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Original Article

Pentoxifylline has favorable preventive effects on experimental chronic pancreatitis model

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 236-241 | Received 05 Nov 2019, Accepted 02 Jan 2020, Published online: 16 Jan 2020

References

  • Steer ML, Waxman I, Freedman S. Chronic pancreatitis. N Engl J Med. 1995;332:1482–1490.
  • Whitcomb DC, Frulloni L, Garg P, et al. Chronic pancreatitis: an international draft consensus proposal for a new mechanistic definition. Pancreatology. 2016;16:218–224.
  • Lohr JM, Dominguez-Munoz E, Rosendahl J, et al. United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU). United European Gastroenterol J. 2017;5:153–199.
  • Apte M, Pirola RC, Wilson JS. Pancreatic stellate cell: physiologic role, role in fibrosis and cancer. Curr Opin Gastroenterol. 2015;31:416–423.
  • Bachem MG, Schneider E, Groß H, et al. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology. 1998;115:421–432.
  • Erkan M, Adler G, Apte MV, et al. StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut. 2012;61:172–178.
  • Sendler M, Beyer G, Mahajan UM, et al. Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis. Gastroenterology. 2015;149:765–776.
  • Sendler M, Dummer A, Weiss FU, et al. Tumour necrosis factor alpha secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice. Gut. 2013;62:430–439.
  • Saito I, Hashimoto S, Saluja A, et al. Intracellular transport of pancreatic zymogens during caerulein supramaximal stimulation. Am J Physiol. 1987;253:G517–G526.
  • Norton ID, Apte MV, Lux O, et al. Chronic ethanol administration causes oxidative stress in the rat pancreas. J Lab Clin Med. 1998;131:442–446.
  • Oliveira TRR, Oliveira GF, Simoes RS, et al. The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats. Acta Cir Bras. 2017;32:559–567.
  • Prasad K, Lee P. Suppression of hypercholesterolemic atherosclerosis by pentoxifylline and its mechanism. Atherosclerosis. 2007;192:313–322.
  • Nathan JD, Romac J, Peng RY, et al. Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor. Pancreas. 2010;39:e24–e30.
  • Neuschwander-Tetri BA, Bridle KR, Wells LD, et al. Repetitive acute pancreatic injury in the mouse induces procollagen alpha1(I) expression colocalized to pancreatic stellate cells. Lab Invest. 2000;80:143–150.
  • Bansod S, Khurana A, Godugu C. Cerulein-induced chronic pancreatitis in Swiss albino mice: an improved short-term model for pharmacological screening. J PharmacolToxicol Methods. 2019;96:46–55.
  • Gul M, Esrefoglu M, Ozturk F, et al. The beneficial effects of pentoxifylline on caerulein-induced acute pancreatitis in rats. Dig Dis Sci. 2009;54:555–563.
  • Mas MR, Isik AT, Yamanel L, et al. Antioxidant treatment with taurine ameliorates chronic pancreatitis in an experimental rat model. Pancreas. 2006;33:77–81.
  • Vege SS, Atwal T, Bi Y, et al. Pentoxifylline treatment in severe acute pancreatitis: a pilot, double-blind, placebo-controlled, randomized trial. Gastroenterology. 2015;149:318–320.

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