Extracellular vesicle-associated soluble CD163 and CD206 in patients with acute and chronic inflammatory liver disease

References

• Sandahl TD, Gronbaek H, Moller HJ, et al. Hepatic macrophage activation and the LPS pathway in patients with alcoholic hepatitis: a prospective cohort study. Am J Gastroenterol. 2014;109(11):1749–1756.
   PubMed Web of Science ®Google Scholar
• Moller HJ, Gronbaek H, Schiodt FV, et al. Soluble CD163 from activated macrophages predicts mortality in acute liver failure. J Hepatol. 2007;47(5):671–676.
   PubMed Web of Science ®Google Scholar
• Kazankov K, Barrera F, Moller HJ, et al. Soluble CD163, a macrophage activation marker, is independently associated with fibrosis in patients with chronic viral hepatitis B and C. Hepatology. 2014;60(2):521–530.
   PubMed Web of Science ®Google Scholar
• Burdo TH, Lentz MR, Autissier P, et al. Soluble CD163 made by monocyte/macrophages is a novel marker of HIV activity in early and chronic infection prior to and after anti-retroviral therapy. J Infect Dis. 2011;204(1):154–163.
   PubMed Web of Science ®Google Scholar
• Andersen MN, Abildgaard N, Maniecki MB, et al. Monocyte/macrophage-derived soluble CD163: a novel biomarker in multiple myeloma. Eur J Haematol. 2014;93(1):41–47.
   PubMed Web of Science ®Google Scholar
• No JH, Moon JM, Kim K, et al. Prognostic significance of serum soluble CD163 level in patients with epithelial ovarian cancer. Gynecol Obstet Invest. 2013;75(4):263–267.
   PubMed Web of Science ®Google Scholar
• Schaer DJ, Schleiffenbaum B, Kurrer M, et al. Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome. Eur J Haematol. 2005;74(1):6–10.
   PubMed Web of Science ®Google Scholar
• Honge BL, Andersen MN, Jespersen S, et al. Brief Report: macrophage activation in HIV-2-infected patients is less affected by antiretroviral treatment-sCD163 in HIV-1, HIV-2, and HIV-1/2 dually infected patients. J Acquir Immune Defic Syndr. 2016;72(3):254–258.
   PubMed Web of Science ®Google Scholar
• Rodgaard-Hansen S, Rafique A, Christensen PA, et al. A soluble form of the macrophage-related mannose receptor (MR/CD206) is present in human serum and elevated in critical illness. Clin Chem Lab Med. 2014;52(3):453–461.
   PubMed Web of Science ®Google Scholar
• Andersen MN, Andersen NF, Rodgaard-Hansen S, et al. The novel biomarker of alternative macrophage activation, soluble mannose receptor (sMR/sCD206): Implications in multiple myeloma. Leuk Res. 2015;39(9):971–975.
   PubMed Web of Science ®Google Scholar
• Saha B, Tornai D, Kodys K, et al. Biomarkers of macrophage activation and immune danger signals predict clinical outcomes in alcoholic hepatitis. Hepatology. 2019;70(4):1134–1149.
   PubMed Web of Science ®Google Scholar
• Etzerodt A, Berg RM, Plovsing RR, et al. Soluble ectodomain CD163 and extracellular vesicle-associated CD163 are two differently regulated forms of ‘soluble CD163’ in plasma. Sci Rep. 2017;7(1):40286.
   PubMed Web of Science ®Google Scholar
• Etzerodt A, Maniecki MB, Moller K, et al. Tumor necrosis factor alpha-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163. J Leukoc Biol. 2010;88(6):1201–1205.
   PubMed Web of Science ®Google Scholar
• Nielsen MC, Andersen MN, Rittig N, et al. The macrophage-related biomarkers sCD163 and sCD206 are released by different shedding mechanisms. J Leukoc Biol. 2019;106(5):1129–1138.
   PubMed Web of Science ®Google Scholar
• Sandahl TD, Jepsen P, Thomsen KL, et al. Incidence and mortality of alcoholic hepatitis in Denmark 1999-2008: a nationwide population based cohort study. J Hepatol. 2011;54(4):760–764.
   PubMed Web of Science ®Google Scholar
• Huang YW, Yang SS, Kao JH. Pathogenesis and management of alcoholic liver cirrhosis: a review. Hepat Med. 2011;3:1–11.
