Does next-generation sequencing of cyst fluid improve management of pancreatic cystic neoplasms?

References

• Valsangkar NP, Morales-Oyarvide V, Thayer SP, et al. 851 resected cystic tumors of the pancreas: a 33-year experience at the Massachusetts General Hospital. Surgery. 2012;152:S4–S12.
   PubMed Web of Science ®Google Scholar
• Brugge WR. Diagnosis and management of cystic lesions of the pancreas. J Gastrointest Oncol. 2015;6:375–388.
   PubMed Web of Science ®Google Scholar
• de Jong K, Nio CY, Hermans JJ, et al. High prevalence of pancreatic cysts detected by screening magnetic resonance imaging examinations. Clin Gastroenterol Hepatol. 2010;8:806–811.
   PubMed Web of Science ®Google Scholar
• de Oliveira PB, Puchnick A, Szejnfeld J, et al. Prevalence of incidental pancreatic cysts on 3 tesla magnetic resonance. PLoS One. 2015;10:e0121317.
   PubMed Web of Science ®Google Scholar
• Lee KS, Sekhar A, Rofsky NM, et al. Prevalence of incidental pancreatic cysts in the adult population on MR imaging. Am J Gastroenterol. 2010;105:2079–2084.
   PubMed Web of Science ®Google Scholar
• Spinelli KS, Fromwiller TE, Daniel RA, et al. Cystic pancreatic neoplasms: observe or operate. Ann Surg. 2004;239:651–657. Discussion 7–9.
   PubMed Web of Science ®Google Scholar
• Wu BU, Sampath K, Berberian CE, et al. Prediction of malignancy in cystic neoplasms of the pancreas: a population-based cohort study. Am J Gastroenterol. 2014;109:121–129; quiz 30.
   PubMed Web of Science ®Google Scholar
• Goh BK, Tan YM, Cheow PC, et al. Cystic lesions of the pancreas: an appraisal of an aggressive resectional policy adopted at a single institution during 15 years. Am J Surg. 2006;192:148–154.
   PubMed Web of Science ®Google Scholar
• Fernandez-del Castillo C, Targarona J, Thayer SP, et al. Incidental pancreatic cysts: clinicopathologic characteristics and comparison with symptomatic patients. Arch Surg. 2003;138:427–423. Discussion 33–4.
   PubMed Web of Science ®Google Scholar
• Ferrone CR, Correa-Gallego C, Warshaw AL, et al. Current trends in pancreatic cystic neoplasms. Arch Surg. 2009;144:448–454.
   PubMedGoogle Scholar
• Tanaka M, Fernandez-del Castillo C, Adsay V, et al. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology. 2012;12:183–197.
   PubMed Web of Science ®Google Scholar
• Adsay N, Kloppel G, Fukushima N, et al. Intraductal neoplasms of the pancreas. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. WHO classification of tumors. Lyon: WHO Press; 2010. p. 304–313.
   Google Scholar
• Balcom JHt, Rattner DW, Warshaw AL, et al. Ten-year experience with 733 pancreatic resections: changing indications, older patients, and decreasing length of hospitalization. Arch Surg. 2001;136:391–398.
   PubMed Web of Science ®Google Scholar
• Williamsson C, Karlsson N, Sturesson C, et al. Impact of a fast-track surgery programme for pancreaticoduodenectomy. Br J Surg. 2015;102:1133–1141.
   PubMed Web of Science ®Google Scholar
• Vege SS, Ziring B, Jain R, Clinical Guidelines C, et al. American gastroenterological association institute guideline on the diagnosis and management of asymptomatic neoplastic pancreatic cysts. Gastroenterology. 2015;148:819–822., American Gastroenterology A. quize12-3.
   PubMed Web of Science ®Google Scholar
• Ge PS, Muthusamy VR, Gaddam S, et al. Evaluation of the 2015 AGA guidelines on pancreatic cystic neoplasms in a large surgically confirmed multicenter cohort. Endosc Int Open. 2017;5:E201–E2E8.
   PubMed Web of Science ®Google Scholar
• Heckler M, Michalski CW, Schaefle S, et al. The Sendai and Fukuoka consensus criteria for the management of branch duct IPMN - A meta-analysis on their accuracy. Pancreatology. 2017;17:255–262.
   PubMed Web of Science ®Google Scholar
• Singhi AD, Zeh HJ, Brand RE, et al. American Gastroenterological Association guidelines are inaccurate in detecting pancreatic cysts with advanced neoplasia: a clinicopathologic study of 225 patients with supporting molecular data. Gastrointest Endosc. 2016;83:1107–1117 e2.
   PubMed Web of Science ®Google Scholar
• Lu X, Zhang S, Ma C, et al. The diagnostic value of EUS in pancreatic cystic neoplasms compared with CT and MRI. Endosc Ultrasound. 2015;4:324–329.
   PubMed Web of Science ®Google Scholar
• Khashab MA, Kim K, Lennon AM, et al. Should we do EUS/FNA on patients with pancreatic cysts? The incremental diagnostic yield of EUS over CT/MRI for prediction of cystic neoplasms. Pancreas. 2013;42:717–721.
   PubMed Web of Science ®Google Scholar
• Zhu H, Jiang F, Zhu J, et al. Assessment of morbidity and mortality associated with EUS-guided FNA for pancreatic cystic lesions: a system review and meta-analysis. Dig Endosc. 2017. [Epub ahead of print].
