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Research Article

Matrix gla protein, a potential marker of tissue remodelling and physiological ageing of the gut in crohn’s disease

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Pages 296-303 | Received 07 Jul 2023, Accepted 19 Nov 2023, Published online: 24 Nov 2023

References

  • Cosnes J, Cattan S, Blain A, et al. Long-term evolution of disease behavior of crohn’s disease. Inflamm Bowel Dis. 2002;8(4):244–250. doi:10.1097/00054725-200207000-00002.
  • Cosnes J, Gower–Rousseau C, Seksik P, et al. Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology. 2011;140(6):1785–1794.e4. doi:10.1053/j.gastro.2011.01.055.
  • Pariente B, Mary JY, Danese S, et al. Development of the lémann index to assess digestive tract damage in patients with crohn’s disease. Gastroenterology. 2015;148(1):52–63.e3. doi:10.1053/J.GASTRO.2014.09.015.
  • Klenske E, Bojarski C, Waldner M, et al. Targeting mucosal healing in crohn’s disease: what the clinician needs to know. Therap Adv Gastroenterol. 2019;12. doi:10.1177/1756284819856865.
  • Shah SC, Colombel JF, Sands BE, et al. Systematic review with meta-analysis: mucosal healing is associated with improved long-term outcomes in crohn’s disease. Aliment Pharmacol Ther. 2016;43(3):317–333. doi:10.1111/apt.13475.
  • Sandborn WJ, Hanauer S, Van Assche G, et al. Treating beyond symptoms with a view to improving patient outcomes in inflammatory bowel diseases. J Crohns Colitis. 2014;8(9):927–935. doi:10.1016/J.CROHNS.2014.02.021.
  • Neurath MF, Travis SPL. Mucosal healing in inflammatory bowel diseases: a systematic review. Gut. 2012;61(11):1619–1635. doi:10.1136/GUTJNL-2012-302830.
  • Rutgeerts P, Vermeire S, Van Assche G. Mucosal healing in inflammatory bowel disease: impossible ideal or therapeutic target? Gut. 2007;56(4):453–455. doi:10.1136/GUT.2005.088732.
  • Buisson A, Gonzalez F, Poullenot F, et al. Comparative acceptability and perceived clinical utility of monitoring tools: a nationwide survey of patients with inflammatory bowel disease. Inflamm Bowel Dis. 2017;23(8):1425–1433. doi:10.1097/MIB.0000000000001140.
  • Kim SY, Kim HS, Park HJ. Adverse events related to colonoscopy: global trends and future challenges. World J Gastroenterol. 2019;25(2):190–204. doi:10.3748/wjg.v25.i2.190.
  • State M, Voiosu T, Voiosu A, et al. Surrogate markers of mucosal healing in inflammatory bowel disease: a systematic review. World J Gastroenterol. 2021;27(16):1828–1840. doi:10.3748/wjg.v27.i16.1828.
  • Krzystek-Korpacka M, Kempiński R, Bromke M, et al. Biochemical biomarkers of mucosal healing for inflammatory bowel disease in adults. Diagnostics. 2020;10(6): 367. doi:10.3390/DIAGNOSTICS10060367.
  • Laserna-Mendieta EJ, Lucendo AJ. Faecal calprotectin in inflammatory bowel diseases: a review focused on meta-analyses and routine usage limitations. Clin Chem Lab Med. 2019;57(9):1295–1307. doi:10.1515/CCLM-2018-1063.
  • Labaere D, Smismans A, Van Olmen A, et al. Comparison of six different calprotectin assays for the assessment of inflammatory bowel disease. United European Gastroenterol J. 2014;2(1):30–37. doi:10.1177/2050640613518201.
  • Amcoff K, Stridsberg M, Lampinen M, et al. Clinical implications of assay specific differences in f-calprotectin when monitoring inflammatory bowel disease activity over time. Scand J Gastroenterol. 2017;52(3):344–350. doi:10.1080/00365521.2016.1256424.
  • Af Björkesten CG, Nieminen U, Turunen U, et al. Surrogate markers and clinical indices, alone or combined, as indicators for endoscopic remission in anti-TNF-treated luminal crohn’s disease. Scand J Gastroenterol. 2012;47(5):528–537. doi:10.3109/00365521.2012.660542.
