1,524
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Cognitive function in patients with irritable bowel syndrome: impairment is common and only weakly correlated with depression/anxiety and severity of gastrointestinal symptoms

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 25-33 | Received 06 Jul 2023, Accepted 01 Sep 2023, Published online: 20 Sep 2023

References

  • Sperber AD, Bangdiwala SI, Drossman DA, et al. Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome Foundation Global Study. Gastroenterology. 2021;160(1):99–114.e3.
  • Drossman DA, Hasler WL. Rome IV – functional GI disorders: disorders of gut-brain interaction. Gastroenterology. 2016;150(6):1257–1261.
  • Black CJ, Ng CE, Goodoory VC, et al. Novel symptom subgroups in individuals with irritable bowel syndrome predict disease impact and burden. Clin Gastroenterol Hepatol. 2023. Epub ahead of print.
  • Lam NCY, Yeung HY, Li WK, et al. Cognitive impairment in irritable bowel syndrome (IBS): a systematic review. Brain Res. 2019;1719(January):274–284.
  • Hu Z, Li M, Yao L, et al. The level and prevalence of depression and anxiety among patients with different subtypes of irritable bowel syndrome: a network meta-analysis. BMC Gastroenterol. 2021;21(1):23.
  • Tarar ZI, Farooq U, Zafar Y, et al. Burden of anxiety and depression among hospitalized patients with irritable bowel syndrome: a nationwide analysis. Ir J Med Sci. 2023. Epub ahead of print.
  • Kinsinger SW. Cognitive-behavioral therapy for patients with irritable bowel syndrome: current insights. Psychol Res Behav Manage. 2017;10:231–237.
  • Eijsbouts C, Zheng T, Kennedy NA, et al. Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders. Nat Genet. 2021;53(11):1543–1552.
  • Elsenbruch S. Abdominal pain in irritable bowel syndrome: a review of putative psychological, neural and neuro-immune mechanisms. Brain Behav Immun. 2011;25(3):386–394.
  • Mayer EA, Labus J, Aziz Q, et al. Role of brain imaging in disorders of brain-gut interaction: a Rome Working Team Report. Gut. 2019;68(9):1701–1715.
  • Hong JY, Naliboff B, Labus JS, et al. Altered brain responses in subjects with irritable bowel syndrome during cued and uncued pain expectation. Neurogastroenterol Motil. 2016;28(1):127–138.
  • Rogers GB, Keating DJ, Young RL, et al. From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways. Mol Psychiatry. 2016;21(6):738–748.
  • Mayer EA, Tillisch K, Gupta A. Gut/brain axis and the microbiota. J Clin Invest. 2015;125(3):926–938.
  • Mayer EA, Ryu HJ, Bhatt RR. The neurobiology of irritable bowel syndrome. Mol Psychiatry. Published online February 2023;28(4):1451–1465.
  • Labus JS, Hollister EB, Jacobs J, et al. Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome. Microbiome. 2017;5(1):49.
  • Wong KMF, Yuen SSY, Mak ADP. Neurocognitive characteristics of individuals with irritable bowel syndrome. East Asian Arch Psychiatry. 2019;29(2):48–56.
  • Blankstein U, Chen J, Diamant NE, et al. Altered brain structure in irritable bowel syndrome: potential contributions of pre-existing and disease-driven factors. Gastroenterology. 2010;138(5):1783–1789.
  • Nan J, Yang W, Meng P, et al. Changes of the postcentral cortex in irritable bowel syndrome patients. Brain Imaging Behav. 2020;14(5):1566–1576.
  • Seminowicz DA, Labus JS, Bueller JA, et al. Regional gray matter density changes in brains of patients with irritable bowel syndrome. Gastroenterology. 2010;139(1):48–57.e2.
  • Ma X, Li S, Tian J, et al. Altered brain spontaneous activity and connectivity network in irritable bowel syndrome patients: a resting-state fMRI study. Clin Neurophysiol. 2015;126(6):1190–1197.
  • Qi R, Liu C, Ke J, et al. Abnormal amygdala resting-state functional connectivity in irritable bowel syndrome. AJNR Am J Neuroradiol. 2016;37(6):1139–1145.
  • Aizawa E, Sato Y, Kochiyama T, et al. Altered cognitive function of prefrontal cortex during error feedback in patients with irritable bowel syndrome, based on fMRI and dynamic causal modeling. Gastroenterology. 2012;143(5):1188–1198.
