Polymorphism of the heat-shock protein gene Hsp70-2, but not polymorphisms of the IL-10 and CD14 genes, is associated with the outcome of Crohn's disease

References

• Guarner F, Malagelada JR. Gut flora in health and disease. Lancet 2003; 361: 512–9
   PubMed Web of Science ®Google Scholar
• Bonen DK, Cho JH. The genetics of inflammatory bowel disease. Gastroenterology 2003; 124: 521–36
   PubMed Web of Science ®Google Scholar
• Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001; 411: 599–603
   PubMed Web of Science ®Google Scholar
• Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001; 411: 603–6
   PubMed Web of Science ®Google Scholar
• Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 2003; 3: 521–33
   PubMed Web of Science ®Google Scholar
• Baldini M, Lohman IC, Halonen M, Erickson RP, Holt PG, Martinez FD. A Polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 1999; 20: 976–83
   PubMed Web of Science ®Google Scholar
• Klein W, Tromm A, Griga T, Fricke H, Folwaczny C, Hocke M, et al. A polymorphism in the CD14 gene is associated with Crohn disease. Scand J Gastroenterol 2002; 37: 189–91
   PubMed Web of Science ®Google Scholar
• Obana N, Takahashi S, Kinouchi Y, Negoro K, Takagi S, Hiwatashi N, et al. Ulcerative colitis is associated with a promoter polymorphism of lipopolysaccharide receptor gene, CD14. Scand J Gastroenterol 2002; 37: 699–704
   PubMed Web of Science ®Google Scholar
• Koss K, Satsangi J, Fanning GC, Welsh KI, Jewell DP. Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies. Genes Immun 2000; 1: 185–90
   PubMed Web of Science ®Google Scholar
• Schreiber S, Heinig T, Thiele HG, Raedler A. Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease. Gastroenterology 1995; 108: 1434–44
   PubMed Web of Science ®Google Scholar
• Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993; 75: 263–74
   PubMed Web of Science ®Google Scholar
• Schmit A, Carol M, Robert F, Bontems P, Houben JJ, Van Gossum A, et al. Dose-effect of interleukin-10 and its immunoregulatory role in Crohn's disease. Eur Cytokine Netw 2002; 13: 298–305
   PubMed Web of Science ®Google Scholar
• Schreiber S, Fedorak RN, Nielsen OH, Wild G, Williams CN, Nikolaus S, et al. Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Crohn's Disease IL-10 Cooperative Study Group. Gastroenterology 2000; 119: 1461–72
   PubMed Web of Science ®Google Scholar
• Fedorak RN, Gangl A, Elson CO, Rutgeerts P, Schreiber S, Wild G, et al. Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group. Gastroenterology 2000; 119: 1473–82
   PubMed Web of Science ®Google Scholar
• Young RA. Stress proteins and immunology. Annu Rev Immunol 1990; 8: 401–20
   PubMed Web of Science ®Google Scholar
• Milner CM, Campbell RD. Structure and expression of the three MHC-linked HSP70 genes. Immunogenetics 1990; 32: 242–51
   PubMed Web of Science ®Google Scholar
• Wischmeyer PE, Musch MW, Madonna MB, Thisted R, Chang EB. Glutamine protects intestinal epithelial cells: role of inducible HSP70. Am J Physiol 1997; 272: G879–84
   PubMed Web of Science ®Google Scholar
• Stulik J, Bures J, Jandik P, Langr F, Kovarova H, Macela A. The different expression of proteins recognized by monoclonal anti-heat shock protein 70 (hsp70) antibody in human colonic diseases. Electrophoresis 1997; 18: 625–8
   PubMed Web of Science ®Google Scholar
• Esaki M, Furuse M, Matsumoto T, Aoyagi K, Jo Y, Yamagata H, et al. Polymorphism of heat-shock protein gene HSP70-2 in Crohn disease: possible genetic marker for two forms of Crohn disease. Scand J Gastroenterol 1999; 34: 703–7
   PubMed Web of Science ®Google Scholar
• Debler J, Schiemann U, Seybold U, Mussack T, Landauer N, Ladurner R, et al. Heat-shock protein HSP70-2 genotypes in patients with Crohn's disease: a more severe clinical course with intestinal complications in presence of the PstI-polymorphism. Eur J Med Res 2003; 8: 120–4
   PubMed Web of Science ®Google Scholar
