Clinical consequences of controversies in gastric physiology

References

• Martinsen TC, Bergh K, Waldum HL. Gastric juice: a barrier against infectious diseases. Basic Clin Pharmacol Toxicol. 2005;96(2):94–102.
   PubMed Web of Science ®Google Scholar
• Kahlson G, Rosengren E, Svahn D, et al. Mobilization and formation of histamine in the gastric mucosa as related to acid secretion. J Physiol (Lond). 1964;174:400–416.
   Google Scholar
• Grossman MI, Konturek SJ. Inhibition of acid secretion in dog by metiamide, a histamine antagonist acting on H2 receptors. Gastroenterology. 1974;66(4):517–521.
   PubMed Web of Science ®Google Scholar
• Berglindh T, Helander HF, Obrink KJ. Effects of secretagogues on oxygen consumption, aminopyrine accumulation and morphology in isolated gastric glands. Acta Physiol Scand. 1976;97(4):401–414.
   PubMedGoogle Scholar
• Soll AH. Potentiating interactions of gastric stimulants on [14 C] aminopyrine accumulation by isolated canine parietal cells. Gastroenterology. 1982;83(1):216–223.
   PubMed Web of Science ®Google Scholar
• Waldum HLS,  A.K, Brenna E. Gastrin: histamine-releasing activity. In: JH W editor. Gastrin. New York: Raven Press; 1993. p. 259–271.
   Google Scholar
• Norlen P, Bernsand M, Konagaya T, et al. ECL-cell histamine mobilization in conscious rats: effects of locally applied regulatory peptides, candidate neurotransmitters and inflammatory mediators. Br J Pharmacol. 2001;134(8):1767–1777.
   PubMed Web of Science ®Google Scholar
• Athmann C, Zeng N, Scott DR, et al. Regulation of parietal cell calcium signaling in gastric glands. Am J Physiol Gastrointest Liver Physiol. 2000;279(5):G1048–1058.
   PubMed Web of Science ®Google Scholar
• Hakanson R, Owman C. Argyrophilic reaction of histamine-containing epithelial cells in murine gastric mucosa. Experientia. 1969;25(6):625–626.
   PubMedGoogle Scholar
• Johnson LR. Control of gastric secretion: no room for histamine? Gastroenterology. 1971;61(1):106–118.
   PubMed Web of Science ®Google Scholar
• Black JW, Duncan WA, Durant CJ, et al. Definition and antagonism of histamine H 2 -receptors. Nature. 1972;236(5347):385–390.
   PubMed Web of Science ®Google Scholar
• Hakanson R, Bottcher G, Ekblad E, et al. Histamine in endocrine cells in the stomach. A survey of several species using a panel of histamine antibodies. Histochemistry. 1986;86(1):5–17.
   PubMedGoogle Scholar
• Kopin AS, Lee YM, McBride EW, et al. Expression cloning and characterization of the canine parietal cell gastrin receptor. Proc Natl Acad Sci USA. 1992;89(8):3605–3609.
   PubMed Web of Science ®Google Scholar
• Nakata H, Matsui T, Ito M, et al. Cloning and characterization of gastrin receptor from ECL carcinoid tumor of Mastomys natalensis. Biochem Biophys Res Commun. 1992;187(2):1151–1157.
   PubMed Web of Science ®Google Scholar
• Bakke I, Qvigstad G, Sandvik AK, et al. The CCK-2 receptor is located on the ECL cell, but not on the parietal cell. Scand J Gastroenterol. 2001;36(11):1128–1133.
   PubMed Web of Science ®Google Scholar
• Waldum HL, Brenna E, Sandvik AK. Relationship of ECL cells and gastric neoplasia. Yale J Biol Med. 1998;71(3–4):325–335.
