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Original Article

Elevated D-Dimer levels correlate with the development of hepatorenal syndrome and a poor outcome in patients with cirrhosis

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Pages 1486-1493 | Received 25 Mar 2022, Accepted 01 Jul 2022, Published online: 14 Jul 2022

References

  • O'Leary JG, Greenberg CS, Patton HM, et al. AGA clinical practice update: coagulation in cirrhosis. Gastroenterology. 2019;157(1):34–43 e31.
  • Tanaka KA, Key NS, Levy JH. Blood coagulation: hemostasis and thrombin regulation. Anesth Analg. 2009;108(5):1433–1446.
  • Zermatten MG, Fraga M, Moradpour D, et al. Hemostatic alterations in patients with cirrhosis: from primary hemostasis to fibrinolysis. Hepatology. 2020;71(6):2135–2148.
  • Tripodi A, Primignani M, Chantarangkul V, et al. An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis. Gastroenterology. 2009;137(6):2105–2111.
  • Davenport A, Sheikh MF, Lamb E, et al. Acute kidney injury in acute-on-chronic liver failure: where does hepatorenal syndrome fit? Kidney Int. 2017;92(5):1058–1070.
  • Egerod Israelsen M, Gluud LL, Krag A. Acute kidney injury and hepatorenal syndrome in cirrhosis. J Gastroenterol Hepatol. 2015;30(2):236–243.
  • Belcher JM, Sanyal AJ, Peixoto AJ, et al. Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury. Hepatology. 2014;60(2):622–632.
  • Moller S, Bendtsen F. The pathophysiology of arterial vasodilatation and hyperdynamic circulation in cirrhosis. Liver Int. 2018;38(4):570–580.
  • Villanueva C, Lopez-Balaguer JM, Aracil C, et al. Maintenance of hemodynamic response to treatment for portal hypertension and influence on complications of cirrhosis. J Hepatol. 2004;40(5):757–765.
  • Stahl E, Karlberg BE, Rammer L. Fibrin deposition in the kidney and renal blood flow during intravascular coagulation in the rat: influence of the renin-angiotensin system. Clin Sci. 1982;62(1):35–41.
  • Zanetto A, Rinder HM, Campello E, et al. Acute kidney injury in decompensated cirrhosis is associated with both hypo-coagulable and hyper-coagulable features. Hepatology. 2020;72(4):1327–1340.
  • Xu Z, Cheng B, Fu S, et al. Coagulative biomarkers on admission to the ICU predict acute kidney injury and mortality in patients with septic shock caused by intra-abdominal infection. Infect Drug Resist. 2019;12:2755–2764.
  • Hingorani SR, Seidel K, Pao E, et al. Markers of coagulation activation and acute kidney injury in patients after hematopoietic cell transplantation. Bone Marrow Transplant. 2015;50(5):715–720.
  • Bhatraju PK, Zelnick LR, Herting J, et al. Identification of acute kidney injury subphenotypes with differing molecular signatures and responses to vasopressin therapy. Am J Respir Crit Care Med. 2019;199(7):863–872.
  • [Chinese guidelines on the management of liver cirrhosis]. Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology. 2019;27:846–865.
  • Simonetto DA, Gines P, Kamath PS. Hepatorenal syndrome: pathophysiology, diagnosis, and management. BMJ. 2020;370:m2687.
  • Nayak SL, Maiwall R, Nandwani A, et al. Management of acute kidney injury in cirrhosis. Hepatol Int. 2013;7(3):813–819.
  • Angeli P, Garcia-Tsao G, Nadim MK, et al. News in pathophysiology, definition and classification of hepatorenal syndrome: a step beyond the international club of ascites (Ica) consensus document. J Hepatol. 2019;71(4):811–822.
  • Angeli P, Gines P, Wong F, et al. Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the international club of ascites. J Hepatol. 2015;62(4):968–974.