   Google Scholar
• Wang QX, Xiao J, Orange M, et al. EUS-guided FNA for diagnosis of pancreatic cystic lesions: a meta-analysis. Cell Physiol Biochem. 2015;36:1197–1209.
   PubMed Web of Science ®Google Scholar
• Gillis A, Cipollone I, Cousins G, et al. Does EUS-FNA molecular analysis carry additional value when compared to cytology in the diagnosis of pancreatic cystic neoplasm? A systematic review. HPB (Oxford). 2015;17:377–386.
   PubMed Web of Science ®Google Scholar
• Soyer OM, Baran B, Ormeci AC, et al. Role of biochemistry and cytological analysis of cyst fluid for the differential diagnosis of pancreatic cysts: a retrospective cohort study. Medicine (Baltimore). 2017;96:e5513.
   PubMed Web of Science ®Google Scholar
• Lim LG, Lakhtakia S, Ang TL, et al. Factors determining diagnostic yield of endoscopic ultrasound guided fine-needle aspiration for pancreatic cystic lesions: a multicentre Asian study. Dig Dis Sci. 2013;58:1751–1757.
   PubMed Web of Science ®Google Scholar
• de Jong K, Poley JW, van Hooft JE, et al. Endoscopic ultrasound-guided fine-needle aspiration of pancreatic cystic lesions provides inadequate material for cytology and laboratory analysis: initial results from a prospective study. Endoscopy. 2011;43:585–590.
   PubMed Web of Science ®Google Scholar
• Hong SK, Loren DE, Rogart JN, et al. Targeted cyst wall puncture and aspiration during EUS-FNA increases the diagnostic yield of premalignant and malignant pancreatic cysts. Gastrointest Endosc. 2012;75:775–782.
   PubMed Web of Science ®Google Scholar
• Ahmad NA, Kochman ML, Brensinger C, et al. Interobserver agreement among endosonographers for the diagnosis of neoplastic versus non-neoplastic pancreatic cystic lesions. Gastrointest Endosc. 2003;58:59–64.
   PubMed Web of Science ®Google Scholar
• van Dijk EL, Auger H, Jaszczyszyn Y, et al. Ten years of next-generation sequencing technology. Trends Genet. 2014;30:418–426.
   PubMed Web of Science ®Google Scholar
• Xuan J, Yu Y, Qing T, et al. Next-generation sequencing in the clinic: promises and challenges. Cancer Lett. 2013;340:284–295.
   PubMed Web of Science ®Google Scholar
• Mafficini A, Amato E, Fassan M, et al. Reporting tumor molecular heterogeneity in histopathological diagnosis. PLoS One. 2014;9:e104979.
   PubMed Web of Science ®Google Scholar
• Jennings LJ, Arcila ME, Corless C, et al. Guidelines for validation of next-generation sequencing-based oncology panels: A joint consensus recommendation of the Association for Molecular Pathology and College of American Pathologists. J Mol Diagn. 2017;19:341–365.
   PubMed Web of Science ®Google Scholar
• Wu J, Matthaei H, Maitra A, et al. Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development. Sci Transl Med. 2011;3:92ra66.
   PubMed Web of Science ®Google Scholar
• Rosenbaum MW, Jones M, Dudley JC, et al. Next-generation sequencing adds value to the preoperative diagnosis of pancreatic cysts. Cancer. 2017;125:41–47.
   PubMed Web of Science ®Google Scholar
• Pea A, Yu J, Rezaee N, et al. Targeted DNA sequencing reveals patterns of local progression in the pancreatic remnant following resection of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. Ann Surg 2017;266:133–141.
   PubMed Web of Science ®Google Scholar
• Young G, Wang K, He J, et al. Clinical next-generation sequencing successfully applied to fine-needle aspirations of pulmonary and pancreatic neoplasms. Cancer Cytopathol. 2013;121:688–694.
   PubMed Web of Science ®Google Scholar
• Amato E, Molin MD, Mafficini A, et al. Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas. J Pathol. 2014;233:217–227.
   PubMed Web of Science ®Google Scholar
• Vila-Navarro E, Vila-Casadesus M, Moreira L, et al. MicroRNAs for detection of pancreatic neoplasia: biomarker discovery by next-generation sequencing and validation in 2 independent cohorts. Ann Surg. 2017;265:1226–1234.
   PubMed Web of Science ®Google Scholar
• Wang J, Paris PL, Chen J, et al. Next generation sequencing of pancreatic cyst fluid microRNAs from low grade-benign and high grade-invasive lesions. Cancer Lett. 2015;356:404–409.
   PubMed Web of Science ®Google Scholar
• Jones M, Zheng Z, Wang J, et al. Impact of next-generation sequencing on the clinical diagnosis of pancreatic cysts. Gastrointest Endosc. 2016;83:140–148.
   PubMed Web of Science ®Google Scholar
• Roy-Chowdhuri S, Roy S, Monaco SE, et al. Big data from small samples: informatics of next-generation sequencing in cytopathology. Cancer. 2017;125:236–244.
   PubMed Web of Science ®Google Scholar
• Roy S, LaFramboise WA, Nikiforov YE, et al. Next-generation sequencing informatics: challenges and strategies for implementation in a clinical environment. Arch Pathol Lab Med. 2016;140:958–975.
   PubMed Web of Science ®Google Scholar
• Vigliar E, Malapelle U, de Luca C, et al. Challenges and opportunities of next-generation sequencing: a cytopathologist's perspective. Cytopathology. 2015;26:271–283.
   PubMed Web of Science ®Google Scholar