   PubMed Web of Science ®Google Scholar
• Bakke I, Qvigstad G, Brenna E, et al. Gastrin has a specific proliferative effect on the rat enterochromaffin-like cell, but not on the parietal cell: a study by elutriation centrifugation. Acta Physiol Scand. 2000;169(1):29–37.
   PubMedGoogle Scholar
• Waldum HL, Brenna E, Sandvik AK, et al. Trophic effect of histamine on the stomach. Scand J Gastroenterol Suppl. 1991;180:137–142.
   PubMedGoogle Scholar
• Fukui H, Kinoshita Y, Maekawa T, et al. Regenerating gene protein may mediate gastric mucosal proliferation induced by hypergastrinemia in rats. Gastroenterology. 1998;115(6):1483–1493.
   PubMed Web of Science ®Google Scholar
• Solcia E, Capella C, Fiocca R, et al. Gastric argyrophil carcinoidosis in patients with Zollinger-Ellison syndrome due to type 1 multiple endocrine neoplasia. A newly recognized association. Am J Surg Pathol. 1990;14(6):503–513.
   PubMed Web of Science ®Google Scholar
• Wilander E. Achylia, pernicious anaemia, ECL cells and gastric carcinoids. Virchows Arch A Pathol Anat Histol. 1980;387(3):371–373.
   PubMed Web of Science ®Google Scholar
• Havu N. Enterochromaffin-like cell carcinoids of gastric mucosa in rats after life-long inhibition of gastric secretion. Digestion. 1986;35(Suppl 1):42–55.
   PubMed Web of Science ®Google Scholar
• Poynter D, Pick CR, Harcourt RA, et al. Association of long lasting unsurmountable histamine H2 blockade and gastric carcinoid tumours in the rat. Gut. 1985;26(12):1284–1295.
   PubMed Web of Science ®Google Scholar
• Poynter D, Selway SA, Papworth SA, et al. Riches SR: changes in the gastric mucosa of the mouse associated with long lasting unsurmountable histamine H2 blockade. Gut. 1986;27(11):1338–1346.
   PubMed Web of Science ®Google Scholar
• Barrett P, Hobbs RC, Coates PJ, et al. Endocrine cells of the human gastrointestinal tract have no proliferative capacity. Histochem J. 1995;27(6):482–486.
   PubMedGoogle Scholar
• Tielemans Y, Willems G, Sundler F, et al. Self-replication of enterochromaffin-like cells in the mouse stomach. Digestion. 1990;45(3):138–146.
   PubMed Web of Science ®Google Scholar
• Blair AJ, 3rd, Richardson CT, Walsh JH, et al. Variable contribution of gastrin to gastric acid secretion after a meal in humans. Gastroenterology. 1987;92(4):944–949.
   PubMed Web of Science ®Google Scholar
• Sjoblom SM, Sipponen P, Karonen SL, et al. Mucosal argyrophil endocrine cells in pernicious anaemia and upper gastrointestinal carcinoid tumours. J Clin Pathol. 1989;42(4):371–377.
   PubMed Web of Science ®Google Scholar
• Sandvik AK, Waldum HL. CCK-B (gastrin) receptor regulates gastric histamine release and acid secretion. Am J Physiol. 1991;260(6 Pt 1):G925–928.
   PubMed Web of Science ®Google Scholar
• Brenna E, Waldum HL. Trophic effect of gastrin on the enterochromaffin like cells of the rat stomach: establishment of a dose response relationship. Gut. 1992;33(10):1303–1306.
   PubMed Web of Science ®Google Scholar
• Waldum HL, Sagatun L, Mjones P. Gastrin and Gastric Cancer. Front Endocrinol (Lausanne). 2017;8:1.
   PubMed Web of Science ®Google Scholar
• Waldum HL, Petersen H. 24-hour intragastric acidity and plasma gastrin after omeprazole treatment and after proximal gastric vagotomy in duodenal ulcer patients. Gastroenterology. 1991;101(1):274.
