Emu Oil reduces disease severity in a mouse model of chronic ulcerative colitis

References

• Sartor RB. Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics. Gastroenterology. 2004;126:1620–1633.
   PubMed Web of Science ®Google Scholar
• Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology. 1998;115:182–205.
   PubMed Web of Science ®Google Scholar
• Rogler G. Chronic ulcerative colitis and colorectal cancer. Cancer Lett. 2014;345:235–241.
   PubMed Web of Science ®Google Scholar
• Feagan BG, Rutgeerts P, Sands BE, et al. Vedolizumab as induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2013;369:699–710.
   PubMed Web of Science ®Google Scholar
• Mehta SJ, Silver AR, Lindsay JO. Review article: strategies for the management of chronic unremitting ulcerative colitis. Aliment Pharmacol Ther. 2013;38:77–97.
   PubMed Web of Science ®Google Scholar
• Cheah KY, Bastian SE, Acott TM, et al. Grape seed extract reduces the severity of selected disease markers in the proximal colon of dextran sulphate sodium-induced colitis in rats. Dig Dis Sci. 2013;58:970–977.
   PubMed Web of Science ®Google Scholar
• Mashtoub S, Hoang BV, Vu M, et al. Clinical and structural effects of traditional Chinese medicine and the herbal preparation, Iberogast, in a rat model of ulcerative colitis. J Evid Based Complementary Altern Med. 2014;19:10–19.
   PubMedGoogle Scholar
• Tenikoff D, Murphy KJ, Le M, et al. Lyprinol (stabilised lipid extract of New Zealand green-lipped mussel): a potential preventative treatment modality for inflammatory bowel disease. J Gastroenterol. 2005;40:361–365.
   PubMed Web of Science ®Google Scholar
• Whitehouse MW, Turner AG, Davis CK, et al. Emu oil(s): a source of non-toxic transdermal anti-inflammatory agents in aboriginal medicine. Inflammopharmacol. 1998;6:1–8.
   PubMedGoogle Scholar
• Snowden JM, Whitehouse MW. Anti-inflammatory activity of emu oils in rats. Inflammopharmacology. 1997;5:127–132.
   PubMedGoogle Scholar
• Abimosleh SM, Lindsay RJ, Butler RN, et al. Emu oil increases colonic crypt depth in a rat model of ulcerative colitis. Dig Dis Sci. 2012;57:887–896.
   PubMed Web of Science ®Google Scholar
• Abimosleh SM, Tran CD, Howarth GS. Emu Oil: a novel therapeutic for disorders of the gastrointestinal tract? J Gastroenterol Hepatol. 2012;27:857–861.
   PubMed Web of Science ®Google Scholar
• Raghu Nadhanan R, Abimosleh SM, Su YW, et al. Dietary emu oil supplementation suppresses 5-fluorouracil chemotherapy-induced inflammation, osteoclast formation, and bone loss. Am J Physiol Endocrinol Metab. 2012;302:E1440–E1449.
   PubMed Web of Science ®Google Scholar
• Abimosleh SM, Tran CD, Howarth GS. Emu oil reduces small intestinal inflammation in the absence of clinical improvement in a rat model of indomethacin-induced enteropathy. Evid Based Complement Alternat Med. 2013;2013:1.
   Web of Science ®Google Scholar
• Mashtoub S, Tran CD, Howarth GS. Emu oil expedites small intestinal repair following 5-fluorouracil-induced mucositis in rats. Exp Biol Med (Maywood). 2013;238:1305–1317.
   PubMed Web of Science ®Google Scholar
• Mashtoub S, Bennett DC, Tran CD, et al. Processing and storage of ratite oils affects primary oxidation status and radical scavenging ability. Anim Prod Sci. 2015;55:1332–1337.
   Web of Science ®Google Scholar
• Mashtoub S, Lampton LS, Eden GL, et al. Emu oil combined with lyprinol reduces small intestinal damage in a rat model of chemotherapy-induced mucositis. Nutr Cancer. 2016;68:1171–1180.
   PubMed Web of Science ®Google Scholar
• Chartier LC, Howarth GS, Lawrance IC, et al. Emu oil improves clinical indicators of disease in a mouse model of colitis-associated colorectal cancer. Dig Dis Sci. 2018;63:135–145.