• Pociot F, Ronningen KS, Nerup J. Polymorphic analysis of the human MHC-linked heat shock protein 70 (HSP70-2) and HSP70-Hom genes in insulin-dependent diabetes mellitus (IDDM). Scand J Immunol 1993; 38: 491–5
   PubMed Web of Science ®Google Scholar
• Lennard-Jones JE. Classification of inflammatory bowel disease. Scand J Gastroenterol 1989; Suppl 170: 2–6
   Web of Science ®Google Scholar
• Gasche C, Scholmerich J, Brynskov J, D'Haens G, Hanauer SB, Irvine EJ, et al. A simple classification of Crohn's disease: report of the working party for the World Congresses of Gastroenterology, Vienna 1998. Inflamm Bowel Dis 1998; 6: 8–15
   Web of Science ®Google Scholar
• Cosnes J, Cattan S, Blain A, Beaugerie L, Carbonnel F, Parc R, et al. Long-term evolution of disease behavior of Crohn's disease. Inflamm Bowel Dis 2002; 8: 244–50
   PubMed Web of Science ®Google Scholar
• Heesen M, Bloemeke B, Kunz D. The cytokine synthesis by heterozygous carriers of the Toll-like receptor 4 Asp299Gly polymorphism does not differ from that of wild type homozygotes. Eur Cytokine Netw 2003; 14: 234–7
   PubMed Web of Science ®Google Scholar
• Heesen M, Kunz D, Rossaint R, Blomeke B. Real-time PCR assay with fluorescent hybridization probes for rapid genotyping of the CD14 promoter polymorphism. Clin Chem 2000; 46: 1866–7
   PubMed Web of Science ®Google Scholar
• Treszl A, Toth-Heyn P, Kocsis I, Nobilis A, Schuler A, Tulassay T, et al. Interleukin genetic variants and the risk of renal failure in infants with infection. Pediatr Nephrol 2002; 17: 713–7
   PubMed Web of Science ®Google Scholar
• Schroeder S, Reck M, Hoeft A, Stuber F. Analysis of two human leukocyte antigen-linked polymorphic heat shock protein 70 genes in patients with severe sepsis. Crit Care Med 1999; 27: 1265–70
   PubMed Web of Science ®Google Scholar
• Madsen KL. Inflammatory bowel disease: lessons from the IL-10 gene-deficient mouse. Clin Invest Med 2001; 24: 250–7
   PubMed Web of Science ®Google Scholar
• Steinhart AH, Feagan BG, Wong CJ, Vandervoort M, Mikolainis S, Croitoru K, et al. Combined budesonide and antibiotic therapy for active Crohn's disease: a randomized controlled trial. Gastroenterology 2002; 123: 33–40
   PubMed Web of Science ®Google Scholar
• Netea MG, van der Graaf C, Van der Meer JW, Kullberg BJ. Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system. J Leukocyte Biol 2004; 75: 749–55
   PubMed Web of Science ®Google Scholar
• Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 2003; 278: 5509–12
   PubMed Web of Science ®Google Scholar
• Comings DE, MacMurray JP. Molecular heterosis: a review. Mol Genet Metab 2000; 71: 19–31
   PubMed Web of Science ®Google Scholar
• Beckman L, Frohlander N. Heterozygosity effects in studies of genetic markers and disease. Hum Hered 1990; 40: 322–9
   PubMed Web of Science ®Google Scholar
• Cario E, Podolsky DK. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 2000; 68: 7010–7
   PubMed Web of Science ®Google Scholar
• Klein W, Tromm A, Griga T, Fricke H, Folwaczny C, Hocke M, et al. The IL-10 gene is not involved in the predisposition to inflammatory bowel disease. Electrophoresis 2000; 21: 3578–82
   PubMed Web of Science ®Google Scholar
• Netea MG, Kullberg BJ, De Jong DJ, Franke B, Sprong T, Naber TH, et al. NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease. Eur J Immunol 2004; 34: 2052–9
   PubMed Web of Science ®Google Scholar
• Singh B, Read S, Asseman C, Malmstrom V, Mottet C, Stephens LA, et al. Control of intestinal inflammation by regulatory T cells. Immunol Rev 2001; 182: 190–200
   PubMed Web of Science ®Google Scholar
• Rook GA, Adams V, Hunt J, Palmer R, Martinelli R, Brunet LR. Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders. Springer Semin Immunopathol 2004; 25: 237–55
   PubMed Web of Science ®Google Scholar
• Musch MW, Ciancio MJ, Sarge K, Chang EB. Induction of heat shock protein 70 protects intestinal epithelial IEC-18 cells from oxidant and thermal injury. Am J Physiol 1996; 270: C429–36
   PubMed Web of Science ®Google Scholar