Serotonin increases protective duodenal bicarbonate secretion via enteric ganglia and a 5-HT₄-dependent pathway

References

• Flemström G. Gastric and duodenal mucosal bicarbonate secretion. Physiology of the gastrointestinal tract3rd ed, LR Johnson, DH Alpers, J Christensen, ED Jacobson, JH Walsh. Raven, New York 1994; 1285–309
   Google Scholar
• Allen A, Flemström G. The gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol 2005; 288: C1–19
   PubMed Web of Science ®Google Scholar
• Guha S, Kaunitz JD. Gastroduodenal mucosal defense: an integrated protective response. Curr Opin Gastroenterol 2002; 18: 650–7
   PubMed Web of Science ®Google Scholar
• Isenberg JI, Selling JA, Hogan DL, Koss MA. Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. N Engl J Med 1987; 316: 374–9
   PubMed Web of Science ®Google Scholar
• Mertz-Nielsen A, Hillingsø J, Frøkiœr H, Bukhave K, Rask-Madsen J. Gastric bicarbonate secretion and release of prostaglandin E2 are increased in duodenal ulcer patients but not in Helicobacter pylori-positive healthy subjects. Scand J Gastroenterol 1996; 31: 38–43
   PubMed Web of Science ®Google Scholar
• Flemström G, Sjöblom M. Epithelial cells and their neighbours. II. New perspectives on efferent signaling between brain, neuroendocrine cells, and gut epithelia. Am J Physiol 2005; 289: G377–80
   PubMed Web of Science ®Google Scholar
• Larsen R, Hansen MB, Bindslev N. Duodenal secretion in humans mediated by the EP4 receptor subtype. Acta Physiol Scand 2005; 185: 133–40
   PubMedGoogle Scholar
• Sjöblom M, Jedstedt G, Flemström G. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Clin Invest 2001; 108: 625–33
   PubMed Web of Science ®Google Scholar
• Sjöblom M, Flemström G. Melatonin in the duodenal lumen is a potent stimulant of mucosal bicarbonate secretion. J Pineal Res 2003; 34: 288–93
   PubMed Web of Science ®Google Scholar
• Hansen MB, Skadhauge E. Signal transduction pathways for serotonin as an intestinal secretagogue. Comp Biochem Physiol A Physiol 1997; 118: 283–90
   PubMed Web of Science ®Google Scholar
• Gershon MD. Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel. Aliment Pharmacol Ther 1999; 13 Suppl 2: 15–30
   PubMed Web of Science ®Google Scholar
• Ormsbee HS, Fondacaro JD. Action of serotonin on the gastrointestinal tract. Proc Soc Exp Biol Med 1985; 178: 333–8
   PubMed Web of Science ®Google Scholar
• Coates MD, Mahoney CR, Linden DR, Sampson JE, Chen J, Blaszyk H, et al. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 2004; 126: 1657–64
   PubMed Web of Science ®Google Scholar
• Raybould HE. Visceral perception: sensory transduction in visceral afferents and nutrients. Gut 2002; 51 Suppl 1: i11–4
   PubMed Web of Science ®Google Scholar
• Hoyer D, Hannon JP, Martin GR. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 2002; 71: 533–54
   PubMed Web of Science ®Google Scholar
• Hirose R, Chang EB. Effects of serotonin on Na+-H+ exchange and intracellular calcium in isolated chicken enterocytes. Am J Physiol 1988; 254: G891–7
   PubMedGoogle Scholar
• Hansen MB, Skadhauge E. Signal transduction pathways for serotonin as an intestinal secretagogue. Comp Biochem Physiol A Physiol 1997; 118: 283–90
   PubMed Web of Science ®Google Scholar
• Flemström G, Sjöblom M, Jedstedt G, Åkerman KE. Short fasting dramatically decreases rat duodenal secretory responsiveness to orexin-A but not to VIP or melatonin. Am J Physiol 2003; 285: G1091–6
   Web of Science ®Google Scholar
• Säfsten B, Flemström G. Effects of gamma-aminobutyric acid and peripheral benzodiazepine ligands on duodenal bicarbonate secretion. Scand J Gastroenterol 1999; 34: 1093–8
   PubMed Web of Science ®Google Scholar
• Chew CS, Säfsten B, Flemström G. Calcium signaling in cultured human and rat duodenal enterocytes. Am J Physiol 1998; 275: G296–304