   PubMed Web of Science ®Google Scholar
• Safholm C, Havu N, Forssell H, et al. Effect of 7 years’ daily oral administration of omeprazole to beagle dogs. Digestion. 1994;55(3):139–147.
   PubMed Web of Science ®Google Scholar
• Calvete O, Reyes J, Zuniga S, et al. Exome sequencing identifies ATP4A gene as responsible of an atypical familial type I gastric neuroendocrine tumour. Hum Mol Genet. 2015;24(10):2914–2922.
   PubMed Web of Science ®Google Scholar
• Fossmark R, Calvete O, Mjones P, et al. ECL-cell carcinoids and carcinoma in patients homozygous for an inactivating mutation in the gastric H(+) K(+) ATPase alpha subunit. APMIS. 2016;124(7):561–566.
   PubMed Web of Science ®Google Scholar
• Trudeau WL, McGuigan JE. Relations between serum gastrin levels and rates of gastric hydrochloric acid secretion. N Engl J Med. 1971;284(8):408–412.
   PubMed Web of Science ®Google Scholar
• Walsh JH, Richardson CT, Fordtran JS. pH dependence of acid secretion and gastrin release in normal and ulcer subjects. J Clin Invest. 1975;55(3):462–468.
   PubMed Web of Science ®Google Scholar
• Petersen H, Johannessen T, Sandvik AK, et al. Relationship between endoscopic hiatus hernia and gastroesophageal reflux symptoms. Scand J Gastroenterol. 1991;26(9):921–926.
   PubMed Web of Science ®Google Scholar
• Nwokolo CU, Smith JT, Gavey C, et al. Tolerance during 29 days of conventional dosing with cimetidine, nizatidine, famotidine or ranitidine. Aliment Pharmacol Ther. 1990;4(Suppl 1):29–45.
   PubMed Web of Science ®Google Scholar
• Waldum HL, Lehy T, Brenna E, et al. Effect of the histamine-1 antagonist astemizole alone or with omeprazole on rat gastric mucosa. Scand J Gastroenterol. 1991;26(1):23–35.
   PubMed Web of Science ®Google Scholar
• Waldum HL, Arnestad JS, Brenna E, et al. Marked increase in gastric acid secretory capacity after omeprazole treatment. Gut. 1996;39(5):649–653.
   PubMed Web of Science ®Google Scholar
• Prewett EJ, Hudson M, Nwokolo CU, et al. Nocturnal intragastric acidity during and after a period of dosing with either ranitidine or omeprazole. Gastroenterology. 1991;100(4):873–877.
   PubMed Web of Science ®Google Scholar
• Larsson H, Carlsson E, Ryberg B, et al. Rat parietal cell function after prolonged inhibition of gastric acid secretion. Am J Physiol. 1988;254(1 Pt 1):G33–39.
   PubMedGoogle Scholar
• Lamberts R, Creutzfeldt W, Stockmann F, et al. Long-term omeprazole treatment in man: effects on gastric endocrine cell populations. Digestion. 1988;39(2):126–135.
   PubMed Web of Science ®Google Scholar
• Kleveland PM, Waldum HL, Larsson H. Gastric acid secretion in the totally isolated, vascularly perfused rat stomach. A selective muscarinic-1 agent does, whereas gastrin does not, augment maximal histamine-stimulated acid secretion. Scand J Gastroenterol. 1987;22(6):705–713.
   PubMed Web of Science ®Google Scholar
• Lind T, Cederberg C, Idstrom JP, et al. 24-hour intragastric acidity and plasma gastrin during long-term treatment with omeprazole or ranitidine in patients with reflux esophagitis. Scand J Gastroenterol. 1991;26(6):620–626.
   PubMed Web of Science ®Google Scholar
• Hatlebakk JG, Katz PO, Kuo B, et al. Nocturnal gastric acidity and acid breakthrough on different regimens of omeprazole 40 mg daily. Aliment Pharm Ther. 1998;12(12):1235–1240.
