77
Views
10
CrossRef citations to date
0
Altmetric
Case Report

Caution in the use of boldo in herbal laxatives: A case of hepatotoxicity

, , , , &
Pages 236-239 | Received 12 Jan 2004, Accepted 29 Jun 2004, Published online: 08 Jul 2009

References

  • Ni H, Simile C, Hardy A. Utilization of complementary and alternative medicine by United States adults: results from the 1999 national health interview survey. Med Care 2002;40: 353–8.
  • Stedman C. Herbal hepatotoxicity. Semin Liver Dis 2002;22:195–206.
  • Stickel F, Seitz H, Hahn E, Schuppan D. Liver toxicity of drugs of plant origin. Z Gastroenterol 2001;39:225–32, 234–7.
  • Stickel F, Poschl G, Seitz H, Waldherr R, Hahn E, Schuppan D. Acute hepatitis induced by greater celandine (Chelidonium majus). Scand J Gastroenterol 2003;38:656–8.
  • Maria V, Victorino R. Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis. Hepatology 1997;26:664–9.
  • Negro F, Mondardini A, Palmas F. Hepatotoxicity of saccharin. N Engl J Med 1994;331:134–5.
  • Moritz K, Grisk A, Schroder L, Siegmund W, Hegewald G, Konigstedt B, et al. Acute and subchronic experiments on the effects of microcrystalline cellulose on various pharmacological and biochemical parameters in mongrel rabbits. Nahrung 1979;23:611–20.
  • Kubinova R, Machala M, Minksova K, Neca J, Suchy V. Chemoprotective activity of boldine: modulation of drug- metabolizing enzymes. Pharmazie 2001;56:242–3.
  • Cederbaum A, Kukielka E, Speisky H. Inhibition of rat liver microsomal lipid peroxidation by boldine. Biochem Pharmacol 1992;44:1765–72.
  • Bannah R, Valenzuela A, Cassels B, Nunez-Vergara L, Speisky H. Cytoprotective and antioxidant effects of boldine on tert-butyl hydroperoxide-induced damage to isolated hepatocytes. Cell Biol Toxicol 1996;12:89–100.
  • Schemeda-Hirschmann G, Rodriguez J, Theoduloz C, Astudillo S, Feresin G, Tapia A. Free-radical scavengers and antioxidants from Peumus boldus Mol. (“Boldo”). Free Radic Res 2003;37: 447–/52.
  • Speisky H, Cassels B, Lissi E, Videla L. Antioxidant properties of the alkaloid boldine in systems undergoing lipid peroxidation and enzyme inactivation. Biochem Pharmacol 1991;41:1575–81.
  • Jang Y, Song J, Shin Y, Han E, Lee C. Protective effect of boldine on oxidative mitochondrial damage in streptozotocin induced diabetic rats. Pharmacol Res 2000;42:361–71.
  • Almeida E, Melo A, Xavier H. Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytother Res 2000;14:99–102.
  • Tavares D, Takahashi C. Evaluation of the genotoxic potential of the alkaloid boldine in mammalian cell systems in vitro and in vivo. Mutat Res 1994;321:139–45.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.