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Original Article: GI Cancer

Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas

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Pages 198-205 | Received 24 Mar 2004, Accepted 11 Aug 2004, Published online: 08 Jul 2009

References

  • Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, et al. The nuclear receptor superfamily: the second decade. Cell 1995;83:835–9.
  • Green S, Tugwood JD, Issemann I. The molecular mechanism of peroxisome proliferator action: a model for species differences and mechanistic risk assessment. Toxicol Lett 1992;64–5. Spec. No.:131–9:131–9.
  • Michalik L, Desvergne B, Dreyer C, Gavillet M, Laurini RN, Wahli W. PPAR expression and function during vertebrate development. Int J Dev Biol 2002;46:105–14.
  • Fajas L, Auboeuf D, Raspe E, Schoonjans K, Lefebvre AM, Saladin R, et al. The organization, promoter analysis, and expression of the human PPARg gene. J Biol Chem 1997; 272:18779–89.
  • Mangelsdorf DJ, Evans RM. The RXR heterodimers and orphan receptors. Cell 1995;83:841–50.
  • Tugwood JD, Issemann I, Anderson RG, Bundell KR, McPheat WL, Green S. The mouse peroxisome proliferator activated receptor recognizes a response element in the 5? flanking sequence of the rat acyl CoA oxidase gene. EMBO J 1992;11:433–9.
  • Auboeuf D, Rieusset J, Fajas L, Vallier P, Frering V, Riou JP, et al. Tissue distribution and quantification of the expression of MRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes 1997;46:1319–27.
  • Latruffe N, Malki MC, Nicolas-Frances V, Clemencet M, Jannin B, Berlot J. Regulation of the peroxisomal beta- oxidation-dependent pathway by peroxisome proliferator- activated receptor alpha and kinases. Biochem Pharmacol 2000;60:1027–32.
  • Jackson L, Wahli W, Michalik L, Watson SA, Morris T, Anderton K, et al. Potential role for peroxisome proliferator activated receptor (PPAR) in preventing colon cancer. Gut 2003;52:1317–22.
  • Oliver WR, Shenk JL, Snaith MR, Russell CS, Plunket KD, Bodkin NL, et al. A selective peroxisome proliferator- activated receptor delta agonist promotes reverse cholesterol transport. PNAS 2001;98:5306–11.
  • Barak Y, Liao D, He W, Ong ES, Nelson MC, Olefsky JM, et al. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. PNAS 2001;99:303–8.
  • Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H, et al. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell 2003;113:159–70.
  • Mansen A, Guardiola-Diaz H, Rafter J, Branting C, Gustafsson JA. Expression of the peroxisome proliferator-acti- vated receptor (PPAR) in the mouse colonic mucosa. Biochem Biophys Res Commun 1996;222:844–51.
  • Lefebvre M, Paulweber B, Fajas L, Woods J, McCrary C, Colombel JF, et al. Peroxisome proliferator-activated receptor γ is induced during differentiation of colon epithelium cells. J Endocrinol 1999;162:331–40.
  • Dubois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA. The Nuclear eicosanoid receptor, PPARγ is aberrantly expressed in colonic cancers. Carcinogenesis 1998;19:49–53.
  • Kitamura S, Miyazaki Y, Shinomura Y, Kondo S, Kanayama S, Matsuzawa Y. Peroxisome proliferator-activated receptor gamma induces growth arrest and differentiation markers of human colon cancer cells. Jpn J Cancer Res 1999;90:75–80.
  • Sarraf P, Mueller E, Jones D, King FJ, DeAngelo DJ, Partridge JB, et al. Differentiation and reversal of malignant changes in colon cancer through PPARg. Nat Med 1998; 4:1046–52.
  • Huin C, Schohn H, Hatier R, Bentejac M, Antunes L, Plenat F, et al. Expression of peroxisome proliferator- activated receptors alpha and gamma in differentiating human colon carcinoma Caco-2 Cells. Biol Cell 2002; 94:15–27.