   PubMed Web of Science ®Google Scholar
• Sanduleanu S, De Bruine A, Stridsberg M, et al. Serum chromogranin A as a screening test for gastric enterochromaffin-like cell hyperplasia during acid-suppressive therapy. Eur J Clin Invest. 2001;31(9):802–811.
   PubMed Web of Science ®Google Scholar
• Wilander E, El-Salhy M, Pitkänen P. Histopathology of gastric carcinoids: a survey of 42 cases. Histopathology. 1984;8(2):183–193.
   PubMed Web of Science ®Google Scholar
• Soga J, Tazawa MD, Ito H. Ultrastructural demonstration of specific secretory granules of Mastomys gastric carcinoids. Acta Med Biol (Niigata). 1969;17(2):119–124.
   PubMedGoogle Scholar
• Poynter D. Long-term effects of reduced gastric acidity in laboratory animals. Digestion. 1985;31:174.
   Web of Science ®Google Scholar
• Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attemt at a histo-clinical classification. Acta pathologica et microbiologica Scandinavica. 1965;64:31–49.
   PubMedGoogle Scholar
• Waldum HL, Haugen OA, Isaksen C, et al. Enterochromaffin-like tumour cells in the diffuse but not the intestinal type of gastric carcinomas. Eur J Gastroenterol Hepatol. 1991;3:245–249.
   Web of Science ®Google Scholar
• Waldum HL, Aase S, Kvetnoi I, et al. Neuroendocrine differentiation in human gastric carcinoma. Cancer. 1998;83(3):435–444.
   PubMed Web of Science ®Google Scholar
• Qvigstad G, Qvigstad T, Westre B, et al. Neuroendocrine differentiation in gastric adenocarcinomas associated with severe hypergastrinemia and/or pernicious anemia. APMIS. 2002;110(2):132–139.
   PubMed Web of Science ®Google Scholar
• Bakkelund K, Fossmark R, Nordrum I, et al. Signet ring cells in gastric carcinomas are derived from neuroendocrine cells. J Histochem Cytochem. 2006;54(6):615–621.
   PubMed Web of Science ®Google Scholar
• Qvigstad G, Sandvik AK, Brenna E, et al. Detection of chromogranin A in human gastric adenocarcinomas using a sensitive immunohistochemical technique. Histochem J. 2000;32(9):551–556.
   PubMedGoogle Scholar
• Martinsen TC, Skogaker NE, Fossmark R, et al. Neuroendocrine cells in diffuse gastric carcinomas: an ultrastructural study with immunogold labeling of chromogranin A. Appl Immunohistochem Mol Morphol. 2010;18(1):62–68.
   PubMedGoogle Scholar
• Sordal O, Qvigstad G, Nordrum IS, et al. The PAS positive material in gastric cancer cells of signet ring type is not mucin. Exp Mol Pathol. 2014;96(3):274–278.
   PubMed Web of Science ®Google Scholar
• Bartley AN, Rashid A, Fournier KF, et al. Neuroendocrine and mucinous differentiation in signet ring cell carcinoma of the stomach: evidence for a common cell of origin in composite tumors. Hum Pathol. 2011;42(10):1420–1429.
   PubMed Web of Science ®Google Scholar
• Nunobe S, Taniguchi H, Katai H, et al. A rare case of poorly differentiated endocrine cell carcinoma of the stomach with signet ring cell differentiation. Gastric Cancer. 2010;13(2):131–134.
   PubMed Web of Science ®Google Scholar
• Thorburn CM, Friedman GD, Dickinson CJ, et al. Gastrin and colorectal cancer: a prospective study. Gastroenterology. 1998;115(2):275–280.
   PubMed Web of Science ®Google Scholar
• Hakanson R, Blom H, Carlsson E, et al. Hypergastrinaemia produces trophic effects in stomach but not in pancreas and intestines. Regul Pept. 1986;13(3–4):225–233.
