Progression of pancreatic morphology in chronic pancreatitis is not associated with changes in quality of life and pain

References

• Wehler M, Reulbach U, Nichterlein R, et al. Health-related quality of life in chronic pancreatitis: a psychometric assessment. Scand J Gastroenterol. 2003;38(10):1083–1089.
   PubMed Web of Science ®Google Scholar
• Pezzilli R, Morselli-Labate AM, Frulloni L, et al. The quality of life in patients with chronic pancreatitis evaluated using the SF-12 questionnaire: a comparative study with the SF-36 questionnaire. Dig Liver Dis. 2006;38(2):109–115.
   PubMedGoogle Scholar
• Kleeff J, Whitcomb DC, Shimosegawa T, et al. Chronic pancreatitis. Nat Rev Dis Prim. 2017;3:1–18.
   Web of Science ®Google Scholar
• Braganza JM, Lee SH, McCloy RF, et al. Chronic pancreatitis. Lancet. 2011;377(9772):1184–1197.
   PubMed Web of Science ®Google Scholar
• Frøkjaer JB, Akisik F, Farooq A, Working group for the International (IAP – APA – JPS – EPC) Consensus Guidelines for Chronic Pancreatitis, et al. Guidelines for the diagnostic cross sectional imaging and severity scoring of chronic pancreatitis. Pancreatology. 2018;18(7):764–773.
   PubMed Web of Science ®Google Scholar
• Tirkes T, Shah ZK, Takahashi N, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, et al. Reporting standards for chronic pancreatitis by using CT, MRI, and MR cholangiopancreatography: the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer. Radiology. 2019;290(1):207–215.
   PubMed Web of Science ®Google Scholar
• Conwell DL, Lee LS, Yadav D, et al. American Pancreatic Association Practice Guidelines in Chronic Pancreatitis: evidence-based report on diagnostic guidelines. Pancreas. 2014;43:1143–1162.  
   PubMed Web of Science ®Google Scholar
• Bieliuniene E, Frøkjaer JB, Pockevicius A, et al. Magnetic resonance imaging as a valid noninvasive tool for the assessment of pancreatic fibrosis. Pancreas. 2019;48(1):85–93.
   PubMed Web of Science ®Google Scholar
• Akisik MF, Aisen AM, Sandrasegaran K, et al. Assessment of chronic pancreatitis: utility of diffusion-weighted MR imaging with secretin enhancement. Radiology. 2009;250(1):103–109.
   PubMed Web of Science ®Google Scholar
• Madzak A, Olesen SS, Haldorsen IS, et al. Secretin-stimulated MRI characterization of pancreatic morphology and function in patients with chronic pancreatitis. Pancreatology. 2017;17(2):228–236.
   PubMed Web of Science ®Google Scholar
• Jensen AR, Matzen P, Malchow-Møller A, The Copenhagen Pancreatitis Study Group, et al. Pattern of pain, duct morphology, and pancreatic function in chronic pancreatitis. A comparative study. Scand J Gastroenterol. 1984;19(3):334–338.
   PubMed Web of Science ®Google Scholar
• Bahuva R, Walsh RM, Kapural ÞL, et al. Morphologic abnormalities are poorly predictive of visceral pain in chronic pancreatitis. Pancreas. 2013;42(1):6–10.
   PubMed Web of Science ®Google Scholar
• Frøkjaer JB, Olesen SS, Drewes AM. Fibrosis, atrophy, and ductal pathology in chronic pancreatitis are associated with pancreatic function but independent of symptoms. Pancreas. 2013;42(7):1182–1187.
   PubMed Web of Science ®Google Scholar
• Koloski NA, Talley NJ, Boyce PM. The impact of functional gastrointestinal disorders on quality of life. Am J Gastroenterol. 2000;95(1):67–71.
   PubMed Web of Science ®Google Scholar
• Steinkohl E, Schou S, Bolvig E, et al. Progression of parenchymal and ductal findings in patients with chronic pancreatitis : a 4-year follow-up MRI study. Eur J Radiol. 2020;125(January):108868.
   PubMedGoogle Scholar
• Lankisch PG, Breuer N, Bruns A, et al. Natural history of acute pancreatitis: a long-term population-based study. Am J Gastroenterol. 2009;104(11):2797–2805.
   PubMed Web of Science ®Google Scholar
• Keller J, Layer P. Diagnosis of pancreatic exocrine insufficiency in chronic pancreatitis. Pancreapedia: The Exocrine Pancreas Knowledge Base. 2015;1–7.
   Google Scholar
• Yadav D, Hawes RH, Brand RE, et al. Alcohol consumption, cigarette smoking and the risk of recurrent acute and chronic pancreatitis. Arch Intern Med. 2009;169(11):1035–1045.
