156
Views
28
CrossRef citations to date
0
Altmetric
CASE REPORT

6-Thioguanine for Crohn's disease during pregnancy: Thiopurine metabolite measurements in both mother and child

, MD, , , , , & show all
Pages 1374-1377 | Received 01 Apr 2005, Published online: 08 Jul 2009

References

  • Derijks LJ, de Jong DJ, Gilissen LP, Engels LG, Hooymans PM, Jansen JB, et al. 6-Thioguanine seems promising in azathioprine- or 6-mercaptopurine-intolerant inflammatory bowel disease patients: a short-term safety assessment. Eur J Gastroenterol Hepatol 2003; 15: 63–7
  • Dubinsky MC, Feldman EJ, Abreu MT, Targan SR, Vasiliauskas EA. Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine. Am J Gastroenterol 2003; 98: 1058–63
  • De Jong D, Mulder CJ, van Sorge AA. Why measure thiopurine methyltransferase activity? Direct administration of 6-thioguanine might be the alternative for 6-mercaptopurine or azathioprine. Gut 2001; 49: 874
  • Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR. Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations. Dig Liver Dis 2005; 37: 282–97
  • Dubinsky MC, Yang H, Hassard PV, Seidman EG, Kam LY, Abreu MT, et al. 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease. Gastroenterology 2002; 122: 904–15
  • Marinaki AM, Ansari A, Duley JA, Arenas M, Sumi S, Lewis CM, et al. Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). Pharmacogenetics 2004; 14: 181–7
  • Dubinsky MC, Vasiliauskas EA, Singh H, Abreu MT, Papadakis KA, Tran T, et al. 6-thioguanine can cause serious liver injury in inflammatory bowel disease patients. Gastroenterology 2003; 125: 298–303
  • Ferrero S, Ragni N. Inflammatory bowel disease: management issues during pregnancy. Arch Gynecol Obstet 2004; 270: 79–85
  • Griffiths M. Acute leukaemia during pregnancy. Lancet 1988; 1: 586
  • Artlich A, Moller J, Tschakaloff A, Schwinger E, Kruse K, Gortner L. Teratogenic effects in a case of maternal treatment for acute myelocytic leukaemia: neonatal and infantile course. Eur J Pediatr 1994; 153: 488–91
  • Volkenandt M, Buchner T, Hiddemann W, van de LJ. Acute leukaemia during pregnancy. Lancet 1988; 1: 1404
  • Requena A, Velasco JG, Pinilla J, Gonzalez-Gonzalez A. Acute leukemia during pregnancy: obstetric management and perinatal outcome of two cases. Eur J Obstet Gynecol Reprod Biol 1995; 63: 139–41
  • Derijks LJ, Gilissen LP, Engels LG, Bos LP, Bus PJ, Lohman JJ, et al. Pharmacokinetics of 6-mercaptopurine in patients with inflammatory bowel disease: implications for therapy. Ther Drug Monit 2004; 26: 311–8
  • Moskovitz DN, Bodian C, Chapman ML, Marion JF, Rubin PH, Scherl E, et al. The effect on the fetus of medications used to treat pregnant inflammatory bowel-disease patients. Am J Gastroenterol 2004; 99: 656–61
  • Francella A, Dyan A, Bodian C, Rubin P, Chapman M, Present DH. The safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study. Gastroenterology 2003; 124: 9–17
  • Herrlinger KR, Fellermann K, Fischer C, Kreisel W, Deibert P, Schoelmerich J, et al. Thioguanine-nucleotides do not predict efficacy of thioguanine in Crohn's disease. Aliment Pharmacol Ther 2004; 19: 1269–76
  • Saarikoski S, Seppala M. Immunosuppression during pregnancy: transmission of azathioprine and its metabolites from the mother to the fetus. Am J Obstet Gynecol 1973; 115: 1100–6

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.