  • Ma C, Battat R, Parker CE, et al. Update on C-reactive protein and fecal calprotectin: are they accurate measures of disease activity in crohn’s disease? Expert Rev Gastroenterol Hepatol. 2019;13(4):319–330. doi:10.1080/17474124.2019.1563481.
  • Pierre N, Salée C, Vieujean S, et al. Review article: distinctions between ileal and colonic crohn’s disease: from physiology to pathology. Aliment Pharmacol Ther. 2021;54(6):779–791. doi:10.1111/apt.16536.
  • Shimshoni E, Adir I, Afik R, et al. Distinct extracellular–matrix remodeling events precede symptoms of inflammation. Matrix Biol. 2021;96:47–68. doi:10.1016/j.matbio.2020.11.001.
  • Khokha R, Murthy A, Weiss A. Metalloproteinases and their natural inhibitors in inflammation and immunity. Nat Rev Immunol. 2013;13(9):649–665. doi:10.1038/nri3499.
  • Karamanos NK, Theocharis AD, Neill T, et al. Matrix modeling and remodeling: a biological interplay regulating tissue homeostasis and diseases. Matrix Biol. 2019;75-76:1–11. doi:10.1016/j.matbio.2018.08.007.
  • Shimshoni E, Yablecovitch D, Baram L, et al. ECM remodelling in IBD: innocent bystander or partner in crime? The emerging role of extracellular molecular events in sustaining intestinal inflammation. Gut. 2015;64(3):367–372. doi:10.1136/GUTJNL-2014-308048.
  • Dong XY, Wu MX, Zhang HM, et al. Association between matrix gla protein and ulcerative colitis according to DNA microarray data. Gastroenterol Rep. 2020;8(1):66–75. doi:10.1093/gastro/goz038.
  • Brnic D, Martinovic D, Zivkovic PM, et al. Inactive matrix gla protein is elevated in patients with inflammatory bowel disease. World J Gastroenterol. 2020;26(32):4866–4877. doi:10.3748/WJG.V26.I32.4866.
  • G F, D A, A V, et al. 3rd european evidence-based consensus on the diagnosis and management of crohn’s disease 2016: part 1: diagnosis and medical management. J Crohns Colitis. 2017;11(1):3–25. doi:10.1093/ECCO-JCC/JJW168.
  • Bitoun A, Blanchi A, Contou JF, et al. Development and validation of an endoscopic index of the severity for crohn’s disease: a prospective multicentre study. Groupe d’Etudes thérapeutiques des affections inflammatoires du tube digestif (GETAID). Gut. 1989;30(7):983–989. doi:10.1136/GUT.30.7.983.
  • Turner D, Ricciuto A, Lewis A, et al. STRIDE-II: an update on the selecting therapeutic targets in inflammatory bowel disease (STRIDE) initiative of the international organization for the study of IBD (IOIBD): determining therapeutic goals for treat-to-Target strategies in IBD. Gastroenterology. 2021;160(5):1570–1583. doi:10.1053/J.GASTRO.2020.12.031.
  • Cellier C, Sahmoud T, Froguel E, et al. Correlations between clinical activity, endoscopic severity, and biological parameters in colonic or ileocolonic crohn’s disease. A prospective multicentre study of 121 cases. The groupe d’Etudes therapeutiques des affections inflammatoires digestives. Gut. 1994;35(2):231–235. doi:10.1136/gut.35.2.231.
  • Schurgers LJ, Barreto DV, Barreto FC, et al. The circulating inactive form of matrix gla protein is a surrogate marker for vascular calcification in chronic kidney disease: a preliminary report. Clin J Am Soc Nephrol. 2010;5(4):568–575. doi:10.2215/CJN.07081009.
  • Puzantian H, Akers SR, Oldland G, et al. Circulating Dephospho-Uncarboxylated matrix gla-protein is associated with kidney dysfunction and arterial stiffness. Am J Hypertens. 2018;31(9):988–994. doi:10.1093/AJH/HPY079.
  • Thamratnopkoon S, Susantitaphong P, Tumkosit M, et al. Correlations of plasma desphosphorylated uncarboxylated matrix gla protein with vascular calcification and vascular stiffness in chronic kidney disease. Nephron. 2017;135(3):167–172. doi:10.1159/000453368.