   PubMed Web of Science ®Google Scholar
• Sjöblom M, Säfsten B, Flemström G. Melatonin-induced calcium signaling in clusters of human and rat duodenal enterocytes. Am J Physiol 2003; 284: G1034–44
   Web of Science ®Google Scholar
• Shariatmadari R, Lund PE, Krijukova E, Sperber GO, Kukkonen JP, Åkerman KE. Reconstitution of neurotransmission by determining communication between differentiated PC12 pheochromocytoma and HEL 92.1.7 erythroleukemia cells. Pflügers Arch 2001; 442: 312–20
   PubMed Web of Science ®Google Scholar
• Beubler E, Bukhave K, Rask-Madsen J. Significance of calcium for the prostaglandin E2-mediated secretory response to 5-hydroxytryptamine in the small intestine of the rat in vivo. Gastroenterology 1986; 90: 1972–7
   PubMed Web of Science ®Google Scholar
• Kellum JM, Budhoo MR, Siriwardena AK, Smith EP, Jebraili SA. Serotonin induces Cl secretion in human jejunal mucosa in vitro via a nonneural pathway at a 5-HT4 receptor. Am J Physiol 1994; 267: G357–63
   PubMedGoogle Scholar
• McLean PG, Coupar IM. Investigation into the effect of 5-hydroxytryptamine on fluid transport in the rat small intestine. Gen Pharmacol 1998; 30: 227–31
   PubMedGoogle Scholar
• Christofi FL, Kim M, Wunderlich JE, Xue J, Suntres Z, Cardounel A, et al. Endogenous adenosine differentially modulates 5-hydroxytryptamine release from a human enterochromaffin cell model. Gastroenterology 2004; 127: 188–202
   PubMed Web of Science ®Google Scholar
• Säfsten B, Jedstedt G, Flemström G. Effects of diazepam and Ro 15-1788 on duodenal bicarbonate secretion in the rat. Gastroenterology 1991; 101: 1031–8
   PubMed Web of Science ®Google Scholar
• Flemström G, Säfsten B, Jedstedt G. Stimulation of mucosal alkaline secretion in rat duodenum by dopamine and dopaminergic compounds. Gastroenterology 1993; 104: 825–33
   PubMed Web of Science ®Google Scholar
• Säfsten B, Flemström G. Dopamine and vasoactive intestinal peptide stimulate cyclic adenosine-3′,5′-monophosphate formation in isolated rat villus and crypt duodenocytes. Acta Physiol Scand 1993; 149: 67–5
   PubMedGoogle Scholar
• Flemström G, Garner A. Gastroduodenal HCO3 transport: characteristics and proposed role in acidity regulation and mucosal protection. Am J Physiol 1982; 242: G183–93
   PubMed Web of Science ®Google Scholar
• Tuo BG, Isenberg JI. Effect of 5-hydroxytryptamine on duodenal mucosal bicarbonate secretion in mice. Gastroenterology 2003; 125: 805–14
   PubMed Web of Science ®Google Scholar
• Tuo BG, Sellers Z, Paulus P, Barrett KE, Isenberg JI. 5-HT induces duodenal mucosal bicarbonate secretion via cAMP- and Ca2 + -dependent signaling pathways and 5-HT4 receptors in mice. Am J Physiol 2004; 286: G444–51
   Web of Science ®Google Scholar
• Roman RM, Fitz JG. Emerging roles of purinergic signaling in gastrointestinal epithelial secretion and hepatobiliary function. Gastroenterology 1999; 116: 964–79
   PubMed Web of Science ®Google Scholar
• Dawson JR, Schwenk M. Isolated epithelial cells. Progr Pharmacol Clin Pharmacol 1989; 7: 21–41
   Google Scholar
• Sun D, Lennernäs H, Welage LS, Barnett JL, Landowski CP, Foster D, et al. Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs. Pharm Res 2002; 19: 1400–16
   PubMed Web of Science ®Google Scholar
• Ladas SD, Tsamouri M, Kouvidou C, Raptis SA. Effects of forceps size and mode of orientation on endoscopic small biopsy evaluation. Gastrointest Endosc 1994; 40: 51–5
   PubMed Web of Science ®Google Scholar
• Bubenik GA. Gastrointestinal melatonin: localization, function, and clinical relevance. Dig Dis Sci 2002; 47: 2336–48
   PubMed Web of Science ®Google Scholar
• Forte LR. Guanylin regulatory peptides: structures, biological activities mediated by cyclic GMP and pathobiology. Regul Pept 1999; 81: 25–39
   PubMed Web of Science ®Google Scholar