   PubMedGoogle Scholar
• Holland-Fischer P, Gronbaek H, Sandahl TD, et al. Kupffer cells are activated in cirrhotic portal hypertension and not normalised by TIPS. Gut. 2011;60(10):1389–1393.
   PubMed Web of Science ®Google Scholar
• Gronbaek H, Sandahl TD, Mortensen C, et al. Soluble CD163, a marker of Kupffer cell activation, is related to portal hypertension in patients with liver cirrhosis. Aliment Pharmacol Ther. 2012;36(2):173–180.
   PubMed Web of Science ®Google Scholar
• Moller HJ, Hald K, Moestrup SK. Characterization of an enzyme-linked immunosorbent assay for soluble CD163. Scand J Clin Lab Invest. 2002;62(4):293–299.
   PubMed Web of Science ®Google Scholar
• Taylor DD, Shah S. Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes. Methods. 2015;87:3–10.
   PubMed Web of Science ®Google Scholar
• Enomoto N, Ikejima K, Bradford BU, et al. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. J Gastroenterol Hepatol. 2000;15(s1):20–25.
   Google Scholar
• Mandrekar P, Bala S, Catalano D, et al. The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. J Immunol. 2009;183(2):1320–1327.
   PubMed Web of Science ®Google Scholar
• Lederer SL, Walters KA, Proll S, et al. Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis. Virol J. 2006;3(1):98.
   PubMed Web of Science ®Google Scholar
• Vogel DY, Glim JE, Stavenuiter AW, et al. Human macrophage polarization in vitro: maturation and activation methods compared. Immunobiology. 2014;219(9):695–703.
   PubMed Web of Science ®Google Scholar
• Adachi Y, Bradford BU, Gao W, et al. Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology. 1994;20(2):453–460.
   PubMed Web of Science ®Google Scholar
• Sandahl TD, Stoy SH, Laursen TL, et al. The soluble mannose receptor (sMR) is elevated in alcoholic liver disease and associated with disease severity, portal hypertension, and mortality in cirrhosis patients. PLoS One. 2017;12(12):e0189345.
   PubMed Web of Science ®Google Scholar
• Bala S, Marcos M, Gattu A, et al. Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals. PLoS One. 2014;9(5):e96864.
   PubMed Web of Science ®Google Scholar
• Chen P, Starkel P, Turner JR, et al. Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice. Hepatology. 2015;61(3):883–894.
   PubMed Web of Science ®Google Scholar
• Li L, Cheng Y, Emrich S, et al. Activation of endothelial cells by extracellular vesicles derived from Mycobacterium tuberculosis infected macrophages or mice. PLoS One. 2018;13(5):e0198337.
   PubMed Web of Science ®Google Scholar
• Giri PK, Schorey JS. Exosomes derived from M. Bovis BCG infected macrophages activate antigen-specific CD4+ and CD8+ T cells in vitro and in vivo. PLoS One. 2008;3(6):e2461.
   PubMed Web of Science ®Google Scholar
• Holder B, Jones T, Sancho Shimizu V, et al. Macrophage exosomes induce placental inflammatory cytokines: a novel mode of maternal-placental messaging. Traffic. 2016;17(2):168–178.
   PubMed Web of Science ®Google Scholar
• Rice TF, Donaldson B, Bouqueau M, et al. Macrophage- but not monocyte-derived extracellular vesicles induce placental pro-inflammatory responses. Placenta. 2018;69:92–95.
   PubMed Web of Science ®Google Scholar
• Saha B, Momen-Heravi F, Furi I, et al. Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90. Hepatology. 2018;67(5):1986–2000.
   PubMed Web of Science ®Google Scholar
• Saha B, Momen-Heravi F, Kodys K, et al. MicroRNA cargo of extracellular vesicles from alcohol-exposed monocytes signals naive monocytes to differentiate into M2 macrophages. J Biol Chem. 2016;291(1):149–159.
   PubMed Web of Science ®Google Scholar
• Morales-Ibanez O, Dominguez M, Ki SH, et al. Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis. Hepatology. 2013;58(5):1742–1756.
   PubMed Web of Science ®Google Scholar
• Koh A, da Silva AP, Bansal AK, et al. Role of osteopontin in neutrophil function. Immunology. 2007;122(4):466–475.
   PubMed Web of Science ®Google Scholar
• Davis BH, Zarev PV. Human monocyte CD163 expression inversely correlates with soluble CD163 plasma levels. Cytometry. 2005;63B(1):16–22.
   Google Scholar