  • Roumeliotis S, Dounousi E, Eleftheriadis T, et al. Association of the inactive circulating matrix gla protein with vitamin K intake, calcification, mortality, and cardiovascular disease: a review. Int J Mol Sci. 2019;20(3):628. doi:10.3390/IJMS20030628.
  • Delanaye P, Krzesinski JM, Warling X, et al. Dephosphorylated-uncarboxylated matrix gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients. BMC Nephrol. 2014;15(1):145. doi:10.1186/1471-2369-15-145.
  • Barrett H, O’Keeffe M, Kavanagh E, et al. Is matrix gla protein associated with vascular calcification? A systematic review. Nutrients. 2018;10(4):415. doi:10.3390/nu10040415.
  • Schlieper G, Westenfeld R, Krüger T, et al. Circulating nonphosphorylated carboxylated matrix gla protein predicts survival in ESRD. J Am Soc Nephrol. 2011;22(2):387–395. doi:10.1681/ASN.2010040339.
  • Jono S, Ikari Y, Vermeer C, et al. Matrix gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography. Thromb Haemost. 2004;91(4):790–794. doi:10.1160/th03-08-0572.
  • Silverberg MS, Satsangi J, Ahmad T, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a working party of the 2005 montreal world congress of gastroenterology. Can J Gastroenterol. 2005;19(Suppl A):5A–36A. doi:10.1155/2005/269076.
  • Pariente B, Torres J, Burisch J, et al. Validation and update of the lémann index to measure cumulative structural bowel damage in crohn’s disease. Gastroenterology. 2021;161(3):853–864.e13. doi:10.1053/J.GASTRO.2021.05.049.
  • Hardie WD, Korfhagen TR, Sartor MA, et al. Genomic profile of matrix and vasculature remodeling in TGF-α-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2007;37(3):309–321. doi:10.1165/rcmb.2006-0455OC.
  • Booth AJ, Hadley R, Cornett AM, et al. Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation. Am J Respir Crit Care Med. 2012;186(9):866–876. doi:10.1164/rccm.201204-0754OC.
  • De Brouwer B, Piscaer I, Von Der Thusen JH, et al. Should vitamin K be supplemented instead of antagonised in patients with idiopathic pulmonary fibrosis? Expert Rev Respir Med. 2018;12(3):169–175. doi:10.1080/17476348.2018.1424544.
  • Miyata KN, Nast CC, Dai T, et al. Renal matrix gla protein expression increases progressively with CKD and predicts renal outcome. Exp Mol Pathol. 2018;105(1):120–129. doi:10.1016/j.yexmp.2018.07.001.
  • Tveitarås MK, Skogstrand T, Leh S, et al. Matrix metalloproteinase-2 knockout and heterozygote mice are protected from hydronephrosis and kidney fibrosis after unilateral ureteral obstruction. PLoS One. 2015;10(12):e0143390. doi:10.1371/journal.pone.0143390.
  • Jerala M, Hauptman N, Kojc N, et al. Expression of fibrosis-related genes in liver and kidney fibrosis in comparison to inflammatory bowel diseases. Cells. 2022;11(3):314. doi:10.3390/cells11030314.
  • Piscaer I, van den Ouweland JMW, Vermeersch K, et al. Low vitamin K status is associated with increased elastin degradation in chronic obstructive pulmonary disease. J Clin Med. 2019;8(8):1116. doi:10.3390/jcm8081116.
  • Janssen R, Vermeer C. Vitamin K deficit and elastolysis theory in pulmonary elasto-degenerative diseases. Med Hypotheses. 2017;108:38–41. doi:10.1016/j.mehy.2017.07.029.
  • Maurice P, Blaise S, Gayral S, et al. Elastin fragmentation and atherosclerosis progression: the elastokine concept. Trends Cardiovasc Med. 2013;23(6):211–221. doi:10.1016/j.tcm.2012.12.004.
  • Robert L, Robert AM, Fülöp T. Rapid increase in human life expectancy: will it soon be limited by the aging of elastin? Biogerontology. 2008;9(2):119–133. doi:10.1007/s10522-007-9122-6.
  • Caluwé R, Verbeke F, De Vriese AS. Evaluation of vitamin K status and rationale for vitamin K supplementation in dialysis patients. Nephrol Dial Transplant. 2020;35(1):23–33. doi:10.1093/ndt/gfy373.
