Wistar Kyoto rats have impaired gastric accommodation compared to Sprague Dawley rats due to increased gastric vagal cholinergic tone

References

• Azpiroz F, Malagelada JR. Importance of vagal input in maintaining gastric tone in the dog. J Physiol 1987; 384: 511–24
   PubMed Web of Science ®Google Scholar
• Takahashi T, Owyang C. Vagal control of nitric oxide and vasoactive intestinal polypeptide release in the regulation of gastric relaxation in rat. J Physiol 1995; 484: 481–92
   PubMed Web of Science ®Google Scholar
• Tack J, Demedts I, Meulemans A, Schuurkes J, Janssens J. Role of nitric oxide in the gastric accommodation reflex and in meal induced satiety in humans. Gut 2002; 51: 219–24
   PubMed Web of Science ®Google Scholar
• Takahashi T, Owyang C. Characterization of vagal pathways mediating gastric accommodation reflex in rats. J Physiol 1997; 504: 479–88
   PubMed Web of Science ®Google Scholar
• Uno H, Arakawa T, Fukuda T, Higuchi K, Kobayashi K. Involvement of capsaicin-sensitive sensory nerves in gastric adaptive relaxation in isolated guinea-pig stomachs. Digestion 1997; 58: 232–9
   PubMed Web of Science ®Google Scholar
• Abrahamsson H, Glise H. Sympathetic nervous control of gastric motility and interaction with vagal activity. Scand J Gastroenterol 1984; 89: 83–7
   Google Scholar
• Lee K-J, Kindt S, Tack J. Pathophysiology of functional dyspepsia. Best Pract Res Clin Gastroenterol 2004; 18: 707–16
   PubMed Web of Science ®Google Scholar
• Gilja OH, Hausken T, Wilhelmsen I, Berstad A. Impaired accommodation of proximal stomach to a meal in functional dyspepsia. Dig Dis Sci 1996; 41: 689–96
   PubMed Web of Science ®Google Scholar
• Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998; 115: 1346–52
   PubMed Web of Science ®Google Scholar
• Boeckxstaens GE, Hirsch DP, Kuiken SD, Heisterkamp SH, Tytgat GN. The proximal stomach and postprandial symptoms in functional dyspeptics. Am J Gastroenterol 2002; 97: 40–8
   PubMed Web of Science ®Google Scholar
• Bredenoord AJ, Chial HJ, Camilleri M, Mullan BP, Murray JA. Gastric accommodation and emptying in evaluation of patients with upper gastrointestinal symptoms. Clin Gastroenterol Hepatol 2003; 1: 264–72
   PubMed Web of Science ®Google Scholar
• Hausken T, Svebak S, Wilhelmsen I, Haug TT, Olafsen K, Pettersson E, et al. Low vagal tone and antral dysmotility in patients with functional dyspepsia. Psychosom Med 1993; 55: 12–22
   PubMed Web of Science ®Google Scholar
• Troncon LE, Thompson DG, Ahluwalia NK, Barlow J, Heggie L. Relations between upper abdominal symptoms and gastric distension abnormalities in dysmotility like functional dyspepsia and after vagotomy. Gut 1995; 37: 17–22
   PubMed Web of Science ®Google Scholar
• Talley NJ, Fung LH, Gilligan IJ, McNeil D, Piper DW. Association of anxiety, neuroticism, and depression with dyspepsia of unknown cause. A case-control study. Gastroenterology 1986; 90: 886–92
   PubMed Web of Science ®Google Scholar
• Haug TT, Svebak S, Hausken T, Wilhelmsen I, Berstad A, Ursin H. Low vagal activity as mediating mechanism for the relationship between personality factors and gastric symptoms in functional dyspepsia. Psychosom Med 1994; 56: 181–6
   PubMed Web of Science ®Google Scholar
• Haug TT, Wilhelmsen I, Ursin H, Berstad A. What are the real problems for patients with functional dyspepsia?. Scand J Gastroenterol 1995; 30: 97–100
   PubMed Web of Science ®Google Scholar
• Berstad A, Olafsson S, Tefera S, Hatlebakk JG, Gilja OH, Hausken T. Controversies in dyspepsia. Eur J Surg 2001; 586: 4–11
   Google Scholar
• Paré WP. The performance of WKY rats on three tests of emotional behavior. Physiol Behav 1992; 51: 1051–6
   PubMed Web of Science ®Google Scholar
• De La Garza R, Mahoney JJ. A distinct neurochemical profile in WKY rats at baseline and in response to acute stress: implications for animal models of anxiety and depression. Brain Res 2004; 1021: 209–18
   PubMed Web of Science ®Google Scholar
• Gunter WD, Shepard JD, Foreman RD, Myers DA, Greenwood-Van Meerveld B. Evidence for visceral hypersensitivity in high-anxiety rats. Physiol Behav 2000; 69: 379–82