   PubMedGoogle Scholar
• Hayakawa Y, Jin G, Wang H, et al. CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis. Gut. 2015;64(4):544–553.
   PubMed Web of Science ®Google Scholar
• Murphy G, Abnet CC, Choo-Wosoba H, Vogtmann E, et al. Serum gastrin and cholecystokinin are associated with subsequent development of gastric cancer in a prospective cohort of Finnish smokers. Int J Epidemiol. 2017;46(3):914–923.
   PubMed Web of Science ®Google Scholar
• Uemura N, Okamoto S, Yamamoto S, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001;345(11):784–789.
   PubMed Web of Science ®Google Scholar
• Zamcheck N, Grable E, Ley A, et al. Occurrence of gastric cancer among patients with pernicious anemia at the Boston City Hospital. N Engl J Med. 1955;252(26):1103–1110.
   PubMed Web of Science ®Google Scholar
• Borch K, Renvall H, Liedberg G. Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemia. Gastroenterology. 1985;88(3):638–648.
   PubMed Web of Science ®Google Scholar
• Waldum HL, Sordal OF, Mjones PG. The Enterochromaffin-like. Int J Mol Sci. 2019;20(10):2444.
   PubMed Web of Science ®Google Scholar
• Camargo MC, Anderson WF, King JB, et al. Divergent trends for gastric cancer incidence by anatomical subsite in US adults. Gut. 2011;60(12):1644–1649.
   PubMed Web of Science ®Google Scholar
• Bergquist JR, Leiting JL, Habermann EB, Cleary SP, et al. Early-onset gastric cancer is a distinct disease with worrisome trends and oncogenic features. Surgery. 2019;166(4):547–555.
   PubMed Web of Science ®Google Scholar
• Waldum HL. The increase in early-onset gastric carcinomas from 1995 is most probably due to the introduction of proton pump inhibitors. Surgery. 2020. DOI:10.1016/j.surg.2020.01.016
   PubMed Web of Science ®Google Scholar
• Cheung KS, Chan EW, Wong AYS, et al. Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study. Gut. 2018;67(1):28–35.
   PubMed Web of Science ®Google Scholar
• Smoak BL, Kelley PW, Taylor DN. Seroprevalence of Helicobacter pylori infections in a cohort of US Army recruits. Am J Epidemiol. 1994;139(5):513–519.
   PubMed Web of Science ®Google Scholar
• Jianu CS, Fossmark R, Viset T, et al. Gastric carcinoids after long-term use of a proton pump inhibitor. Aliment Pharmacol Ther. 2012;36(7):644–649.
   PubMed Web of Science ®Google Scholar
• Cavalcoli F, Zilli A, Conte D, et al. Gastric neuroendocrine neoplasms and proton pump inhibitors: fact or coincidence? Scand J Gastroenterol. 2015;50(11):1397–1403.
   PubMed Web of Science ®Google Scholar
• Procter Gamble Company/Astra Zeneca LP. Omeprazole magnesium tablets. NDA (New Drug Application). 2000;21:229.
   Google Scholar
• Jianu CS, Lange OJ, Viset T, et al. Gastric neuroendocrine carcinoma after long-term use of proton pump inhibitor. Scand J Gastroenterol. 2012;47(1):64–67.
   PubMed Web of Science ®Google Scholar
• Solcia E, Rindi G, Silini E, et al. Enterochromaffin-like (ECL) cells and their growths: relationships to gastrin, reduced acid secretion and gastritis. Baillieres Clin Gastroenterol. 1993;7(1):149–165.
   PubMedGoogle Scholar
• Mjones P, Nordrum IS, Sordal O, et al. Expression of the Cholecystokinin-B Receptor in neoplastic gastric cells. Horm Cancer. 2018;9(1):40–54.
   PubMed Web of Science ®Google Scholar
• Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet (London, England). 1984;323(8390):1311–1315.
