Local application of adipose-derived mesenchymal stem cells supports the healing of fistula: prospective randomised study on rat model of fistulising Crohn’s disease

References

• Schwartz DA, Loftus EV Jr., Tremaine WJ, et al. The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota. Gastroenterology. 2002;122:875–880.
   PubMed Web of Science ®Google Scholar
• Ford AC, Sandborn WJ, Khan KJ, et al. Efficacy of biological therapies in inflammatory bowel disease: systematic review and meta-analysis. Am J Gastroenterol. 2011;106:644–659.
   PubMed Web of Science ®Google Scholar
• West RL, van der Woude CJ, Hansen BE, et al. Clinical and endosonographic effect of ciprofloxacin on the treatment of perianal fistulae in Crohn’s disease with infliximab: a double-blind placebo-controlled study. Aliment Pharmacol Ther. 2004;20:1329–1336.
   PubMed Web of Science ®Google Scholar
• Pearson DC, May GR, Fick GH, et al. Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis. Ann Intern Med. 1995;123:132–142.
   PubMed Web of Science ®Google Scholar
• Regueiro M, Mardini H. Treatment of perianal fistulizing Crohn's disease with infliximab alone or as an adjunct to exam under anesthesia with seton placement. Inflamm Bowel Dis. 2003;9:98–103.
   PubMed Web of Science ®Google Scholar
• Molendijk I, Nuij VJ, van der Meulen-de Jong AE, et al. Disappointing durable remission rates in complex Crohn's disease fistula. Inflamm Bowel Dis. 2014;20:2022–2028.
   PubMed Web of Science ®Google Scholar
• Singh UP, Singh NP, Singh B, et al. Stem cells as potential therapeutic targets for inflammatory bowel disease. Front Biosci (Schol Ed). 2010;2:993–1008.
   PubMedGoogle Scholar
• Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 2005; 105:1815–1822.
   PubMed Web of Science ®Google Scholar
• Phinney DG, Prockop DJ. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair: current views. Stem Cells. 2007;25:2896–2902.
   PubMed Web of Science ®Google Scholar
• Newman RE, Yoo D, LeRoux MA, et al. Treatment of inflammatory diseases with mesenchymal stem cells. Inflamm Allergy Drug Targets. 2009;8:110–123.
   PubMedGoogle Scholar
• García-Olmo D, García-Arranz M, Herreros D, et al. A phase I clinical trial of the treatment of Crohn’s fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum. 2005;48:1416–1423.
   PubMed Web of Science ®Google Scholar
• Garcia-Olmo D, Herreros D, Pascual I, et al. Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial. Dis Colon Rectum. 2009;52:79–86.
   PubMed Web of Science ®Google Scholar
• Ciccocioppo R, Bernardo ME, Sgarella A, et al. Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn’s disease. Gut. 2011;60:788–798.
   PubMed Web of Science ®Google Scholar
• Mannon PJ. Remestemcel-L: human mesenchymal stem cells as an emerging therapy for Crohn's disease. Expert Opin Biol Ther. 2011;11:1249–1256.
   PubMed Web of Science ®Google Scholar
• Guadalajara H, Herreros D, De-La-Quintana P, et al. Long-term follow-up of patients undergoing adipose-derived adult stem cell administration to treat complex perianal fistulas. Int J Colorectal Dis. 2012;27:595–600.
   PubMed Web of Science ®Google Scholar
• Cho YB, Lee WY, Park KJ, et al. Autologous adipose tissue-derived stem cells for the treatment of Crohn’s fistula: a phase I clinical study. Cell transplant. 2013;22:279–285.
   PubMed Web of Science ®Google Scholar
• Lee WY, Park KJ, Cho YB, et al. Autologous adipose tissue-derived stem cells treatment demonstrated favorable and sustainable therapeutic effect for Crohn’s fistula. Stem Cells. 2013;31:2575–2581.
   PubMed Web of Science ®Google Scholar
• de la Portilla F, Alba F, García-Olmo D, et al. Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn’s disease: results from a multicenter phase I/IIa clinical trial. Int J Colorectal Dis. 2013;28:313–323.
   PubMed Web of Science ®Google Scholar
• Ciccocioppo R, Gallia A, Sgarella A, et al. Long-term follow-up of Crohn disease fistulas after local injections of bone marrow-derived mesenchymal stem cells. Mayo Clin Proc. 2015;90:747–755.
   PubMed Web of Science ®Google Scholar
• Cho YB, Park KJ, Yoon SN, et al. Long-term results of adipose-derived stem cell therapy for the treatment of Crohn's fistula. Stem Cells Transl Med. 2015;4:532–537.
   PubMed Web of Science ®Google Scholar
• Garcia-Olmo D, Guadalajara H, Rubio-Perez I, et al. Recurrent anal fistulae: limited surgery supported by stem cells. World J Gastroenterol. 2015;21:3330–3336.
