Acute expression of hepatitis C core protein in adult mouse liver: Mitochondrial stress and apoptosis

References

• Liang TJ, Heller T. Pathogenesis of hepatitis C-associated hepatocellular carcinoma. Gastroenterology 2004; 127: S62–71
   PubMed Web of Science ®Google Scholar
• Cooper S Erickson AL Adams EJ Kansopon J. Analysis of a successful immune response against hepatitis C virus. Immunity 1999;10:439–49. 2002;169:3447–58.
   PubMed Web of Science ®Google Scholar
• Collier JD, Woodall T, Wight DG, Shore S, Gimson AE, Alexander GJ. Predicting progressive hepatic fibrosis stage on subsequent liver biopsy in chronic hepatitis C virus infection. J Viral Hepat 2005; 12: 74–80
   PubMedGoogle Scholar
• Ghany MG, Kleiner DE, Alter H, Doo E, Khokar F, Promrat K, et al. Progression of fibrosis in chronic hepatitis C. Gastroenterology 2003; 124: 97–104
   PubMed Web of Science ®Google Scholar
• Koike K, Moriya K. Metabolic aspects of hepatitis C viral infection: steatohepatitis resembling but distinct from NASH. J Gastroenterol 2005; 40: 329–36
   PubMedGoogle Scholar
• Ray RB, Ray R, Collier JD. Hepatitis C virus core protein: intriguing properties and functional relevance. FEMS Microbiol Lett 2001; 202: 149–56
   PubMed Web of Science ®Google Scholar
• Tsutsumi T, Suzuki T, Moriya K, Shintani Y, Fujie H, Miyoshi H, et al. Hepatitis C virus core protein activates ERK and p38 MAPK in cooperation with ethanol in transgenic mice. Hepatology 2003; 38: 820–8
   PubMedGoogle Scholar
• Okuda M, Li K, Beard MR, Showalter LA, Scholle F, Lemon SM, et al. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 2002; 122: 366–75
   PubMed Web of Science ®Google Scholar
• Alonzi T, Agrati C, Costabile B, Cicchini C, Amicone L, Cavallari C, et al. Steatosis and intrahepatic lymphocyte recruitment in hepatitis C virus transgenic mice. J Gen Virol 2004; 85: 1509–20
   PubMedGoogle Scholar
• Korenaga M, Wang T, Li Y, Showalter LA, Chan T, Sun J, et al. Hepatitis C virus core protein inhibits mitochondrial electron transport and increases ROS production. J Biol Chem 2005; 280: 37481–8
   PubMed Web of Science ®Google Scholar
• Lerat H, Honda M, Beard MR, Loesch K, Sun J, Yang Y, et al. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 2002; 122: 352–65
   PubMed Web of Science ®Google Scholar
• Moriya K, Fujie H, Shintani Y, Yotsuyanagi H, Tsutsumi T, Ishibashi K, et al. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med 1998; 4: 1065–7
   PubMed Web of Science ®Google Scholar
• Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Tsukamoto K, Kimura S, et al. Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. Gastroenterology 2004; 126: 840–8
   PubMed Web of Science ®Google Scholar
• Yap SH, Willems M, Van den Oord J, Habets W, Middeldorp JM, Hellings JA, et al. Detection of hepatitis C virus antigen by immuno-histochemical staining: a histological marker of hepatitis C virus infection. J Hepatol 1994; 20: 275–81
   PubMed Web of Science ®Google Scholar
• Wakita T, Taya C, Katsume A, Kato J, Yonekawa H, Kanegae Y, et al. Efficient conditional transgene expression in hepatitis C virus cDNA transgenic mice mediated by the Cre/loxP system. J Biol Chem 1998; 273: 9001–6
   PubMed Web of Science ®Google Scholar
• Kistner A, Gossen M, Zimmermann F, Jerecic J, Ullmer C, Lubbert H, et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci USA 1996; 93: 10933–8
   PubMed Web of Science ®Google Scholar
• Bukh J, Purcell RH, Miller RH. Sequence analysis of the core gene of 14 hepatitis C virus genotypes. Proc Natl Acad Sci USA 1994; 91: 8239–43
   PubMed Web of Science ®Google Scholar
• Wang R, Ferrell LD, Faouzi S, Maher JJ, Bishop JM. Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. J Cell Biol 2001; 153: 1023–34
   PubMed Web of Science ®Google Scholar
• Desai BN, Myers BR, Schreiber SL. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc Natl Acad Sci USA 2002; 99: 4319–24
   PubMed Web of Science ®Google Scholar
• Shachaf CM, Kopelman AM, Arvanitis C, Karlsson A, Beer S, Mandl S, et al. MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature 2004; 431: 1112–7
   PubMed Web of Science ®Google Scholar
• Suzuki R, Sakamoto S, Tsutsumi T, Rikimaru A, Tanaka K, Shimoike T, et al. Molecular determinants for subcellular localization of hepatitis C virus core protein. J Virol 2005; 79: 1271–81
   PubMedGoogle Scholar
• Schwer B, Ren S, Pietschmann T, Kartenbeck J, Kaehlcke K, Bartenschlager R, et al. Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol 2004; 78: 7958–68
   PubMed Web of Science ®Google Scholar
• Powis G, Montfort WR. Properties and biological activities of thioredoxins. Annu Rev Biophys Biomol Struct 2001; 30: 421–55
   PubMedGoogle Scholar
• Tanaka T, Hosoi F, Yamaguchi-Iwai Y, Nakamura H, Masutani H, Ueda S, et al. Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis. Embo J 2002; 21: 1695–703
   PubMed Web of Science ®Google Scholar
• Conrad M, Jakupoglu C, Moreno SG, Lippl S, Banjac A, Schneider M, et al. Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol 2004; 24: 9414–23
   PubMed Web of Science ®Google Scholar
• Nouri-Aria KT, Sallie R, Mizokami M, Portmann BC, Williams R. Intrahepatic expression of hepatitis C virus antigens in chronic liver disease. J Pathol 1995; 175: 77–83
   PubMedGoogle Scholar
• Rullier A, Trimoulet P, Urbaniak R, Winnock M, Zauli D, Ballardini G, et al. Immunohistochemical detection of HCV in cirrhosis, dysplastic nodules, and hepatocellular carcinomas with parallel tissue quantitative RT-PCR. Mod Pathol 2001; 14: 496–505
   PubMedGoogle Scholar
• Santolini E, Migliaccio G, La Monica N. Biosynthesis and biochemical properties of the hepatitis C virus core protein. J Virol 1994; 68: 3631–41
   PubMed Web of Science ®Google Scholar
• McLauchlan J, Lemberg MK, Hope G, Martoglio B. Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets. Embo J 2002; 21: 3980–8
   PubMed Web of Science ®Google Scholar
• Yasui K, Wakita T, Tsukiyama-Kohara K, Funahashi SI, Ichikawa M, Kajita T, et al. The native form and maturation process of hepatitis C virus core protein. J Virol 1998; 72: 6048–55
   PubMed Web of Science ®Google Scholar
• Jaeckel E, Cornberg M, Wedemeyer H, Santantonio T, Mayer J, Zankel M, et al. German Acute Hepatitis C Therapy Group. Treatment of acute hepatitis C with interferon alfa-2b. N Engl J Med 2001; 345: 1452–7
   PubMed Web of Science ®Google Scholar
• Schaible UE, Winau F, Sieling PA, Fischer K, Collins HL, Hagens K, et al. Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis. Nat Med 2003; 9: 1039–46
   PubMed Web of Science ®Google Scholar