¹³C-methacetin and ¹³C-galactose breath tests can assess restricted liver function even in early stages of primary biliary cirrhosis

References

• Klatt S, Taut C, Mayer D, Adler G, Beckh K. Evaluation of the 13C-methacetin breath test for quantitative liver function testing. Z Gastroenterol 1997; 35: 609–14
   PubMed Web of Science ®Google Scholar
• Krumbiegel P, Gunther K, Faust H, Mobius G, Hirschberg K, Schneider G. Nuclear medicine liver function tests for pregnant women and children. Breath tests with 14C-methacetin and 13C-methacetin. Eur J Nucl Med 1985; 10: 129–33
   PubMedGoogle Scholar
• Lara Baruque S, Razquin M, Jimenez I, Vazquez A, Gisbert JP, Pajares JM. 13C-phenylalanine and 13C-methacetin breath test to evaluate functional capacity of hepatocyte in chronic liver disease. Dig Liver Dis 2000; 32: 226–32
   PubMedGoogle Scholar
• Adamek RJ, Goetze O, Boedeker C, Pfaffenbach B, Luypaerts A, Geypens B. 13C-methacetin breath test: isotope-selective nondispersive infrared spectrometry in comparison to isotope ratio mass spectrometry in volunteers and patients with liver cirrhosis. Z Gastroenterol 1999; 37: 1139–43
   PubMed Web of Science ®Google Scholar
• Pfaffenbach B, Gotze O, Szymanski C, Hagemann D, Adamek RJ. The 13C-methacetin breath test for quantitative noninvasive liver function analysis with an isotope-specific nondispersive infrared spectrometer in liver cirrhosis. Dtsch Med Wochenschr 1998; 123: 1467–71
   PubMed Web of Science ®Google Scholar
• Zipprich A, Meiss F, Steudel N, Sziegoleit U, Fleig WE, Kleber G. 13C-Methacetin metabolism in patients with cirrhosis: relation to disease severity, haemoglobin content and oxygen supply. Aliment Pharmacol Ther 2003; 17: 1559–62
   PubMed Web of Science ®Google Scholar
• Petrolati A, Festi D, De Berardinis G, Colaiocco-Ferrante L, Di Paolo D, Tisone G, et al. 13C-methacetin breath test for monitoring hepatic function in cirrhotic patients before and after liver transplantation. Aliment Pharmacol Ther 2003; 18: 785–90
   PubMed Web of Science ®Google Scholar
• Shreeve WW, Shoop JD, Ott DG, McInteer BB. Test for alcoholic cirrhosis by conversion of [14C]- or [13C]-galactose to expired CO2. Gastroenterology 1976; 71: 98–101
   PubMed Web of Science ®Google Scholar
• Festi D, Capodicasa S, Sandri L, Colaiocco-Ferrante L, Stanisicia T, Vitacolonna E, et al. Measurement of hepatic functional mass by means of 13C-methacetin and 13C-phenylalanine breath tests in chronic liver disease: comparison with Child-Pugh score and serum bile acid levels. World J Gastroenterol 2005; 11: 142–8
   PubMed Web of Science ®Google Scholar
• Braden B, Faust D, Sarrazin U, Zeuzem S, Dietrich CF, Caspary WF, et al. 13C-methacetin breath test as liver function test in patients with chronic hepatitis C virus infection. Aliment Pharmacol Ther 2005; 21: 179–85
   PubMed Web of Science ®Google Scholar
• Saadeh S, Behrens PW, Parsi MA, Carey WD, Connor JT, Grealis M, et al. The utility of the 13C-galactose breath test as a measure of liver function. Aliment Pharmacol Ther 2003; 18: 995–1002
   PubMed Web of Science ®Google Scholar
• Giannini EG, Fasoli A, Borro P, Botta F, Malfatti F, Fumagalli A, et al. 13C-galactose breath test and 13C-aminopyrine breath test for the study of liver function in chronic liver disease. Clin Gastroenterol Hepatol 2005; 3: 279–85
   PubMed Web of Science ®Google Scholar
• Matsumoto K, Suehiro M, Iio M, Kawabe T, Shiratori Y, Okano K, et al. 13C-methacetin breath test for evaluation of liver damage. Dig Dis Sci 1987; 32: 344–8
   PubMed Web of Science ®Google Scholar
• Ludwig J. The pathology of primary biliary cirrhosis and autoimmune cholangitis. Baillieres Best Pract Res Clin Gastroenterol 2000; 14: 601–13
   PubMed Web of Science ®Google Scholar
• Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 1982; 143: 29–36
   PubMed Web of Science ®Google Scholar
• Degre D, Bourgeois N, Boon N, Le Moine O, Louis H, Donckier V, et al. Aminopyrine breath test compared to the MELD and Child-Pugh scores for predicting mortality among cirrhotic patients awaiting liver transplantation. Transpl Int 2004; 17: 31–8
   PubMed Web of Science ®Google Scholar
• Lindskov J. The quantitative liver function as measured by the galactose elimination capacity. Acta Med Scand 1982; 212: 295–302
   PubMedGoogle Scholar
• Tygstrup N. The galactose elimination capacity in control subjects and in patients with cirrhosis of the liver. Acta Med Scand 1964; 175: 281–9
   PubMedGoogle Scholar
• Zein CO, Angulo P, Lindor KD. When is liver biopsy needed in the diagnosis of primary biliary cirrhosis?. Clin Gastroenterol Hepatol 2003; 1: 89–95
   PubMed Web of Science ®Google Scholar
• Mion F, Rousseau M, Scoazec JY, Berger F, Minaire Y. 13C]-Galactose breath test: correlation with liver fibrosis in chronic hepatitis C. Eur J Clin Invest 1999; 29: 624–9
   PubMed Web of Science ®Google Scholar
• Mion F, Rousseau M, Paliard PL. 13C galactose breath test: early indicator of liver fibrosis in hepatitis C infection. Gut 1998; 43(Suppl 3)S25–7
   Google Scholar