   PubMed Web of Science ®Google Scholar
• Molendijk I, Bonsing BA, Roelofs H, et al. Allogeneic bone marrow-derived mesenchymal stromal cells promote healing of refractory perianal fistulas in patients with Crohn's disease. Gastroenterology. 2015;149:918–927.
   PubMed Web of Science ®Google Scholar
• Panés J, García-Olmo D, Van Assche D, Colombel JF, Reinisch W, Baumgart DC, etet al. A phase III randomised controlled trial of Cx601, expanded allogeneic adipose-derived mesenchymal stem cells (eASC), for complex perianal fistulas in Crohn’s disease. J Crohns Colitis 2016;10(Suppl1):S1.
   Web of Science ®Google Scholar
• Mizrahi N, Wexner SD, Zmora O, et al. Endorectal advancement flap: are there predictors of failure? Dis Colon Rectum. 2002;45:1616–1621.
   PubMed Web of Science ®Google Scholar
• Sonoda T, Hull T, Piedmonte MR, et al. Outcomes of primary repair of anorectal and rectovaginal fistulas using the endorectal advancement flap. Dis Colon Rectum. 2002;45:1622–1628.
   PubMed Web of Science ®Google Scholar
• Bültmann O, Philipp C, Ladeburg M, et al. Creation of a caecostoma in mice as a model of an enterocutaneous fistula. Res Exp Med (Berl). 1998;198:215–228.
   PubMedGoogle Scholar
• Hakamata Y, Murakami T, Kobayashi E. Firefly rats as an organ/cellular source for long-term in vivo bioluminescent imaging. Transplantation. 2006;81:1179–1184.
   PubMed Web of Science ®Google Scholar
• Kasahara NI, Kikuchi T, Doi J. Luminescence-based assay to screen preservation solutions for optimal ability to maintain viability of rat intestinal grafts. Transplant Proc. 2013;45:2486–2490.
   PubMed Web of Science ®Google Scholar
• Sandborn WJ, Fazio VW, Feagan BG, American Gastroenterological Association Clinical Practice Committee, et al. AGA technical review on perianal Crohn's disease. Gastroenterology. 2003;125:1508–1530.
   PubMed Web of Science ®Google Scholar
• Volpe BB, Santos Duarte Ada S, Ribeiro TB, et al. Mesenchymal stromal cells from adipose tissue attached to suture material enhance the closure of enterocutaneous fistulas in a rat model. Cytotherapy. 2014;16:1709–1719.
   PubMed Web of Science ®Google Scholar
• Hamamoto H, Gorman JH, 3rd., Ryan LP, et al. Allogeneic mesenchymal precursor cell therapy to limit remodeling after myocardial infarction: the effect of cell dosage. Ann Thorac Surg. 2009;87:794–801.
   PubMed Web of Science ®Google Scholar
• Zaim M, Karaman S, Cetin G, et al. Donor age and long-term culture affect differentiation and proliferation of human bone marrow mesenchymal stem cells. Ann Hematol. 2012;91:1175–1186.
   PubMed Web of Science ®Google Scholar
• Strem BM, Hicok KC, Zhu M, et al. Multipotential differentiation of adipose tissue-derived stem cells. Keio J Med. 2005;54:132–141.
   PubMed Web of Science ®Google Scholar
• De Ugarte DA, Morizono K, Elbarbary A, et al. Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs (Print). 2003;174:101–109.
   PubMed Web of Science ®Google Scholar
• van der Bogt KE, Schrepfer S, Yu J, et al. Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart. Transplantation. 2009;87:642–652.
   PubMed Web of Science ®Google Scholar
• Dai M, Xu P, Hou M, et al. In vivo imaging of adipose-derived mesenchymal stem cells in female nude mice after simulated childbirth injury. Exp Ther Med. 2015; 9:372–376.
   PubMed Web of Science ®Google Scholar
• Vilalta M, Dégano IR, Bagó J, et al. Biodistribution, long-term survival, and safety of human adipose tissue-derived mesenchymal stem cells transplanted in nude mice by high sensitivity non-invasive bioluminescence imaging. Stem Cells Dev. 2008;17:993–1003.
   PubMed Web of Science ®Google Scholar
• Bernardo ME, Pagliara D, Locatelli F. Mesenchymal stromal cell therapy: a revolution in regenerative medicine? Bone Marrow Transplant. 2012;47:164–171.
   PubMed Web of Science ®Google Scholar
• Nakagami H, Maeda K, Morishita R, et al. Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells. Arterioscler Thromb Vasc Biol. 2005;25:2542–2547.
   PubMed Web of Science ®Google Scholar
• Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care–associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36:309–332.
   PubMed Web of Science ®Google Scholar
• Jackson WM, Nesti LJ, Tuan RS. Concise review: clinical transplantation of wound healing therapies based on mesenchymal stem cells. Stem Cells Transl Med. 2012;1:44–50.
   PubMed Web of Science ®Google Scholar