287
Views
64
CrossRef citations to date
0
Altmetric
Original Article

Histopathology of liver biopsies from a thiopurine-naïve inflammatory bowel disease cohort: Prevalence of nodular regenerative hyperplasia

, , , , , , , , & show all
Pages 604-608 | Received 23 Jul 2007, Published online: 08 Jul 2009

References

  • Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR. Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations. Dig Liver Dis 2005; 37: 282–97
  • de Jong DJ, Derijks LJ, Naber AH, Hooymans PM, Mulder CJ. Safety of thiopurines in the treatment of inflammatory bowel disease. Scand J Gastroenterol 2003; Suppl 239: 69–72
  • Dubinsky MC, Vasiliauskas EA, Singh H, Abreu MT, Papadakis KA, Tran T, et al. 6-thioguanine can cause serious liver injury in inflammatory bowel disease patients. Gastroenterology 2003; 125: 298–303
  • Seiderer J, Zech CJ, Reinisch W, Lukas M, Diebold J, Wrba F, et al. A multicenter assessment of liver toxicity by MRI and biopsy in IBD patients on 6-thioguanine. J Hepatol 2005; 43: 303–9
  • Geller SA, Dubinsky MC, Poordad FF, Vasiliauskas EA, Cohen AH, Abreu MT, et al. Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel disease. Am J Surg Pathol 2004; 28: 1204–11
  • Reshamwala PA, Kleiner DE, Heller T. Nodular regenerative hyperplasia: not all nodules are created equal. Hepatology 2006; 44: 7–14
  • International Working Party.Terminology of nodular hepatocellular lesions. Hepatology 1995;22:983–93.
  • The French METAVIR Cooperative Study Group. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. Hepatology 1994;20:15–20.
  • Kleiner DE, Brent EM, van Natta M, Behling C, Contos MJ, Cumming OW, et al. Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313–21
  • Thomas CH. Ulceration of the colon with a much enlarged fatty liver. Transactions of the Pathology Society of Philadelphia 1873; 4: 87–8
  • Daniel F, Cadranel JF, Seksik P, Cazier A, Duong Van Huyen JP, et al. Azathioprine induced nodular regenerative hyperplasia in IBD patients. Gastroenterol Clin Biol 2005; 29: 600–3
  • Russmann S, Zimmermann A, Krähenbühl S, Kern B, Reichen J. Veno-occlusive disease, nodular regenerative hyperplasia and hepatocellular carcinoma after azathioprine treatment in a patient with ulcerative colitis. Eur J Gastroenterol Hepatol 2001; 13: 287–90
  • Naber AH, van Haelst U, Yap SH. Nodular regenerative hyperplasia of the liver: an important cause of portal hypertension in non-cirrhotic patients. J Hepatol 1991; 12: 94–9
  • Buffet C, Cantarovitch M, Pelletier G, Fabre M, Martin E, Charpentier B, et al. Three cases of nodular regenerative hyperplasia of the liver following renal transplantation. Nephrol Dial Transplant 1988; 3: 327–30
  • Haboubi NY, ALi HH, Whitwell HL, Ackrill P. Role of endothelial cell injury in the spectrum of azathioprine-induced liver disease after renal transplant: light microscopy and ultrastructural observations. Am J Gastroenterol 1988;83:256–61.
  • Fonseca V, Havard CW. Portal hypertension secondary to azathioprine in myasthenia gravis. Postgrad Med J 1988; 64: 950–2
  • Gane E, Portmann B, Saxena R, Wong P, Ramage J, Williams R. Nodular regenerative hyperplasia of the liver graft after liver transplantation. Hepatology 1994; 20: 88–94
  • Breen DP, Marinaki AM, Arenas M, Hayes PC. Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation. Liver Transpl 2005; 11: 826–33
  • Vernier-Massouille G, Cosnes J, Lemann M, Marteau P, Reinisch W, Laharie D, et al. Nodular regenerative hyperplasia in patients with inflammatory bowel disease treated with azathioprine. Gut 2007; 56: 1404–9
  • Wanless IR. Micronodular transformation (nodular regenerative hyperplasia) of the liver: a report of 64 cases among 2,500 autopsies and a new classification of benign hepatocellular nodules. Hepatology 1990; 11: 787–97
  • Holtmann M, Schreiner O, Köhler H, Denzer U, Neurath M, Galle PR, et al. Veno-occlusive disease (VOD) in Crohn's disease (CD) treated with azathioprine. Dig Dis Sci 2003; 48: 1503–5
  • Stoneham S, Lennard L, Coen P, Lilleyman J, Saha V. Veno-occlusive disease in patients receiving thiopurines during maintenance therapy for childhood acute lymphoblastic leukaemia. Br J Haematol 2003; 123: 100–2
  • Jacobi AM, Feist E, Rudolph B, Burmester GR. Sinusoidal dilatation: a rare side effect of azathioprine. Ann Rheum Dis 2004; 63: 1702–3
  • Eade MN, Cooke WT, Brooke BN. Liver disease in ulcerative colitis. Lancet 1970; 2: 718
  • Eade MN, Cooke WT, Williams JA. Liver disease in Crohn's disease. A study of 100 consecutive patients. Scand J Gastroenterol 1971; 6: 199–204
  • Mattila J, Aitola P, Matikainen M. Liver lesions found at colectomy in ulcerative colitis: correlation between findings and biochemical parameters. J Clin Pathol 1994; 47: 1019–21
  • Aitola P, Matikainen M, Aitola P. Hepatobiliary changes in patients with ulcerative colitis, with special reference to the effect of proctocolectomy. Scand J Gastroenterol 1998; 33: 113–7

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.