   PubMed Web of Science ®Google Scholar
• Bayati A, Astin M, Ekman C, Mattsson H. Wistar Kyoto rats have impaired gastric adaptive accommodation in response to gastric distension. Gastroenterology 2003; 124: A677
   Google Scholar
• Brouillet E, Roeda D, Valette H, Fuseau C, Guyot MC, Crouzel C. In vivo metabolites of N omega-nitro-L-arginine methyl ester: methanol and N omega-nitro-L-arginine. Eur J Pharmacol 1995; 293: 487–90
   PubMedGoogle Scholar
• Motterlini R, Hidalgo A, Sammut I, Shah KA, Mohammed S, Srai K, et al. A precursor of the nitric oxide donor SIN-1 modulates the stress protein heme oxygenase-1 in rat liver. Biochem Biophys Res Commun 1996; 225: 167–72
   PubMedGoogle Scholar
• Ruwart MJ, Klepper MS, Rush BD. Clonidine delays small intestinal transit in the rat. J Pharmacol Exp Ther 1980; 212: 487–90
   PubMed Web of Science ®Google Scholar
• Lunding JA, Tefera S, Bayati A, Gilja OH, Mattsson H, Hausken T, et al. Pressure-induced gastric accommodation studied with a new distension paradigm. Abnormally low accommodation rate in patients with functional dyspepsia. Scand J Gastroenterol 2006; 41: 0000–00
   Google Scholar
• Crema F, Moro E, Nardelli G, de Ponti F, Frigo G, Crema A. Role of tachykininergic and cholinergic pathways in modulating canine gastric tone and compliance in vivo. Pharmacol Res 2002; 45: 341–7
   PubMed Web of Science ®Google Scholar
• Lidums I, Hebbard GS, Holloway RH. Effect of atropine on proximal gastric motor and sensory function in normal subjects. Gut 2000; 47: 30–6
   PubMed Web of Science ®Google Scholar
• Bruley des Varannes S, Parys V, Ropert A, Chayvialle JA, Roze C, Galmiche JP. Erythromycin enhances fasting and postprandial proximal gastric tone in humans. Gastroenterology 1995; 109: 32–9
   PubMed Web of Science ®Google Scholar
• Holtmann G, Goebell H, Jockenhoevel F, Talley NJ. Altered vagal and intestinal mechanosensory function in chronic unexplained dyspepsia. Gut 1998; 42: 501–6
   PubMedGoogle Scholar
• Thumshirn M, Camilleri M, Saslow SB, Williams DE, Burton DD, Hanson RB. Gastric accommodation in non-ulcer dyspepsia and the roles of Helicobacter pylori infection and vagal function. Gut 1999; 44: 55–64
   PubMed Web of Science ®Google Scholar
• Lunding JA, Bayati A, Gilja OH, Mattsson H, Hausken T, Berstad A. Pressure-induced gastric accommodation in functional dyspepsia. Effect of autonomic manipulation. Neurogastroenterol Motil 2004; 16: 851–2
   Google Scholar
• Kuiken SD, Vergeer M, Heisterkamp SH, Tytgat GN, Boeckxstaens GE. Role of nitric oxide in gastric motor and sensory functions in healthy subjects. Gut 2002; 51: 212–8
   PubMed Web of Science ®Google Scholar
• Coulie B, Tack J, Sifrim D, Andrioli A, Janssens J. Role of nitric oxide in fasting gastric fundus tone and in 5-HT1 receptor-mediated relaxation of gastric fundus. Am J Physiol 1999; 276: G373–7
   PubMed Web of Science ®Google Scholar
• Tack J, Demedts I, Dehondt G, Caenepeel P, Fischler B, Zandecki M, et al. Clinical and pathophysiological characteristics of acute-onset functional dyspepsia. Gastroenterology 2002; 122: 1738–47
   PubMed Web of Science ®Google Scholar
• Thumshirn M, Camilleri M, Choi MG, Zinsmeister AR. Modulation of gastric sensory and motor functions by nitrergic and alpha2-adrenergic agents in humans. Gastroenterology 1999; 116: 573–85
   PubMed Web of Science ®Google Scholar
• De Ponti F, Giaroni C, Cosentino M, Lecchini S, Frigo G. Adrenergic mechanisms in the control of gastrointestinal motility: from basic science to clinical applications. Pharmacol Ther 1996; 69: 59–78
   PubMed Web of Science ®Google Scholar
• Leclere PG, Lefebvre RA. Presynaptic modulation of cholinergic neurotransmission in the human proximal stomach. Br J Pharmacol 2002; 135: 135–42
   PubMed Web of Science ®Google Scholar
• James AN, Ryan JP, Parkman HP. Effects of clonidine and tricyclic antidepressants on gastric smooth muscle contractility. Neurogastroenterol Motil 2004; 16: 143–53
   PubMedGoogle Scholar