T, Higuchi S, Hayashida M, Ishii H. Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males. Cancer Epidemi Biomarkers Prev 1996;5:99-102.
  • Takeshita T, Morimoto K. Self-reported alcohol-associated symptoms and drinking behavior in three ALDH2 genotypes among Japanese university students. Alcoholism 1999; 23: 1065-9.
  • Yang CS, Yoo JS, Ishizaki H, Hong JY. Cytochrome P450 IIE1: roles in nitrosamine metabolism and mechanisms of regulation. Drag Metab Rev 1990;22:147-59.
  • Hildesheim A, Anderson LM, Chen CJ, Cheng YJ, Brinton LA, Daly AK, et al. CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan. J Natl Cancer Inst 1997; 89:1207-12.
  • Gonzalez MV, Alvarez V, Pello MF, Menendez MJ, Suarez C, Goto B. Genetic polymorphism of N-acetyltransferase-2, glutathione S-transferase-M1, and cytochromes P450IIE1 and P450IID6 in the susceptibility to head and neck cancer. J Clin Pathol 1998;51:294-8.
  • Lin DX, Tang YM, Peng Q, Lu SX, Ambrosone CB, Kadlubar FF. Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferases Tl, Pl, and Ml and cytochrome P450 2E1. Cancer Epidemiol Biomarkers Prevention 1998;7:1013-8.
  • Sumida A, Kinoshita K, Fukuda T, Matshuda H, Yamamoto I, Inaba T, et al. Relationship between mRNA levels quantified by reverse transcription-competitive PCR and metabolic activity of CYP3A4 and CYP2E1 in human liver. Biochem Biophys Res Commun 1999;262:499-503.

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