   Google Scholar
• Parsonnet J, Friedman GD, Vandersteen DP, et al. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med. 1991;325(16):1127–1131.
   PubMed Web of Science ®Google Scholar
• Hansson LE, Nyren O, Hsing AW, et al. The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N Engl J Med. 1996;335(4):242–249.
   PubMed Web of Science ®Google Scholar
• Kamangar F, Dawsey SM, Blaser MJ, et al. Opposing risks of gastric cardia and noncardia gastric adenocarcinomas associated with Helicobacter pylori seropositivity. J Natl Cancer Inst. 2006;98(20):1445–1452.
   PubMedGoogle Scholar
• Waldum HL, Hauso O, Sordal OF, et al. Gastrin may mediate the carcinogenic effect of helicobacter pylori infection of the stomach. Dig Dis Sci. 2015;60(6):1522–1527.
   PubMed Web of Science ®Google Scholar
• Take S, Mizuno M, Ishiki K, et al. Risk of gastric cancer in the second decade of follow-up after Helicobacter pylori eradication. J Gastroenterol. 2020;55(3):281–288.
   PubMed Web of Science ®Google Scholar
• Valle J, Seppälä K, Sipponen P, et al. Disappearance of gastritis after eradication of Helicobacter pylori. A morphometric study. Scand J Gastroenterol. 1991;26(10):1057–1065.
   PubMed Web of Science ®Google Scholar
• van der Hulst RW, van der Ende A, Dekker FW, et al. Effect of Helicobacter pylori eradication on gastritis in relation to cagA: a prospective 1-year follow-up study. Gastroenterology. 1997;113(1):25–30.
   PubMed Web of Science ®Google Scholar
• Vannella L, Lahner E, Osborn J, et al. Systematic review: gastric cancer incidence in pernicious anaemia. Aliment Pharmacol Ther. 2013;37(4):375–382.
   PubMed Web of Science ®Google Scholar
• Graham DY, Zou WY. Guilt by association: intestinal metaplasia does not progress to gastric cancer. Curr Opin Gastroenterol. 2018;34(6):458–464.
   PubMed Web of Science ®Google Scholar
• Waldum HL, Fossmark R. Role of autoimmune gastritis in gastric cancer. Clin Transl Gastroenterol. 2019;10(9):e00080.
   PubMedGoogle Scholar
• Correa P. Human gastric carcinogenesis: a multistep and multifactorial process–First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res. 1992;52(24):6735–6740.
   PubMed Web of Science ®Google Scholar
• Pittayanon R, Rerknimitr R, Klaikaew N, et al. The risk of gastric cancer in patients with gastric intestinal metaplasia in 5-year follow-up. Aliment Pharmacol Ther. 2017;46(1):40–45.
   PubMed Web of Science ®Google Scholar
• Kinoshita H, Hayakawa Y, Koike K. Metaplasia in the stomach-precursor of gastric cancer? Int J Mol Sci. 2017;18(10):2063.
   PubMed Web of Science ®Google Scholar
• Houghton J, Stoicov C, Nomura S, et al. Gastric cancer originating from bone marrow-derived cells. Science. 2004;306(5701):1568–1571.
   PubMed Web of Science ®Google Scholar
• Goldenring JR, Nam KT. Oxyntic atrophy, metaplasia, and gastric cancer. Prog Mol Biol Transl Sci. 2010;96:117–131.
   PubMed Web of Science ®Google Scholar
• Nomura S, Yamaguchi H, Ogawa M, et al. Alterations in gastric mucosal lineages induced by acute oxyntic atrophy in wild-type and gastrin-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2005;288(2):G362–375.
   PubMed Web of Science ®Google Scholar
• Hayakawa Y, Fox JG, Wang TC. Isthmus stem cells are the origins of metaplasia in the gastric corpus. Cell Mol Gastroenterol Hepatol. 2017;4(1):89–94.
   PubMed Web of Science ®Google Scholar