   Google Scholar
• Whitcomb DC, Yadav D, Adam S, North American Pancreatic Study Group, et al. Multicenter approach to recurrent acute and chronic pancreatitis in the United States: The North American Pancreatitis Study 2 (NAPS2). Pancreatology. 2008;8(4-5):520–531.
   PubMed Web of Science ®Google Scholar
• Fitzsimmons D, Kahl S, Butturini G, et al. Symptoms and quality of life in chronic pancreatitis assessed by structured interview and the EORTC QLQ-C30 and QLQ-PAN26. Am J Gastroenterology. 2005;100(4):918–926.
   PubMed Web of Science ®Google Scholar
• Mendoza T, Mayne T, Rublee D, et al. Reliability and validity of a modified Brief Pain Inventory short form in patients with osteoarthritis. Eur J Pain. 2006;10(4):353–361.
   PubMed Web of Science ®Google Scholar
• Hardt PD, Marzeion AM, Schnell-Kretschmer H, et al. Fecal elastase 1 measurement compared with endoscopic retrograde cholangiopancreatography for the diagnosis of chronic pancreatitis. Pancreas. 2002;25(1):e6–9.
   PubMedGoogle Scholar
• Wilcox CM, Yadav D, Ye T, et al. Chronic pancreatitis pain pattern and severity are independent of abdominal imaging findings. Clin Gastroenterol Hepatol. 2015;13(3):552–560.
   Google Scholar
• Sneeuw KC, Aaronson NK, Sprangers MA, et al. Comparison of patient and proxy EORTC QLQ-C30 ratings in assessing the quality of life of cancer patients. J Clin Epidemiol. 1998;51(7):617–631.
   PubMed Web of Science ®Google Scholar
• Pezzilli R, Fantini L. Chronic pancreatitis: assessing the quality of life. J Pancreas. 2005;6(4):406–409.
   PubMedGoogle Scholar
• Mmd A, Sø SO, Lp J, et al. MRI assessed pancreatic morphology and exocrine function are associated with disease burden in chronic pancreatitis. Eur J Gastroenterol Hepatol. 2017;29(11):1269–1275.
   PubMed Web of Science ®Google Scholar
• Mokrowiecka A, Pińkowski D, Małecka-Panas E. Assessment of quality of life in patients with chronic pancreatitis. Med Sci Monit. 2011;17(10):583–588.
   Web of Science ®Google Scholar
• Olesen SS, Krauss T, Demir IE, et al. Towards a neurobiological understanding of pain in chronic pancreatitis: mechanisms and implications for treatment. Pain Rep. 2017;2(6):e625.
   PubMedGoogle Scholar
• Poulsen JL, Olesen SS, Malver LP, et al. Pain and chronic pancreatitis: A complex interplay of multiple mechanisms. World J Gastroenterol. 2013;19(42):7282–7291.
   PubMed Web of Science ®Google Scholar
• Uc A, Andersen DK, Bellin MD, et al. Chronic pancreatitis in the 21st century - research challenges and opportunities: summary of a National Institute of Diabetes and Digestive and kidney diseases workshop. Pancreas. 2016;45(10):1365–1375.
   Google Scholar
• Drewes AM, Olesen AE, Farmer AD, et al. Gastrointestinal pain. Nat Rev Dis Primers. 2020;6(1):1.
   PubMed Web of Science ®Google Scholar
• Arendt-Nielsen L, Morlion B, Perrot S, et al. Assessment and manifestation of central sensitisation across different chronic pain conditions. Eur J Pain. 2018;22(2):216–241.
   PubMed Web of Science ®Google Scholar
• Bornman PC, Marks IN, Girdwood AH, et al. Is pancreatic duct obstruction or stricture a major cause of pain in calcific pancreatitis? Br J Surg. 1980;67(6):425–428.
   PubMed Web of Science ®Google Scholar
• Philippe MF, Benabadji S, Barbot-Trystram L, et al. Pancreatic volume and endocrine and exocrine functions in patients with diabetes. Pancreas. 2011;40(3):359–363.
   PubMed Web of Science ®Google Scholar
• Walkowiak J, Herzig KH. Fecal elastase-1 is decreased in villous atrophy regardless of the underlying disease. Eur J Clin Invest. 2001;31(5):425–430.
   PubMed Web of Science ®Google Scholar
• Singh VK, Haupt ME, Geller DE, et al. Less common etiologies of exocrine pancreatic insufficiency. World J Gastroenterol. 2017;23(39):7059–7076.
   PubMed Web of Science ®Google Scholar