Higher proliferative capacity of T lymphocytes from patients with Crohn disease than from ulcerative colitis is disclosed by use of Herpesvirus saimiri-transformed T-cell lines

References

• Schreiber S, Raedler A, Stenson WF, MacDermott RP. The role of the mucosal immune system in inflammatory bowel disease. Gastroenterol Clin North Am 1992;21:451–502.
   PubMed Web of Science ®Google Scholar
• Strober W, Fuss IJ, Blumberg RS. The immunology of mucosal models of inflammation. Annu Rev Immunol 2002;20:495–549.
   PubMed Web of Science ®Google Scholar
• Pallone F, Monteleone G. Interleukin 12 and Th1 responses in inflammatory bowel disease. Gut 1998;43:735–6.
   PubMed Web of Science ®Google Scholar
• Stronkhorst A, Radema S, Yong SL, Bijl H, ten Berge IJ, Tytgat GN, et al. CD4 antibody treatment in patients with active Crohn’s disease: a phase 1 dose-finding study. Gut 1997;40:320–7.
   PubMed Web of Science ®Google Scholar
• Selby WS, Jewell DP. T lymphocyte subsets in inflammatory bowel disease: peripheral blood. Gut 1983;24:99–10.
   PubMed Web of Science ®Google Scholar
• Schreiber S, Raedler A, Conn AR, Rombeau JL, MacDermott RP. Increased in vitro release of soluble interleukin 2 receptor by colonic lamina propria mononuclear cells in inflammatory bowel disease. Gut 1992;33: 236–41.
   Google Scholar
• Mueller C, Knoflach P, Zielinski CC. T-cell activation in Crohn’s disease. Increased levels of soluble interleukin-2 receptor in serum and in supernatants of stimulated peripheral blood mononuclear cells. Gastroenterology 1990;98: 639–46.
   Google Scholar
• Roman LI, Manzano L, De La Hera A, Abreu L, Rossi I, Alvarez- Mon et al. Expanded CD4+CD45RO+ phenotype and defective proliferative response in T lymphocytes from patients with Crohn’s disease. Gastroenterology 1996;110:1008–19.
   Google Scholar
• Biesinger B, Muller-Fleckenstein I, Simmer B, Lang G, Wittmann S, Platzer E, et al. Stable growth transformation of human T lymphocytes by Herpesvirus saimiri. Proc Natl Acad Sci 1992;89:3116–9.
   PubMed Web of Science ®Google Scholar
• Mittrucker HW, Muller-Fleckenstein I, Fleckenstein B, Fleischer B. CD2-mediated autocrine growth of Herpesvirus saimiri-transformed human T lymphocytes. J Exp Med 1992;176:909–39.
   PubMed Web of Science ®Google Scholar
• Rivero-Carmena M, Porras O, Peláez B, Pacheco-Castro A, Gatti RA, Regueiro JR, et al. Membrane and transmembrane signaling in Herpesvirus saimiri-transformed human CD4(+) and CD8(+) T lymphocytes is ATM-independent. Int Immunol 2000;12: 927–35.
   Google Scholar
• Martín-Villa JM, Ferre-López S, López-Suárez JC, Pérez-Blas M, Castellano-Tortajada G, Sánchez-Gómez F, et al. Succesful in vitro immortalization of human intestinal mucosal lymphocytes with Herpesvirus saimiri. Tissue Antigens 1998;52:430–44.
   PubMedGoogle Scholar
• Hildebrandt M, Rose M, Ruter J, Salama A, Monnikes H, Klapp BF. Dipeptidyl peptidase IV (DP IV, CD26) in patients with inflammatory bowel disease. Scand J Gastroenterol 2001; 36: 1067–72.
   PubMed Web of Science ®Google Scholar
• Suzuki A, Sugimura K, Ohtsuka K, Hasegawa K, Suzuki K, Ishizuka K, et al. Fas/Fas ligand expression and characteristics of primed CD45RO+ T cells in the inflamed mucosa of ulcerative colitis. Scand J Gastroenterol 2000;35:1278–83.
   PubMedGoogle Scholar
• Meenan J, Spaans J, Grool TA, Pals ST, Tytgat GN, van Deventer SJ. Altered expression of alpha 4 beta 7, a gut homing integrin, by circulating and mucosal T cells in colonic mucosal inflammation. Gut 1997;40: 241–6.
   Google Scholar
• Crucian B, Dunne P, Friedman H, Ragsdale R, Pross S, Widen R. Alterations in levels of CD28—/CD8+ suppressor cell precursor and CD45RO+/CD4+ memory T lymphocytes in the peripheral blood of multiple sclerosis patients. Clin Diagn Lab Immunol 1995;2:249–52.
   PubMedGoogle Scholar
• Warrington KJ, Vallejo AN, Weyand CM, Goronzy JJ. CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation. Blood 2003;101:3543–9.
   PubMedGoogle Scholar
• Ginaldi L, De Martinis M, D’Ostilio A, Marini L, Loreto F, Modesti M, et al. Changes in the expression of surface receptors on lymphocyte subsets in the elderly: quantitative flow cytometric analysis. Am J Hematol 2001;67:63–72.
   Google Scholar
• Perez-Machado MA, Espinosa LM, de la Madrigal EJ, Abrieu L, Lorente GM, Alvarez-Mon M. Impaired mitogenic response of peripheral blood T cells in ulcerative colitis is not due to apoptosis. Dig Dis Sci 1999;44:2530–7.
   Google Scholar
• Kugathasan S, Willis J, Dahms BB, O’Riordan MA, Hupertz V, Binion DG, et al. Intrinsic hyperreactivity of mucosal T cells to interlukin-2 in pediatric Crohn’s disease. J Pediatr 1998; 133 Suppl 5:675–81.
   Google Scholar
• Ina K, Itoh J, Fukushima K, Kusugami K, Yamaguchi T, Kyohane K, et al. Resistance of Crohn’s disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance. J Immunol 1999;163:1081–90.
   PubMed Web of Science ®Google Scholar
• Valeri AP, Pérez-Blas M, Gutiérrez A, López-Santalla M, Aguilera N, Rodriguez-Juan C, et al. Intrinsic defects explain altered proliferative responses of T lymphocytes and HVS-derived T-cell lines in gastric adenocarcinoma. Cancer Immunol Immunother 2003;52:708–14.
   PubMed Web of Science ®Google Scholar
• Weiss A, Littman IR. Signal transduction by lymphocyte antigen receptors. Cell 1994;76:263–74.
   PubMed Web of Science ®Google Scholar
• Isakov N, Biesinger B. Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products. Eur J Biochem 2000;267:3413–21.
   PubMedGoogle Scholar
• Agnholt J, Kaltoft K. Infliximab downregulates interferongamma production in activated gut T lymphocytes from patients with Crohn’s disease. Cytokine 2001;15:212–22.
   PubMed Web of Science ®Google Scholar
• Jacquot S, Modigliani R, Kuzniak I, Boumsell L, Bensussan A. Enhanced CD3 monoclonal antibody induced proliferation of colonic mucosal T lymphocytes in Crohn’s disease patients free of corticosteroid or immunosuppressor treatment. Clin Immunol Immunopathol 1996;79: 20–4.
   Google Scholar