  • Mindikoglu AL, Pappas SC. New developments in hepatorenal syndrome. Clin Gastroenterol Hepatol. 2018;16(2):162–177 e161.
  • Amin AA, Alabsawy EI, Jalan R, et al. Epidemiology, pathophysiology, and management of hepatorenal syndrome. Semin Nephrol. 2019;39(1):17–30.
  • Matsuo S, Yasuda Y, Imai E, et al. Current status of estimated glomerular filtration rate (eGFR) equations for Asians and an approach to create a common eGFR equation. Nephrology. 2010;15(Suppl 2):45–48.
  • Adam EH, Mohlmann M, Herrmann E, et al. Assessment of hemostatic profile in patients with mild to advanced liver cirrhosis. WJG. 2020;26(17):2097–2110.
  • Agarwal B, Gatt A, Riddell A, et al. Hemostasis in patients with acute kidney injury secondary to acute liver failure. Kidney Int. 2013;84(1):158–163.
  • Cheung KL, Bouchard BA, Cushman M. Venous thromboembolism, factor VIII and chronic kidney disease. Thromb Res. 2018;170:10–19.
  • Catella J, Bertoletti L, Mismetti P, et al. Severe renal impairment and risk of bleeding during anticoagulation for venous thromboembolism. J Thromb Haemost. 2020;18(7):1728–1737.
  • Lan-Ting H, You-Ming C, Li-Xin W, et al. Clinicopathological factors for tubulointerstitial injury in lupus nephritis. Clin Rheumatol. 2020;39(5):1617–1626.
  • Luo E, Wang D, Liu B, et al. The value of d-Dimer level in predicting contrast-induced acute kidney injury in patients with acute ST-Segment elevation myocardial infarction after PCI. Clin Appl Thromb Hemost. 2020;26:1076029620944492.
  • Lin KY, Chen HC, Jiang H, et al. Predictive value of admission D-dimer for contrast-induced acute kidney injury and poor outcomes after primary percutaneous coronary intervention. BMC Nephrol. 2020;21(1):90.
  • Wang B, Jiang Q, Wu X. Association of D-dimers with acute kidney injury in pregnant women: a retrospective study. J Int Med Res. 2020;48(11):300060520966899.
  • Wardle EN, Taylor G. Fibrin breakdown products and fibrinolysis in renal disease. J Clin Pathol. 1968;21(2):140–146.
  • Suarez-Alvarez B, Liapis H, Anders HJ. Links between coagulation, inflammation, regeneration, and fibrosis in kidney pathology. Lab Invest. 2016;96(4):378–390.
  • Levi M, van der Poll T. Inflammation and coagulation. Crit Care Med. 2010;38(2 Suppl):S26–S34.
  • Boesen EI, Krishnan KR, Pollock JS, et al. ETA activation mediates angiotensin II-induced infiltration of renal cortical T cells. J Am Soc Nephrol. 2011;22(12):2187–2192.
  • Alehagen U, Aaseth J, Lindahl TL, et al. Dietary supplementation with selenium and coenzyme Q10 prevents increase in plasma D-Dimer while lowering cardiovascular mortality in an elderly Swedish population. Nutrients. 2021;13(4):1344.
  • Lange CM. Systemic inflammation in hepatorenal syndrome – a target for novel treatment strategies? Liver Int. 2019;39(7):1199–1201.
  • Sole C, Sola E, Huelin P, et al. Characterization of inflammatory response in hepatorenal syndrome: relationship with kidney outcome and survival. Liver Int. 2019;39(7):1246–1255.
  • Kalambokis GN, Tsiakas I, Christaki M, et al. Systemic hemodynamic response to terlipressin predicts development of hepatorenal syndrome and survival in advanced cirrhosis. Eur J Gastroenterol Hepatol. 2018;30(6):659–667.
  • Zhang S, He LL, Wang XH, et al. A novel scoring model for predicting mortality risk in patients with cirrhosis and hepatorenal syndrome. Eur J Gastroenterol Hepatol. 2018;30(8):938–943.
  • Park J, Kim SU, Choi HJ, et al. Predictive role of the D-Dimer level in acute kidney injury in living donor liver transplantation: a retrospective observational cohort study. J Clin Med. 2022;11:450.

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