   PubMed Web of Science ®Google Scholar
• Mashtoub S, Cheah KY, Lymn KA, et al. Intestinal homeostasis is restored in mice following a period of intestinal growth induced by orally administered Emu Oil. Exp Biol Med (Maywood). 2018;234:945–952.
   Web of Science ®Google Scholar
• Mashtoub S. Potential therapeutic applications for Emu Oil. Lipid Technol. 2017;29:28–31.
   Google Scholar
• Valatas V, Vakas M, Kolios G. The value of experimental models of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases. Am J Physiol Gastrointest Liver Physiol. 2013;305:G763–G785.
   PubMed Web of Science ®Google Scholar
• Mashtoub S, Ghaemi R, Lawrance IC, et al. Emu oil attenuates disease severity in mouse models of colitis and inflammation-associated colorectal cancer. Gastroenterology. 2016;150:1154.
   Web of Science ®Google Scholar
• Portolesi R, Powell BC, Gibson RA. Competition between 24:5n-3 and ALA for delta 6 desaturase may limit the accumulation of DHA in HepG2 cell membranes. J Lipid Res. 2007;48:1592–1598.
   PubMed Web of Science ®Google Scholar
• Howarth GS, Xian CJ, Read LC. Predisposition to colonic dysplasia is unaffected by continuous administration of insulin-like growth factor-I for twenty weeks in a rat model of chronic inflammatory bowel disease. Growth Factors. 2000;18:119–133.
   PubMed Web of Science ®Google Scholar
• Jirkof P, Leucht K, Cesarovic N, et al. Burrowing is a sensitive behavioural assay for monitoring general wellbeing during dextran sulfate sodium colitis in laboratory mice. Lab Anim. 2013;47:274–283.
   PubMed Web of Science ®Google Scholar
• Camuesco D, Gálvez J, Nieto A, et al. Dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, attenuates colonic inflammation in rats with DSS-induced colitis. J Nutr. 2005;135:687–694.
   PubMed Web of Science ®Google Scholar
• Sanchez-Fidalgo S, Cardeno A, Sanchez-Hidalgo M, et al. Dietary extra virgin olive oil polyphenols supplementation modulates DSS-induced chronic colitis in mice. J Nutr Biochem. 2013;24:1401–1413.
   PubMed Web of Science ®Google Scholar
• Howarth GS, Xian CJ, Read LC. Insulin-like growth factor-I partially attenuates colonic damage in rats with experimental colitis induced by oral dextran sulphate sodium. Scand J Gastroenterol. 1998;33:180–190.
   PubMed Web of Science ®Google Scholar
• Carlsson AH, Yakymenko O, Olivier I, et al. Faecalibacterium prausnitzii supernatant improves intestinal barrier function in mice DSS colitis. Scand J Gastroenterol. 2013;48:1136–1144.
   PubMed Web of Science ®Google Scholar
• Meddings JB, Swain MG. Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat. Gastroenterology. 2000;119:1019–1028.
   PubMed Web of Science ®Google Scholar
• Yoganathan S, Nicolosi R, Wilson T, et al. Antagonism of croton oil inflammation by topical emu oil in CD-1 mice. Lipids. 2003;38:603–607.
   PubMed Web of Science ®Google Scholar
• Miller AL, Flecknell PA, Leach MC, et al. A comparison of a manual and an automated behavioural analysis method for assessing post-operative pain in mice. Appl Animal Behav Sci. 2011;131:138–144.
   Web of Science ®Google Scholar
• Jirkof P. Burrowing and nest building behavior as indicators of well-being in mice. J Neurosci Methods. 2014;234:139–146.
   PubMed Web of Science ®Google Scholar
• Emge JR, Huynh K, Miller EN, et al. Modulation of the microbiota-gut-brain axis by probiotics in a murine model of inflammatory bowel disease. Am J Physiol Gastrointestinal Liver Physiol. 2016;310:G989–G998.
   PubMed Web of Science ®Google Scholar
• Deacon RM. Burrowing: a sensitive behavioural assay, tested in five species of laboratory rodents. Behav Brain Res. 2009;200:128–133.
   PubMed Web of Science ®Google Scholar
• Bennett DC, Code WE, Godin DV, et al. Comparison of the antioxidant properties of emu oil with other avian oils. Aust J Exp Agric. 2008;48:1345–1350.
   Google Scholar