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Scandinavian Journal of Gastroenterology Volume 41, 2006 - Issue 6
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ORIGINAL ARTICLE

Vascular endothelial growth factor (VEGF164) ameliorates intestinal epithelial injury in vitro in IEC-18 and Caco-2 monolayers via induction of TGF-β release from epithelial cells

K. Bulut Department of Medicine I, St. Josef-Hospital, Ruhr-University, Bochum, GermanyCorrespondence[email protected]
, M.D,
C. Pennartz Department of Medicine I, St. Josef-Hospital, Ruhr-University, Bochum, Germany
,
P. Felderbauer Department of Medicine I, St. Josef-Hospital, Ruhr-University, Bochum, Germany
,
N. Ansorge Department of Medicine I, St. Josef-Hospital, Ruhr-University, Bochum, Germany
,
M. Banasch Department of Medicine I, St. Josef-Hospital, Ruhr-University, Bochum, Germany
,
F. Schmitz Department of Medicine I, St. Josef-Hospital, Ruhr-University, Bochum, Germany
,
W. E. Schmidt Department of Medicine I, St. Josef-Hospital, Ruhr-University, Bochum, Germany
&
P. Hoffmann Department of Medicine I, St. Josef-Hospital, Ruhr-University, Bochum, Germany
 show all
Pages 687-692 | Received 11 Aug 2005, Published online: 08 Jul 2009

References

  • Ferrara N. Vascular endothelial growth factor. Eur J Cancer 1996; 32A: 2413–22
  • Berse B, Van de Water L, Dvorak HF, Senger DR. Vascular permeability (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages and tumors. Mol Biol Cell 1992; 3: 211–20
  • Leung DW, Cachianes G, Kuang W-J, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246: 1306–9
  • Folkman J. Seminars in medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. N Engl J Med 1995; 333: 1757–63
  • Kohno T, Mizukami H, Suzuki M, Saga Y, Takei Y, Shimpo M. Interleukin-10-mediated inhibition of angiogenesis and tumor growth in mice bearing VEGF-producing ovarian cancer. Cancer Res 2003; 63: 5091–4
  • Stoeltzing O, Liu W, Reinmuth N, Fan F, Parikh AA, Bucana CD. Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I autocrine loop in human pancreatic cancer. Am J Pathol 2003; 163: 1001–11
  • Alon T, Hemo I, Itin A, Pe'er J, Stone J, Keshet E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1995; 1: 1024–8
  • Massod R, Cai J, Zheng T, et al. Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS-Kaposi sarcoma. Proc Natl Acad Sci USA 1997; 94: 979–84
  • Ferrer FA, Miller LJ, Lindquist R, Kowalczyk P, Laudone VP, Albertsen PC, et al. Expression of vascular endothelial growth factor receptors in human prostate cancer. Urology 1999; 54: 567–72
  • Ziegler BL, Valtieri M, Porada GA, DE Maria R, Muller R, Masella B, et al. KDR receptor: a key marker defining hematopoietic stem cells. Science 1999; 285: 1553–8
  • Siafakas CG, Anatolitou F, Fusunyan RD, Walker WA, Sanderson IR. Vascular endothelial growth factor (VEGF) is present in human breast milk and its receptor is present on intestinal epithelial cells. Pediatr Res 1999; 45: 652–7
  • Bousvaros A, Leichtner A., Zurakowski D, Kwon J, Law T, Keough K, et al. Elevated serum vascular endothelial growth factor in children and young adults with Crohn's disease. Dig Dis Sci 1999; 44: 424–30
  • Griga T, Voigt E, Gretzer B, Brasch F, May B. Increased production of vascular endothelial endothelial growth factor by intestinal mucosa of patients with inflammatory bowel disease. Hepatogastroenterology 1999; 46: 920–3
  • Griga T, May B, Pfisterer O, Müller KM, Brasch F. Immunhistochemical localization of vascular endothelial growth factor in colonic mucosa of patients with inflammatory bowel disease. Hepatogastroenterology 2002; 49: 116–23
  • Murohara T, Horowitz JR, Silver M, Tsurumi Y, Chen D, Sullivan A, et al. Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin. Circulation 1998; 97: 99–107
  • Koolwijk P, van Erck M, de Vree WJ, Vermeer MA, Weich HA, Hanemaaijer R, et al. Cooperative effects of TNFalpha, bFGF and VEGF on the formation of tubular structures of human microvascular endothelial cells in a fibrin matrix. Role of urokinase activity. J Cell Biol 1996; 132: 1177–88
  • Pintavorn P, Ballermann BJ. TGF-beta and the endothelium during immune injury. Kidney Int 1997; 51: 1401–12
  • Cucina A, Borelli V, Randone B, Coluccia P, Sapienza P, Cavallaro A. Vascular endothelial growth factor increases the migration of smooth muscle cells through the mediation of growth factors released by endothelial cells. J Surg Res 2003; 109: 16–23
  • Dignass AU, Podolsky DK. Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor beta. Gastroenterology 1993; 105: 1323–32
  • Bulut K, Meier JJ, Ansorge N, Felderbauer P, Schmitz F, Hoffmann P, et al. Glucagon-like peptide 2 improves intestinal wound healing through induction of epithelial cell migration in vitro evidence for a a TGF-beta mediated effect. Reg Peptides 2004; 121: 137–43
  • Ciacci C, Lind SE, Podolsky DK. Transforming growth factor regulation of migration in wounded rat intestinal epithelial monolayers. Gastroenterology 1993; 105: 93–101
  • Dignass AU, Tsunekawa S, Podolsky DK. Fibroblast growth factors modulate intestinal epithelial cell growth and migration. Gastroenterology 1994; 106: 1254–62

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