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Scandinavian Journal of Gastroenterology Volume 52, 2017 - Issue 6-7
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Original Article

Incidence and predictive factors for positive 75SeHCAT test: improving the diagnosis of bile acid diarrhoea

Iain Alexander MurrayDepartment of Gastroenterology, Royal Cornwall Hospital, Truro, Cornwall, UK; Correspondence[email protected]
,
Linzi Karen MurrayDepartment of Gastroenterology, Royal Cornwall Hospital, Truro, Cornwall, UK;
,
Kathy Louise WoolsonDepartment of Gastroenterology, Royal Cornwall Hospital, Truro, Cornwall, UK;
,
Hisham SherfiDepartment of Gastroenterology, Royal Cornwall Hospital, Truro, Cornwall, UK;
,
Ivor DixonDepartment of Nuclear Medicine, Royal Cornwall Hospital, Truro, Cornwall, UK;
,
Joanne PalmerDepartment of Research and Development, Royal Cornwall Hospital, Truro, Cornwall, UK
&
Tom SulkinDepartment of Nuclear Medicine, Royal Cornwall Hospital, Truro, Cornwall, UK;
show all
Pages 698-703 | Received 10 Jan 2017, Accepted 18 Feb 2017, Published online: 05 Mar 2017

References

  • Hofmann AF. The syndrome of ileal disease and the broken enterohepatic circulation: cholerheic enteropathy. Gastroenterology. 1967;52:752–757.
  • Merrick MV, Eastwood MA, Ford MJ. Is bile acid malabsorption underdiagnosed? An evaluation of accuracy of diagnosis by measurement of SeHCAT retention. Br Med J (Clin Res Ed). 1985;290:665–668.
  • Barkun A, Love J, Gould M, et al. Bile acid diarrhoea in chronic diarrhea: pathophysiology and treatment. Can J Gastroenterol. 2013;27:653–659.
  • Walters JRF. Bile acid diarrhoea and FGF19: new views on diagnosis, pathogenesis and therapy. Nat Rev Gastroenterol Hepatol. 2014;11:426–434.
  • Rössel P, Sortsøe JH, Qvist P, et al. Prognosis of adult-onset idiopathic bile acid malabsorption. Scand J Gastroenterol. 1999;34:587–590.
  • Valentin N, Camilleri M, Altayar O, et al. Biomarkers for bile acid diarrhoea in functional bowel disorder with diarrhoea: a systematic review and meta-analysis. Gut. 2016;65:1951–1959.
  • Ferraris R, Carosso R, Fiorentini MT, et al. Enzymatic determination of faecal bile acids. A simple test for bile acid malabsorption. Boll Soc Ital Biol Sper. 1980;56:15–21.
  • Camilleri M, Nadeau A, Tremaine WJ, et al. Measurement of serum 7alpha-hydroxy-4-cholesten-3-one (or 7alphaC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tandem mass spectrometry. Neurogastroenterol Motil. 2009;21:734–e43.
  • National Institute for Health and Care Excellence. 2012. [2015-12-21]. webcite Diagnostics Guidance 7: SeHCAT (tauroselcholic 75 selenium acid) for the investigation of diarrhoea due to bile acid diarrhoea in people with diarrhoea-predominant irritable bowel syndrome (IBS-D) or Crohn's disease without ileal resection. Available from: https://www.nice.org.uk/guidance/dg7.
  • Slattery SA, Niaz O, Aziz Q, et al. Systematic review with meta-analysis: the prevalence of bile acid malabsorption in the irritable bowel syndrome with diarrhoea. [Review]. Aliment Pharmacol Ther. 2015;42:3–11.
  • Aziz I, Mumtaz S, Bholah H, et al. High prevalence of idiopathic bile acid diarrhea among patients with diarrhea-predominant irritable bowel syndrome based on Rome III criteria. Clin Gastroenterol Hepatol. 2015;13:1650–1655.e2.
  • Smith MJ, Perkins AC. A survey of the clinical use of SeHCAT in the UK. Nucl Med Commun. 2013;34:306–313.
  • Summers JA, Peacock J, Coker B, et al. Multicentre prospective survey of SeHCAT provision and practice in the UK. BMJ Open Gastroenterol. 2016;3:e000091.
  • Wedlake L, A'Hern R, Russell D, et al. Systematic review: the prevalence of idiopathic bile acid diarrhoea as diagnosed by SeHCAT scanning in patients with diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther. 2009;30:707–717.
  • IBM Corp. Released 2013. IBM SPSS Statistics for Windows, Version 22.0. Armonk (NY): IBM Corp.
  • Ford GA, Preece JD, Davies IH, et al. Use of the SeHCAT test in the investigation of diarrhoea. Postgrad Med J. 1992;68:272–276.
  • Khalid U, Lalji A, Stafferton R, et al. Bile acid malabsoption: a forgotten diagnosis? Clin Med (Lond). 2010;10:124–126.
  • Gracie DJ, Kane JS, Mumtaz S, et al. Prevalence of, and predictors of, bile acid malabsorption in outpatients with chronic diarrhea. Neurogastroenterol Motil. 2012;24:983–e538.
  • Borghede MK, Schlutter JM, Agnholt JS, et al. Bile acid malabsorption investigated by selenium-75-homocholic acid taurine (75SeHCAT) scans: causes and treatment responses to cholestyramine in 298 patients with chronic watery diarrhoea. Eur J Int Med. 2011;22:e137–e140.
  • Wildt S, Norby Rasmussen S, Lysgard Madsen J, et al. Bile acid malabsorption in patients with chronic diarrhoea: clinical value of SeHCAT test. Scand J Gastroenterol. 2003; 38:826–830.
  • Walters JR, Johnston IM, Nolan JD, et al. The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid. Aliment Pharmacol Ther. 2015;41:54–64.
  • Westergaard H. Bile acid malabsorption. Curr Treat Options Gastroenterol. 2007;10:28–33.

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