  • Gupta RA, Tan J, Krause WF, Geraci MW, Willson TM, Dey SK, et al. Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. Proc Natl Acad Sci USA 2000;97:13275–80.
  • Lefebvre M, Chen I, Desreumaux P, Najib J, Fruchart JC, Geboes K, et al. Activation of the peroxisome proliferator- activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/ Mice. Nat Med 1998;4:1053–7.
  • Saez E, Tontonoz P, Nelson MC, Alvarez JG, Ming UT, Baird SM, et al. Activators of the nuclear receptor PPARγ enhance colon polyp formation. Nat Med 1998;4:1058–61.
  • Fodde R. The APC gene in colorectal cancer. Eur J Cancer 2002;38:867–71.
  • Girnun GD, Smith WM, Drori S, Sarraf P, Mueller E, Eng C, et al. APC-dependent suppression of colon carcinogenesis by PPARγ. PNAS 2002;99:13771–6.
  • Shimada T, Kojima K, Yoshiura K, Hiraishi H, Terano A. Characteristics of the peroxisome proliferator activated receptor gamma (PPARγ) ligand induced apoptosis in colon cancer cells. Gut 2002;50:658–64.
  • He TC, Chan TA, Vogelstein B, Kinzler KW. PPAR8 is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 1999;99:335–45.
  • Wu GD. A nuclear receptor to prevent colon cancer. N Engl J Med 2000;342:651–3.
  • Lewis D, Lichtenstein GR, Stein RB, Deren JJ, Judge TA, Fogt F, et al. An open-label trial of the PPAR-γ ligand rosiglitazone for active ulcerative colitis. Am J Gastroenterol 2001;96:3323–8.
  • Pedersen G, Saermark T, Giese B, Hansen A, Drag B, Brynskov J. A simple method to establish short-term cultures of normal human colonic epithelial cells from endoscopic biopsy specimens. Comparison of isolation methods, assessment of viability and metabolic activity. Scand J Gastroenterol 2000;35:772–80.
  • Pedersen G, Saermark T, Bendtzen K, Brynskov J. Cultures of human colonic epithelial cells isolated from endoscopical biopsies from patients with inflammatory bowel disease. Effect of IFN-gamma, TNF-alpha and IL-1beta on viability, butyrate oxidation and IL-8 secretion. Autoimmunity 2000; 32:255–63.
  • Pedersen G, Saermark T, Horn T, Giese B, Bendtzen K, Brynskov J. Cytokine-induced impairment of short-chain fatty acid oxidation and viability in human colonic epithelial cells. Cytokine 2000;12:1400–4.
  • Brynskov J, Foegh P, Pedersen G, Ellervik C, Kirkegaard T, Bingham A, et al. Tumour necrosis factor alpha converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease. Gut 2002;51:37–43.
  • Perner A, Andresen L, Pedersen G, Rask-Madsen J. Superoxide production and expression of NAD(P)H Oxidases by transformed and primary human colonic epithelial cells. Gut 2003;52:231–6.
  • Laborda J. 36B4 CDNA used as an estradiol-independent mrna control is the CDNA for human acidic ribosomal phosphoprotein PO. Nucleic Acids Res 1991;19:3998.
  • Gupta RA, Brockman JA, Sarraf P, Willson TM, Dubois RN. Target genes of peroxisome proliferator-activated receptor gamma in colorectal cancer cells. J Biol Chem 2001;276:29681–7.
  • Hodgkinson P, Ye S. Microarray analysis of peroxisome proliferator-activated receptor-[gamma] induced changes in gene expression in macrophages. Biochem Biophys Res Commun 2003;308:505–10.
  • Liu Y, Peterson DA, Kimura H, Schubert D. Mechanism of Cellular 3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazo- lium bromide (MTT) reduction. J Neurochem 1997; 69:581–93.
  • Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994;124: 619–26.
  • McKay DM, Philpott DJ, Perdue MH. Review article: in vitro models in inflammatory bowel disease research: a critical review. Aliment Pharmacol Ther 1997;11 Suppl 3:70–80.

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