  • Schurgers LJ, Uitto J, Reutelingsperger CP. Vitamin K-dependent carboxylation of matrix gla-protein: a crucial switch to control ectopic mineralization. Trends Mol Med. 2013;19(4):217–226. doi:10.1016/j.molmed.2012.12.008.
  • Lee JS, Basalyga DM, Simionescu A, et al. Elastin calcification in the rat subdermal model is accompanied by up-regulation of degradative and osteogenic cellular responses. Am J Pathol. 2006;168(2):490–498. doi:10.2353/ajpath.2006.050338.
  • Mithieux SM, Weiss AS. Elastin. Adv Protein Chem. 2005;70:437–461. doi:10.1016/S0065-3233(05)70013-9.
  • Krasinski SD, Russell RM, Furie BC, et al. The prevalence of vitamin K deficiency in chronic gastrointestinal disorders. Am J Clin Nutr. 1985;41(3):639–643. doi:10.1093/ajcn/41.3.639.
  • Fabisiak N, Fabisiak A, Watala C, et al. Fat-soluble vitamin deficiencies and inflammatory bowel disease: systematic review and Meta-Analysis. J Clin Gastroenterol. 2017;51(10):878–889. doi:10.1097/MCG.0000000000000911.
  • Kuwabara A, Tanaka K, Tsugawa N, et al. High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease. Osteoporos Int. 2009;20(6):935–942. doi:10.1007/S00198-008-0764-2.
  • Zallot C, Quilliot D, Chevaux JB, et al. Dietary beliefs and behavior among inflammatory bowel disease patients. Inflamm Bowel Dis. 2013;19(1):66–72. doi:10.1002/IBD.22965.
  • Lucendo AJ, De Rezende LC. Importance of nutrition in inflammatory bowel disease. World J Gastroenterol. 2009;15(17):2081–2088. doi:10.3748/WJG.15.2081.
  • Gilbert KA, Rannels SR. Glucocorticoid effects on vitamin K-dependent carboxylase activity and matrix gla protein expression in rat lung. Am J Physiol Lung Cell Mol Physiol. 2003;285(3):L569–77. doi:10.1152/ajplung.00426.2002.
  • Wei FF, Huang QF, Zhang ZY, et al. Inactive matrix gla protein is a novel circulating biomarker predicting retinal arteriolar narrowing in humans. Sci Rep. 2018;8(1):15088. doi:10.1038/S41598-018-33257-6.
  • Pivin E, Ponte B, Pruijm M, et al. Inactive matrix gla-protein is associated with arterial stiffness in an adult Population-Based study. Hypertension. 2015;66(1):85–92. doi:10.1161/HYPERTENSIONAHA.115.05177.
  • Liabeuf S, Olivier B, Vemeer C, et al. Vascular calcification in patients with type 2 diabetes: the involvement of matrix gla protein. Cardiovasc Diabetol. 2014;13(1):85. doi:10.1186/1475-2840-13-85.
  • Wei FF, Thijs L, Zhang ZY, et al. The risk of nephrolithiasis is causally related to inactive matrix gla protein, a marker of vitamin K status: a mendelian randomization study in a flemish population. Nephrol Dial Transplant. 2018;33(3):514–522. doi:10.1093/NDT/GFX014.
  • Sardana M, Vasim I, Varakantam S, et al. Inactive matrix gla-protein and arterial stiffness in type 2 diabetes mellitus. Am J Hypertens. 2017;30(2):196–201. doi:10.1093/AJH/HPW146.
  • Dai L, Li L, Erlandsson H, et al. Functional vitamin K insufficiency, vascular calcification and mortality in advanced chronic kidney disease: a cohort study. PLoS One. 2021;16(2):e0247623. doi:10.1371/JOURNAL.PONE.0247623.
  • Viegas CSB, Costa RM, Santos L, et al. Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: implications for calcification-related chronic inflammatory diseases. PLoS One. 2017;12(5):e0177829. doi:10.1371/journal.pone.0177829.
  • Feng Y, Liao Y, Huang W, et al. Mesenchymal stromal cells-derived matrix gla protein contribute to the alleviation of experimental colitis article. Cell Death Dis. 2018;9(6):691. doi:10.1038/s41419-018-0734-3.
  • Schurgers LJ, Vermeer C. Determination of phylloquinone and menaquinones in food: effect of food matrix on circulating vitamin K concentrations. Haemostasis. 2000;30(6):298–307. doi:10.1159/000054147.

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