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Original Article

An activating gucy2c mutation causes impaired contractility and fluid stagnation in the small bowel

ORCID Icon, ORCID Icon, ORCID Icon, , ORCID Icon, & ORCID Icon show all
Pages 1308-1315 | Received 26 Apr 2016, Accepted 05 Jun 2016, Published online: 24 Jun 2016

References

  • Fiskerstrand T, Arshad N, Haukanes BI, et al. Familial diarrhea syndrome caused by an activating GUCY2C mutation. N Engl J Med. 2012;366:1586–1595.
  • Muller T, Rasool I, Heinz-Erian P, et al. Congenital secretory diarrhoea caused by activating germline mutations in GUCY2C. Gut. 2015. [Epub ahead of print]. doi: 10.1136/gutjnl-2015-309441.
  • Sindic A. Current understanding of guanylin peptides actions. ISRN Nephrol. 2013;2013:813648.
  • Basu N, Saha S, Khan I, et al. Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21. J Biol Chem. 2014;289:581–593.
  • Brierley SM. Guanylate cyclase-C receptor activation: unexpected biology. Curr Opin Pharmacol. 2012;12:632–640.
  • Bryant AP, Busby RW, Bartolini WP, et al. Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci. 2010;86:760–765.
  • Deloose E, Tack JF. Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling. Am J Physiol Gastrointest Liver Physiol. 2015;310:G228–G233.
  • Andresen V, Camilleri M, Busciglio IA, et al. Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome. Gastroenterology. 2007;133:761–768.
  • Gilja OH. Ultrasound in gastroenterology. Expert Rev Gastroenterol Hepatol. 2008;2:5–8.
  • Nylund K, Jirik R, Mezl M, et al. Quantitative contrast-enhanced ultrasound comparison between inflammatory and fibrotic lesions in patients with Crohn's disease. Ultrasound Med Biol. 2013;39:1197–1206.
  • Nylund K. Ultrasound in patients with Crohn disease – in vitro and in vivo characterization of the gastrointestinal wall. Ultraschall Med. 2010;31:438.
  • Panes J, Bouhnik Y, Reinisch W, et al. Imaging techniques for assessment of inflammatory bowel disease: Joint ECCO and ESGAR evidence-based consensus guidelines. J Crohns Colitis. 2013;7:556–585.
  • Hveem K, Sun WM, Hebbard G, et al. Relationship between ultrasonically detected phasic antral contractions and antral pressure. Am J Physiol Gastrointest Liver Physiol. 2001;281:G95–G101.
  • Odegaard S, Nesje LB, Hoff DA, et al. Morphology and motor function of the gastrointestinal tract examined with endosonography. World J Gastroenterol. 2006;12:2858–2863.
  • Rao SS, Camilleri M, Hasler WL, et al. Evaluation of gastrointestinal transit in clinical practice: position paper of the American and European neurogastroenterology and motility societies. Neurogastroenterol Motil. 2011;23:8–23.
  • Mirk P, Foschi R, Minordi LM, et al. Sonography of the small bowel after oral administration of fluid: an assessment of the diagnostic value of the technique. Radiol Med. 2012;117:558–574.
  • Nylund K, Hausken T, Odegaard S, et al. Gastrointestinal wall thickness measured with transabdominal ultrasonography and its relationship to demographic factors in healthy subjects. Ultraschall Med. 2012;33:E225–E232.
  • Bartusek D, Valek V, Husty J, et al. Small bowel ultrasound in patients with celiac disease. retrospective study. Eur J Radiol. 2007;63:302–306.
  • Rettenbacher T, Hollerweger A, Macheiner P, et al. Adult celiac disease: US signs. Radiology. 1999;211:389–394.
  • Khalaf A, Hoad CL, Spiller RC, et al. Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution. World J Gastrointest Pathophysiol. 2015;6:140–149.
  • Detmer PR, Bashein G, Hodges T, et al. 3D ultrasonic image feature localization based on magnetic scanhead tracking: in vitro calibration and validation. Ultrasound Med Biol. 1994;20:923–936.
  • Gilja OH, Detmer PR, Jong JM, et al. Intragastric distribution and gastric emptying assessed by three-dimensional ultrasonography. Gastroenterology. 1997;113:38–49.
  • Gilja OH, Hausken T, Olafsson S, et al. In vitro evaluation of three-dimensional ultrasonography based on magnetic scanhead tracking. Ultrasound Med Biol. 1998;24:1161–1167.
  • Bland JM, Altman DG. Measuring agreement in method comparison studies. Stat Methods Med Res. 1999;8:135–160.
  • Hollerweger A, Wustner M, Dirks K. Bowel obstruction: sonographic evaluation. Ultraschall Med. 2015;36:216–238.
  • Terrin G, Tomaiuolo R, Passariello A, et al. Congenital diarrheal disorders: an updated diagnostic approach. Int J Mol Sci. 2012;13:4168–4185.
  • Castro J, Harrington AM, Hughes PA, et al. Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate. Gastroenterology. 2013;145:1334–1346.
  • Feng B, Kiyatkin ME, La JH, et al. Activation of guanylate cyclase-C attenuates stretch responses and sensitization of mouse colorectal afferents. J Neurosci. 2013;33:9831–9839.
  • Silos-Santiago I, Hannig G, Eutamene H, et al. Gastrointestinal pain: unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation. Pain. 2013;154:1820–1830.
  • De Man JG, De Winter BY, Herman AG, et al. Study on the cyclic GMP-dependency of relaxations to endogenous and exogenous nitric oxide in the mouse gastrointestinal tract. Br J Pharmacol. 2007;150:88–96.
  • Bennet SM, Ohman L, Simren M. Gut microbiota as potential orchestrators of irritable bowel syndrome. Gut Liver. 2015;9:318–331.
  • Evans PR, Bak YT, Shuter B, et al. Gastroparesis and small bowel dysmotility in irritable bowel syndrome. Dig Dis Sci. 1997;42:2087–2093.
  • Undseth R, Berstad A, Klow NE, et al. Abnormal accumulation of intestinal fluid following ingestion of an unabsorbable carbohydrate in patients with irritable bowel syndrome: an MRI study. Neurogastroenterol Motil. 2014;26:1686–1693.
  • Malagelada C, De LF, Segui S, et al. Functional gut disorders or disordered gut function? Small bowel dysmotility evidenced by an original technique. Neurogastroenterol Motil. 2012;24:223–225.
  • Serra J, Villoria A, Azpiroz F, et al. Impaired intestinal gas propulsion in manometrically proven dysmotility and in irritable bowel syndrome. Neurogastroenterol Motil. 2010;22:401–402.
  • Dietrich CF. Significance of abdominal ultrasound in inflammatory bowel disease. Digest Dis. 2009;27:482–493.
  • Baumgart DC, Muller HP, Grittner U, et al. US-based real-time elastography for the detection of fibrotic gut tissue in patients with stricturing Crohn disease. Radiology. 2015;275:889–899.

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