αPix interacts with Helicobacter pylori CagA to induce IL-8 expression in gastric epithelial cells

References

• Blaser MJ. Helicobacter pylori and the pathogenesis of gastroduodenal inflammation. J Infec Dis 1990; 161: 626–33
   PubMed Web of Science ®Google Scholar
• Parsonnet J, Friedman GD, Vandersteen DP, Chang Y. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 1991; 325: 1127–31
   PubMed Web of Science ®Google Scholar
• Akopypants N, Clifton W, Kersulyte D, Crabtree JE, Youree BE, Reece CA, et al. Analyses of the cag pathogenicity island of Helicobacter pylori. Mol Microbiol 1998; 28: 37–53
   PubMedGoogle Scholar
• Keates S, Keates AC, Warny M, Peek RM, Jr, Murray PG, Kelly CP. Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag − Helicobacter pylori. J Immunol 1999; 163: 5552–9
   PubMed Web of Science ®Google Scholar
• Stein M, Bagnoli F, Halenbeck R, Rappuoli R, Fantl WJ, Covacci A. c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol Microbiol 2002; 43: 971–80
   PubMed Web of Science ®Google Scholar
• Higashi H, Tsutsumi R., Muto S, Sugiyama T, Azuma T, Asaka M, et al. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 2002; 295: 683–6
   PubMed Web of Science ®Google Scholar
• Mimuro H, Suzuki T, Tanaka T, Asahi M, Haas R, Sasakawa C. Grb2 is a key mediator of Helicobacter pylori CagA protein activities. Mol Cell 2002; 10: 745–55
   PubMedGoogle Scholar
• Oliveira MJ, Costa AC, Costa AM, Henriques L, Suriano G, Atherton JC, et al. Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner. J Biol Chem 2006; 281: 34888–96
   PubMedGoogle Scholar
• Sharma SA, Tummuru MK, Blasér MJ, Kerr LD. Activation of IL-8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-κB in gastric epithelial cells. J Immunol 1998; 160: 2401–7
   PubMed Web of Science ®Google Scholar
• Segal ED, Cha J, Lo J, Falkow S, Tompkins LS. Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc Natl Acad Sci USA 1999; 96: 14559–64
   PubMed Web of Science ®Google Scholar
• Moss SF, Sordillo EM, Abdalla AM, Makarov V, Hanzely Z, Perez-Perez GI, et al. Increased gastric epithelial cell apoptosis associated with colonization with cagA + Helicobacter pylori strains. Cancer Res 2001; 61: 1406–11
   PubMed Web of Science ®Google Scholar
• Fan XG, Chua A, Fan XJ, Keeling PW. Increased gastric production of interleukin-8 and tumor necrosis factor in patients with Helicobacter pylori infection. J Clin Pathol 1995; 48: 133–6
   PubMed Web of Science ®Google Scholar
• Baggiolini M, Loetscher P, Moser B. Interleukin-8 and the chemokine family. Int J Immunopharmacol 1995; 17: 103–8
   PubMed Web of Science ®Google Scholar
• Brandt S, Kwok T, Hartig R, König W, Backert S. NF-κB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. Proc Natl Acad Sci USA 2005; 102: 9300–5
   PubMed Web of Science ®Google Scholar
• Kim SY, Lee YC, Kim HK, Blaser MJ. Helicobacter pylori CagA transfection of gastric epithelial cells induces interleukin-8. Cell Microbiol 2006; 8: 97–106
   PubMed Web of Science ®Google Scholar
• Baek HY, Lim JW, Kim H. Interaction between the Helicobacter pylori CagA and α-Pix in gastric epithelial AGS cells. Ann NY Acad Sci 2007; 1096: 18–23
   PubMedGoogle Scholar
• Manser E, Loo TH, Koh CG, Zhao ZS, Chen XQ, Tan L, et al. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol Cell 1998; 1: 183–92
   PubMed Web of Science ®Google Scholar
• Foryst-Ludwig A, Naumann M. p21-activated kinase 1 activates the nuclear factor κ (NF-κB)-inducing kinase-IκB kinases NF-κB pathway and proinflammatory cytokines in Helicobacter pylori infection. J Biol Chem 2000; 275: 39779–85
   PubMedGoogle Scholar
• Neumann M, Foryst-Ludwig A, Klar S, Schweitzer K, Naumann M. The PAK1 autoregulatory domain is required for interaction with NIK in Helicobacter pylori-induced NF-κB activation. Biol Chem 2006; 387: 79–86
   PubMed Web of Science ®Google Scholar
• Seo JH, Lim JW, Kim H, Kim KH. Helicobacter pylori in a Korean isolate activates mitogen-activated protein kinases, AP-1, and NF-κB and induces chemokine expression in gastric epithelial AGS cells. Lab Invest 2004; 84: 49–62
   PubMed Web of Science ®Google Scholar
• Lim JW, Kim H, Kim KH. Expression of Ku70 and Ku80 mediated by NF-κB and cyclooxygenase-2 is related to proliferation of human gastric cancer cells. J Biol Chem 2002; 277: 46093–100
   PubMedGoogle Scholar
• Strandberg Y, Gray C, Vuocolo T, Donaldson L, Broadway M, Tellam R. Lipopolysaccharide and lipoteichoic acid induce different innate immune responses in bovine mammary epithelial cells. Cytokine 2005; 31: 72–86
   PubMed Web of Science ®Google Scholar
• Churin Y, Kardalinou E, Meyer TF, Naumann M. Pathogenicity island-dependent activation of Rho GTPases Rac1 and Cdc42 in Helicobacter pylori infection. Mol Microbiol 2001; 40: 815–23
   PubMedGoogle Scholar
• Yoshii S, Tanaka M, Otsuki Y, Wang DY, Guo RJ, Zhu Y, et al. αPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase. Oncogene 1999; 18: 5680–90
   PubMed Web of Science ®Google Scholar
• Daniel RH, Zenke FT, Bokoch GM. αPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms. J Biol Chem 1999; 274: 6047–50
   PubMedGoogle Scholar
• Hofmann C, Shepelev M, Chernoff J. The genetics of Pak. J Cell Sci 2004; 117: 4343–54
   PubMed Web of Science ®Google Scholar
• Chang YJ, Wu MS, Lin JT, Pestell RG, Blaser MJ, Chen CC. Mechanisms for Helicobacter pylori CagA-induced cyclin D1 expression that affect cell cycle. Cellular Microbiol 2006; 8: 1740–52
   PubMedGoogle Scholar
• Foryst-Ludwig A, Naumann M. p21-activated kinase 1 activates the nuclear factor kappa B (NF-kappa B)-inducing kinase-Iκ B kinases NF-κB pathway and proinflammatory cytokines in Helicobacter pylori infection. J Biol Chem 2000; 275: 39779–85
   PubMedGoogle Scholar
• Bagrodia S, Bailey D, Lenard Z, Hart M, Guan JL, Premont RT, et al. A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. J Boil Chem 1999; 274: 22393–400
   PubMed Web of Science ®Google Scholar
• Snider JL, Allison C, Bellaire BH, Ferrero RL, Cardelli JA. The beta1 integrin activates JNK independent of CagA, and JNK activation is required for Helicobacter pylori CagA + -induced motility of gastric cancer cells. J Biol Chem 2008; 283: 13952–63
   PubMedGoogle Scholar
• Zhao ZS, Manser E, Lim L. Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation. Mol Cell Biol. 2000; 20: 3906–17
   PubMedGoogle Scholar