  • Bagga D, Reichert JL, Koschutnig K, et al. Probiotics drive gut microbiome triggering emotional brain signatures. Gut Microbes. 2018;9(6):486–496.
  • Lew LC, Hor YY, Yusoff NAA, et al. Probiotic Lactobacillus plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults: a randomised, double-blind, placebo-controlled study. Clin Nutr. 2019;38(5):2053–2064.
  • Tillisch K, Labus J, Kilpatrick L, et al. Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology. 2013;144(7):1394–1401.e4.
  • Rao SSC, Rehman A, Yu S, et al. Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis article. Clin Transl Gastroenterol. 2018;9(6):162.
  • Tooley KL. Effects of the human gut microbiota on cognitive performance, brain structure and function: a narrative review. Nutrients. 2020;12(10):3009.
  • Salami M. Interplay of good bacteria and central nervous system: cognitive aspects and mechanistic considerations. Front Neurosci. 2021;15:613120.
  • Lundervold AJ, Hillestad EMR, Lied GA, et al. Assessment of self-reported executive function in patients with irritable bowel syndrome using a machine-learning framework. J Clin Med. 2023;12(11):3771.
  • Lee SP, Sung IK, Kim JH, et al. The effect of emotional stress and depression on the prevalence of digestive diseases. J Neurogastroenterol Motil. 2015;21(2):273–282.
  • Zamani M, Alizadeh-Tabari S, Zamani V. Systematic review with meta-analysis: the prevalence of anxiety and depression in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 2019;50(2):132–143.
  • Simpson CA, Mu A, Haslam N, et al. Feeling down? A systematic review of the gut microbiota in anxiety/depression and irritable bowel syndrome. J Affect Disord. 2020;266:429–446.
  • Mudyanadzo TA, Hauzaree C, Yerokhina O, et al. Irritable bowel syndrome and depression: a shared pathogenesis. Cureus. Published online August 2018;10(8):e3178.
  • Liu Y, Zhang L, Wang X, et al. Similar fecal microbiota signatures in patients with diarrhea-predominant irritable bowel syndrome and patients with depression. Clin Gastroenterol Hepatol. 2016;14(11):1602–1611.e5.
  • Randolph C, Tierney MC, Mohr E, et al. The repeatable battery for the assessment of neuropsychological status (RBANS): preliminary clinical validity. J Clin Exp Neuropsychol. 1998;20(3):310–319.
  • Berentsen B, Nagaraja BH, Teige EP, et al. Study protocol of the Bergen brain-gut-microbiota-axis study. Medicine (Baltimore). 2020;99(37):e21950. No(e21950)(July).
  • Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–370.
  • Francis CY, Morris J, Whorwell PJ. The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress. Aliment Pharmacol Ther. 1997;11(2):395–402.
  • Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillside (NJ): Lawrence Erlbaum; 1988.
  • Moore DJ, Eccleston C, Keogh E. Cognitive load selectively influences the interruptive effect of pain on attention. Pain. 2017;158(10):2035–2041.
  • Moriarty O, McGuire BE, Finn DP. The effect of pain on cognitive function: a review of clinical and preclinical research. Prog Neurobiol. 2011;93(3):385–404.
  • Patrick KS, Sanborn V, Gunstad J, et al. Poorer cognitive performance is associated with gastrointestinal symptoms in otherwise healthy young adults. Dig Dis. 2023;41(1):74–79.
  • Sugaya N, Shirotsuki K, Nakao M. Cognitive behavioral treatment for irritable bowel syndrome: a recent literature review. Biopsychosoc Med. 2021;15(1):23.
  • Sarter L, Heider J, Kirchner L, et al. Cognitive and emotional variables predicting treatment outcome of cognitive behavior therapies for patients with medically unexplained symptoms: a meta-analysis. J Psychosom Res. 2021;146:110486.
  • Leeming ER, Johnson AJ, Spector TD, et al. Effect of diet on the gut microbiota: rethinking intervention duration. Nutrients. 2019;11(12):2862.
  • Thaiss CA, Zeevi D, Levy M, et al. Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell. 2014;159(3):514–529.
  • Raudeberg R, Iverson G L, Hammar Å. Norms matter: U.S. normative data under-estimate cognitive deficits in Norwegians with schizophrenia spectrum disorders. Clin Neuropsychol. 2019;33(sup1):58–74.