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Original Articles

Diagnostic and therapeutic challenge of unclassifiable enteropathies with increased intraepithelial CD103+ CD8+ T lymphocytes: a single center case series

, , ORCID Icon, ORCID Icon &
Pages 889-898 | Received 21 Feb 2021, Accepted 14 May 2021, Published online: 31 May 2021

References

  • Leonard MM, Lebwohl B, Rubio-Tapia A, et al. AGA clinical practice update on the evaluation and management of seronegative enteropathies: expert review. Gastroenterology. 2021;160(1):437–444.
  • Jorgensen SF, Reims HM, Frydenlund D, et al. A cross-sectional study of the prevalence of gastrointestinal symptoms and pathology in patients with common variable immunodeficiency. Am J Gastroenterol. 2016;111(10):1467–1475.
  • Venhoff N, Emmerich F, Neagu M, et al. The role of HLA DQ2 and DQ8 in dissecting celiac-like disease in common variable immunodeficiency. J Clin Immunol. 2013;33(5):909–916.
  • Smyrk TC. Practical approach to the flattened duodenal biopsy. Surg Pathol Clin. 2017;10(4):823–839.
  • Marthey L, Cadiot G, Seksik P, et al. Olmesartan-associated enteropathy: results of a national survey. Aliment Pharmacol Ther. 2014;40(9):1103–1109.
  • Schiepatti A, Sanders DS, Aziz I, et al. Clinical phenotype and mortality in patients with idiopathic small bowel villous atrophy: a dual-centre international study. Eur J Gastroenterol Hepatol. 2020;32(8):938–949.
  • Soderquist CR, Patel N, Murty VV, et al. Genetic and phenotypic characterization of indolent T-cell lymphoproliferative disorders of the gastrointestinal tract. Haematologica. 2020;105(7):1895–1906.
  • Akram S, Murray JA, Pardi DS, et al. Adult autoimmune enteropathy: Mayo Clinic Rochester experience. Clin Gastroenterol Hepatol. 2007;5(11):1282–1290.
  • DeGaetani M, Tennyson CA, Lebwohl B, et al. Villous atrophy and negative celiac serology: a diagnostic and therapeutic dilemma. Am J Gastroenterol. 2013;108(5):647–653.
  • Aziz I, Peerally MF, Barnes JH, et al. The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000–2015). Gut. 2017;66(9):1563–1572.
  • Masia R, Peyton S, Lauwers GY, et al. Gastrointestinal biopsy findings of autoimmune enteropathy: a review of 25 cases. Am J Surg Pathol. 2014;38(10):1319–1329.
  • Umetsu SE, Brown I, Langner C, et al. Autoimmune enteropathies. Virchows Arch. 2018;472(1):55–66.
  • Chander U, Leeman-Neill RJ, Bhagat G. Pathogenesis of enteropathy-associated T cell lymphoma. Curr Hematol Malig Rep. 2018;13(4):308–317.
  • Ciccocioppo R, Croci GA, Biagi F, et al. Intestinal T-cell lymphoma with enteropathy-associated T-cell lymphoma-like features arising in the setting of adult autoimmune enteropathy. Hematol Oncol. 2018;36(2):481–488.
  • Malamut G, Verkarre V, Callens C, et al. Enteropathy-associated T-cell lymphoma complicating an autoimmune enteropathy. Gastroenterology. 2012;142(4):726–729 e3.
  • Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127(20):2375–2390.
  • Vivas S, Ruiz de Morales JM, Ramos F, et al. Alemtuzumab for refractory celiac disease in a patient at risk for enteropathy-associated T-cell lymphoma. N Engl J Med. 2006;354(23):2514–2515.
  • Swamy M, Jamora C, Havran W, et al. Epithelial decision makers: in search of the 'epimmunome. Nat Immunol. 2010;11(8):656–665.
  • Workel HH, Komdeur FL, Wouters MC, et al. CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma. Eur J Cancer. 2016;60:1–11.
  • Ishibashi H, Nimura S, Ishitsuka K, et al. High expression of intestinal homing receptor CD103 in adult T-cell leukemia/lymphoma, similar to 2 other CD8+ T-cell lymphomas. Am J Surg Pathol. 2016;40(4):462–470.
  • Zundler S, Becker E, Spocinska M, et al. Hobit- and Blimp-1-driven CD4(+) tissue-resident memory T cells control chronic intestinal inflammation. Nat Immunol. 2019;20(3):288–300.
  • Zundler S, Schillinger D, Fischer A, et al. Blockade of alphaEbeta7 integrin suppresses accumulation of CD8(+) and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo. Gut. 2017;66(11):1936–1948.
  • Zundler S, Neurath MF. Novel insights into the mechanisms of gut homing and antiadhesion therapies in inflammatory bowel diseases. Inflamm Bowel Dis. 2017;23(4):617–627.
  • Vermeire S, O'Byrne S, Keir M, et al. Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial. Lancet. 2014;384(9940):309–318.
  • Tew GW, Hackney JA, Gibbons D, et al. Association between response to etrolizumab and expression of integrin alphaE and granzyme A in colon biopsies of patients with ulcerative colitis. Gastroenterology. 2016;150(2):477–487 e9.
  • Villanacci V, Lougaris V, Ravelli A, et al. Clinical manifestations and gastrointestinal pathology in 40 patients with autoimmune enteropathy. Clin Immunol. 2019;207:10–17.
  • Hill SM, Milla PJ, Bottazzo GF, et al. Autoimmune enteropathy and colitis: is there a generalised autoimmune gut disorder? Gut. 1991;32(1):36–42.
  • Casis B, Fernandez-Vazquez I, Barnardos E, et al. Autoimmune enteropathy in an adult with autoimmune multisystemic involvement. Scand J Gastroenterol. 2002;37(9):1012–1016.
  • Sharma A, Choung RS, Wang XJ, et al. Features of adult autoimmune enteropathy compared with refractory celiac disease. Clin Gastroenterol Hepatol. 2018;16(6):877–883 e1.
  • Robbins G, Tracht J, Davis D, et al. New treatment option for autoimmune enteropathy: a rare case of intractable diarrhea treated with vedolizumab. ACG Case Rep J. 2018;5:e92.

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